CN103932735A - Ultrasound attenuation coefficient compensating system and liver fat detecting system based on ultrasound - Google Patents
Ultrasound attenuation coefficient compensating system and liver fat detecting system based on ultrasound Download PDFInfo
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- CN103932735A CN103932735A CN201410027165.8A CN201410027165A CN103932735A CN 103932735 A CN103932735 A CN 103932735A CN 201410027165 A CN201410027165 A CN 201410027165A CN 103932735 A CN103932735 A CN 103932735A
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Abstract
The invention relates to an ultrasound attenuation coefficient compensating system and a liver fat detecting system based on ultrasound. An ultrasound generator emits the pulse ultrasound to the liver portion, an ultrasound receiver receives echo signals of the ultrasound, an ultrasound attenuation coefficient obtaining module obtains a liver echo attenuation coefficient, an ultrasound attenuation coefficient compensating module obtains a compensating value of the attenuation coefficient by setting up standard liver models with different thicknesses, measuring ultrasound attenuation coefficients of the standard liver models with the different thicknesses and comparing the measured ultrasound attenuation coefficients with the attenuation coefficient measured through an ultrasound attenuation formula, and the compensated ultrasound attenuation coefficient is obtained through the compensating value. The liver fat detecting system obtains a liver fat content formula through linear correlation. According to the technical scheme, the ultrasound attenuation coefficient compensating system and the liver fat detecting system are simple, convenient to use, practical, accurate and reliable.
Description
Technical field
The present invention relates to a kind of ultrasonic attenuation coefficient bucking-out system and liver fat detection system based on ultrasonic, relate in particular to a kind of ultrasonic attenuation coefficient bucking-out system based on ultrasonic frequency and the liver fat detection system based on decay and fat content relation.
Background technology
Along with the development of ultrasonic technique, utilize the development of ultrasonic technique and medical skill, the requirement that hepatic lesions is carried out to noninvasive test more and more becomes the emphasis of research.Prior art detects and how to estimate qualitatively by ultrasonoscopy for liver fat, also there is the research of carrying out ultrasonic attenuation coefficient and carry out quantitative analysis, but due to for somatometry, in ultrasonic attenuation coefficient computational process, there is the impact of scattering and diffraction, therefore, be difficult to determine its compensation method.Therefore, in liver fat quantitative detection system, relatively effective method few.
Summary of the invention
The technical problem that the present invention solves is: build a kind of ultrasonic attenuation coefficient bucking-out system and liver fat detection system based on ultrasonic, overcome prior art and lack compared with the technical problem of effective method in calculating ultrasonic attenuation coefficient is difficult to have compensation and hepatic fat content testing process.
Technical scheme of the present invention is: build a kind of ultrasonic attenuation coefficient bucking-out system based on ultrasonic, comprise supersonic generator, ultrasonic receiver, ultrasonic attenuation coefficient acquisition module, ultrasonic attenuation coefficient compensating module, liver fat detection module, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, and described ultrasonic attenuation coefficient acquisition module obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, f
c(t) mid frequency of expression ultrasonic signal, t express time, c represents the spread speed of ultrasound wave in liver; Described ultrasonic attenuation coefficient compensating module is by setting up the standard liver die body of different-thickness, contrast and obtain its offset by measuring attenuation quotient that the ultrasonic attenuation coefficient of this different-thickness standard liver die body and above-mentioned ultrasonic attenuation coefficient formula measure, obtain the ultrasonic attenuation coefficient after compensation by offset.
Further technical scheme of the present invention is: the frequency of described ultrasonic signal is ultrasonic signal mid frequency.
Further technical scheme of the present invention is: described ultrasonic attenuation coefficient is relevant to the thickness of thing to be detected.
Further technical scheme of the present invention is: described ultrasonic attenuation coefficient compensating module, by repeatedly measuring and obtain ultrasonic attenuation coefficient, is got its meansigma methods.
Technical scheme of the present invention is: build a kind of liver fat detection system based on ultrasonic, comprise supersonic generator, ultrasonic receiver, ultrasonic attenuation coefficient acquisition module, ultrasonic attenuation coefficient compensating module, liver fat detection module, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, and described ultrasonic attenuation coefficient acquisition module obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, f
c(t) mid frequency of expression ultrasonic signal, t express time, c represents the spread speed of ultrasound wave in liver; Described ultrasonic attenuation coefficient compensating module is by setting up the standard liver die body of different-thickness, contrast and obtain its offset by measuring attenuation quotient that the ultrasonic attenuation coefficient of this different-thickness standard liver die body and above-mentioned ultrasonic attenuation coefficient formula measure, obtain the ultrasonic attenuation coefficient after compensation by offset, described liver fat detection module is set up the corresponding relation of hepatic fat content and ultrasonic attenuation coefficient by measurement, obtain hepatic fat content according to the ultrasonic attenuation coefficient after compensation.
Further technical scheme of the present invention is: by repeatedly measuring hepatic fat content and ultrasonic attenuation coefficient, set up the corresponding lists of hepatic fat content and ultrasonic attenuation coefficient.
Further technical scheme of the present invention is: also comprise denoising module, described denoising module is removed noise signal to the ultrasonic signal receiving.
Technical scheme of the present invention is: build a kind of liver fat detection system based on ultrasonic, comprise supersonic generator, ultrasonic receiver, ultrasonic attenuation coefficient acquisition module, obtain Liver and kidney echo intensity than the strength ratio acquisition module of H, liver fat detection module, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, and described ultrasonic attenuation coefficient acquisition module obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, f
c(t) mid frequency of expression ultrasonic signal, t express time, c represents the spread speed of ultrasound wave in liver; Described liver fat detection module obtains hepatic fat content according to following formula: S=63H+168a-28, and wherein S represents hepatic fat content, a represents liver echo attenuation coefficient.
Further technical scheme of the present invention is: also comprise denoising module, described denoising module is removed noise signal to the ultrasonic signal receiving.
Technique effect of the present invention is: build a kind of ultrasonic attenuation coefficient bucking-out system and liver fat detection system based on ultrasonic, comprise supersonic generator, ultrasonic receiver, ultrasonic attenuation coefficient acquisition module, ultrasonic attenuation coefficient compensating module, liver fat detection module, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, described ultrasonic attenuation coefficient compensating module is by setting up the standard liver die body of different-thickness, contrast and obtain its offset by measuring attenuation quotient that the ultrasonic attenuation coefficient of this different-thickness standard liver die body and above-mentioned ultrasonic attenuation coefficient formula measure, obtain the ultrasonic attenuation coefficient after compensation by offset.Described liver fat detection system obtains hepatic fat content formula by its linear correlation.Described liver fat detection system is also by setting up the thickness compensation that carries out of 3D standard die body, thus the ultrasonic attenuation coefficient after being compensated, then according to setting up one-to-one relationship, thereby obtain fat content corresponding to ultrasonic attenuation coefficient.The brightness of image level value that the art of this patent scheme obtains by the ultrasound echo signal of liver, calculates liver echo attenuation coefficient more accurately, then by Liver and kidney echo intensity to when liver echo attenuation coefficient to liver fat detection by quantitative.Facilitate simple and practical, accurately and reliably.
Brief description of the drawings
Fig. 1 is the structural representation of a kind of ultrasonic attenuation coefficient bucking-out system of the present invention.
Fig. 2 is the structural representation of a kind of detection system of the present invention.
Fig. 3 is the structural representation of another kind of detection system of the present invention.
Detailed description of the invention
Below in conjunction with specific embodiment, technical solution of the present invention is further illustrated.
As shown in Figure 1, the specific embodiment of the present invention is: build a kind of ultrasonic attenuation coefficient bucking-out system based on ultrasonic, comprise supersonic generator 1, ultrasonic receiver 2, ultrasonic attenuation coefficient acquisition module 4, ultrasonic attenuation coefficient compensating module, liver fat detection module 6, described supersonic generator 1 is to liver position emission pulse ultrasonic, described ultrasonic receiver 2 receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module 4 obtains liver echo attenuation coefficient, described ultrasonic attenuation coefficient acquisition module 4 obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, f
c(t) mid frequency of expression ultrasonic signal, t express time, c represents the spread speed of ultrasound wave in liver, described ultrasonic attenuation coefficient compensating module is by setting up the standard liver die body of different-thickness, contrast and obtain its offset by measuring attenuation quotient that the ultrasonic attenuation coefficient of this different-thickness standard liver die body and above-mentioned ultrasonic attenuation coefficient formula measure, obtain the ultrasonic attenuation coefficient after compensation by offset.
In specific embodiment, described ultrasonic attenuation coefficient acquisition module 4 obtains liver echo attenuation coefficient, and described ultrasonic attenuation coefficient acquisition module 4 obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, fc (t) represents the mid frequency of ultrasonic signal, t express time.
The ultrasonic signal that is gaussian-shape by frequency spectrum transmits known in tissue: hyperacoustic echo intensity is exponential damping in certain medium, that is:
V
t=V
0×e
-afct
Wherein: V
trepresent hyperacoustic echo power spectrum density, V
0represent hyperacoustic initial echo power spectrum density, a represents attenuation quotient, and c represents ultrasonic velocity, and t represents the transmission time, and f represents the mid frequency of ultrasonic signal.
And the ultrasonic spectral of definition power n is as follows:
M
n(t)=∫ f
n| V
t| df, wherein, M
n(t) integration of the product that represents hyperacoustic power and frequency n power to frequency.
, M
n(t)=∫ V
0× e
-afctdf.
Mid frequency is:
Mid frequency variable is:
By deriving of integral sign, obtain:
Ultrasonic attenuation coefficient a:.
Described ultrasonic attenuation coefficient compensating module is by setting up the standard liver die body of different-thickness, contrast and obtain its offset by measuring attenuation quotient that the ultrasonic attenuation coefficient of this different-thickness standard liver die body and above-mentioned ultrasonic attenuation coefficient formula measure, obtain the ultrasonic attenuation coefficient after compensation by offset.
Specific implementation process is as follows: because ultrasonic attenuation coefficient is the function in ultrasonic velocity and transmission time,, and the amassing as transmission range of ultrasonic velocity and transmission time, and in its transmission range, relate to the thickness of liver therefore, therefore, ultrasonic attenuation coefficient is relevant with the thickness of liver.Therefore, set up the standard liver die body of different-thickness.
Measure the ultrasonic attenuation coefficient of this standard liver die body, can adopt the ultrasonic attenuation coefficient of this standard liver die body of transmission measurement, then with determine corresponding speed and the ultrasonic attenuation coefficient in transmission time under mid frequency by this formula, by relatively, obtain its offset.By setting up the ultrasonic attenuation coefficient offset of multiple liver thickness, comprise the ultrasonic attenuation coefficient compensation of multi-thickness liver, then by this compensation corresponding relation of setting up, make the ultrasonic attenuation coefficient of multiple liver obtain compensation, obtain the ultrasonic attenuation coefficient after compensation by offset.In specific embodiment, described ultrasonic attenuation coefficient compensating module, by repeatedly measuring and obtain ultrasonic attenuation coefficient, is got its meansigma methods.In specific embodiment, also comprise denoising module 7, described denoising module 7 is removed noise signal to the ultrasonic signal receiving.
As shown in Figure 2, the specific embodiment of the present invention is: build a kind of liver fat detection system based on ultrasonic, comprise supersonic generator 1, ultrasonic receiver 2, ultrasonic attenuation coefficient acquisition module 4, ultrasonic attenuation coefficient compensating module, liver fat detection module 6, described supersonic generator 1 is to liver position emission pulse ultrasonic, described ultrasonic receiver 2 receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module 4 obtains liver echo attenuation coefficient, described ultrasonic attenuation coefficient acquisition module 4 obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, f
c(t) mid frequency of expression ultrasonic signal, t express time, c represents the spread speed of ultrasound wave in liver, described ultrasonic attenuation coefficient compensating module is by setting up the standard liver die body of different-thickness, contrast and obtain its offset by measuring attenuation quotient that the ultrasonic attenuation coefficient of this different-thickness standard liver die body and above-mentioned ultrasonic attenuation coefficient formula measure, obtain the ultrasonic attenuation coefficient after compensation by offset, described liver fat detection module 6 is set up the corresponding relation of hepatic fat content and ultrasonic attenuation coefficient by measurement, obtain hepatic fat content according to the ultrasonic attenuation coefficient after compensation.
Specific embodiment of the invention process is: described liver fat detection module 6 is set up the corresponding relation of hepatic fat content and ultrasonic attenuation coefficient by measurement, obtains hepatic fat content according to the ultrasonic attenuation coefficient after compensation.Adopt [
1h] in the experiment of hepatic fat content measured of NMR (Nuclear Magnetic Resonance) spectrum, known ultrasonic Liver and kidney echo ratio and ultrasonic liver echo attenuation coefficient and hepatic fat content are linear.Thus, hepatic fat content and ultrasonic attenuation coefficient linear correlation, by measuring the fat content under multiple attenuation quotient, set up its one-to-one relationship, then according to calculating the ultrasonic attenuation coefficient obtaining, can obtain according to this ultrasonic attenuation coefficient of liver the fat content of this liver.In specific embodiment, by repeatedly measuring hepatic fat content and ultrasonic attenuation coefficient, set up the corresponding lists of hepatic fat content and ultrasonic attenuation coefficient.In specific embodiment, also comprise denoising module 7, described denoising module 7 is removed noise signal to the ultrasonic signal receiving.
As shown in Figure 3, the specific embodiment of the present invention is: build a kind of liver fat detection system based on ultrasonic, comprise supersonic generator 1, ultrasonic receiver 2, ultrasonic attenuation coefficient acquisition module 4, obtain Liver and kidney echo intensity than the strength ratio acquisition module 5 of H, liver fat detection module 6, described supersonic generator 1 is to liver position emission pulse ultrasonic, described ultrasonic receiver 2 receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module 4 obtains liver echo attenuation coefficient, described ultrasonic attenuation coefficient acquisition module 4 obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, f
c(t) mid frequency of expression ultrasonic signal, t express time, c represents the spread speed of ultrasound wave in liver, described liver fat detection module 6 obtains hepatic fat content according to following formula: S=63H+168a-28, and wherein S represents hepatic fat content, a represents liver echo attenuation coefficient.In specific embodiment, also comprise denoising module 7, described denoising module 7 is removed noise signal to the ultrasonic signal receiving.
Adopt [
1h] in the experiment of hepatic fat content measured of NMR (Nuclear Magnetic Resonance) spectrum, ultrasonic Liver and kidney echo ratio is the strongest to the predictive ability of hepatic fat content.By [
1h] experiment of hepatic fat content measured of NMR (Nuclear Magnetic Resonance) spectrum, known ultrasonic Liver and kidney echo ratio and ultrasonic liver echo attenuation coefficient and hepatic fat content are linear, by introducing 3D simulation human abdomen model, ultrasonic Liver and kidney echo ratio and liver echo attenuation coefficient are carried out to standardization, by adopting multiple linear regression analysis screening from the using ultrasonic quantitative index of each body measurement parameter and markization to can be used for estimating the main quantitative parameter of liver fat.Concrete acquisition methods is: first set up the linear equation about ultrasonic Liver and kidney echo ratio and ultrasonic liver echo attenuation coefficient and hepatic fat content, that is: and C=xH+ya+z, wherein, x, y, z is linear equation coefficient.Simulate human abdomen's models for several times by 3D and measure hepatic fat content, ultrasonic Liver and kidney echo ratio and ultrasonic liver echo attenuation coefficient, get its meansigma methods, can obtain linear equation coefficient x, y, z, wherein, linear equation coefficient x, y, z is also quantitative parameter, forms hepatic fat content computing formula by these quantitative parameters and liver echo attenuation coefficient:
S=63H+168a-28, wherein S represents hepatic fat content, a represents liver echo attenuation coefficient.
Strength ratio acquisition module 55 obtains respectively the echo intensity of liver and the echo intensity of kidney, then obtains its ratio H.Thus: obtain hepatic fat content by ultrasonic Liver and kidney echo ratio and liver echo attenuation coefficient.
Technique effect of the present invention is: build a kind of ultrasonic attenuation coefficient bucking-out system and liver fat detection system based on ultrasonic, comprise supersonic generator 1, ultrasonic receiver 2, ultrasonic attenuation coefficient acquisition module 4, ultrasonic attenuation coefficient compensating module, liver fat detection module 6, described supersonic generator 1 is to liver position emission pulse ultrasonic, described ultrasonic receiver 2 receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module 4 obtains liver echo attenuation coefficient, described ultrasonic attenuation coefficient compensating module is by setting up the standard liver die body of different-thickness, contrast and obtain its offset by measuring attenuation quotient that the ultrasonic attenuation coefficient of this different-thickness standard liver die body and above-mentioned ultrasonic attenuation coefficient formula measure, obtain the ultrasonic attenuation coefficient after compensation by offset.Described liver fat detection system obtains hepatic fat content formula by its linear correlation.Described liver fat detection system is also by setting up the thickness compensation that carries out of 3D standard die body, thus the ultrasonic attenuation coefficient after being compensated, then according to setting up one-to-one relationship, thereby obtain fat content corresponding to ultrasonic attenuation coefficient.The brightness of image level value that the art of this patent scheme obtains by the ultrasound echo signal of liver, calculates liver echo attenuation coefficient more accurately, then by Liver and kidney echo intensity to when liver echo attenuation coefficient to liver fat detection by quantitative.Facilitate simple and practical, accurately and reliably.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.
Claims (8)
1. the ultrasonic attenuation coefficient bucking-out system based on ultrasonic, it is characterized in that, comprise supersonic generator, ultrasonic receiver, ultrasonic attenuation coefficient acquisition module, ultrasonic attenuation coefficient compensating module, liver fat detection module, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, and described ultrasonic attenuation coefficient acquisition module obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, f
c(t) mid frequency of expression ultrasonic signal, t express time, c represents the spread speed of ultrasound wave in liver; Described ultrasonic attenuation coefficient compensating module is by setting up the standard liver die body of different-thickness, contrast and obtain its offset by measuring attenuation quotient that the ultrasonic attenuation coefficient of this different-thickness standard liver die body and above-mentioned ultrasonic attenuation coefficient formula measure, obtain the ultrasonic attenuation coefficient after compensation by offset.
2. the ultrasonic attenuation coefficient bucking-out system based on ultrasonic according to claim 1, is characterized in that the thickness positive correlation of ultrasonic attenuation coefficient and thing to be detected described in described ultrasonic attenuation coefficient compensating module.
3. the ultrasonic attenuation coefficient bucking-out system based on ultrasonic according to claim 1, is characterized in that, described ultrasonic attenuation coefficient compensating module, by repeatedly measuring and obtain ultrasonic attenuation coefficient, is got its meansigma methods.
4. the liver fat detection system based on ultrasonic, it is characterized in that, comprise supersonic generator, ultrasonic receiver, ultrasonic attenuation coefficient acquisition module, ultrasonic attenuation coefficient compensating module, liver fat detection module, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, and described ultrasonic attenuation coefficient acquisition module obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, f
c(t) mid frequency of expression ultrasonic signal, t express time, c represents the spread speed of ultrasound wave in liver; Described ultrasonic attenuation coefficient compensating module is by setting up the standard liver die body of different-thickness, contrast and obtain its offset by measuring attenuation quotient that the ultrasonic attenuation coefficient of this different-thickness standard liver die body and above-mentioned ultrasonic attenuation coefficient formula measure, obtain the ultrasonic attenuation coefficient after compensation by offset, described liver fat detection module is set up the corresponding relation of hepatic fat content and ultrasonic attenuation coefficient by measurement, obtain hepatic fat content according to the ultrasonic attenuation coefficient after compensation.
5. the liver fat detection system based on ultrasonic according to claim 4, is characterized in that, by repeatedly measuring hepatic fat content and ultrasonic attenuation coefficient, sets up the corresponding lists of hepatic fat content and ultrasonic attenuation coefficient.
6. the liver fat detection system based on ultrasonic according to claim 4, is characterized in that, also comprises denoising module, and described denoising module is removed noise signal to the ultrasonic signal receiving.
7. the liver fat detection system based on ultrasonic, it is characterized in that, comprise supersonic generator, ultrasonic receiver, ultrasonic attenuation coefficient acquisition module, the strength ratio acquisition module that obtains Liver and kidney echo intensity ratio, liver fat detection module, described supersonic generator is to liver position emission pulse ultrasonic, described ultrasonic receiver receives hyperacoustic echo signal, described ultrasonic attenuation coefficient acquisition module obtains liver echo attenuation coefficient, and described ultrasonic attenuation coefficient acquisition module obtains ultrasonic attenuation coefficient a according to following formula:
wherein: a represents liver echo attenuation coefficient, b
2represent ultrasonic echo power spectrum signal distribution variance, f
c(t) mid frequency of expression ultrasonic signal, t express time, c represents the spread speed of ultrasound wave in liver; Described liver fat detection module obtains hepatic fat content according to following formula: S=63H+168a-28, and wherein S represents hepatic fat content, and a represents liver echo attenuation coefficient, and H represents Liver and kidney echo intensity ratio.
8. the liver fat detection system based on ultrasonic according to claim 7, is characterized in that, also comprises denoising module, and described denoising module is removed noise signal to the ultrasonic signal receiving.
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Application publication date: 20140723 |