CN103919616A - Device and method for artificial organ surface blood coagulation detection - Google Patents
Device and method for artificial organ surface blood coagulation detection Download PDFInfo
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- CN103919616A CN103919616A CN201410187452.5A CN201410187452A CN103919616A CN 103919616 A CN103919616 A CN 103919616A CN 201410187452 A CN201410187452 A CN 201410187452A CN 103919616 A CN103919616 A CN 103919616A
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Abstract
The invention discloses a device for artificial organ surface blood coagulation detection. Capacitive sensors are arranged on an artificial organ, a non-physical contact detection mode is adopted, the blood coagulation area is detected through the edge effect between every two adjacent capacitive sensors, an electrostatic field is generated between two pole plates of a capacitor, whether blood coagulation happens or not or whether blood concentration of the blood coagulation area suddenly changes or not is judged according to changes of the capacitance, and early judgment and blood coagulation detection are achieved. The capacitive sensors are fixed in an array mode, the specific blood coagulation position can be more accurately judged, the blood coagulation situation can be better judged, and information is accurately fed back to a doctor in time. By the adoption of the MEMS capacitive sensors, microminiaturization and high integration level of the sensors can be achieved, the high density of the array of the sensors can be achieved, and meanwhile, the micro sensors are simple in structure. Due to the non-physical contact detection, and due to the fact that the capacitive sensors are arranged on the lower side of an anticoagulation coating, the reliability of the capacitive sensors is improved, and the service life of the capacitive sensors is prolonged.
Description
Technical field
The invention belongs to medical checkout equipment technical field, be specifically related to a kind of device and detection method for artificial organ surface Hemostasis examination.
Background technology
Artificial organ is the Prosthesis who temporarily or permanently replaces some organ major function of health.Use and have more widely: 1. artificial lung (oxygenator) test lung is carried out the device of O2 and CO2 exchange, makes body include the venous oxygen that oxygen is low be combined into the arterial blood high containing oxygen by oxygenator.2. artificial heart (blood pump).The device that replaces cardiac ejection function, structure is similar to pump, can drive blood flow to overcome resistance along one-way flow.Artificial heart and artificial lung are collectively referred to as heart-lung machine, in nineteen fifty-three first for human body, are mainly applicable to complicated operation on heart.3. artificial kidney (hemodialyzer).Artificial organ has a wide range of applications in medical science, is significant for the treatment of suffering from the afunction of various tissues, organ or the patient of dysfunction disease.Widen the approach of disease treatment, increased the chance that patient is rescued, and still continued that increasing patient is benefited.
In artificial organ, taking artificial heart as example, also have biocompatibility issues with tissue, blood etc., wherein artificial organ surface contacts the blood coagulation problem causing with blood, and artificial organ and human body are all existed to very large harm.Blood coagulation is the chemical chain reaction process of series of complex, has the mechanism that maintains blood proper flow in human body, neither hemorrhage, also can not cause thrombosis.But, when body whole body or local blood coagulation system are strengthened or anticoagulation system weakens, fibrinolytic (thrombolytic) ability declines or anti-fibrinolytic strengthens, for example, under the effect of some inducement (having the existence of artificial organ), just may cause the thrombosis of thrombosis or formation can not be cleared out external, blood is ubiquitous, and thrombosis or thromboembolism can occur in any position of health, causes that vascular flow obviously reduces one group of disease of interrupting even completely.If thrombosis occurs in tremulous pulse, can cause organ or tissue's severe ischemic of blood supply or blood flow to interrupt, as cerebral blood supply insufficiency, unstable angina pectoris; Also can cause organ or tissue because of ischemia necrosis, as acute myocardial infarction, apoplexy.If thrombosis occurs in vein, as deep venous thrombosis of lower limbs can cause lower limb blood backflow obstacle, cause edema and impaired function of vein etc.
Thromboembolism is established thrombosis in heart or blood vessel, and after coming off, antegrade blood flow stops up the syndrome of other important organ blood vessels.As patients with atrial fibrillation often has thrombosis in left atrium.Once thrombosis comes off, can get lodged in cerebrovascular by antegrade blood flow, cause cerebral tissue necrosis (cerebral embolism); Deep vein thrombosis of lower extremity comes off, and can stop up pulmonary artery (pulmonary infarction), causes acute right heart failure, serious caused death.
If the disease that some are caused by blood coagulation or thrombosis is controlled at pathogenetic " upstream " stage of disease, judgement early and detection blood coagulation, the meaning of preventing for these major diseases is so by self-evident.
After material is as foreign body implant into body, cause such as thrombosis, inflammation, toxic reaction and many bad reactions such as carcinogenic.Wherein in the time that implant contacts with blood, by protedogenous product absorption and hematoblastic sticking.It is generally acknowledged, after embedded material contacts with blood, its protein and lipid are adsorbed on material surface, because the conformation of these molecules changes, cause each composition in blood to interact, thereby bring out the intrinsic coagulation reaction with thrombin activation; Then there is the cell component such as platelet, erythrocyte and be attached to protein surface, the platelet generation degeneration that those are sticked will discharge the III factor and impels the activation of blood coagulation system, generation blood coagulation reaction, and then form thrombosis, the formation of Intravascular Thrombus also can cause fatal consequence.Therefore, the bio-medical material of artificial blood vessel, artificial heart haematodocha, prosthetic heart valve film, artificial lung etc. not only will have the elasticity similar to human vas and ductility and good fatigue durability etc., more to there is good anticoagulant property antibacterium adhesion, do not produce thrombosis at material surface, do not cause platelet, the infection centered by biomaterial does not occur.
Artificial organ and blood contacting surface mainly adopt the material with anticoagulant property to process or apply on surface at present, manufacturing cost and the difficulty of organ are not only increased, but also can not play anticoagulant function completely, once generation blood coagulation, only have to just reflecting by clinical manifestation when more serious, often patient is caused to great misery and serious consequence.
Therefore, in view of above problem, be necessary to propose a kind of Hemostasis examination device, can judge more accurately the position of concrete blood coagulation, a situation arises better judge blood coagulation, promptly and accurately to doctor's feedback information, the disease that blood coagulation or thrombosis can be caused is controlled at pathogenetic " upstream " stage of disease, judgement early and detection blood coagulation, guarantee patient's health.
Summary of the invention
In view of this, the invention provides a kind of device and detection method for artificial organ surface Hemostasis examination.By capacitance sensor is set, can judge more accurately the position of concrete blood coagulation, a situation arises better to judge blood coagulation, promptly and accurately give doctor's feedback information, the disease that blood coagulation or thrombosis can be caused is controlled at pathogenetic " upstream " stage of disease, judgement early and detection blood coagulation, guarantee patient's health.
A kind of device for artificial organ surface Hemostasis examination proposing according to object of the present invention, this device comprises capacitance sensor, described capacitance sensor is fixed on the surface of described artificial organ, the outside of described capacitance sensor is coated with one deck anticoagulant coatings, and described capacitance sensor is equally distributed multiple;
Between adjacent two capacitance sensors, there is edge effect, make the excitation pole plate of electric capacity and receive between pole plate to produce electrostatic field, judge the blood coagulation phenomenon on artificial organ surface by the variation of Detection capacitance.
Preferably, described capacitance sensor is array format distribution.
Preferably, described capacitance sensor is MEMS capacitance sensor.
Preferably, described anticoagulant coatings is diamond coatings.
Preferably, described artificial organ adopts the materials processing with anticoagulant property.
A kind of artificial organ surface Hemostasis examination method, adopts the described device for artificial organ surface Hemostasis examination, and concrete steps are as follows:
(1), machine-shaping artificial organ, and be fixedly installed capacitance sensor on the surface of artificial organ, and capacitance sensor is array distribution;
(2), apply a side anticoagulant coatings in the outside of capacitance sensor, cover capacitance sensor completely;
(3), artificial organ is applied in human body, the excitation pole plate of electric capacity and receive between pole plate and produce electrostatic field, in the time that normal blood is flowed through artificial organ surface, excitation pole plate is the value of rule variation with the electric capacity receiving between pole plate; In the time having sludged blood or blood coagulation regional concentration to change, will change the electrolyte between electric capacity two-plate, therefore can cause electric capacity to produce larger change, whether there is haemoconcentration sudden change thereby judge whether to occur blood coagulation or this region;
(4), by capacitance variations signal feedback output, offer doctor and carry out judgement in early stage and diagnosis and treatment, the mode of capacitance sensor employing array, can accurately judge the particular location of artificial organ blood coagulation.
Compared with prior art, disclosed by the inventionly for the artificial organ surface device of Hemostasis examination and the advantage of detection method be:
1, by capacitance sensor is set on artificial organ, adopt the detection mode of non-physical contact, use the edge effect between adjacent two capacitance sensors to detect blood coagulation region, between the excitation pole plate of electric capacity and reception pole plate, produce electrostatic field, whether have haemoconcentration sudden change, judgement early and detect blood coagulation if judging whether to occur blood coagulation or this region according to the change of capacitance.
2, by capacitance sensor is fixed on below anticoagulant coatings in the mode of array, can judge more accurately the position of concrete blood coagulation, a situation arises better to judge blood coagulation, promptly and accurately give doctor's feedback information.
3, by adopting MEMS capacitance sensor can realize microminiaturization and the high integration of sensor, thereby can realize the high density of sensor array, this microsensor is simple in structure simultaneously, can not produce large impact to artificial organ structural design.
4, owing to detecting by non-physical contact formula, and capacitance sensor is arranged to the downside of anticoagulant coatings, ensures reliability and long service life that capacitance sensor is high.
Brief description of the drawings
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, to the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
Fig. 1 is the structural representation of a kind of device for artificial organ surface Hemostasis examination disclosed by the invention.
Fig. 2 is the local scattergram that amplifies of capacitance sensor.
The title of the numeral in figure or the corresponding component of alphabetical representative:
1, artificial organ 2, anticoagulant coatings 3, capacitance sensor 4, sludged blood
A, excitation pole plate B, reception pole plate C, electric field
Detailed description of the invention
Artificial organ and blood contacting surface mainly adopt the material with anticoagulant property to process or apply on surface at present, manufacturing cost and the difficulty of organ are not only increased, but also can not play anticoagulant function completely, once generation blood coagulation, only have to just reflecting by clinical manifestation when more serious, often patient is caused to great misery and serious consequence.
The present invention is directed to deficiency of the prior art, a kind of device and detection method for artificial organ surface Hemostasis examination is provided.By capacitance sensor is set, can judge more accurately the position of concrete blood coagulation, a situation arises better to judge blood coagulation, promptly and accurately give doctor's feedback information, the disease that blood coagulation or thrombosis can be caused is controlled at pathogenetic " upstream " stage of disease, judgement early and detection blood coagulation, guarantee patient's health.
To be clearly and completely described technical scheme of the present invention by detailed description of the invention below.Obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiment.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtaining under creative work prerequisite, belong to the scope of protection of the invention.
As shown in Figure 1, for a device for artificial organ surface Hemostasis examination, this device comprises capacitance sensor 3, and capacitance sensor 3 is fixed on the surface of artificial organ 1, the outside of capacitance sensor 3 is coated with one deck anticoagulant coatings 2, and capacitance sensor 3 is equally distributed multiple.Wherein anticoagulant coatings can be diamond coatings, realizes anticoagulation characteristic, avoid blood to produce blood coagulation phenomenon on its surface, but also other anticoagulant materials of anticoagulant coatings does not specifically limit.
Owing to there is edge effect between adjacent two capacitance sensors, make the excitation pole plate A of electric capacity and receive between pole plate B to produce electrostatic field, judge the blood coagulation phenomenon on artificial organ surface by the variation of Detection capacitance.Between electric capacity excitation pole plate and reception pole plate, produce electrostatic field, in the time that normal blood is flowed through artificial organ surface, excitation pole plate and the electric capacity receiving between pole plate are the value that rule changes.In the time having sludged blood or blood coagulation regional concentration to change, will change the electrolyte between electric capacity two-plate, therefore can cause electric capacity to produce larger change, whether there is haemoconcentration sudden change thereby judge whether to occur blood coagulation or this region.
In addition, owing to detecting by non-physical contact formula, and capacitance sensor is arranged to the downside of anticoagulant coatings, ensures high reliability and the long service life of capacitance sensor.
As shown in Figure 2, capacitance sensor is array format and distributes, and can judge more accurately the position of concrete blood coagulation, and a situation arises better to judge blood coagulation, promptly and accurately give doctor's feedback information.
Capacitance sensor is MEMS capacitance sensor, can realize microminiaturization and the high integration of sensor, thereby can realize the high density of sensor array, and this microsensor is simple in structure simultaneously, can not produce large impact to artificial organ structural design.
Artificial organ adopts the materials processing with anticoagulant property.
Artificial organ surface Hemostasis examination method, concrete steps are as follows:
(1), machine-shaping artificial organ, and be fixedly installed capacitance sensor on the surface of artificial organ, and capacitance sensor is array distribution;
(2), apply a side anticoagulant coatings in the outside of capacitance sensor, cover capacitance sensor completely;
(3), artificial organ is applied in human body, the excitation pole plate of electric capacity and receive between pole plate and produce electrostatic field, in the time that normal blood is flowed through artificial organ surface, excitation pole plate is the value of rule variation with the electric capacity receiving between pole plate; In the time having sludged blood or blood coagulation regional concentration to change, will change the electrolyte between electric capacity two-plate, therefore can cause electric capacity to produce larger change, whether there is haemoconcentration sudden change thereby judge whether to occur blood coagulation or this region;
(4), by capacitance variations signal feedback output, offer doctor and carry out judgement in early stage and diagnosis and treatment, the mode of capacitance sensor employing array, can accurately judge the particular location of artificial organ blood coagulation.
The invention discloses a kind of device and detection method for artificial organ surface Hemostasis examination, by capacitance sensor is set on artificial organ, adopt the detection mode of non-physical contact, use the edge effect between adjacent two capacitance sensors to detect blood coagulation region, between the excitation pole plate of electric capacity and reception pole plate, produce electrostatic field, whether have haemoconcentration sudden change, judgement early and detect blood coagulation if judging whether to occur blood coagulation or this region according to the change of capacitance.By capacitance sensor is fixed on below anticoagulant coatings in the mode of array, can judge more accurately the position of concrete blood coagulation, a situation arises better to judge blood coagulation, promptly and accurately give doctor's feedback information.
By adopting MEMS capacitance sensor can realize microminiaturization and the high integration of sensor, thereby can realize the high density of sensor array, this microsensor is simple in structure simultaneously, can not produce large impact to artificial organ structural design.
Owing to detecting by non-physical contact formula, and capacitance sensor is arranged to the downside of anticoagulant coatings, ensures high reliability and the long service life of capacitance sensor.
To the above-mentioned explanation of the disclosed embodiments, make professional and technical personnel in the field can realize or use the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiment, General Principle as defined herein can, in the situation that not departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention will can not be restricted to these embodiment shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (6)
1. the device for artificial organ surface Hemostasis examination, it is characterized in that, this device comprises capacitance sensor, described capacitance sensor is fixed on the surface of described artificial organ, the outside of described capacitance sensor is coated with one deck anticoagulant coatings, and described capacitance sensor is equally distributed multiple;
Between adjacent two capacitance sensors, there is edge effect, make the excitation pole plate of electric capacity and receive between pole plate to produce electrostatic field, judge the blood coagulation phenomenon on artificial organ surface by the variation of Detection capacitance.
2. the device for artificial organ surface Hemostasis examination as claimed in claim 1, is characterized in that, described capacitance sensor is array format and distributes.
3. the device for artificial organ surface Hemostasis examination as claimed in claim 1, is characterized in that, described capacitance sensor is MEMS capacitance sensor.
4. the device for artificial organ surface Hemostasis examination as claimed in claim 1, is characterized in that, described anticoagulant coatings is diamond coatings.
5. the device for artificial organ surface Hemostasis examination as claimed in claim 1, is characterized in that, described artificial organ adopts the materials processing with anticoagulant property.
6. an artificial organ surface Hemostasis examination method, is characterized in that, adopts the device for artificial organ surface Hemostasis examination described in claim 1-5 any one, and concrete steps are as follows:
(1), machine-shaping artificial organ, and be fixedly installed capacitance sensor on the surface of artificial organ, and capacitance sensor is array distribution;
(2), apply a side anticoagulant coatings in the outside of capacitance sensor, cover capacitance sensor completely;
(3), artificial organ is applied in human body, the excitation pole plate of electric capacity and receive between pole plate and produce electrostatic field, in the time that normal blood is flowed through artificial organ surface, excitation pole plate is the value of rule variation with the electric capacity receiving between pole plate; In the time having sludged blood or blood coagulation regional concentration to change, will change the electrolyte between electric capacity two-plate, therefore can cause electric capacity to produce larger change, whether there is haemoconcentration sudden change thereby judge whether to occur blood coagulation or this region;
(4), by capacitance variations signal feedback output, offer doctor and carry out judgement in early stage and diagnosis and treatment, the mode of capacitance sensor employing array, can accurately judge the particular location of artificial organ blood coagulation.
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Cited By (6)
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