CN103893996B - Stacked nano-material solid-phase extraction column - Google Patents
Stacked nano-material solid-phase extraction column Download PDFInfo
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- CN103893996B CN103893996B CN201410143082.5A CN201410143082A CN103893996B CN 103893996 B CN103893996 B CN 103893996B CN 201410143082 A CN201410143082 A CN 201410143082A CN 103893996 B CN103893996 B CN 103893996B
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Abstract
The invention discloses a stacked nano-material solid-phase extraction column. The stacked nano-material solid-phase extraction column consists of a column core, a nano-material and a sealing layer; a solid column body with a certain length is obtained by cutting; a dense thin shell fabric which is covered with a nano-material layer with certain weight uniformly wraps around the column core for a plurality of layers; an outer seal is fixed, so that the stacked nano-material solid-phase extraction column is formed. The manufacturing process of the solid-phase extraction column is simplified; the extraction columns manufactured in batches have the high reproducibility; particularly, for large-size and high-density liquid samples, the column passing resistance is low, the speed is high, and the extraction time is shortened.
Description
Technical field
The invention belongs to trace or trace materials separation, purifying, concentration technique field, be specially a kind of stacked nano material solid-phase extraction column.
Background technology
Isolation technics has related to the various aspects of modern society's productive life, the mensuration of DNA sequence analysis, Leaf proteins, carbohydrate etc. in the separation and Extraction of noble element or compound, food and environment trace analysis, life science, needs to take advanced separation and concentration technology invariably.At present, people are deep recognizes that isolation technics hinders a bottleneck of the industry industrialized developments such as green technology, biotechnology and food medicine.Reaching separation and purification effect by absorption is one of main path solving separation and concentration problem, and the application of novel separation sorbing material is the focus of research.Existing sorbing material is of a great variety, pattern is various, and size mostly is particle or the fiber of micron size.Recently there is the sorbing material of nano-scale, nano material size is little, there is large specific surface thus cause nano material atomicity to increase and surface atom coordination deficiency, thus surface atom has very high activity, easily be combined with other atom, show than micro materials more by force, more stable absorption property.
The solid phase extraction techniques (publication number CN1806880A, CN101947393A, CN201906484U) that to have occurred with electrospun nanofiber material be in recent years adsorbent, but reported nano material post manually operates electrospinning material to insert in post, there is certain difference in the degree of tightness of thus loading, produce certain impact to the adsorption rate of sample and eluting rate, reappearance is comparatively difficult to grasp; For high concentration, it is large that large volume, viscous samples cross column resistance, and speed is slow, and consuming time, effort, limits its range of application.For this problem, present invention employs brand-new nano material loading method, use uniform fold to have the fine and close thin type fabric of the layer of nanomaterial of certain mass to realize the preparation of nano material post along the method that post core is closely wound.The method realizes fiber by adjustment device for spinning and process conditions and is uniformly distributed on thin type fabric, post technique processed also more easily realizes mechanized operation, therefore, overcome bottleneck problem prepared by existing electrospun nanofiber column of material, pillar quality is easy to control, improve the extraction efficiency of pillar comprehensively, extend its scope of application.
Summary of the invention
Technical problem: the object of the present invention is to provide a kind of stacked nano material solid-phase extraction column and preparation method thereof, solve existing nano material solid-phase extraction column preparation process to be difficult to realize mechanization, complex operation, extraction time is long, reappearance is wayward, large volume, enriched sample is difficult to the problem of post.
Technical scheme: for solving these problems of the prior art, technical scheme provided by the invention is:
The axle center of this solid-phase extraction column is provided with post core, and be interval with layer of nanomaterial and fine and close thin type precoat successively at the excircle of post core, its number of plies be interval with is more than 3 layers, and outermost layer is aluminium foil glue-line.
Described layer of nanomaterial is prepared by the mode of electrospinning, comprises electro spinning nano fiber, electrospun nanofiber particle.
Beneficial effect: relative to scheme of the prior art, advantage of the present invention is:
1. increase the contact area of sample and solid phase extraction filler, more be conducive to the advantage playing nano material: the specific surface of nano material is large, adsorption capacity is larger than common column packing, nano material is placed on fine and close flat thin fabric by the present invention, Stationary liquid is formed by multilaminate coiled mode, all separation layer is added between each layer nano adsorber, further increase the contact area of nano material and object, compared with existing filled type nano material post, add solid-phase media and the interactional area of object, thus improve adsorption rate.
2. nano material filler distribution is more even: the present invention just can realize being uniformly distributed of nano material by methods such as receiving screen adjustment preparing in electrospun nanofiber materials process, solve the difficult problem that hand-filling nano material post is difficult to control uniformity preferably, and simplify the preparation process of solid-phase extraction column, convenient to operation, favorable reproducibility, pillar extraction precision significantly improves.
3. resistance is less: in pillar of the present invention, nano material exists in a layered fashion, the thin type fabric of alternating floor densification between each layer adsorbent, can play the effect of shunting sample liquid, when extraction sample especially large volume, viscous samples, resistance is little, crosses post speed fast, shortens extraction time.
4. be easy to industrialization: novel nano-material solid-phase extraction column of the present invention is fast easy to make, be easy to realize mass, mechanization production, overcome manual operations to be difficult to quality control, to be difficult to a difficult problem for expanding production, make the solid-phase extraction column based on nano material produce and use convenient.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described:
Fig. 1 is the structural representation of embodiment of the present invention nano material solid-phase extraction column,
Fig. 2 is the post cored structure schematic diagram of embodiment of the present invention nano material solid-phase extraction column,
Fig. 3 is the electrospun nanofiber material schematic diagram of embodiment of the present invention nano material solid-phase extraction column,
Fig. 4 is the nano material post schematic diagram of embodiment of the present invention nano material solid-phase extraction column,
Fig. 5 is the aluminium foil rubber seal post schematic diagram of embodiment of the present invention nano material solid-phase extraction column,
Wherein have: post core 1, layer of nanomaterial 2, fine and close thin type precoat 3, aluminium foil glue-line 4.
Detailed description of the invention
Below in conjunction with specific embodiment, such scheme is described further.Should be understood that these embodiments are for illustration of the present invention instead of limit the scope of the invention.The implementation condition adopted in embodiment can be for further adjustments according to the condition of concrete producer, and the implementation condition not noting name is generally the condition in normal experiment.
As shown in Figure 1, this stacked nano material solid-phase extraction column, comprises internal layer support section and post core 1 to embodiment; The layer of nanomaterial 2 i.e. electro spinning nano fiber (containing aluminium foil as fine and close thin type fabric 3) of intermediate materials part; Outer hermetic unit and aluminium foil glue-line 4.
As shown in Figure 2, described post core 1 is the solid cylindrical material (can be the materials such as macromolecule, metal, glass) of the contamination-free release cutting required column length.
As shown in Figure 3, utilize electrospinning processes to be collected in equably on aluminium-foil paper by nanofiber, cut the fibrage (containing aluminium foil) of suitable quality size with reference to column length.
As shown in Figure 4, by the above-mentioned layers of nanofibers 2(cut out containing aluminium foil) two ends and post core 1 justify align, reel layer by layer along post core 1 and stack up.
As shown in Figure 5, cut the aluminium foil glue-line 4 of appropriate amount with reference to column length, the fibrolaminar pillar of winding is placed on aluminium foil glue-line 4, justify align, fixing along the winding sealing of pillar periphery.
Foregoing invention, only for technical conceive of the present invention and feature are described, its object is to person skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.The equivalence that all Spirit Essences according to the present invention do exchanges or modifies, and all should be encompassed within protection scope of the present invention.
Claims (2)
1. a stacked nano material solid-phase extraction column, it is characterized in that the axle center of this solid-phase extraction column is provided with post core (1), layer of nanomaterial (2) and fine and close thin type precoat (3) is interval with successively at the excircle of post core (1), every one deck layer of nanomaterial (2) and every one deck dense thin shape precoat (3) successively interval are arranged, the number of plies of layer of nanomaterial (2) and fine and close thin type precoat (3) is more than 3 layers, and outermost layer is aluminium foil glue-line (4).
2. stacked nano material solid-phase extraction column according to claim 1, is characterized in that described layer of nanomaterial (2) is prepared by the mode of electrospinning, comprises electro spinning nano fiber, electrospun nanofiber particle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410143082.5A CN103893996B (en) | 2014-04-10 | 2014-04-10 | Stacked nano-material solid-phase extraction column |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410143082.5A CN103893996B (en) | 2014-04-10 | 2014-04-10 | Stacked nano-material solid-phase extraction column |
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| Publication Number | Publication Date |
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| CN103893996A CN103893996A (en) | 2014-07-02 |
| CN103893996B true CN103893996B (en) | 2015-06-03 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0446970B1 (en) * | 1989-09-06 | 1993-09-22 | Hewlett-Packard Company | A solid-phase extraction cartridge |
| CN1806880A (en) * | 2005-12-19 | 2006-07-26 | 东南大学 | Solid phase micro-extraction device based on nanometer fiber |
| CN1928527A (en) * | 2006-09-15 | 2007-03-14 | 东南大学 | Functional nano-fiber based method for extracting and enriching pollutants in water |
| CN101796407A (en) * | 2005-09-29 | 2010-08-04 | 全技术联合公司 | Composite chromatography column |
| JP2010169613A (en) * | 2009-01-26 | 2010-08-05 | Sigma-Aldrich Japan Kk | Method and assist device for analyzing liquid composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7261813B2 (en) * | 2004-08-10 | 2007-08-28 | Clemson University | Monolithic structures comprising polymeric fibers for chemical separation by liquid chromatography |
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2014
- 2014-04-10 CN CN201410143082.5A patent/CN103893996B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0446970B1 (en) * | 1989-09-06 | 1993-09-22 | Hewlett-Packard Company | A solid-phase extraction cartridge |
| CN101796407A (en) * | 2005-09-29 | 2010-08-04 | 全技术联合公司 | Composite chromatography column |
| CN1806880A (en) * | 2005-12-19 | 2006-07-26 | 东南大学 | Solid phase micro-extraction device based on nanometer fiber |
| CN1928527A (en) * | 2006-09-15 | 2007-03-14 | 东南大学 | Functional nano-fiber based method for extracting and enriching pollutants in water |
| JP2010169613A (en) * | 2009-01-26 | 2010-08-05 | Sigma-Aldrich Japan Kk | Method and assist device for analyzing liquid composition |
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| CN103893996A (en) | 2014-07-02 |
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