CN103893237A - Composition containing hairy deerhorn and olive extract - Google Patents
Composition containing hairy deerhorn and olive extract Download PDFInfo
- Publication number
- CN103893237A CN103893237A CN201410149383.9A CN201410149383A CN103893237A CN 103893237 A CN103893237 A CN 103893237A CN 201410149383 A CN201410149383 A CN 201410149383A CN 103893237 A CN103893237 A CN 103893237A
- Authority
- CN
- China
- Prior art keywords
- fructus canarii
- canarii albi
- compositions
- albi extract
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention relates to a composition including hairy deerhorn and an olive extract. The composition can be applied to foods, healthy foods or pharmaceuticals as an antioxidant, wherein the weight ratio of hairy deerhorn to the olive extract is (1-50): (1-1,000). By using the composition, superoxide anion free radicals and hydroxyl radicals in reactive oxygen free radicals can be inhibited and cleared remarkably.
Description
Technical field
The present invention relates to a kind of compositions that antioxidant uses at food, health food or pharmaceuticals, particularly a kind of compositions that contains Cornu Cervi Pantotrichum and Fructus Canarii albi extract of can be used as.
Background technology
China has entered aged tendency of population society, the society that brings because of aged tendency of population, economy, health etc. all will become great politics, the economic problems of Future Society, adopt effective method to delay physiology, pathological change that older population occurs, reduce the aged's health risk causing due to age ageing, improve quality of life of old people, by the burden that alleviates greatly Future in China society and politics and economic development and bear.
People why can be old and feeble gradually, and one of numerous theories are free radical theorys, and to be also that research worker is universally recognized cause old and feeble one of the main reasons to this theory.Old and feeble free radical theory thinks, the generation development of old and feeble and relevant many chronic diseases is all that the oxygen-derived free radicals in body produces too much or body antioxidant capacity declines, and relation between the two is unbalance and cause.In the free radical relevant to body, reactive oxygen free radical (ROS) is the most important, is to have highly reactive O
2metabolite, mainly comprise ultra-oxygen anion free radical, hydroxyl radical free radical and hydrogen peroxide etc., under normal circumstances, people's interior free yl is always in continuous generation and in the dynamic equilibrium of constantly eliminating, if interior free yl produces too much or is unbalance due to free radical scavenging systemic-function obstacle, will cause the infringement to body tissue, cause oxidative stress; Free-radical oxidation stress damage biomolecule, comprise protein, mitochondrion, DNA and lipid peroxy body, in body, the function of some important enzymes also can be damaged, cause cell membrane polyvalent unsaturated fatty acid peroxidization, thereby cause corresponding disease, as cardiovascular disease, immunologic function degression and cancer and diabetes etc. such as the neurodegenerative diseases such as alzheimer disease, cataract and other visual disorders, parkinson disease and atherosclerosis, apoplexy.Remove excessive reactive oxygen free radical effectively reducing human because of age and environment cause aging.There is on the market at present multiple antioxidant, as SOD, vitamin C, E, A, coenzyme Q10, anthocyanidin, resveratrol etc.This type of antioxidant is often subject to being permitted multifactorial impact, as unstable in the C solution in water of supporting one's family, see that auroral poles easily decomposes, and vitamin E is water insoluble, easily oxidized, and some other antioxidant half-life is short, molecular weight is difficult for permeate through cell membranes greatly, some exists antigenicity etc.The material that antioxidant activity is found in research from natural biological is by external extensive attention, as now conventional anthocyanidin, resveratrol etc. are compared with the antioxidant of synthetic, natural biological antioxidant have multiple action, effect lasting stability, action temperature and, the advantage such as widely applicable, toxic and side effects light, economy is easy to get.Therefore, the natural anti-reflecting oxide of exploitation high-efficiency low-toxicity, the antioxidation of raising body, keeps generation and the elimination of free radical to reach balance, and slow down aging and prevent disease etc. are of great importance.
Cornu Cervi Pantotrichum is as Chinese medicine, conventional have sika deer velvet antler and a cervus elaphus linnaeus, the disease such as be mainly used in that treatment is dizzy, deaf, order is dark, sexual impotence, spermatorrhea, cold womb are infertile, weakness and emaciation, Mental fatigue, fear of cold, spinal column cold type of pain, muscles and bones flaccidity are soft, bleeding not during menses, carbuncle of yin nature are not held back and prolonged illness is deficient.Modern study shows, Cornu Cervi Pantotrichum chemical composition more complicated, mainly contains three major types active substance, protein and peptide, steroid and polyamine compounds.Cornu Cervi Pantotrichum and extract thereof have the effect of certain lipotropism matter and free radical resisting oxidation; but its conventional dose is larger; as " Chinese Pharmacopoeia " 2010 editions regulations; it is 1000～3000mg that day takes dosage; the malaise symptoms that often can cause producing that old people produces dizzy conjunctival congestion, has sore throat, oral ulcer, uneasy sleeping at night or hypertension etc. is difficult to bear, can not carry out daily taking for a long time.The eating method of Cornu Cervi Pantotrichum mainly contains, and is prepared into piece of antler and pulverizes and take after mixing it with water, and is prepared into hairy antler capsules, and deer antler wine, makes tea, cook congee, and stewed chicken etc.
In olive fruits or Folium olive, comprise a large amount of polyphenol compounds, as oleuropein, hydroxytyrosol etc.This its function of class polyphenol compound enjoys people's concern in recent years.Research shows that this type of polyphenol compound has non-oxidizability and the removing ability to free radical, can remove endogenous and exogenous free radical and oxide, thereby has the oxidized effect of the low-density albumen (LDL) of inhibition.But this type of polyphenol compound chemical property is extremely unstable, under low temperature or room temperature state, in the short period, (<6 month) will lose relevant biological activity because of oxidation, causing crowd to take effect differs, even there is safety issue, be difficult to meet the needs of taking for a long time.
Fructus Canarii albi extract is that Fructus Canarii albi extract is on sale in the market, can be used as medical material from the material of Chinese olive tree fruit or leaf extraction, health food, and cosmetics use, and its instructions of taking is: be prepared into tablet, capsule, powder etc. are taken.
Summary of the invention
The invention provides a kind of compositions of the antioxidant activity with synergistic function.
Compositions of the present invention, is characterized in that: formed as active fraction preparation by Cornu Cervi Pantotrichum and Fructus Canarii albi extract, wherein Cornu Cervi Pantotrichum and Fructus Canarii albi extract part by weight are 1～50:1～1000.
Preferably, wherein Cornu Cervi Pantotrichum and Fructus Canarii albi extract part by weight are 10～25:250～500.
Particularly preferred, wherein Cornu Cervi Pantotrichum and Fructus Canarii albi extract part by weight are 10～25:250.
Most preferred, Pulveratum Cornu Cervi Pantotrichum: the part by weight=25:250 of Fructus Canarii albi extract
Compositions of the present invention, wherein Cornu Cervi Pantotrichum is Pulveratum Cornu Cervi Pantotrichum, can buy and obtain from the market, or prepare according to art methods, as the preparation method of Pulveratum Cornu Cervi Pantotrichum can adopt the method for Fig. 3, (adopting Mastersizer2000 Ma Erwen laser diffraction analyzer to measure the particle diameter of Penis et testis cervi micropowder, the fine and soft powder of particle diameter distribution width <30 μ m).
Compositions of the present invention, wherein Fructus Canarii albi extract comprises the hydroxytyrosol of oleuropein and its aquation.Can buy and obtain from the market, or according to art methods preparation, as the preparation method of Fructus Canarii albi extract can adopt the method for Fig. 4.
Adopt fluidized bed opposed jet mill technology to pulverize to Cornu Cervi Pantotrichum above, can at utmost ensure the reservation of effective constituent of pilose antler, the most effectively reduce the absorption of day dose, ensure to have realized antioxidative effect simultaneously, old people can be taken for a long time and rare untoward reaction is anti-raw.
Above with CO
2supercritical extraction Folium olive obtains the Fructus Canarii albi extract of oleuropein and hydroxytyrosol, the loss that can effectively avoid organic solvent to cause; Adopted solid dispersion technology subsequently, guarantee wherein stablizing of polyphenol compound physicochemical property, can effectively meet compositions stability at normal temperatures, what is more important adopts solid dispersion technology manufactured goods after ingesting, to have reliable safety and effectiveness.
Compositions of the present invention, also can add as required and prepare the needed carrier of food, health product and drug products.For this reason, the present invention also provides the preparation method of the present composition, and described method is by Pulveratum Cornu Cervi Pantotrichum, and Fructus Canarii albi extract mixes, and adds if desired carrier material, is prepared into any dosage form that is applicable to taking according to preparation routine techniques.
Preferably, the present invention is by Pulveratum Cornu Cervi Pantotrichum, and Fructus Canarii albi extract is prepared into a kind of finely dispersed blend, is more further processed into preparation.Described blend, its preparation method is as follows: Fructus Canarii albi extract adds in dispersion soln, stirs, and Fructus Canarii albi extract is dissolved completely, adds the deer micropowder of aforementioned proportion to stir suspendible and mixes, cooling rapidly after, pulverize, obtain the blend of Cornu Cervi Pantotrichum Fructus Canarii albi extract.
Preferably, the preparation method of blend of the present invention is as follows: select Penis et testis cervi micropowder, Fructus Canarii albi extract, both part by weight=10～25:250; Use dispersion soln to micropowder, Folium olive extract disperses, and is prepared into above-mentioned blend.Wherein said dispersion soln is selected from PEG6000, polyvidone (PVP), and mannitol, the liquid that ethyl cellulose is prepared as dispersant or semiliquid material, for by Penis et testis cervi micropowder, Fructus Canarii albi extract is dispersed, preferably PEG6000.
In blend, Penis et testis cervi micropowder, the part by weight between Fructus Canarii albi extract and dispersant three is: 10～25:250:120～750, preferred, Penis et testis cervi micropowder, the part by weight between Fructus Canarii albi extract and dispersant three is: 10～25:250:250.
Active ingredient components using above-mentioned blend as the present composition, add as required carrier components, be prepared into the arbitrary form that is applicable to taking according to routine techniques, in compositions, the part by weight of blend is 0.01%-99.99%, and carrier components part by weight is 0.01%-99.99%.
Compositions of the present invention, also can comprise medicine or food or health product acceptable carrier or additive, as: vitamin (as vitamin A, B, C, D, E etc.), many kinds of metal ions electrolyte replenisher (as potassium sodium calcium magnesium plasma supplement), correctives (essence, sweeting agent etc.), filler (lactose, starch, dextrin, cellulose derivative etc.), lubricant (magnesium stearate, Pulvis Talci, differential silica gel etc.), binding agent (starch slurry, polyvidone, cellulose derivative) etc.
Compositions of the present invention, the dosage form that the finished product of preparing according to preparation technique is taken, comprises oral tablet, hard capsule, soft capsule, oral liquid, granule, powder, dry suspension, effervescent, slow-release oral agent.
Another object of the present invention is to provide the application of compositions of the present invention in Scavenger of ROS free radical.
Confirm through test, compositions of the present invention has the effect of Synergistic for removing ultra-oxygen anion free radical and hydroxyl radical free radical.
The research of present composition Synergistic antioxidant activity is as follows:
1, the removing synergistic function to ultra-oxygen anion free radical
Xanthine and xanthine oxidase response system in simulation body, get Cornu Cervi Pantotrichum Fructus Canarii albi extract blend prepared by embodiment 1 and be prepared into variable concentrations test liquid, separately establish blank group, Pulveratum Cornu Cervi Pantotrichum group, Folium olive extract group, be prepared into equally variable concentrations test liquid, get above-mentioned test liquid 50 μ l, by anti-ultra-oxygen anion free radical testing cassete description operation, add successively reaction reagent, 37 DEG C of water bath with thermostatic control reaction 40min, add developer cessation reaction, mix, after standing 10min, measure absorbance at 550nm place.Calculate suppression ratio.Result shows that blend has stronger inhibitory action to ultra-oxygen anion free radical, with matched group Cornu Cervi Pantotrichum group, the comparison of Fructus Canarii albi extraction battery, Cornu Cervi Pantotrichum matched group suppression ratio is about 30%, and Folium olive extract group is about 50%, and blend suppression ratio approximately 92%, obviously be better than matched group, have the effect of Synergistic, experimental result is shown in accompanying drawing 1.
2, the scavenging action to hydroxyl radical free radical
According to Fenton reaction principle, the blend of getting Cornu Cervi Pantotrichum Fructus Canarii albi extract prepared by embodiment 1 is prepared into the test liquid of variable concentrations, separately establish blank group, Pulveratum Cornu Cervi Pantotrichum group, Folium olive extract group, be prepared into equally variable concentrations test liquid, getting above-mentioned test liquid 0.2ml operates by hydroxyl free based assays test kit description, add successively reaction examination Liu, 37 DEG C of water bath with thermostatic control reaction 1min, add immediately developer upper reaction eventually, mix, room temperature is placed 20min, measures absorbance, and calculate suppression ratio at 550nm place.Experimental result is shown in accompanying drawing, shows that blend has very strong inhibitory action to hydroxyl radical free radical, and Cornu Cervi Pantotrichum matched group suppression ratio is about 40%, and Folium olive extract group is about 55%, and blend suppression ratio approximately 95% is obviously better than matched group, have the effect of Synergistic, experimental result is shown in accompanying drawing 2.
Brief description of the drawings
The removing synergism of Fig. 1 blend to ultra-oxygen anion free radical
The removing synergism of Fig. 2 blend to hydroxyl radical free radical
Fig. 3 Penis et testis cervi micropowder preparation flow figure
Fig. 4 Fructus Canarii albi extract preparation flow figure
Detailed description of the invention
Below by specific embodiment, further illustrate the present invention, following embodiment is only for the present invention is described, and the present invention is not limited.
The preparation of Penis et testis cervi micropowder: Cornu Cervi Pantotrichum is pulverized 1h → Penis et testis cervi micropowder (adopting Mastersizer2000 Ma Erwen laser diffraction analyzer to measure the particle diameter of Penis et testis cervi micropowder, the fine and soft powder of particle diameter distribution width <30 μ m) through scraping hair → segmentation → section → pulverizing → mistake 80 mesh sieves → freezing → employing fluidized bed opposed jet mill machine.
The preparation of Fructus Canarii albi extract: 80 mesh sieves → pack into reactor → CO is cleaned → dry → pulverized → cross to Folium olive
2supercritical extraction (20 DEG C keep 20h) → separation → Fructus Canarii albi extract.
Penis et testis cervi micropowder: the part by weight=25:250 of Fructus Canarii albi extract
The preparation of blend:
Operation: the PEG6000 that gets 140g weight, be heated to 70 DEG C, stirring and dissolving is complete, adds the Fructus Canarii albi extract of 250g weight to stir 15 minutes, dissolves completely, add again the Penis et testis cervi micropowder of 25g weight to stir, be uniformly dispersed, and it is cooling to put into rapidly ice-water bath, after solidifying, pulverize, obtain solid blend.
Show through In Vitro Dissolution result of the test, the blend of gained, taking hydroxytyrosol as detecting index, reaches and dissolves completely for 10 minutes, and Penis et testis cervi micropowder, Fructus Canarii albi extract and PEG6000 blend, the dissolving of its hydroxytyrosol needs 55 minutes completely.
The preparation of antioxidation capsule
Penis et testis cervi micropowder: Fructus Canarii albi extract=25:250
Operation: the preparation of blend, as embodiment 1, is got the blend after pulverizing, adds micropowder silica gel, mixes, filled capsules and get final product.
Show through In Vitro Dissolution test: show through In Vitro Dissolution test: 45 minutes hydroxytyrosol dissolutions of the capsule made through solid dispersion technology exceed one times of the dissolution that simple physical is mixed made capsule.
The preparation of antioxidation capsule
Penis et testis cervi micropowder: Fructus Canarii albi extract=25:250
Operation: get the PEG6000 of 250g weight, the preparation of blend, as embodiment 1, is got the blend after pulverizing, adds micropowder silica gel, mixes, filled capsules and get final product.
Show through In Vitro Dissolution test: show through In Vitro Dissolution test: 45 minutes hydroxytyrosol dissolutions of the capsule made through solid dispersion technology exceed one times of the dissolution that simple physical is mixed made capsule.
Embodiment 4
The preparation of antioxidation granule:
Penis et testis cervi micropowder: Fructus Canarii albi extract=15:250
Operation: the PEG6000 that gets 250g weight, be heated to 70 DEG C, stirring and dissolving is complete, adds the Fructus Canarii albi extract of 250g weight to stir 15 minutes, dissolves completely, add again the Penis et testis cervi micropowder of 15g weight to stir, be uniformly dispersed, and it is cooling to put into rapidly ice-water bath, after solidifying, pulverize, obtain solid blend.
Show through In Vitro Dissolution result of the test, the blend of gained, taking hydroxytyrosol as detecting index, reaches and dissolves completely for 15 minutes, and Penis et testis cervi micropowder, Fructus Canarii albi extract and PVPk30 blend, the dissolving of its hydroxytyrosol needs 50 minutes completely.
The blend of gained adds lactose, binding agent to granulate, and dries subpackage and obtains granule.
The preparation of antioxidation slow releasing capsule:
Embodiment 5
Penis et testis cervi micropowder: Folium olive extract=50:1000
Operation: get the ethyl cellulose of 50g weight, add ethanol stirring and dissolving complete, add the Fructus Canarii albi extract of 100g weight to grind 30 minutes, wave loose ethanol, dry, pulverize, obtain solid blend.
The blend of gained adds starch, and lactose, magnesium stearate mix, capsule charge, the sustainable release of this capsule 12 hours.
Embodiment 6
The preparation of antioxidation dry suspension:
Penis et testis cervi micropowder: Folium olive extract=25:250
Operation: the PEG6000 that gets 500g weight, be heated to 70 DEG C, stirring and dissolving is complete, adds the Fructus Canarii albi extract of 250g weight to stir 15 minutes, dissolves completely, add again the Penis et testis cervi micropowder of 25g weight to stir, be uniformly dispersed, and it is cooling to put into rapidly ice-water bath, after solidifying, pulverize, obtain solid blend.
The blend of gained adds lactose, sodium carboxymethyl cellulose, sweeting agent, essence etc. to mix subpackage to obtain dry suspension.
Embodiment 7
The preparation of antioxidation tablet:
Penis et testis cervi micropowder: Folium olive extract=10:250
Operation: the PEG6000 that gets 750g weight, be heated to 70 DEG C, stirring and dissolving is complete, adds the Fructus Canarii albi extract of 250g weight to stir 15 minutes, dissolves completely, add again the Penis et testis cervi micropowder of 10g weight to stir, be uniformly dispersed, and it is cooling to put into rapidly ice-water bath, after solidifying, pulverize, obtain solid blend.
The blend of gained adds vertical compression lactose, and carboxymethyl starch is received, magnesium stearate, silicon dioxide mix homogeneously, and tabletting obtains tablet.Show through In Vitro Dissolution result of the test, the tablet of gained, taking hydroxytyrosol as detecting index, reaches stripping in 20 minutes complete.
Embodiment 8
The preparation of antioxidation tablet:
Penis et testis cervi micropowder: Folium olive extract=10:250
Operation: get the mannitol of 250g weight, suitable quantity of water, grinds, adds the Fructus Canarii albi extract of 250g weight to grind 30 minutes, then adds the Penis et testis cervi micropowder of 10g weight to grind, and is uniformly dispersed, and after oven dry, pulverizes, and obtains solid blend.
The blend of gained adds vertical compression lactose, and carboxymethyl starch is received, magnesium stearate, silicon dioxide mix homogeneously, and tabletting obtains tablet.Show through In Vitro Dissolution result of the test, the tablet of gained, taking hydroxytyrosol as detecting index, reaches stripping in 20 minutes complete.
Embodiment 9
The preparation of antioxidation tablet:
Penis et testis cervi micropowder: Folium olive extract=10:250
Operation: the polyvidone of getting 500g weight, add appropriate ethanol, stirring and dissolving is complete, adds the Fructus Canarii albi extract of 250g weight to stir 30 minutes, dissolves completely, add again the Penis et testis cervi micropowder of 10g weight to stir, be uniformly dispersed, and it is cooling to put into rapidly ice-water bath, after baking and curing, pulverize, obtain solid blend.
The blend of gained adds vertical compression lactose, and carboxymethyl starch is received, magnesium stearate, silicon dioxide mix homogeneously, and tabletting obtains tablet.Show through In Vitro Dissolution result of the test, the tablet of gained, taking hydroxytyrosol as detecting index, reaches stripping in 15 minutes complete.
Claims (10)
1. a compositions, is characterized in that: formed as active fraction preparation by Cornu Cervi Pantotrichum and Fructus Canarii albi extract, wherein Cornu Cervi Pantotrichum and Fructus Canarii albi extract part by weight are 1～50:1～1000.
2. according to the compositions of claim 1, wherein Cornu Cervi Pantotrichum and Fructus Canarii albi extract part by weight are 10～25:250～500.
3. according to the compositions of claim 1, wherein Cornu Cervi Pantotrichum and Fructus Canarii albi extract part by weight are 10～25:250.
4. according to the compositions of claim 1, wherein Cornu Cervi Pantotrichum is Pulveratum Cornu Cervi Pantotrichum, Fructus Canarii albi extract refers to that extraction obtains material from olive fruits or Folium olive, and its composition comprises oleuropein and/or hydroxytyrosol, and wherein Pulveratum Cornu Cervi Pantotrichum and Fructus Canarii albi extract part by weight are 10～25:250.
5. according to the compositions of claim 1, contain the blend that Pulveratum Cornu Cervi Pantotrichum and Fructus Canarii albi extract are made, described blend is that Fructus Canarii albi extract is joined in dispersion soln, stir, Fructus Canarii albi extract is dissolved completely, then adds deer micropowder to stir suspendible to mix, cooling rapidly after, pulverize, obtain, wherein said dispersion soln is selected from: PEG6000, polyvidone, mannitol, ethyl cellulose.
6. according to the compositions of claim 5, wherein said blend, Penis et testis cervi micropowder, the part by weight between Fructus Canarii albi extract and dispersion soln three is: 10～25:250:120～750.
7. according to the compositions of claim 5, wherein said blend, Penis et testis cervi micropowder, the part by weight between Fructus Canarii albi extract and dispersion soln three is: 10～25:250:250.
8. according to the compositions of claim 5, also can add as required and prepare the needed carrier of food, health product and drug products.
9. according to the compositions of claim 6, be selected from: tablet, capsule, granule, powder, oral liquid, dry suspension, effervescent, slow releasing preparation.
10. compositions claimed in claim 1 is in the application of preparing in the food of antioxidant activity, health product and medicine, described application, there is slow down aging, improve or alleviate aging, improve old people's life quality, reduce or alleviate the physiology producing in aging course, the risk that pathology sharply changes generation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410149383.9A CN103893237B (en) | 2014-04-14 | 2014-04-14 | A kind of containing Cornu Cervi Pantotrichum with the compositions of Fructus Canarii albi extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410149383.9A CN103893237B (en) | 2014-04-14 | 2014-04-14 | A kind of containing Cornu Cervi Pantotrichum with the compositions of Fructus Canarii albi extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103893237A true CN103893237A (en) | 2014-07-02 |
| CN103893237B CN103893237B (en) | 2016-08-17 |
Family
ID=50985024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410149383.9A Active CN103893237B (en) | 2014-04-14 | 2014-04-14 | A kind of containing Cornu Cervi Pantotrichum with the compositions of Fructus Canarii albi extract |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103893237B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001076579A1 (en) * | 2000-04-06 | 2001-10-18 | Perricone Nicholas V | Treatment of skin damage using olive oil polyphenols |
| CN103083359A (en) * | 2013-02-25 | 2013-05-08 | 新疆南京同仁堂健康药业有限公司 | Cervus elaphus linnaeus active soft capsules and production process thereof |
-
2014
- 2014-04-14 CN CN201410149383.9A patent/CN103893237B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001076579A1 (en) * | 2000-04-06 | 2001-10-18 | Perricone Nicholas V | Treatment of skin damage using olive oil polyphenols |
| CN103083359A (en) * | 2013-02-25 | 2013-05-08 | 新疆南京同仁堂健康药业有限公司 | Cervus elaphus linnaeus active soft capsules and production process thereof |
Non-Patent Citations (4)
| Title |
|---|
| 南京中医药大学编著: "《中药大辞典第二版(下册)》", 31 March 2006, article "鹿茸", pages: 3108 * |
| 杨静等: "气流粉碎机超微粉碎鹿茸的研究", 《特产研究》, vol. 34, no. 4, 31 December 2012 (2012-12-31), pages 16 - 19 * |
| 梁文权主编: "《药剂学》", 30 September 2005, article "片剂", pages: 132-135 * |
| 黄北川: "橄榄多酚中酪醇等成分的分离纯化研究", 《中国优秀硕士学位论文全文数据库》, 15 February 2012 (2012-02-15) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103893237B (en) | 2016-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3240555B1 (en) | Multi-supplement compositions | |
| CN102871936B (en) | Nano-carrier loaded with rhodiola rosea extract and preparation method and application thereof | |
| Omidizadeh et al. | Cardioprotective compounds of red pitaya (Hylocereus polyrhizus) fruit | |
| CN103478523B (en) | Coffee-flavored Maca and pollen buccal tablet | |
| CN104383156B (en) | A kind of composition with weight-reducing and blood fat reducing function and preparation method thereof and purposes | |
| CN107441236A (en) | A kind of Astaxanthin In Haematococcus Pluvialis liver protecting product and preparation method thereof | |
| US20120034201A1 (en) | Composition for regulating lipid metabolism | |
| CN106035938A (en) | Lutein ester tableting candy and preparation method thereof | |
| CN103893237B (en) | A kind of containing Cornu Cervi Pantotrichum with the compositions of Fructus Canarii albi extract | |
| KR101906992B1 (en) | Method for manufacturing functional materials using sea cucumber and sea grapes | |
| CN104857105A (en) | Soft capsule based on raspberry fruit oil and application and preparation method thereof | |
| US20160278417A1 (en) | Nutritionally Enhanced Fraction From Rice Bran And Method of Lowering Insulin Resistance Using Same | |
| CN105310932B (en) | Cosmetic composition containing tomato fruit extraction and preparation method thereof | |
| JP5783552B2 (en) | Body fat reducing agent and body fat reducing food | |
| CN105101817A (en) | Edible composition, preparation method therefor, and food product comprising the composition | |
| CN105748350A (en) | Method for preparing coated type free-radical scavenger | |
| JP2002047193A (en) | Composition for prophylaxis or treatment of allergic dermatitis | |
| CN105901722A (en) | Euphausia superba oil healthcare capsule for preventing Alzheimer's disease | |
| CN105055260A (en) | Novel walnut skin-care product for babies and preparation method thereof | |
| CN101961105B (en) | Health-care food with antioxidant effect | |
| CN105146542B (en) | The health food and preparation method of anti-oxidation function | |
| CN103006534A (en) | Lip mask powder for lip care and preparation method thereof | |
| WO2013131998A2 (en) | Vegetal material-based compositions comprising hydrophilic and lipophilic complexes, and method for their preparation thereof | |
| Muhsin et al. | The possible protective effect of green tea extract against methotrexate-induced liver injury in male rats | |
| RU2308282C2 (en) | Composition for prophylaxis of damage action of microwave irradiation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |