CN103889314B - Use the physical length in multiple detecting refractive index eyes - Google Patents

Use the physical length in multiple detecting refractive index eyes Download PDF

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CN103889314B
CN103889314B CN201280051232.9A CN201280051232A CN103889314B CN 103889314 B CN103889314 B CN 103889314B CN 201280051232 A CN201280051232 A CN 201280051232A CN 103889314 B CN103889314 B CN 103889314B
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segmentation
iol
length
physical length
refractive index
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CN103889314A (en
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M·J·辛普森
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Novartis AG
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Novartis AG
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Abstract

In certain embodiments, the physical length of mensuration eyes includes the optical length measuring each segmentation of multiple segmentations of the axle of described eyes, and the most each segmentation is corresponding to a part for described eyes.Measure the refractive index of each segmentation.The physical length of each segmentation measures according to described optical length and the described refractive index of described segmentation.

Description

Use the physical length in multiple detecting refractive index eyes
Technical field
The disclosure relates generally to eyes and measures, and relates more specifically to use the thing in multiple detecting refractive index eyes Reason length.
Background technology
Intraocular lens (IOL) is the prosthetic lens of implantable eyes.IOL reflects by described by the refractive power of IOL The light of amount.The IOL number of degrees can be by the feature calculation of the eyes of patient.The IOL with the suitable number of degrees should be used, in order to correct rightly The vision of patient.Simplification hypothesis is generally made for calculating the known technology of the IOL number of degrees.But, these hypothesis can obtain at certain Possibility inappropriate IOL number of degrees value under a little situations.
Summary of the invention
In certain embodiments, the physical length measuring eyes includes measuring each point of multiple segmentations of the axle of eyes The optical length of section, the most each segmentation is corresponding to a part for eyes.Measure the refractive index of each segmentation.The thing of each segmentation Reason length measures according to optical length and the refractive index of described segmentation.
Accompanying drawing explanation
Referring now to accompanying drawing, it is more fully described the exemplary of the disclosure by way of example, in the accompanying drawings:
Fig. 1 and Fig. 2 illustrates the embodiment of the system and method for calculating intraocular lens (IOL) number of degrees;
Fig. 3 illustrates an embodiment of the method for the position for calculating IOL;And
Fig. 4 illustrates an embodiment of the method for using adjustable refractive index length.
Detailed description of the invention
Referring now to describing and accompanying drawing, show in detail disclosed equipment, the exemplary of system and method. Describe and accompanying drawing is not intended to detailed or otherwise claim is limited to or is defined in shown in accompanying drawing and retouches Particular disclosed in stating.Although accompanying drawing represents possible embodiment, but accompanying drawing is not necessarily drawn to scale and Some feature can be exaggerated, remove or cross-section is to be better described embodiment.
Fig. 1 and Fig. 2 illustrates the embodiment of the system and method for calculating intraocular lens (IOL) number of degrees.Real at some Executing in scheme, the IOL number of degrees also refer to the various features of IOL, such as shape, size and the refractive power of IOL.Calculate IOL degree Number refers to measure the suitable IOL concrete eyes being made to eyesight optimum.It is suitable that the pre-operative data that can use eyes measures IOL。
Fig. 1 includes figure 10, and it illustrates the embodiment of part of eyes.The part of eyes includes cornea 24 and crystalline lens (or crystalline lens (lens)) 26 and retina 30, and the axle 20 of eyes.Cornea 24 is the eyes directed the light to crystalline lens 26 Clear outer portion.Crystalline lens 26 is the transparent part of facies posterior iridis, and its help focuses the light on retina 30.Retina 30 for serving as a contrast the light-sensitive tissue at ocular region.Retina 30 converts the light to be sent to the electric pulse of brain by optic nerve.Axle 20 may refer to the optical axis, and light is along the described optical axis through eyes to retina 30.
Figure 10 also illustrates that intraocular lens (IOL) 28.IOL28 is the synthesis crystalline lens of implantable eyes.IOL28 is permissible It is the little plastics crystalline lens (or optic) with button loop, the suitable position that IOL28 is maintained in pouch by described button loop at inside ofeye Put.During cataract operation, from pouch, remove crystalline lens material, and after surgery, pouch is shunk and is maintained at by IOL28 Appropriate location.The feature of pouch and IOL28 affects the final axial location of IOL28.The feature of IOL28 can include the IOL number of degrees The layout of design (including the shape of IOL28, size (such as, thickness and diameter)) with IOL28 and part (such as optic and Button loop).
In certain embodiments, the calculating of the IOL number of degrees can by some parameter (as the number of degrees of cornea 24 and cornea 24, IOL28 and retina 30 are along the position of axle 20) take into account.Figure 10 illustrates the embodiment measuring some parameter.Such as, cornea The shape of the cornea measured by (such as) Topography System can be taken into account by data.Can directly estimate the position of IOL28, as with Under be more fully described.Wavefront calculations can be used with by these parametric measurements IOL number of degrees.
Fig. 2 illustrates that system 50 and described system 50 can be used for calculating the IOL number of degrees.System 50 includes one or more interface 52, logic 54 and one or more memorizer 56.Interface 52 includes one or more user interface 60 (UI) and one or many Individual measurement apparatus 62.Logic includes one or more input module 64 and IOL number of degrees computer 68.Input module 64 includes position Module 70 and corneal data module 74.Memorizer 56 stores the information of system 50, such as, used by position module 70 or calculate Refractive index 80 and positional information 82.
System 50 can be used for creating the accurate ray tracing model of eyes.Described model allows user to measure the postoperative of eyes Physical parameter, this can be used for improved model.System 50 can be used for being precisely calculated the IOL number of degrees, such as the target in 1D or 0.5D The number of degrees.
UI60 allows user's reception from the output of computerized system and/or to provide input into described computerization system System.The example of UI60 includes keyboard, display, mouse, mike, speaker or other user's interface device.Measurement apparatus 62 Measure one or more features of eyes.The example of measurement apparatus includes Wavefront sensor and optical coherent chromatographic imaging (Optical Coherence Tomography;Or optics Low coherence reflectometry technique (Optical Low OCT) Coherence Reflectometry;OLCR) optical bio meter (such as LENSTAR biometer).
Input module 64 generates the input of IOL number of degrees computer 68, to allow computer 68 to calculate the IOL number of degrees.Position mould Block 70 measures some part position along axle 20 of eyes.In certain embodiments, position includes the corneal position of cornea, crystalline substance The crystalline lens forward position of shape body, lenticular crystalline lens rear positions and amphiblestroid retinal location.Corneal position is Cornea 24 is along the position of axle 20.The forward position of crystalline lens 26 is the position on crystalline lens 26 surface close to ocular region, and The rear positions of crystalline lens 26 is the position of the lens surface close to ocular region.Retinal location is retina 30 surface Position.
Position module 70 can be by measuring position or by being calculated by one or more received measurement results and/or value Position locates.Such as, can by with optical bio meter systems measurement measure axial length, crystalline lens forward position and/or Crystalline lens rear positions.
Position module 70 can measure the position of IOL28 by directly being estimated position by measurement result.Some embodiment party In case, position module can according to the feature of the feature of IOL and/or eyes (as the cornea number of degrees, axial length, crystalline lens forward position and/ Or crystalline lens rear positions) calculate IOL position.This embodiment it is more fully described with reference to Fig. 3.
Position module 70 adjustable position is to provide more accurate positional value.In certain embodiments, position module 70 The refractive index of the segmentation of axle 20 can be measured and according to adjustable refractive index position.This enforcement it is more fully described with reference to Fig. 4 Example.
Corneal data module 74 measures the data describing cornea 24, such as the cornea number of degrees and topography.Can with any suitably Mode measures corneal data.In certain embodiments, according to the keratometry K pH-value determination pH corneal data of cornea.Cornea dissipates Luminosity is measuring of corneal curvature radius, and K value provides the estimation combining the number of degrees of front and rear anterior corneal surface.At some In embodiment, corneal topography system can measure and generate the refraction diagram of cornea.Refraction diagram can be by the cornea degree on cornea The change of number is taken into account.
In certain embodiments, measure according to the physical form (such as, the front and rear surface of cornea) of cornea Corneal data.Zernike polynomial (Zernike polynomial) can be used to describe topography.In some cases, rear portion Anterior corneal surface may be assumed that as spherical, and radius is less than the radius of anterior corneal surface (such as, before about 0.8 (such as 0.84) Portion's radius).In other cases, the surface of cornea can be approximated to be trochoidal surface or circular cone surpasses ring surface.Can also utilize The asphericity of varying level.In other cases, (such as) ultrasonic or Si Kaimupufu glug (Scheimpflug) can be passed through Measure systematic survey posterior cornea topography.In certain embodiments, physics corneal topography may be used for creating eyes Ray tracing model.
IOL number of degrees computer 68 measures the number of degrees of IOL28.In certain embodiments, IOL number of degrees computer 68 is by cornea Data, IOL position and retinal location calculate the IOL number of degrees.The IOL number of degrees can be measured, so that IOL28 (in conjunction with cornea 24) exists The position focusedimage of retina 30.Such as, insert having the IOL approximating the correct number of degrees in eye model, and then The regulation IOL number of degrees are until image focusing.Focal position can be according to any suitable method, such as, uses particular ray, calculates To wavefront, logical burnt modulation transfer function (MTF) (MTF) or focus on the other side of light and calculate.In certain embodiments, IOL degree Number computer 68 can include ray tracing or other suitable software.In certain embodiments, when measuring optic position It is contemplated that button loop.
In certain embodiments, other factors can be taken into account by the calculating of the IOL number of degrees.Such as, can survey in the calculation Measure and use pupil diameter.As another embodiment, pupil can be taken into account about the bias of cornea.
Fig. 3 illustrates an embodiment of the method for calculating IOL position.In certain embodiments, IOL position can be counted Calculate as the distance becoming predetermined ratio between crystalline lens forward position 110 with crystalline lens rear positions 112.
In an embodiment, thickness T is the distance between forward position 110 and rear positions 112.The thickness of IOL optic (and further feature of IOL) can change with the IOL number of degrees.When calculating IOL position, the IOL of the required number of degrees of approximation can be used. Can describe IOL position by distance D, wherein IOL28 is positioned at distance D at rear, forward position 110.Can use that IOL's is any Suitably part is as the reference point of IOL, such as the center of button loop, anterior IOL surface, the front portion of optic edge or center, or light The center of the department of the Chinese Academy of Sciences.IOL position can be estimated in any suitable manner.In certain embodiments, distance D can be thickness T Predetermined ratio.Such as, distance D can be the value in 0.3x thickness T to 0.7x thickness T range, such as D=0.4T.
In certain embodiments, can by by postoperative position compared with preoperative parameter, and locate and parameter Between dependency, by clinical data measure distance D.
Fig. 4 illustrates an embodiment of the method for using adjustable refractive index distance.In the embodiment illustrated, axle 20 are divided into different segmentation, and described different segmentations are each through the different medium of the different piece corresponding to eyes.Cornea segmentation 120 pass crystalline lens 26 through cornea 24, aqueous humor segmentation 124 through aqueous humor 125, crystalline lens segmentation 126, and vitreous humor divides Section 130 is through vitreous humor 131.
Light passes the physical distance (or length) that optical distance (or length) is optical path and the medium in the path of medium The product of refractive index.Refractive index can be (such as) group index.Measurement apparatus generally measures the distance along axle 20 as light Learn distance.Optical distance can use refractive index to be converted into physical distance.Known measurement apparatus is divided for all differences along axle 20 Duan Tongchang uses identical refractive index (such as mean refractive index).But, some embodiment is for making along the different medium of axle 20 By different refractive indexs, this can improve degree of accuracy.
In these embodiments, the optical length of each segmentation can be measured.Can use as herein described any suitably Segmentation, such as, the segmentation between anterior cornea position and retinal location.The refractive index of each segmentation can be measured.Can be according to dividing The optical length of section and refractive index calculate the physical length of each segmentation.Can according to calculated physical length regulate one or Multiple positions.Such as, adjustable position is to mate physical length.
The optical length of segmentation can be measured in any suitable manner.In certain embodiments, estimating of segmentation can be obtained Survey physical length.Also it is available for measuring one or more estimation refractive indexs of physical length.Can be according to the estimation thing of segmentation Reason length and estimation refractive index calculate the optical length of each segmentation.
Refractive index can be measured in any suitable manner.In some cases, can be from memory access refractive index.Such as, The actual refractive index of IOL is storable in memorizer and accesses from described memorizer.In other cases, can be by experience number According to calculating refractive index.Such as, the length pair of at least one of physical length of IOL perioperatively estimation axle can be obtained.Every pair Preoperative physical length and postoperative physical length can be included.Postoperative physical length can include that the IOL of the IOL that intra-operative inserted is thick Degree.In some cases, such as, when using mean refractive index to carry out the sized data from preoperative and post-operative eye, axial length Can seem different.The preoperative physical length that can measure generation every pair is substantially equal to the refractive index of postoperative physical length.Such as, adjustable Joint refractive index is until axial length is identical.The refractive index producing equal length can be considered as to be worth more accurately.
Any suitable value can be used in the calculation.Such as, can be by directly measuring physics IOL thickness or by measuring eye IOL in eyeball measures IOL thickness.In some cases, the one or more value of scalable so that they the most accurately Physical context is described.Such as, ray tracing model can be more accurate model or predict more preferable model for IOL.
In certain embodiments, physical length can be used to calculate IOL position.In these embodiments, crystalline substance can be measured The length of shape body segmentation.By the length of the length of crystalline lens segmentation He other segmentation, crystalline lens forward position and crystalline can be measured Body rear positions.Then IOL position can be calculated by crystalline lens forward position, crystalline lens rear positions and other parameter.Such as, IOL position can use calculated below:
ACDIOL=C0+C1*ACDPreoperative+C2*LTPreoperative+C3*AL+C4*KAveragely
Wherein ACDIOLRepresent the prediction anterior chamber depth (ACD) of IOL, C0For systematic offset, ACDPreoperativeRepresent lenticular art Front ACD, LTPreoperativeRepresenting preoperative lens thickness, AL represents the axial length of eyes, and KAveragelyRepresent average angle film thickness number.ACD can table Show the distance of anterior face from the anterior face of cornea to IOL.Can in the preoperative with one group of eye of postoperative measurement, to measure system Numerical value.Any suitable value can be used for coefficient, such as C0=[-8 ,-1], such as C0=-3.774;C1=[0.5,0.9], such as C1= 0.675;C2=[0.1,0.7], such as C2=0.356;C3=[0,0.3], such as C3=0.091;And C4=[0,0.3], such as C4= 0.056。
In other embodiments, the distance of the physical reference position (such as the center of button loop) that can use to IOL.Reference position Can use following mensuration:
ACDIOL+D=C0+C1*ACDPreoperative+C2*LTPreoperative+C3*AL+C4*KAveragely
Wherein D is the distance from the anterior face of IOL to reference plane.For the different IOL number of degrees, distance D can be Different.Actual optics and the physical Design with the IOL of the correct approximation number of degrees can be used for the IOL number of degrees and calculate.
In certain embodiments, physical length can be used to calculate the IOL number of degrees.IOL position and corneal data can be as herein Described it is measured.Retinal location can be measured by physical length.Then can be according to corneal data, IOL position and retina position Put the IOL number of degrees calculating IOL.
The assembly of systems and devices disclosed herein can include interface, logic, memorizer and/or other suitable element, Any described assembly may each comprise hardware and/or software.Interface can receive input, transmission exports, processes input and/or defeated Go out, and/or perform other and suitably operate.Logic can be with the operation of executive module, such as, performs instruction to be generated defeated by input Go out.Logic can encode in memory, and when being performed by computer, can perform operation.Logic can be processor, such as one Or multiple computer, one or more microprocessor, one or more application, and/or other logic.Memorizer can store letter Cease and one or more tangible, computer-readable and/or executable storage medium of computer can be included.Memorizer Example includes that computer storage (such as, random access memory (RAM) or read only memory (ROM)), massive store are situated between Matter (such as, hard disk), movable storage medium (such as, compact disk (CD) or digital video disk (DVD)), data base And/or the network storage (such as, server), and/or other computer-readable medium.
In a particular embodiment, can there be computer program, software, computer executable instructions and/or can by coding One or more computer-readable mediums of the instruction performed by computer perform the operation of embodiment.In specific embodiments In, can by storage, be implemented on and/or encode computer program and/or there is storage and/or the computer program of coding One or more computer-readable mediums perform operation.
Although describing the disclosure according to some embodiment, but the amendment of embodiment (as changed, substituting, Add, omit and/or other amendment) will be apparent for those skilled in the art.Therefore, can be without departing from the scope of the invention In the case of embodiment is made amendment.Such as, systems and devices disclosed herein can be made amendment.System and the group of equipment Part can be integrated or single, and the operation of system and equipment can be performed by more, less or other assembly.As Another embodiment, can make amendment to method disclosed herein.Method can include more, less or other step, and walks Suddenly can perform in any suitable order.
Without departing from the present invention, other amendment is possible.Such as, it is described in concrete actual application Middle explanation embodiment, but other application will be apparent for those skilled in the art.It addition, field discussed herein will There is future development, and disclosed system, equipment and method will be used together with described future development.
The scope of the present invention should not determine with reference to describing.According to patent statute, describe and use exemplary solution Release and illustrate principle and the operator scheme of the present invention.Description makes others skilled in the art can utilize various embodiment In system, equipment and method, and can have various amendment, but shall not be applied to determine the scope of the present invention.
The scope of the present invention should determine with reference to the four corner of the equivalent that claim and claim are authorized to. Unless made contrary being explicitly indicated herein, otherwise all authority requires that term should give its widest reasonable dismissal and such as Its its ordinary meaning understood by one of ordinary skill in the art.Such as, unless claim provides clear and definite contrary restriction, otherwise odd number The use of article (e.g. ,/kind, described etc.) should be read as the one or more indicated element of narration.Implement as another Example, " each/kind " refers to each member or each member of set subset of set, wherein set can include zero, one or More than one element.In a word, the present invention can revise, and not should with reference to description, and should with reference to claim and its equivalence The four corner of thing determines the scope of the present invention.

Claims (12)

1. for the method measuring one or more physical length of eyes, comprising:
Measuring the optical length of each segmentation of multiple segmentations of the axle of described eyes, each segmentation is corresponding to the one of described eyes Part;
Measure the refractive index of each segmentation of the plurality of segmentation in the following manner to obtain multiple refractive index:
Obtaining multiple length pair, every pair includes preoperative physical length and postoperative physical length, every couple of estimate described axle at least one The physical length of part, and
Measuring the plurality of refractive index, it show that the described preoperative physical length of every pair is substantially equal to described postoperative physical length;
Described optical length and the physics of each segmentation of the described refractive index the plurality of segmentation of calculating according to described segmentation are long Degree is to obtain multiple physical length;And
Use physical length calculates the IOL number of degrees of the IOL of the vision correcting described eyes.
2. the method for claim 1, described segmentation includes at least one in following segmentation: corresponding to the cornea of cornea Segmentation, corresponding to lenticular crystalline lens segmentation, corresponding to the aqueous humor segmentation of aqueous humor part and corresponding to vitreous humor part Vitreous humor segmentation.
3. the method for claim 1, described mensuration optical length farther includes:
Obtain the estimation physical length of each segmentation;
Obtain one or more estimation refractive indexs of the plurality of segmentation;And
Described estimation physical length according to described segmentation and the institute of at least one described estimation refractive index each segmentation of calculating State optical length.
4. the method for claim 1, described mensuration refractive index farther includes:
Obtaining multiple length pair, every pair includes preoperative physical length and postoperative physical length, every couple of estimate described axle at least one The physical length of part, described postoperative physical length includes the IOL length corresponding to IOL;And
Use the physics the plurality of refractive index of IOL length measurment directly measured of described IOL length.
5. the method for claim 1, it farther includes the IOL position by IOL calculated below:
Measure the crystalline lens section length of the crystalline lens segmentation of the plurality of segmentation;
Crystalline lens forward position and crystalline lens rear positions is measured by described crystalline lens section length;And
Described IOL position is calculated by described crystalline lens forward position and described crystalline lens rear positions.
6. the method for claim 1, it farther includes the IOL number of degrees by IOL calculated below:
The amphiblestroid retinal location of described eyes is calculated according to described physical length;
The IOL position of IOL is calculated by the crystalline lens segmentation of the plurality of segmentation;
Measure the cornea number of degrees of the cornea of described eyes;And
The described IOL number of degrees of described IOL are calculated according to the described cornea number of degrees, described IOL position and described retinal location.
7. for measuring a system for one or more physical length of eyes, comprising:
Measurement apparatus, its one or more features being configured to measure eyes;
Memorizer, it is configured to store positional information;And
One or more processors, it is configured to:
Measuring the optical length of each segmentation of multiple segmentations of the axle of described eyes, each segmentation is corresponding to the one of described eyes Part;
Measure the refractive index of each segmentation of the plurality of segmentation in the following manner to obtain multiple refractive index:
Utilizing described measurement apparatus to obtain multiple length pair, every pair includes preoperative physical length and postoperative physical length, estimates for every pair Survey at least one of physical length of described axle;And
Measuring the plurality of refractive index, it show that the described preoperative physical length of every pair is substantially equal to described postoperative physical length;
Described optical length and the physics of each segmentation of the described refractive index the plurality of segmentation of calculating according to described segmentation are long Degree is to obtain multiple physical length;And
Use physical length calculates the IOL number of degrees of the IOL of the vision correcting described eyes.
8. system as claimed in claim 7, described segmentation includes at least one in following segmentation: corresponding to the cornea of cornea Segmentation, corresponding to lenticular crystalline lens segmentation, corresponding to the aqueous humor segmentation of aqueous humor part and corresponding to vitreous humor part Vitreous humor segmentation.
9. system as claimed in claim 7, described mensuration optical length farther includes:
Described measurement apparatus is utilized to obtain the estimation physical length of each segmentation;
Obtain one or more estimation refractive indexs of the plurality of segmentation;And
Described estimation physical length according to described segmentation and the institute of at least one described estimation refractive index each segmentation of calculating State optical length.
10. system as claimed in claim 7, described mensuration refractive index farther includes:
Utilizing described measurement apparatus to obtain multiple length pair, every pair includes preoperative physical length and postoperative physical length, estimates for every pair Surveying at least one of physical length of described axle, described postoperative physical length includes the IOL length corresponding to IOL;And
Use the physics the plurality of refractive index of IOL length measurment directly measured of described IOL length.
11. systems as claimed in claim 7, the one or more processor is further configured to by calculated below The IOL position of IOL:
Utilize the crystalline lens section length of the crystalline lens segmentation of the described measurement apparatus the plurality of segmentation of mensuration;
Crystalline lens forward position and crystalline lens rear positions is measured by described crystalline lens section length;And
Described IOL position is calculated by described crystalline lens forward position and described crystalline lens rear positions.
12. systems as claimed in claim 7, the one or more processor is further configured to by calculated below The IOL number of degrees of IOL:
The amphiblestroid retinal location of described eyes is calculated according to described physical length;
The IOL position of IOL is calculated by the crystalline lens segmentation of the plurality of segmentation;
Utilize the cornea number of degrees of the cornea of the described measurement apparatus described eyes of mensuration;And
The described IOL number of degrees of described IOL are calculated according to the described cornea number of degrees, described IOL position and described retinal location.
CN201280051232.9A 2011-10-19 2012-10-10 Use the physical length in multiple detecting refractive index eyes Active CN103889314B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/276,983 US8632178B2 (en) 2011-10-19 2011-10-19 Determining physical lengths in an eye using multiple refractive indices
US13/276,983 2011-10-19
PCT/US2012/059495 WO2013059043A1 (en) 2011-10-19 2012-10-10 Determining physical lengths in an eye using multiple refractive indices

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Publication Number Publication Date
CN103889314A CN103889314A (en) 2014-06-25
CN103889314B true CN103889314B (en) 2016-11-30

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7883208B2 (en) * 2008-04-04 2011-02-08 AMO Groingen B.V. Systems and methods for determining intraocular lens power
CN102106716A (en) * 2009-12-29 2011-06-29 尼德克株式会社 Apparatus for measuring ocular axial length

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7883208B2 (en) * 2008-04-04 2011-02-08 AMO Groingen B.V. Systems and methods for determining intraocular lens power
CN102106716A (en) * 2009-12-29 2011-06-29 尼德克株式会社 Apparatus for measuring ocular axial length

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