CN103880645A - Method for synthesizing magnesium stearate from stearic acid - Google Patents
Method for synthesizing magnesium stearate from stearic acid Download PDFInfo
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- CN103880645A CN103880645A CN201210566025.9A CN201210566025A CN103880645A CN 103880645 A CN103880645 A CN 103880645A CN 201210566025 A CN201210566025 A CN 201210566025A CN 103880645 A CN103880645 A CN 103880645A
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- stearic acid
- magnesium stearate
- water
- synthetic method
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Lubricants (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A disclosed method for synthesizing magnesium stearate from stearic acid comprises the following steps: (1) according to weight ratio, taking 20-60 parts of stearic acid, 15-30 parts of a magnesium oxide, 2-9 parts of a catalyst and 2-6 parts of water; (2) mixing 20-60 parts of stearic acid, 15-30 parts of the magnesium oxide, 2-9 parts of the catalyst and 2-6 parts of water under a normal pressure, stirring at 40-70 DEG C with a stirring speed of 110-140 rpm for 10-25 min for fully dissolving the mixture; (3) cooling to 60-80 DEG C, continuing to react for 10-20 min, filtering, isolating a solid matter, discarding the filtrate, drying the isolated material in a drying oven with a temperature of 70-85 DEG C for 3-5 h, so as to obtain magnesium stearate. The method for synthesizing magnesium stearate from stearic acid is reasonable in formula, time-saving, material-saving, environment-friendly, low in cost and easy for popularization.
Description
Technical field
The present invention relates to organic compound synthesis technical field, be specifically related to a kind of synthetic method of preparing Magnesium Stearate of stearic acid.
Background technology
Magnesium Stearate is the light fine powder without grittiness of white; Micro-have a special smell; There is soapy feeling with skin contact.Main as lubricant, antisticking agent, glidant.The granulation of suitable especially oils, extract medicament, the particle of making has good mobility and compressibility.In direct compression, be used as glidant.Also can be used as flocculating aids, finings and drip infusion, and the suspending agent of liquid preparation, thickening material.Magnesium Stearate is widely used in makeup, food and pharmaceutical preparation industry, be mainly used in the lubricant releasing agent of tablet, also can be used as the batching of makeup and coordinate for the stablizer of polyvinyl chloride and the siccative of paint with calcium soap, zinc soap, having produced good Social benefit and economic benefit.Magnesium Stearate, as the pharmaceutical excipient of widespread use, it has been generally acknowledged that oral nontoxic.
It is second-rate that Magnesium Stearate is produced in current technical process, foreign matter content is high, salinity weight, technological process of production complexity, large to raw material disposal workload, in production process, to consume a large amount of raw material caustic soda, a large amount of water, electricity and fuel, a large amount of waste water that the by product generating in reaction contains sodium sulfate, cost recovery is high, directly exhaust emission environment.
Summary of the invention
For the deficiencies in the prior art, technical problem to be solved by this invention is, provide a kind of and fill a prescription rationally, the material-saving that saves time, protection of the environment, with low cost, be easy to the synthetic method of preparing Magnesium Stearate of stearic acid promoted.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of synthetic method of preparing Magnesium Stearate of stearic acid, comprises the following steps:
(1) get by weight stearic acid 20-60 part, oxide compound 15-30 part of magnesium, catalyzer 2-9 part, water 2-6 part proportioning;
(2) under normal pressure, get oxide compound 15-30 part, catalyzer 2-9 part, water 2-6 part of stearic acid 20-60 part, magnesium, at the temperature of 40-70 ℃, stir 10-25 minute fully to dissolve with the stirring velocity of 110-140rpm;
(3) be then cooled to 60-80 ℃, then react 10-20 minute, filter, isolate solid substance, discard filtrate, by the material separating dry 3-5 hour in the baking oven of 70-85 ℃, obtain Magnesium Stearate.
The synthetic method of preparing Magnesium Stearate of above-mentioned stearic acid, the pH value of described water is 7-10.
The synthetic method advantage of preparing Magnesium Stearate of stearic acid of the present invention is:
1, the synthetic method of preparing Magnesium Stearate of stearic acid of the present invention, the present invention, compared with existing processing method, has technical process simple, formula rationally, the material-saving that saves time, protection of the environment, with low cost, be easy to promote.
Embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1, a kind of synthetic method of preparing Magnesium Stearate of stearic acid, comprises the following steps:
(1) get by weight 20 parts of stearic acid, 15 parts of the oxide compounds of magnesium, 2 parts of catalyzer, 2 parts of proportionings of water;
(2) under normal pressure, get 2 parts of 15 parts of oxide compounds, catalyzer, 2 parts, the water of 20 parts of stearic acid, magnesium, at the temperature of 40 ℃, stir 10 minutes fully to dissolve with the stirring velocity of 110rpm;
(3) be then cooled to 60 ℃, then react 10 minutes, filter, isolate solid substance, discard filtrate, the material separating is dried to 3 hours in the baking oven of 70 ℃, obtain Magnesium Stearate.
The pH value of above-mentioned water is 7-10.
Embodiment 2, a kind of synthetic method of preparing Magnesium Stearate of stearic acid, comprises the following steps:
(1) get by weight 40 parts of stearic acid, 20 parts of the oxide compounds of magnesium, 7 parts of catalyzer, 4 parts of proportionings of water;
(2) under normal pressure, get 7 parts of 20 parts of oxide compounds, catalyzer, 4 parts, the water of 40 parts of stearic acid, magnesium, at the temperature of 50 ℃, stir 15 minutes fully to dissolve with the stirring velocity of 125rpm;
(3) be then cooled to 70 ℃, then react 15 minutes, filter, isolate solid substance, discard filtrate, the material separating is dried to 4 hours in the baking oven of 80 ℃, obtain Magnesium Stearate.
The pH value of above-mentioned water is 7-10.
Embodiment 3, a kind of synthetic method of preparing Magnesium Stearate of stearic acid, comprises the following steps:
(1) get by weight 60 parts of stearic acid, 30 parts of the oxide compounds of magnesium, 9 parts of catalyzer, 6 parts of proportionings of water;
(2) under normal pressure, get 9 parts of 30 parts of oxide compounds, catalyzer, 6 parts, the water of 60 parts of stearic acid, magnesium, at the temperature of 70 ℃, stir 25 minutes fully to dissolve with the stirring velocity of 140rpm;
(3) be then cooled to 80 ℃, then react 20 minutes, filter, isolate solid substance, discard filtrate, the material separating is dried to 5 hours in the baking oven of 85 ℃, obtain Magnesium Stearate.
The pH value of above-mentioned water is 7-10.
Certainly, above-mentioned explanation is not limitation of the present invention, and the present invention is also not limited to above-mentioned giving an example; those skilled in the art; in essential scope of the present invention, variation, change, interpolation or the replacement made, all should belong to protection scope of the present invention.
Claims (2)
1. the synthetic method of preparing Magnesium Stearate of stearic acid, is characterized in that: comprise the following steps:
(1) get by weight stearic acid 20-60 part, oxide compound 15-30 part of magnesium, catalyzer 2-9 part, water 2-6 part proportioning;
(2) under normal pressure, get oxide compound 15-30 part, catalyzer 2-9 part, water 2-6 part of stearic acid 20-60 part, magnesium, at the temperature of 40-70 ℃, stir 10-25 minute fully to dissolve with the stirring velocity of 110-140rpm;
(3) be then cooled to 60-80 ℃, then react 10-20 minute, filter, isolate solid substance, discard filtrate, by the material separating dry 3-5 hour in the baking oven of 70-85 ℃, obtain Magnesium Stearate.
2. the synthetic method of preparing Magnesium Stearate of stearic acid according to claim 1, is characterized in that: the pH value of described water is 7-10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210566025.9A CN103880645A (en) | 2012-12-24 | 2012-12-24 | Method for synthesizing magnesium stearate from stearic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201210566025.9A CN103880645A (en) | 2012-12-24 | 2012-12-24 | Method for synthesizing magnesium stearate from stearic acid |
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| CN103880645A true CN103880645A (en) | 2014-06-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210566025.9A Pending CN103880645A (en) | 2012-12-24 | 2012-12-24 | Method for synthesizing magnesium stearate from stearic acid |
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| CN (1) | CN103880645A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016109856A1 (en) | 2015-01-02 | 2016-07-07 | Melaleuca, Inc. | Multi-supplement compositions |
| WO2016109852A2 (en) | 2015-01-02 | 2016-07-07 | Melaleuca, Inc. | Bacterial compositions |
| US10137164B2 (en) | 2015-01-02 | 2018-11-27 | Melaleuca, Inc. | Dietary supplement compositions |
-
2012
- 2012-12-24 CN CN201210566025.9A patent/CN103880645A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016109856A1 (en) | 2015-01-02 | 2016-07-07 | Melaleuca, Inc. | Multi-supplement compositions |
| WO2016109852A2 (en) | 2015-01-02 | 2016-07-07 | Melaleuca, Inc. | Bacterial compositions |
| US10137164B2 (en) | 2015-01-02 | 2018-11-27 | Melaleuca, Inc. | Dietary supplement compositions |
| US11207388B2 (en) | 2015-01-02 | 2021-12-28 | Melaleuca, Inc. | Multi-supplement compositions |
| US11273195B2 (en) | 2015-01-02 | 2022-03-15 | Melaleuca, Inc. | Dietary supplement compositions |
| EP3973972A1 (en) | 2015-01-02 | 2022-03-30 | Melaleuca, Inc. | Multi-supplement compositions |
| EP4019028A1 (en) | 2015-01-02 | 2022-06-29 | Melaleuca, Inc. | Bacterial compositions |
| US11433107B2 (en) | 2015-01-02 | 2022-09-06 | Melaleuca, Inc. | Bacterial compositions |
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Application publication date: 20140625 |