CN103864777A

CN103864777A - Simple synthesis method of scopolamine butylbromide

Info

Publication number: CN103864777A
Application number: CN201410116091.5A
Authority: CN
Inventors: 彭学东; 张梅; 赵金召; 陈晓龙
Original assignee: ZHANGJIAGANG WEISHENG BIOLOGICAL PHARMACEUTICAL CO Ltd
Current assignee: ZHANGJIAGANG WEISHENG BIOLOGICAL PHARMACEUTICAL CO Ltd
Priority date: 2014-03-27
Filing date: 2014-03-27
Publication date: 2014-06-18

Abstract

The invention belongs to the technical field of organic synthesis and particularly relates to a simple synthesis method of scopolamine butylbromide. The simple synthesis method comprises the following steps of dissolving scopolamine butylbromide into tetrahydrofuran, adding n-butyl bromide, and heating for realizing reflux reaction; after the reaction is ended, cooling through an ice bath, and removing liquid at an upper layer to obtain a crude product of scopolamine butylbromide; recrystallizing the crude product twice by using methanol to obtain scopolamine butylbromide with the total yield of more than 60%. Tetrahydrofuran is used as a reaction medium in the method, so that the reaction temperature is raised, and the reaction period is shortened; after the reaction is ended, tetrahydrofuran can be repeatedly used, so that the production cost is reduced, and the environment pollution is reduced.

Description

A kind of simple method for synthesizing of Scopolamine Butylbromide

Technical field

The invention belongs to technical field of organic synthesis, be specifically related to a kind of simple method for synthesizing of Scopolamine Butylbromide.

Background technology

Scopolamine Butylbromide chemistry is by name: bromination 6 β, 7 beta epoxide-3 Alpha-hydroxy-8-butyl-l α H, 5 α H-tropane (-)-tropates.It is first synthetic in nineteen fifty by Germany, after this its pharmacology, clinical and internal metabolism has been carried out to more deep research.This medicine is similar to coromegine to smooth muscle spasmolysis effect, and its side effect to heart, expansion pupil, nervus centralis is much smaller than coromegine.Be mainly used in clinically treating vascular smooth muscle spasm, courage renal colic, gastrointestinal spasm pain of shock patient etc.

The synthetic method of the Scopolamine Butylbromide of bibliographical information mainly contains following several:

A kind of taking tetrahydrofuran (THF) as reaction medium, 65 DEG C of back flow reaction 120h of Scopolamine and bromination of n-butane, make Scopolamine Butylbromide, and yield is 65%; Another kind reacts Scopolamine and bromination of n-butane to 40h, yield 55%. in 85 DEG C

The synthetic of current domestic Scopolamine Butylbromide is mainly reaction medium with acetonitrile, but its reaction time is long, and yield is on the low side; Second method is by bromination of n-butane for reaction medium, and its boiling point is high compared with acetonitrile, and toxicity is larger, brings larger pressure to environment and safety.

Summary of the invention

The object of the invention is to overcome the above-mentioned shortcoming of prior art, provide a kind of yield higher, with short production cycle, to the synthetic method of environment and the less Scopolamine Butylbromide of security threat.

Concrete, a kind of synthesis technique of Scopolamine Butylbromide, it comprises the following steps: (1) fourth bromine east henbane alkali is in tetrahydrofuran (THF) and bromination of n-butane heating reflux reaction.Scopolamine is dissolved in tetrahydrofuran (THF), adds bromination of n-butane, heating reflux reaction, reacts complete, and ice bath is cooling, removes supernatant liquid, obtains Scopolamine Butylbromide crude product.In above-mentioned preparation method, Scopolamine and bromination of n-butane ratio are 1g:0.25 ~ 0.5ml, the ratio of Scopolamine and tetrahydrofuran (THF) is 1g:0.5 ~ 1ml, temperature of reaction is 75 ~ 85 DEG C, reaction times is 20 ~ 50h, optimum Scopolamine and bromination of n-butane and tetrahydrofuran (THF) ratio are 1g:0.3ml:0.6ml, but answering temperature is 80 DEG C, and the reaction times is 35h.(2) Scopolamine Butylbromide crude product is refining.By the first step gained lower floor recrystallizing methanol twice for solid, both Scopolamine Butylbromide.In above-mentioned preparation method, recrystallization methanol usage is 3 ~ 5 times of Scopolamine Butylbromide crude product weight.

Embodiment

Embodiment 1:(1) fourth bromine east henbane alkali is in tetrahydrofuran (THF) and bromination of n-butane heating reflux reaction.8.6g Scopolamine is dissolved in 4ml tetrahydrofuran (THF), adds 1.8ml bromination of n-butane, 80 DEG C of heating reflux reaction 35h, react complete, and ice bath is cooling, removes supernatant liquid, obtain Scopolamine Butylbromide crude product 8.5g.(2) Scopolamine Butylbromide crude product is refining.By 25ml recrystallizing methanol twice for the first step gained 8.5g crude product, both obtained Scopolamine Butylbromide 7.9g.

Embodiment 2:(1) fourth bromine east henbane alkali is in tetrahydrofuran (THF) and bromination of n-butane heating reflux reaction.10g Scopolamine is dissolved in 6ml tetrahydrofuran (THF), adds 3ml bromination of n-butane, 80 DEG C of heating reflux reaction 35h, react complete, and ice bath is cooling, removes supernatant liquid, obtain Scopolamine Butylbromide crude product 9.8g.(2) Scopolamine Butylbromide crude product is refining.By 30ml recrystallizing methanol twice for the first step gained 9.8g crude product, both obtained Scopolamine Butylbromide 9.6g.

Embodiment 3:(1) fourth bromine east henbane alkali is in tetrahydrofuran (THF) and bromination of n-butane heating reflux reaction.20g Scopolamine is dissolved in 12ml tetrahydrofuran (THF), adds 6ml bromination of n-butane, 80 DEG C of heating reflux reaction 35h, react complete, and ice bath is cooling, removes supernatant liquid, obtain Scopolamine Butylbromide crude product 20g.(2) Scopolamine Butylbromide crude product is refining.By 60ml recrystallizing methanol twice for the first step gained 20g crude product, both obtained Scopolamine Butylbromide 18g.

Claims

1. a synthesis technique for Scopolamine Butylbromide, is characterized in that Scopolamine to be dissolved in tetrahydrofuran (THF), adds bromination of n-butane, heating reflux reaction; React complete, ice bath is cooling, removes supernatant liquid, obtains Scopolamine Butylbromide crude product; By recrystallizing methanol twice for Scopolamine Butylbromide crude product, obtain Scopolamine Butylbromide.

2. the synthesis technique of a kind of Scopolamine Butylbromide according to claim 1, is characterized in that Scopolamine and bromination of n-butane ratio are 1g:0.25 ~ 0.5ml; The ratio of Scopolamine and tetrahydrofuran (THF) is 1g:0.5 ~ 1ml.

3. the synthesis technique of a kind of Scopolamine Butylbromide according to claim 1, is characterized in that temperature of reaction is 75 ~ 85 DEG C, and the reaction times is 20 ~ 50h.

4. the synthesis technique of a kind of Scopolamine Butylbromide according to claim 1, is characterized in that using after completion of the reaction ice bath cooling, and its temperature is 0 ~ 5 DEG C.

5. the synthesis technique of a kind of Scopolamine Butylbromide according to claim 1, is characterized in that recrystallization methanol usage is 3 ~ 5 times of Scopolamine Butylbromide crude product weight.