CN103861203B - Ultrasonic cavitation cloud feeding device and method - Google Patents
Ultrasonic cavitation cloud feeding device and method Download PDFInfo
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- CN103861203B CN103861203B CN201410103085.6A CN201410103085A CN103861203B CN 103861203 B CN103861203 B CN 103861203B CN 201410103085 A CN201410103085 A CN 201410103085A CN 103861203 B CN103861203 B CN 103861203B
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Abstract
The present invention relates to a kind of ultrasonic cavitation cloud feeding device and method, this device comprises: transducer, for converting electrical energy into vibrational energy, by radiating surface, vibrational energy is sent to fluid, and after vibrational energy and fluid effect, generate the first ultrasonic wave; Reflecting surface, be used for receiving the first ultrasonic wave, by the first ultrasonic reflections to fluid, the first ultrasonic wave and fluid effect after reflection generate the second ultrasonic wave, the second ultrasonic wave and the first ultrasonic wave form standing-wave sound field, standing-wave sound field acts on fluid and forms cavitation cloud, thereby the particle that makes to enter in cavitation cloud moves in cavitation cloud along the determined direction of standing-wave sound field. Ultrasonic cavitation cloud feeding device of the present invention and method have realized under the state that fluid is static around still can complete transporting of particle, and can exactly particle directed transport and fixed point be discharged into destination, therefore this device can conduct drugs to affected area, has important using value at medical field.
Description
Technical field
The present invention relates to mass transfer field, relate in particular to a kind of ultrasonic cavitation cloud feeding device and method.
Background technology
Nowadays with realize medicine orientation carry and fixed point be released to object targeted therapy become medical science,Especially the study hotspot of the PCI to tumour, the ultrasonic technology that transports is defeated with the orientation that realizes medicineSend and fix a point to be released to object targeted therapy field and there is potential, huge application prospect.
Existing is the mode that ultrasound microbubble contrast agent combines with gene and medicine. Ultrasound microbubble contrast agentBe the microvesicle that includes gas, outer shell component can be albumin, lipid, surfactant and macromolecule polyThing etc. Gene and medicine can stick to microvesicle surface or be wrapped in microvesicle inside. By intravenous injection,Microvesicle can reach target organ or target tissue. Carry out ultrasonic irradiation at affected area, ultrasonic cavitation effect makesThe permeability of cell membrane, gene or medicine that microvesicle carries enter histocyte, thereby reach treatmentObject. But this mode positioning performance is strong not, because the scope of ultrasonic irradiation is wider, really existsThe microvesicle that affected area plays a role is also few. Can improve drug delivery and utilize cavitation cloud to transport technologyPositioning precision, increasing action, in the microvesicle quantity of affected area, improves drug delivery efficiency, improves treatment effectReally.
Summary of the invention
The object of the invention is for the deficiencies in the prior art, provide a kind of ultrasonic cavitation cloud feeding device andMethod, it is anti-that this device and method sends to ultrasonic wave and reflecting surface after fluid by transducer by vibrational energyThe standing-wave sound field that the ultrasonic wave of penetrating forms, standing-wave sound field acts on the cavitation cloud that fluid forms, and regulates transducingThe position of device and reflecting surface and phase place are adjusted position and the direction of standing-wave sound field, thereby make to enter cavitationParticle in cloud moves in cavitation cloud along the determined direction of standing-wave sound field, has realized fluid aroundUnder static state, still can complete transporting of particle, and can be exactly by particle directed transport andFixed point is discharged into destination.
For achieving the above object, first aspect present invention provides a kind of ultrasonic cavitation cloud feeding device, shouldDevice comprises: transducer, for converting electrical energy into vibrational energy, sends to vibrational energy by radiating surfaceFluid, generates the first ultrasonic wave after vibrational energy and fluid effect; Reflecting surface, for receiving the first ultrasonic wave,By the first ultrasonic reflections, to fluid, the first ultrasonic wave and fluid effect after reflection generate the second ultrasonic wave,The second ultrasonic wave and the first ultrasonic wave form standing-wave sound field, and standing-wave sound field acts on fluid and forms cavitation cloud,Thereby the particle that makes to enter in cavitation cloud moves in cavitation cloud along the determined direction of standing-wave sound field.
Preferably, the operating frequency of transducer is 10kHz-50MHz.
Preferably, the amplitude of standing-wave sound field is 50kPa-200kPa.
Preferably, standing-wave sound field acts on fluid and forms cavitation cloud and specifically comprise: the structure of cavitation cloud is soundLichtenberg's figures structure.
Preferably, particle is solid particle, bubble, is insoluble to drop and the acoustic contrast agent of fluid.
Second aspect present invention provides a kind of ultrasonic cavitation cloud transportation method, and the method comprises: transducerConvert electrical energy into vibrational energy, by radiating surface, vibrational energy is sent to fluid; Vibrational energy and fluid effectRear generation the first ultrasonic wave; Reflecting surface receives the first ultrasonic wave, by the first ultrasonic reflections to fluid; InsteadThe first ultrasonic wave and fluid effect after penetrating generate the second ultrasonic wave; The second ultrasonic wave and the first ultrasonic waveformBecome standing-wave sound field; Standing-wave sound field acts on fluid and forms cavitation cloud, thus make to enter in cavitation cloudGrain thing moves in cavitation cloud along the determined direction of standing-wave sound field.
Preferably, the second ultrasonic wave and the first ultrasonic wave formation standing-wave sound field specifically comprise: regulate transducerWith position and the phase place of reflecting surface, thereby regulate the first ultrasonic wave and the second hyperacoustic phase place and direction,Determine that thus the first ultrasonic wave and the second ultrasonic wave form position and the direction of standing-wave sound field.
Preferably, the particle entering in cavitation cloud is transported in cavitation cloud along the determined direction of standing-wave sound fieldMoving specifically comprise: enter particle in cavitation cloud along the low-pressure amplitude region of standing-wave sound field to standing wave soundThe high pressure amplitude region direction of field moves in cavitation cloud.
The beneficial effect that the present invention brings is: ultrasonic cavitation cloud feeding device provided by the invention and method are realShowed under the state that fluid is static around and still can complete transporting of particle, and can be exactly byGrain thing directed transport and fixed point are discharged into destination, and therefore this device can conduct drugs to affected area,Medical field has important using value, and the PCI of tumour is had to potential application prospect.
Brief description of the drawings
Fig. 1 is applied to showing of targeted therapy for the ultrasonic cavitation cloud feeding device that the embodiment of the present invention one providesIntention;
The ultrasonic cavitation cloud feeding device schematic diagram that Fig. 2 provides for the embodiment of the present invention two;
The ultrasonic cavitation cloud feeding device that Fig. 3 provides for the embodiment of the present invention two produces the schematic diagram of cavitation cloud;
Fig. 4 is the schematic diagram that in the embodiment of the present invention two, ultrasonic cavitation cloud feeding device forms cavitation cloud;
Fig. 5 is the structure chart of the embodiment of the present invention two cavitation clouds;
Fig. 6 is the movement locus of particle in cavitation cloud in the embodiment of the present invention two;
The ultrasonic cavitation cloud transportation method flow chart that Fig. 7 provides for the embodiment of the present invention.
Detailed description of the invention
Below by drawings and Examples, technical scheme of the present invention is described in further detail.
The invention discloses a kind of ultrasonic cavitation cloud feeding device and method, ultrasonic cavitation cloud of the present invention is defeatedShipping unit sends to vibrational energy by transducer the ultrasonic waveform of ultrasonic wave after fluid and reflecting surface reflectionThe standing-wave sound field becoming, standing-wave sound field acts on the cavitation cloud that fluid forms, adjusting transducer and reflecting surfacePosition and phase place are adjusted position and the direction of standing-wave sound field, thereby make to enter the particle in cavitation cloudMove in cavitation cloud along the determined direction of standing-wave sound field. Realize under the state that fluid is static around,This ultrasonic cavitation cloud feeding device still can complete transporting of particle. This device is widely used in medical treatment neckTerritory, can conduct drugs to affected area.
Fig. 1 is applied to showing of targeted therapy for the ultrasonic cavitation cloud feeding device that the embodiment of the present invention one providesIntention. As shown in Figure 1, the fluid 13 in embodiment mono-is blood, and particle is acoustic contrast agent. ChangeCan convert electrical energy into vibrational energy by device 11, by the radiating surface of transducer 11, vibrational energy be sent to blood,After vibrational energy and blood effect, generate the first ultrasonic wave; Reflecting surface 12 receives the first ultrasonic wave, will the first surpassAcoustic reflection is to blood, and the first ultrasonic wave and blood effect after reflection generate the second ultrasonic wave, the second surpassSound wave and the first ultrasonic wave form standing-wave sound field, and standing-wave sound field acts on blood and forms cavitation cloud, now entersThe contrast preparation entering in cavitation cloud arrives affected area along the determined direction of standing-wave sound field.
The ultrasonic cavitation cloud feeding device schematic diagram that Fig. 2 provides for the embodiment of the present invention two. As shown in Figure 2,Transducer 11 is mainly used in, by radiating surface, vibrational energy is sent to fluid 13, and vibrational energy and fluid 13 are doneWith rear generation the first ultrasonic wave, reflecting surface 12 is for receiving the first ultrasonic wave from fluid 13, and generalThe first ultrasonic reflections is to this process of fluid 13.
The ultrasonic cavitation cloud feeding device that Fig. 3 provides for the embodiment of the present invention two produces the schematic diagram of cavitation cloud.As shown in Figure 3, the ultrasonic cavitation cloud feeding device that the embodiment of the present invention two provides need to be immersed in stream completely13 li of bodies, transducer in a ultrasonic cavitation cloud feeding device 11 at least one, reflecting surface 12 is at leastOne.
In conjunction with Fig. 2 and Fig. 3, ultrasonic cavitation cloud feeding device is described, this device comprises: transducer11 and reflecting surface 12.
Transducer 11 is immersed in 13 li of fluids after wrapping up with guard shield, and the effect of guard shield is in order to preventTransducer 11 leaks electricity, and the operating frequency of transducer 11 is 10kHz-50MHz. When provided by the invention ultrasonicBefore the work of cavitation cloud feeding device, need first transducer 11 to be immersed in completely to 13 li of fluids, thenRestart transducer 11, burn out because of zero load to prevent transducer 11.
Because the too little meeting of the second ultrasonic energy causes forming standing wave, so the border of reflecting surface 12Be well bounds, can make like this second hyperacoustic energy attenuation less. Transducer as the case may be11 can be focused transducer, and reflecting surface 12 can be concave surface, because energy centralization effect makes the first to surpassSound wave and the second ultrasonic energy increase. The ultrasonic cavitation cloud feeding device providing in the embodiment of the present invention twoIn, reflecting surface 12 can be glass container, transducer 11 is immersed in the glass appearance that fluid 13 is housed completelyIn device, glass container wall is exactly reflecting surface 12.
Fluid 13 can be water, blood etc., and the similar liquid with mobility, if for medical fieldCarry out the directed transport of medicine, fluid 13 majorities are blood. In the embodiment of the present invention two, fluid 13Be preferably the aqueous solution.
Transducer 11, for converting electrical energy into vibrational energy, sends to fluid by radiating surface by vibrational energy13, after vibrational energy and fluid 13 effects, generate the first ultrasonic wave.
Particularly, transducer 11 specifically also comprises radiating surface, and transducer 11 shakes for converting electrical energy intoKinetic energy, sends to the aqueous solution by radiating surface by vibrational energy, after vibrational energy and aqueous solution effect, generates firstUltrasonic wave. The operating frequency of transducer 11 is 10kHz-50MHz. Owing to forming the standing-wave sound field of cavitation cloudAmplitude is at least 50kPa, and the amplitude that cavity is repelled in high pressure amplitude region is at least 200kPa, so stayThe amplitude of wave sound field is 50kPa-200kPa.
Reflecting surface 12, for receiving the first ultrasonic wave, by the first ultrasonic reflections to fluid 13, after reflectionThe first ultrasonic wave and fluid 13 effect generate the second ultrasonic waves, the second ultrasonic wave and the formation of the first ultrasonic waveStanding-wave sound field, standing-wave sound field acts on fluid 13 and forms cavitation cloud, thereby make to enter in cavitation cloudGrain thing moves in cavitation cloud along the determined direction of standing-wave sound field.
Particularly, reflecting surface 12 is for receiving the first ultrasonic wave from fluid 13, more ultrasonic by firstWave reflection, to fluid 13, now, contains the vibrational energy being sent by transducer 11 and acts on stream in fluid 13The first ultrasonic wave of body 13 rear formation and reflecting surface 12 are by the first ultrasonic reflections reflux 13 and fluidThe second ultrasonic wave after 13 effects, then the second ultrasonic wave and the stack of the first ultrasonic wave form standing-wave sound field,Standing-wave sound field acts on fluid 13 and forms cavitation cloud.
Fig. 4 is the schematic diagram that in the embodiment of the present invention two, ultrasonic cavitation cloud feeding device forms cavitation cloud. Fig. 5For the structure chart of the embodiment of the present invention two cavitation clouds. As shown in Figure 4, standing-wave sound field acts on fluid 13Form cavitation cloud, the structure of cavitation cloud is sound Lichtenberg's figures structure particularly. As shown in Figure 5, cavitation cloudStructure be sound Lichtenberg's figures structure, be also dendritic morphology, cavitation cloud periphery a bit, as A point BAny point in some C point D point or E point, throws in a small particle, and particle is at standing wave soundUnder the active force of field, move to F point along the dendritic morphology of cavitation cloud.
Fig. 6 is the movement locus of particle in cavitation cloud in the embodiment of the present invention two. As shown in Figure 6,Particle dendritic morphology along cavitation cloud under the active force of standing-wave sound field moves to from A point the rail that F is orderedMark figure, the particle that enters into cavitation cloud is tied at sound Lichtenberg's figures along the determined direction of standing-wave sound fieldIn the cavitation cloud of structure, move, wherein standing-wave sound field determined transport direction be from low-pressure amplitude region toHigh pressure amplitude regional movement, so particle is from low-pressure amplitude region to high pressure amplitude regional movement.Particle is the material that solid, gas or liquid etc. are insoluble to fluid 13 in this ultrasonic cavitation cloud feeding device,For example: bubble, drop, acoustic contrast agent. So this device can be by regulating transducer 11 and reflectionThe position of face 12 and phase place, thus the first ultrasonic wave and the second hyperacoustic phase place and direction regulated, thusDetermine that the first ultrasonic wave and the second ultrasonic wave form position and the direction of standing-wave sound field.
In the ultrasonic cavitation cloud feeding device providing in the embodiment of the present invention two, transducer 11 at least one,Reflecting surface 12 at least one, in the time that transducer 11 and reflecting surface 12 are all several, some by regulatingPosition and the phase place of individual transducer 11 and several reflectings surface 12, thus the first ultrasonic wave and second regulatedUltrasonic wave forms position and the direction of standing-wave sound field, further determines the fortune that enters the particle in cavitation cloudMoving path.
Meanwhile, in ultrasonic cavitation cloud feeding device, the transducer 11 of two same frequencys also can form skyChange cloud, two ultrasonic wave stack formation standing-wave sound fields that transducer 11 sends, now adjust two transducers11 position or phase place realize the position and the direction that regulate standing-wave sound field, also can add multiple same frequencysMore than 11 reflecting surface 12 of transducer realized the control to standing-wave sound field position and direction.
For example, transducer 11 is attached on skin, on skin, smears some couplants, make more how ultrasonicWave energy propagates in body, has two or more such same frequency transducers 11, the blood vessel of specifying like thisInterior formation standing wave, determines lesions position and cavitation cloud node location by modes such as B ultrasonic, adjusts transducer11 positions and phase place are adjusted cavitation cloud node location, and cavitation cloud node location is overlapped with lesions position.Inject acoustic contrast agent to internal blood vessel, contrast preparation is many microvesicles, and these microvesicles are under the effect of sound fieldConstantly expand and shrink, because the second order Bjerknes power between the main Bjerknes power of sound field and microvesicle,Because the interaction force between suffered sound field power and the microvesicle of microvesicle forms cavitation cloud, cavitation cloud is by micro-Bubble together with stick on microvesicle surface or be wrapped in microvesicle inside DNA or drug delivery to affected area.
Therefore, the ultrasonic cavitation cloud feeding device that the embodiment of the present invention two provides, will shake by transducer 11Kinetic energy sends to the standing-wave sound field that ultrasonic wave that ultrasonic wave after fluid 13 and reflecting surface 12 reflect forms,Standing-wave sound field acts on the cavitation cloud that fluid 13 forms, by regulating the position of transducer 11 and reflecting surface 12Put position and the direction of adjusting standing-wave sound field with phase place, thereby determine that the particle entering in cavitation cloud existsThe path of moving in cavitation cloud. Under the state that fluid 13 is static so around, particle still can be automaticArrival destination, the positioning performance of this device is accurate.
The ultrasonic cavitation cloud transportation method flow chart that Fig. 7 provides for the embodiment of the present invention. This ultrasonic cavitation cloudTransportation method is the ultrasonic cavitation cloud feeding device providing based on the embodiment of the present invention. As shown in Figure 7, originallyEmbodiment specifically comprises the following steps:
Step 201, transducer 11 convert electrical energy into vibrational energy, by radiating surface, vibrational energy are sent toFluid 13.
Particularly, fluid 13 is the liquid of mobility, and in embodiments of the present invention, fluid 13 is preferablyThe aqueous solution. Transducer 11 specifically also comprises radiating surface, and transducer 11 converts electrical energy into vibrational energy, logicalVibrational energy is sent to the aqueous solution by overshoot face, after vibrational energy and aqueous solution effect, generates the first ultrasonic wave.
After step 202, vibrational energy and fluid 13 effects, generate the first ultrasonic wave. Transducer 11 sends feedwaterThe vibrational energy of solution and aqueous solution effect generate the first ultrasonic wave.
Step 203, reflecting surface 12 receive the first ultrasonic wave, by the first ultrasonic reflections to fluid 13.
Particularly, in the device providing in the embodiment of the present invention, transducer 11 be immersed in be completely equipped with water-solubleIn the glass container of liquid, glass container wall is exactly reflecting surface 12. Reflecting surface 12 receives from of the aqueous solutionOne ultrasonic wave, then by the first ultrasonic reflections to the aqueous solution.
The first ultrasonic wave after step 204, reflection and fluid 13 effects generate the second ultrasonic wave. Glass holdsWall to the aqueous solution, and generates the second ultrasonic wave with aqueous solution effect by the first ultrasonic reflections.
Step 205, the second ultrasonic wave and the first ultrasonic wave form standing-wave sound field.
Particularly, behind step 203 and 204, in the aqueous solution, there are two different ultrasonic waves, firstThe vibrational energy that ultrasonic wave sends from transducer 11 acts on the sound wave forming after the aqueous solution, the second ultrasonic waveFrom glass container wall by the first ultrasonic reflections backwater solution and with aqueous solution effect after sound wave, thenThe second ultrasonic wave and the stack of the first ultrasonic wave form standing-wave sound field. By regulating transducer 11 and reflecting surface 12Position and phase place, thereby regulate the first ultrasonic wave and the second hyperacoustic phase place and direction, determine thusThe first ultrasonic wave and the second ultrasonic wave form position and the direction of standing-wave sound field.
Step 206, standing-wave sound field act on fluid 13 and form cavitation cloud, thereby make to enter in cavitation cloudParticle move in cavitation cloud along the determined direction of standing-wave sound field.
Particularly, standing-wave sound field acts on the aqueous solution and forms cavitation cloud, and the structure of cavitation cloud is that sound Lee front yard is richGraph structure. The particle that enters into cavitation cloud along the determined direction of standing-wave sound field at sound Lichtenberg's figuresIn the cavitation cloud of structure, move, wherein the determined direction that transports of standing-wave sound field is from low-pressure amplitude regionTo high pressure amplitude regional movement, so particle is transported from low-pressure amplitude region to high pressure amplitude regionMoving.
Therefore, the ultrasonic cavitation cloud transportation method that the embodiment of the present invention provides, by transducer by vibrational energySend to the standing-wave sound field that ultrasonic wave that ultrasonic wave after fluid 13 and reflecting surface 12 reflect forms, standing waveThe cavitation cloud that sound field reflecting forms in fluid 13, by regulating position and the phase of transducer and reflecting surface 12Position and the direction of standing-wave sound field adjusted in position, thereby determines that the particle entering in cavitation cloud is at cavitation cloudThe path of middle motion. The method has realized under the state that fluid 13 is static around, and particle still can be certainlyMoving arrival destination. The method is widely used in medical field, and the method positioning performance is accurate, can be byThe directed conveying of medicine and fixed point are discharged into affected area, and the PCI of tumour is had to potential application prospect.
Professional should further recognize, describes in conjunction with embodiment disclosed hereinThe unit of each example and algorithm steps, can come with electronic hardware, computer software or the combination of the twoRealize, for the interchangeability of hardware and software is clearly described, in the above description according to functionComposition and the step of each example have been described in general manner. These functions are come with hardware or software mode actuallyCarry out, depend on application-specific and the design constraint of technical scheme. Professional and technical personnel can be to oftenIndividual specifically should being used for realized described function with distinct methods, but this realization should not be thoughtExceed scope of the present invention.
The method of describing in conjunction with embodiment disclosed herein or the step of algorithm can be used hardware, processingThe software module that device is carried out, or the combination of the two is implemented. Software module can be placed in random access memory(RAM), internal memory, read-only storage (ROM), electrically programmable ROM, electrically erasable ROM,Known any other form in register, hard disk, moveable magnetic disc, CD-ROM or technical fieldStorage medium in.
Above-described detailed description of the invention, carries out object of the present invention, technical scheme and beneficial effectFurther description, institute it should be understood that the foregoing is only the specific embodiment of the present invention and, the protection domain being not intended to limit the present invention, within the spirit and principles in the present invention all, institute doesAny amendment, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. a ultrasonic cavitation cloud feeding device, described device comprises transducer and reflecting surface, its feature existsIn:
Described transducer, for converting electrical energy into vibrational energy, sends described vibrational energy by radiating surfaceGive fluid, after described vibrational energy and described fluid effect, generate the first ultrasonic wave;
Described reflecting surface, for receiving described the first ultrasonic wave, by described the first ultrasonic reflections to described inFluid, described the first ultrasonic wave and described fluid effect after reflection generate the second ultrasonic wave, described secondUltrasonic wave and described the first ultrasonic wave form standing-wave sound field, and described standing-wave sound field acts on described fluid and formsCavitation cloud, thus make to enter particle in described cavitation cloud along the determined direction of described standing-wave sound fieldIn described cavitation cloud, move.
2. ultrasonic cavitation cloud feeding device according to claim 1, is characterized in that described transducingThe operating frequency of device is 10kHz-50MHz.
3. ultrasonic cavitation cloud feeding device according to claim 1, is characterized in that described standing waveThe amplitude of sound field is 50kPa-200kPa.
4. ultrasonic cavitation cloud feeding device according to claim 1, is characterized in that described standing waveSound field reflecting forms cavitation cloud in described fluid and specifically comprises: the structure of described cavitation cloud is sound Lichtenberg's figuresStructure.
5. ultrasonic cavitation cloud feeding device according to claim 1, is characterized in that described particleThing is solid particle, bubble, be insoluble to drop and the acoustic contrast agent of described fluid.
6. a ultrasonic cavitation cloud transportation method, is characterized in that, described method comprises:
Transducer converts electrical energy into vibrational energy, by radiating surface, described vibrational energy is sent to fluid;
After described vibrational energy and described fluid effect, generate the first ultrasonic wave;
Reflecting surface receives described the first ultrasonic wave, by extremely described fluid of described the first ultrasonic reflections;
Described the first ultrasonic wave and described fluid effect after reflection generate the second ultrasonic wave;
Described the second ultrasonic wave and described the first ultrasonic wave form standing-wave sound field;
Described standing-wave sound field acts on described fluid and forms cavitation cloud, thereby makes to enter in described cavitation cloudParticle move in described cavitation cloud along the determined direction of described standing-wave sound field.
7. ultrasonic cavitation cloud transportation method according to claim 6, is characterized in that described secondUltrasonic wave and described the first ultrasonic wave form standing-wave sound field and specifically comprise: regulate described transducer and described anti-Penetrate position and the phase place of face, thereby regulate described the first ultrasonic wave and described the second hyperacoustic phase place and sideTo, determine that thus the first ultrasonic wave and the second ultrasonic wave form position and the direction of standing-wave sound field.
8. ultrasonic cavitation cloud transportation method according to claim 6, is characterized in that, described in enterParticle in the described cavitation cloud tool that moves in described cavitation cloud along the determined direction of described standing-wave sound fieldBody comprises: enter particle in described cavitation cloud along the low-pressure amplitude region of described standing-wave sound field to instituteThe high pressure amplitude region direction of stating standing-wave sound field moves in described cavitation cloud.
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| CN104138736B (en) * | 2014-08-19 | 2016-08-31 | 中国科学院声学研究所 | A kind of ultrasonic cavitation device |
| CN107907373A (en) * | 2017-11-29 | 2018-04-13 | 中国科学院声学研究所 | A kind of particulate matter sampler and its system |
| CN111773177A (en) * | 2020-07-16 | 2020-10-16 | 南京大学 | Method for realizing fixed-point release of drug particles by using acoustic radiation force |
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| CN102095796A (en) * | 2010-11-12 | 2011-06-15 | 中国科学院声学研究所 | Device and method for detecting fluid cavitation by combining active ultrasonic with passive acoustics |
| CN102548614A (en) * | 2009-04-15 | 2012-07-04 | 皇家飞利浦电子股份有限公司 | Tumor treatment using ultrasound cavitation |
| CN203861768U (en) * | 2014-03-19 | 2014-10-08 | 中国科学院声学研究所 | Ultrasonic cavitation cloud transporting device |
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| CN102548614A (en) * | 2009-04-15 | 2012-07-04 | 皇家飞利浦电子股份有限公司 | Tumor treatment using ultrasound cavitation |
| CN102095796A (en) * | 2010-11-12 | 2011-06-15 | 中国科学院声学研究所 | Device and method for detecting fluid cavitation by combining active ultrasonic with passive acoustics |
| CN203861768U (en) * | 2014-03-19 | 2014-10-08 | 中国科学院声学研究所 | Ultrasonic cavitation cloud transporting device |
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