CN103860496A - Bazedoxifene acetate dispersing tablet and preparation method thereof - Google Patents
Bazedoxifene acetate dispersing tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a bazedoxifene acetate dispersing tablet, and a preparation method and application thereof. The bazedoxifene acetate dispersing tablet comprises the following components in percentage by weight: 5-40 percent of bazedoxifene acetate, 10-50 percent of filler, 10-50 percent of disintegrating agent, 10-50 percent of acidifying agent, 0.1-15 percent of adhesive and 0.1-20 percent of lubricant and glidant. Compared with a common tablet, the bazedoxifene acetate dispersing tablet does not contain surfactant, has excellent solubility, dispersibility and disintegration, and can be completely disintegrated in 1 minute. The bazedoxifene acetate dispersing tablet prepared by adopting the method has the advantages of high solubility, good bioavailability, quick in-vivo distribution, stable quality and good taste; the preparation method is simple and practical, and is suitable for industrial production.
Description
Invention field
The present invention relates to chemical pharmacy field, be specifically related to a kind of bazedoxifene acetate dispersible tablet and preparation method thereof.
Background of invention
Since nearly over half a century, the quality of life problem that improves menopausal women more and more receives publicity, and hormone replacement therapy (HRT) has been widely used in climacteric and postmenopausal women.Although accumulated Observational data evidence for many years, in healthy menopausal women, use the pros and cons problem of HRT still among inquiring into.People, on the one hand in the more scientific more rational HRT scheme of further investigation, are applicable to the more preferably medicine of menopausal women on the one hand in searching.Selective estrogen receptor modulators (SERMS) is the medicine of a class synthetic, in some tissues, plays estrogen-like effects, plays the effect of estrogen antagonist sample in other tissues, is expected to for preventing and treating Menopausal diseases.Tamoxifen is first generation SERM, at mammary gland performance estrogenic antagonist, has been successfully used to the auxiliary treatment of breast carcinoma, but endometrium is had to stimulation.Bazedoxifene acetate (Bazedoxifene) is second filial generation SERM, to bone and Cardiovasculai appearance in patient estrogen-like effects, and at uterus and mammary gland performance estrogenic antagonist, has better potential applicability in clinical practice.
Osteoporosis chief reason is calcareous from skeletal tissue's loss, makes skeleton bulking, becomes fragile, dies down, thereby easily fracture.After women's menolipsis, may reduce because of estrogenic synthetic quantity, and osteoporosis easily occurs.The fracture of its Chang Bingfa vertebra, wrist and hip, and can increase and aggravation along with the age.
WAY 140424 (Bazedoxifene) is selective estrogen receptor modulators (SERM), and it presents the tissue-selective estrogen receptor agonist activity to skeleton and lipid metabolism, and does not stimulate uterus and breast tissue.In preclinical study, compressing bone strength and histomorphometricall that WAY 140424 shows the improvement that is better than raloxifene (raloxifene) distribute.This is supported by II phase clinical effectiveness, the biochemical marker of its announcement WAY 140424 reduction bone resorption.
These data show that WAY 140424 may show: a) than more bone protective effect when low dosage of current commercial SERM; b) effect of ametria agonist, c) the low potentiality to the easypro contracting flushing of induction of vascular and d) improvement of serum lipid distribution.In addition, data also show that WAY 140424 suppresses the propagation of breast cancer cell of estradiol-stimulations, and it implies the SERM that WAY 140424 also may can reduce breast carcinoma occurrence risk as other and works.
Bazedoxifene acetate dispersible tablet provided by the invention adopts acidulant by its parcel or wraps up mutually, thereby reach the effect of embedding, and through repetition test, each component screening is arrived to weight ratio of the present invention, the dispersible tablet steady quality obtaining, stripping is fast, in body, distribute rapidly, bioavailability is high, and dispersibility, disintegrative are good, can disintegrate in 1 minute complete, and this product is not containing surfactant, and can reduce stimulates body.
Summary of the invention
The invention provides a kind of new bazedoxifene acetate dispersible tablet, is that the interpolation surfactant existing according to existing bazedoxifene acetate ordinary tablet has the problems such as stimulation, bioavailability are not high to body.The invention provides a kind of bazedoxifene acetate dispersible tablet, adopt acidulant by its parcel or parcel mutually, thereby reach the effect of embedding, and through repetition test by each component screening to weight ratio of the present invention, the dispersible tablet steady quality obtaining, stripping is fast, in body, distributes rapidly, and bioavailability is high, dispersibility, disintegrative are good, can disintegrate in 1 minute complete, and this product is containing surfactant, and can reduce stimulates body.
On the one hand, the invention provides a kind of bazedoxifene acetate dispersible tablet, a kind of bazedoxifene acetate dispersible tablet, it comprises as follows according to the component of percetage by weight meter: bazedoxifene acetate 5～40%, filler 10～50%, disintegrating agent 10～50%, acidulant 10～50%, binding agent 0.1～15%, lubricant and fluidizer 0.1～20%.
Some embodiments therein, bazedoxifene acetate dispersible tablet of the present invention, it comprises as follows according to the component of percetage by weight meter: bazedoxifene acetate 20%, filler 30%, disintegrating agent 25%, acidulant 20%, binding agent 2%, lubricant and fluidizer 3%.
Some embodiments therein, bazedoxifene acetate dispersible tablet of the present invention, wherein, described filler is a kind of in starch, Icing Sugar, dextrin, lactose, microcrystalline Cellulose, mannitol, sorbitol or xylitol or their mixture.
Some embodiments therein, bazedoxifene acetate dispersible tablet of the present invention, wherein, described disintegrating agent is a kind of in microcrystalline Cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose sodium, crospolyvinylpyrrolidone, crosslinked carboxymethyl fecula sodium, dried starch or their mixture.
Some embodiments therein, bazedoxifene acetate dispersible tablet of the present invention, wherein, described acidulant is a kind of in citric acid, lactic acid, acetic acid, ethanedioic acid, malonic acid, succinic acid, tartaric acid, adipic acid, malic acid, nicotinic acid, pectic acid, ascorbic acid, caffeic acid, fumaric acid, maleic acid, phosphoric acid solution, aspartic acid, glutamic acid, succinic acid or their mixture.
Some embodiments therein, bazedoxifene acetate dispersible tablet of the present invention, wherein, described binding agent is a kind of in hypromellose, sodium carboxymethyl cellulose, starch, pregelatinized Starch, polyvidone, gelatin, Polyethylene Glycol, ethanol, water or their mixture.
Some embodiments therein, bazedoxifene acetate dispersible tablet of the present invention, wherein, described lubricant and fluidizer are a kind of of micropowder silica gel, magnesium stearate, silicon dioxide, Pulvis Talci, Polyethylene Glycol apoplexy due to endogenous wind or their mixture.
On the other hand, the invention provides a kind of preparation method of bazedoxifene acetate dispersible tablet, it comprises the steps: that (1) sieve bazedoxifene acetate and pharmaceutic adjuvant respectively; Binding agent be dissolved in concentration be 85% or following alcoholic solution or aqueous solution in after, then the acidulant of recipe quantity is dissolved in the solution containing binding agent, obtain acid solution; (2) bazedoxifene acetate is mixed homogeneously with filler, disintegrating agent, fluidizer after adopting the made acid solution embedding of step (1), adds binding agent, mixes, and makes soft material; (3) soft material is crossed to 14～30 mesh sieves, 40～60 DEG C dry, 14～30 order granulate; (4) add lubricant, mix homogeneously; (5) tabletting, makes bazedoxifene acetate dispersible tablet.
Some embodiments therein, the preparation method of bazedoxifene acetate dispersible tablet of the present invention, wherein, described in step (2), be that bazedoxifene acetate and acid solution are passed through to fluid bed embedding with sour embedding, or bazedoxifene acetate is put into together with acid solution to colloid mill and sheared, drier.
The prescription ratio of bazedoxifene acetate dispersible tablet of the present invention is not by teaching material or other reference material gained, but by the testing program gained conforming with the regulations in a large number, made dispersible tablet has carried out quality research, meets " Chinese Pharmacopoeia " 2010 editions two and make by oneself about dispersible tablet and other requirement of quality standard.In research, find the obvious existing conventional tablet of dissolution of technical solution of the present invention.
Compared with prior art, the present invention has following beneficial effect:
(1) bazedoxifene acetate is made tablet formulation by the present invention, belongs to the whole world pioneering, can improve like this its bioavailability;
(2) the present invention granulates after adopting acidulant to process in the preparation of bazedoxifene acetate dispersible tablet, greatly improves its bioavailability;
(3) tablet formulation that the present invention makes, compared with ordinary tablet, stripping is rapid, and disintegrative is good, and disintegrate completely in 1 minute absorbs soon, and bioavailability is high, stable in properties;
(4) tablet formulation that the present invention makes, does not use surface active agent solubilization in manufacturing process, reduce body is stimulated, and has reduced the untoward reaction of medicine, has increased patient's compliance.
Excipient of the present invention comprises, but be not limited to, ion-exchanger, aluminum, aluminium stearate, lecithin, serum albumin, as human albumin, buffer substance is as phosphate, glycine, sorbic acid, potassium sorbate, the partial glycerol ester admixture of saturated vegetable fatty acid, water, salt or electrolyte, as protamine sulfate, sodium hydrogen phosphate, potassium hydrogen phosphate, sodium chloride, zinc salt, colloid silicon, magnesium trisilicate, polyvinylpyrrolidone, polyacrylate, wax, polyethylene-polyoxypropylene-blocking-up polymer, lanoline, sugar, as lactose, dextrose plus saccharose, starch is as corn starch and potato starch, the derivant of cellulose and it is as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate, natural gum powder, Fructus Hordei Germinatus, gelatin, Pulvis Talci, adjuvant is as cocoa butter and suppository wax, oily as Oleum Arachidis hypogaeae semen, Oleum Gossypii semen, safflower oil, Oleum Sesami, olive oil, Semen Maydis oil and Oleum Glycines, glycols compound, as propylene glycol and Polyethylene Glycol, esters is as ethyl oleate and ethyl laurate, agar, buffer agent is as magnesium hydroxide and aluminium hydroxide, alginic acid, pyrogen-free water, Deng oozing salt, Lin Ge (family name) solution, ethanol, phosphate buffer solution, and other nontoxic proper lubrication agent are as sodium laurylsulfate and magnesium stearate, coloring agent, releasing agent, coating dress material, sweeting agent, flavoring agent and spice, antiseptic and antioxidant.
Pharmaceutical composition of the present invention can also optionally contain one or more diluent.The example of diluent comprises mannitol, sorbitol, biphosphate calcium dihydrate, microcrystalline Cellulose and efflorescence cellulose.Preferred diluent is microcrystalline Cellulose.Microcrystalline Cellulose can be obtained from several suppliers, comprises Avicel PH101, Avicel PH102, Avicel PH103, Avicel PH105 and Avicel PH200 that FMC Corporation manufactures.
Pharmaceutical composition of the present invention can also optionally contain disintegrating agent.Disintegrating agent can be the one in several modified starches, modified cellulose polymer or polycarboxylic acids, such as crosslinked Carboxymethyl cellulose sodium, Explotab, polacrilin potassium and calcium carboxymethylcellulose (CMCCalcium).In one embodiment, disintegrating agent is croscarmellose sodium.Croscarmellose sodium NF type A obtains with trade name " Ac-di-sol " on market.
Pharmaceutical composition of the present invention can also optionally contain one or more surfactants or wetting agent.Surfactant can be anion, cation or neutral surface active agent.Anion surfactant comprises sodium lauryl sulfate, dodecyl sodium sulfate, oleyl sodium sulfate and the sodium laurate mixing with stearate and Talcum.Cationic surfactant comprises benzalkonium chloride and alkyl trimethyl ammonium bromide.Neutral surface active agent comprises glycerol list olein, polyoxyethylene sorbitan fatty acid ester, polyvinyl alcohol and anhydro sorbitol fat.The embodiment of wetting agent comprises poloxamer, polyoxyethylene alkyl ether, castor oil derivatives and polyoxyethylene 8 stearate fat.
The present invention can also optionally join antioxidant in preparation, thereby gives its chemical stability.Antioxidant is selected from the extract of a-tocopherol, Y-tocopherol, S-tocopherol, tocopherol enrichment natural origin, sodium or calcium salt, the Vitamin C acyl cetylate of L-AA and it, amass wealth by heavy taxation propyl propionate, amass wealth by heavy taxation misery ester, amass wealth by heavy taxation sour dodecyl ester, Yoshinox BHT (BHT) and butylated hydroxyanisol (BHA).In one embodiment, antioxidant is BHT or BHA.
The preferred dosage form of drug composition of the present invention is the tablet of preparing by compression method.Described tablet can carry out film with the mixture such as hydroxypropyl cellulose and hydroxypropyl emthylcellulose, contains titanium dioxide and/or other coloring agent, such as ferrum oxide, dyestuff and Se Dian in this mixture; The mixture of polyvinyl alcohol (PVA) and Polyethylene Glycol (PEG), contains titanium dioxide and/or other coloring agent, such as ferrum oxide, dyestuff and Se Dian; Or any other suitable instant-free coating agent.Coating provides taste masked and other stability to final tablet.What commercially available film provided for Colorcon is preparation mixture of powders
The present invention can also add sweeting agent and/or fumet.
Detailed description of the invention
Further explain the present invention below in conjunction with embodiment, but embodiment does not limit in any form to the present invention.
Embodiment 1
Bazedoxifene acetate 100g
Lactose 120g
Crospolyvinylpyrrolidone 25g
Carboxymethylstach sodium 50g
Hydroxypropyl methylcellulose 4g
Micropowder silica gel 15g
Magnesium stearate 10g
Water 60g
95% ethanol 126g
Make 1000.
Preparation method:
Step 1: the bazedoxifene acetate of having pulverized and pharmaceutic adjuvant are crossed respectively to 120 mesh sieves, and hydroxypropyl methylcellulose first uses hot water swelling, is stirred to dissolving, then adds ethanol, makes concentration of alcohol reach 70%.
Step 2: by recipe quantity, bazedoxifene acetate, lactose, polyvinylpolypyrrolidone, micropowder silica gel are mixed to equal Uniform, add the solution of hypromellose described in step 1 to make soft material.
Step 3: made soft material in step 2 is crossed to 18 mesh sieves and granulate, 50 DEG C dry, and moisture is 2.6%, 18 mesh sieve granulate.
Step 4: mix homogeneously with magnesium stearate making granule in step 3.
Step 5: semi-finished product detect, and determine sheet weight, and tabletting, obtains bazedoxifene acetate dispersible tablet.
Embodiment 1 dispersible tablet smooth in appearance, dispersibility meets relevant regulations, but dissolution is poor.
Embodiment 2
Bazedoxifene acetate 100g
Lactose 80g
Crospolyvinylpyrrolidone 14g
Carboxymethylstach sodium 20g
Hydroxypropyl methylcellulose 3.5g
Citric acid 100g
Micropowder silica gel 15g
Magnesium stearate 7.5g
Water 60g
95% ethanol 80g
Make 1000.
Preparation method:
Step 1: the bazedoxifene acetate of having pulverized and pharmaceutic adjuvant are crossed respectively to 120 mesh sieves, and hydroxypropyl methylcellulose first uses hot water swelling, is stirred to dissolving, then adds ethanol, makes concentration of alcohol reach 70%.Separately get above-mentioned hydroxypropyl methylcellulose solution 50g, add 60g water, add citric acid mix homogeneously.
Step 2: recipe quantity bazedoxifene acetate and citric acid solution in step 1 are mixed homogeneously with recipe quantity lactose, crospolyvinylpyrrolidone, carboxymethylstach sodium, micropowder silica gel after fluid bed acid embedding, adds described in step 1, to remain hypromellose solution and make soft material.
Step 3: made soft material in step 2 is crossed to 16 mesh sieves and granulate, 50 DEG C dry, and moisture is 2.5%, 16 mesh sieve granulate.
Step 4: mix homogeneously with magnesium stearate making granule in step 3.
Step 5: semi-finished product detect, and determine sheet weight, and tabletting, obtains bazedoxifene acetate dispersible tablet.
Embodiment 2 has added acidulant, has reduced the amount of disintegrating agent, and technique is optimized on the basis of embodiment 1, after first acidification, granulates again, finds dispersible tablet smooth in appearance, and dissolution is better, can disintegrate completely in 2min.
Embodiment 3
Bazedoxifene acetate 100g
Crospolyvinylpyrrolidone 40g
Carboxymethylstach sodium 40g
Hydroxypropyl methylcellulose 3.5g
Citric acid 100g
Micropowder silica gel 15g
Magnesium stearate 7.5g
Water 90g
95% ethanol 54g
Make 1000.
Preparation method is with embodiment 2.
Implementing 3 increases crospolyvinylpyrrolidone, carboxymethylstarch sodium content, and dispersible tablet dispersibility meets 2010 editions pharmacopeia requirements, and dissolution is better.
Embodiment 4
It is identical that embodiment 4 and embodiment 3 write out a prescription, and selects different acidify embedding modes, and bazedoxifene acetate and acidulant solution are put into colloid mill and sheared, then spraying is dry.The indices of dispersible tablet and the embodiment 3 made dispersible tablet there was no significant difference of writing out a prescription.
Embodiment 5
Bazedoxifene acetate 100g
Lactose 80g
Crospolyvinylpyrrolidone 30g
Carboxymethylstach sodium 50g
Starch 3.5g
Citric acid 70g
Malic acid 30g
Micropowder silica gel 15g
Magnesium stearate 7.5g
Water 114g
Make 1000.
Preparation method:
Step 1: the bazedoxifene acetate of having pulverized and pharmaceutic adjuvant are crossed respectively to 120 mesh sieves, and starch adds water and makes starch slurry.Get the starch slurry 50g preparing, stir and add 94g water, then add citric acid, mix equal Uniform.
Step 2: recipe quantity bazedoxifene acetate is mixed homogeneously with recipe quantity lactose, crospolyvinylpyrrolidone, carboxymethylstach sodium, micropowder silica gel, malic acid after fluid bed acid embedding with part acid solution in step 1, adds remaining starch slurry described in step 1 to make soft material.
Step 3: made soft material in step 2 is crossed to 24 mesh sieves and granulate, 60 DEG C dry, and moisture is 2.5%, 24 mesh sieve granulate.
Step 4: mix homogeneously with magnesium stearate making granule in step 3.
Step 5: semi-finished product detect, and determine sheet weight, and tabletting, obtains bazedoxifene acetate dispersible tablet.
Embodiment 5 starch in replace hydroxypropyl methylcellulose, all the other are constant, find that made dispersible tablet hardness declines to some extent at equal pressure condition lower sheeting, but also meet 2010 editions pharmacopeia dispersible tablet standards.
Embodiment 6
Bazedoxifene acetate 100g
Starch 80g
Crospolyvinylpyrrolidone 25g
Carboxymethylstach sodium 50g
Hydroxypropyl methylcellulose 3g
Succinic acid 100g
Micropowder silica gel 15g
Magnesium stearate 8g
Water 70g
95% ethanol 51g
Make 1000.
Preparation method is with embodiment 2.
Embodiment 6 changes filler, and replace lactose with starch, and succinic acid is replaced to citric acid, the made dispersible tablet there was no significant difference of dispersible tablet and embodiment 3, dispersibility and dissolution are all better.
Embodiment 7
Bazedoxifene acetate 100g
Icing Sugar 80g
Crospolyvinylpyrrolidone 25g
Carboxymethylstach sodium 50g
Hydroxypropyl methylcellulose 3.5g
Citric acid 100g
Micropowder silica gel 15g
Magnesium stearate 7.5g
Water 70g
95% ethanol 51g
Make 1000.
Preparation method is with implementing 2.
Embodiment 7 changes filler, replaces lactose with Icing Sugar, all the other with embodiment 3 together, the made dispersible tablet there was no significant difference of dispersible tablet and embodiment 3, dispersibility and dissolution are all better.
Embodiment 8
Bazedoxifene acetate 100g
Starch 80g
Crospolyvinylpyrrolidone 25g
Carboxymethylstach sodium 50g
Hydroxypropyl methylcellulose 3.5g
Malic acid 100g
Micropowder silica gel 15g
Magnesium stearate 7.5g
Water 70g
95% ethanol 51g
Make 1000.
Preparation method is with embodiment 7.
The made dispersible tablet smooth in appearance of embodiment 8, dissolution are good, and dispersibility is slightly poorer than adopting the dispersible tablet of citric acid, but adopts the dispersible tablet of succinic acid to get well.
Biological test
(1) table 1 is for selling the dissolution comparative result of bazedoxifene acetate ordinary tablet in bazedoxifene acetate dispersible tablet and market.
With reference to dissolution method (2010 editions two annex XC bis-methods of Chinese Pharmacopoeia).
The comparison of ordinary tablet cumulative percentage dissolution is sold in table 1 bazedoxifene acetate dispersible tablet and market
As can be seen from Table 1, the dissolution in vitro of bazedoxifene acetate dispersible tablet in 10-30min is obviously better than ordinary tablet.
(2) bazedoxifene acetate dispersible tablet assay
Measure with reference to high-efficient liquid phase technique (two annex VD of Chinese Pharmacopoeia version in 2010).
Table 2 bazedoxifene acetate dispersible tablet assay
| Batch | Bazedoxifene acetate dispersible tablet content (%) |
| Batch 1 | 99.78 |
| Batches 2 | 100.37 |
| Batches 3 | 100.25 |
As can be seen from Table 2, the content of the bazedoxifene acetate dispersible tablet requirement that conforms with the regulations.
(3) the quality stability comparison of bazedoxifene acetate dispersible tablet
Bazedoxifene acetate dispersible tablet accelerated test: the bazedoxifene acetate dispersible tablet of blister package is put under 2 DEG C of 40 DEG C of scholars of temperature, relative humidity 75% scholar's 5% condition and placed six months, outcome quality is stable, and indices is as shown in table 3.
Six months accelerated test testing results of table 3 bazedoxifene acetate dispersible tablet
| Inspection batch | Outward appearance | Disintegration | Dispersing uniformity | Dissolution % | Content % |
| Batch 1 | Faint yellow smooth | 39 | Conform with the regulations | 100.25 | 100.14 |
| Batches 2 | Faint yellow smooth | 40 | Conform with the regulations | 100.34 | 100.18 |
| Batches 3 | Faint yellow smooth | 40 | Conform with the regulations | 99.98 | 99.98 |
Claims (9)
1. a bazedoxifene acetate dispersible tablet, it comprises as follows according to the component of percetage by weight meter: bazedoxifene acetate 5～40%, filler 10～50%, disintegrating agent 10～50%, acidulant 10～50%, binding agent 0.1～15%, lubricant and fluidizer 0.1～20%.
2. bazedoxifene acetate dispersible tablet according to claim 1, it comprises as follows according to the component of percetage by weight meter: bazedoxifene acetate 20%, filler 30%, disintegrating agent 25%, acidulant 20%, binding agent 2%, lubricant and fluidizer 3%.
3. bazedoxifene acetate dispersible tablet according to claim 1 and 2, wherein, described filler is a kind of in starch, Icing Sugar, dextrin, lactose, microcrystalline Cellulose, mannitol, sorbitol or xylitol or their mixture.
4. bazedoxifene acetate dispersible tablet according to claim 1 and 2, wherein, described disintegrating agent is a kind of in microcrystalline Cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose sodium, crospolyvinylpyrrolidone, crosslinked carboxymethyl fecula sodium, dried starch or their mixture.
5. bazedoxifene acetate dispersible tablet according to claim 1 and 2, wherein, described acidulant is a kind of in citric acid, lactic acid, acetic acid, ethanedioic acid, malonic acid, succinic acid, tartaric acid, adipic acid, malic acid, nicotinic acid, pectic acid, ascorbic acid, caffeic acid, fumaric acid, maleic acid, phosphoric acid solution, aspartic acid, glutamic acid, succinic acid or their mixture.
6. bazedoxifene acetate dispersible tablet according to claim 1 and 2, wherein, described binding agent is a kind of in hypromellose, sodium carboxymethyl cellulose, starch, pregelatinized Starch, polyvidone, gelatin, Polyethylene Glycol, ethanol, water or their mixture.
7. bazedoxifene acetate dispersible tablet according to claim 1 and 2, wherein, described lubricant and fluidizer are a kind of of micropowder silica gel, magnesium stearate, silicon dioxide, Pulvis Talci, Polyethylene Glycol apoplexy due to endogenous wind or their mixture.
8. a preparation method for bazedoxifene acetate dispersible tablet described in any one claim in claim 1-7, it comprises the steps: that (1) sieve bazedoxifene acetate and pharmaceutic adjuvant respectively; Binding agent be dissolved in concentration be 85% or following alcoholic solution or aqueous solution in after, then the acidulant of recipe quantity is dissolved in the solution containing binding agent, obtain acid solution; (2) bazedoxifene acetate is mixed homogeneously with filler, disintegrating agent, fluidizer after adopting the made acid solution embedding of step (1), adds binding agent, mixes, and makes soft material; (3) soft material is crossed to 14～30 mesh sieves, 40～60 DEG C dry, 14～30 order granulate; (4) add lubricant, mix homogeneously; (5) tabletting, makes bazedoxifene acetate dispersible tablet.
9. the preparation method of bazedoxifene acetate dispersible tablet according to claim 8, wherein, described in step (2), be that bazedoxifene acetate and acid solution are passed through to fluid bed embedding with sour embedding, or bazedoxifene acetate put into together with acid solution to colloid mill and sheared, drier.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546794A (en) * | 2015-01-05 | 2015-04-29 | 万特制药(海南)有限公司 | Bazedoxifene acetate capsule and preparation method thereof |
| CN110237078A (en) * | 2019-05-24 | 2019-09-17 | 深圳大学 | Application of the bazedoxifene acetate in Killing Mycobacterium Tuberculosis drug |
| CN112076163A (en) * | 2019-06-14 | 2020-12-15 | 四川科伦药物研究院有限公司 | Pharmaceutical composition of bazedoxifene acetate tablets and preparation method thereof |
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| CN1929835A (en) * | 2004-01-13 | 2007-03-14 | 惠氏公司 | Treatment of aromatase inhibitor therapy-related osteoporosis |
| CN102266300A (en) * | 2011-07-14 | 2011-12-07 | 广东药学院 | Gefitinib dispersible tablet and preparation method and application thereof |
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2014
- 2014-03-14 CN CN201410093546.6A patent/CN103860496A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1929835A (en) * | 2004-01-13 | 2007-03-14 | 惠氏公司 | Treatment of aromatase inhibitor therapy-related osteoporosis |
| CN102266300A (en) * | 2011-07-14 | 2011-12-07 | 广东药学院 | Gefitinib dispersible tablet and preparation method and application thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546794A (en) * | 2015-01-05 | 2015-04-29 | 万特制药(海南)有限公司 | Bazedoxifene acetate capsule and preparation method thereof |
| CN110237078A (en) * | 2019-05-24 | 2019-09-17 | 深圳大学 | Application of the bazedoxifene acetate in Killing Mycobacterium Tuberculosis drug |
| CN110237078B (en) * | 2019-05-24 | 2022-02-18 | 深圳大学 | Application of bazedoxifene acetate in anti-mycobacterium tuberculosis drugs |
| CN112076163A (en) * | 2019-06-14 | 2020-12-15 | 四川科伦药物研究院有限公司 | Pharmaceutical composition of bazedoxifene acetate tablets and preparation method thereof |
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Application publication date: 20140618 |