CN103845377A - Method for extracting chamomile flavonoid by continuous counter-current ultrasound wave - Google Patents
Method for extracting chamomile flavonoid by continuous counter-current ultrasound wave Download PDFInfo
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- CN103845377A CN103845377A CN201210519075.1A CN201210519075A CN103845377A CN 103845377 A CN103845377 A CN 103845377A CN 201210519075 A CN201210519075 A CN 201210519075A CN 103845377 A CN103845377 A CN 103845377A
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- chamomile
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- flos matricariae
- matricariae chamomillae
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Abstract
The invention relates to a method for extracting chamomile flavonoid, and particularly relates to a method for extracting chamomile flavonoid by a continuous counter-current ultrasound wave. The method is a method for extracting flavonoid from a chamomile crushing material and an extracting solvent in a continuous counter-current under the ultrasonic wave intensification condition. The method comprises the following steps: crushing a chamomile flower head into 5-40 meshes of chamomile crushing material; feeding the chamomile crushing material to a material inlet of an extruder by using a feeder at normal temperature and normal pressure, wherein the chamomile crushing material evenly passes through an ultrasonic wave intensification part of the extractor under drive of a spiral stirrer, simultaneously, the solvents injected from solvent inlets at the upper part and the tail part of the ultrasonic wave intensification part of the extractor form convection current to fully mix and extract the chamomile crushing material and the solvent according to a certain ratio; controlling the extracted ultrasonic wave frequency at 20-30KHz, and controlling the extraction time at 20-40 minutes. The method disclosed by the invention is large in handling capacity of the chamomile crushing material, continuous to run, full to extract and high in solvent recovery rate, and great extraction of the chamomile flavonoid is facilitated.
Description
Technical field
The present invention relates to a kind of extracting method of Flos Matricariae chamomillae total flavones, specifically a kind of method of continuous flow upstream supersound extraction Flos Matricariae chamomillae total flavones.
Background technology
The production technology of plant extract has the methods such as solvent distillation extraction, supercritical extraction, carbon dioxide extract at low temperature at present.Flos Matricariae chamomillae total flavones extracts the main solvent distillation extracting method that adopts at present, extracts solvent and adopts petroleum ether, methanol, normal hexane, ethanol etc., and because solvent price is high, solvent extraction yield is in addition low, shade deviation.We are by adopting the analysis and research of Continuous Countercurrent Extraction technology, ultrasonic wave extraction, grope through overtesting, Flos Matricariae chamomillae total flavones adopts continuous flow upstream ultrasonic extraction, extracting temperature and pressure remains under room temperature, normal pressure, it is that the distillation extraction method of extracting solvent has improved more than 50% that extraction ratio adopts ethanol, and extraction time foreshortened in 40 minutes.Contrast in supercritical extraction with carbon dioxide, find that carbon dioxide its penetration in the time of supercriticality is extremely strong, the impurity such as waxiness, fatty acid in Flos Matricariae chamomillae crushed material is extracted simultaneously, brings difficulty to subsequent treatment simultaneously.And the method for carbon dioxide extract at low temperature Flos Matricariae chamomillae total flavones, although extraction ratio is higher, investment cost is high, treating capacity is less.
Summary of the invention
The object of this invention is to provide a kind ofly enhance productivity, the method for solvent recovering rate is higher, equipment investment is few continuous dynamic ultrasound ripple countercurrent extraction Flos Matricariae chamomillae total flavones.
Main contents of the present invention: after deliberation solvent (petroleum ether, methanol, normal hexane, ethanol etc.) under normal temperature and pressure and ultrasound-enhanced condition its dissolubility and penetration stronger, the Flos Matricariae chamomillae total flavones extracting is unaffected at normal temperature condition undertissue cell, can ensure better biological activity.In addition, the omnidistance adverse current state of extractor, each section of concentration difference keeps larger, ensured to use the solvent of minimum to reach best extraction effect.Concrete grammar is: Flos Matricariae chamomillae head inflorescence is crushed to after 15 1 80 orders, at room temperature, under normal pressure, Flos Matricariae chamomillae crushed material is sent into extractor material inlet with batcher, Flos Matricariae chamomillae crushed material is under the promotion of screw mixer, evenly by the intensified by ultrasonic wave part of extractor, the solvent simultaneously being injected by intensified by ultrasonic wave part top and the afterbody solvent inlet of extractor forms convection current and carries out abundant mixed extraction, Flos Matricariae chamomillae crushed material and solvent are in 1:3-1:6 ratio, extracting ultrasonic frequency was controlled at for 20-30 KHz extraction times and is controlled at the extracting method of 20-40 minute.Method Flos Matricariae chamomillae crushed material treating capacity of the present invention is large, and operation continuously, extracts fully, and solvent recovering rate is higher, is conducive to a large amount of extractions of Flos Matricariae chamomillae total flavones.Solution in residue after extracting is carried out to cryoconcentration after extruding, filtration, can realize the recycling of solvent.Residue after extruding can be used as feedstuff after dried simultaneously, fertilizer utilizes again, has both improved economic benefit, has avoided again the pollution to environment.
Method of the present invention has the following advantages compared with the prior art:
Flos Matricariae chamomillae crushed material treating capacity is large, and operation continuously, and in the material of extraction, impurity is less, and solvent recovering rate is higher, and ultrasonic device investment is less, extracts temperature low (room temperature) and is conducive to the stable of Flos Matricariae chamomillae total flavones.There is the feature of extracting under room temperature, normal pressure compared with solvent distillation extraction method, can effectively protect the active component of extract, shorten extraction time more than 2/3 simultaneously; There is the little feature of investment compared with supercritical equipment; To have technological process quite simple with carbon dioxide extract at low temperature, the feature that technical requirement is low.
Detailed description of the invention
Embodiment 1:
Flos Matricariae chamomillae head inflorescence is crushed to 5 orders, under room temperature, normal pressure, Flos Matricariae chamomillae crushed material is sent into extractor material inlet with batcher, Flos Matricariae chamomillae crushed material is under the promotion of screw mixer, evenly by the intensified by ultrasonic wave part of extractor, the solvent simultaneously being injected by intensified by ultrasonic wave part top and the afterbody solvent inlet of extractor forms convection current and carries out abundant mixed extraction, wherein Flos Matricariae chamomillae crushed material and solvent are in 1:3 ratio, hyperacoustic frequency is, 20kHz, extraction time is controlled at 40 minutes.Solution after extraction reclaims solvent after extruding, the solution filter after extruding is carried out to cryoconcentration simultaneously, can realize the recycling of solvent; Residue after extruding can be used as feedstuff after dried simultaneously, fertilizer utilizes again, has both improved economic benefit, has avoided again the pollution to environment.
Embodiment 2;
Flos Matricariae chamomillae head inflorescence is crushed to 20 orders, under room temperature, normal pressure, Flos Matricariae chamomillae crushed material is sent into extractor material inlet with batcher, Flos Matricariae chamomillae crushed material is under the promotion of screw mixer, evenly by the intensified by ultrasonic wave part of extractor, the solvent simultaneously being injected by intensified by ultrasonic wave part top and the afterbody solvent inlet of extractor forms convection current and carries out abundant mixed extraction, wherein Flos Matricariae chamomillae crushed material and solvent are in 1:4 ratio, hyperacoustic frequency is 25kHz, and extraction time is controlled at 30 minutes.Solution after extraction reclaims solvent after extruding, the solution filter after extruding is carried out to cryoconcentration simultaneously, can realize the recycling of solvent; Residue after extruding can be used as feedstuff after dried simultaneously, fertilizer utilizes again, has both improved economic benefit, has avoided again the pollution to environment.
Embodiment 3:
Flos Matricariae chamomillae head inflorescence is crushed to 40 orders, under room temperature, normal pressure, Flos Matricariae chamomillae crushed material is sent into extractor material inlet with batcher, Flos Matricariae chamomillae crushed material is under the promotion of screw mixer, evenly by the intensified by ultrasonic wave part of extractor, the solvent simultaneously being injected by intensified by ultrasonic wave part top and the afterbody solvent inlet of extractor forms convection current and carries out abundant mixed extraction, wherein Flos Matricariae chamomillae crushed material and solvent are in 1:6 ratio, hyperacoustic frequency is 30kHz, and extraction time is controlled at 20 minutes.Solution after extraction reclaims solvent after extruding, the solution filter after extruding is carried out to cryoconcentration simultaneously, can realize the recycling of solvent; Residue after extruding can be used as feedstuff after dried simultaneously, fertilizer utilizes again, has both improved economic benefit, has avoided again the pollution to environment.
Claims (2)
1. a method for continuous flow upstream ultrasonic extraction Flos Matricariae chamomillae total flavones, is characterized in that adopting Continuous Countercurrent Extraction technology and ultrasonic technology to combine and carries out the method for Flos Matricariae chamomillae total flavones extraction.
2. the method for a continuous flow upstream ultrasonic extraction Flos Matricariae chamomillae total flavones, its feature is being crushed to Flos Matricariae chamomillae head inflorescence 5-40 object Flos Matricariae chamomillae crushed materials, at room temperature, under normal pressure, Flos Matricariae chamomillae crushed material is sent into extractor material inlet with batcher, Flos Matricariae chamomillae crushed material is under the promotion of screw mixer, evenly by the intensified by ultrasonic wave part of extractor, the solvent simultaneously being injected by intensified by ultrasonic wave part top and the afterbody solvent inlet of extractor forms convection current and carries out abundant mixed extraction, Flos Matricariae chamomillae crushed material and solvent 1:3-1:6 in proportion, hyperacoustic frequency is 20-30kHz, extraction time is controlled at 20-40 minutes, by the solution in residue after extracting through extruding, after filtration, carry out cryoconcentration, can realize the recycling of solvent, residue drying after extruding can be used as feedstuff after processing simultaneously, fertilizer utilizes again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210519075.1A CN103845377A (en) | 2012-12-06 | 2012-12-06 | Method for extracting chamomile flavonoid by continuous counter-current ultrasound wave |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210519075.1A CN103845377A (en) | 2012-12-06 | 2012-12-06 | Method for extracting chamomile flavonoid by continuous counter-current ultrasound wave |
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| CN103845377A true CN103845377A (en) | 2014-06-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210519075.1A Pending CN103845377A (en) | 2012-12-06 | 2012-12-06 | Method for extracting chamomile flavonoid by continuous counter-current ultrasound wave |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129311A (en) * | 2007-09-18 | 2008-02-27 | 陈苏莉 | Creamier formulation containing turmeric and extractive of flax seed and method of producing the same |
| WO2009083612A2 (en) * | 2008-01-02 | 2009-07-09 | Groschup Martin H | Flavonoid as means for the prophylaxis and treatment of neurodegenerative and other protein folding-aberration diseases |
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2012
- 2012-12-06 CN CN201210519075.1A patent/CN103845377A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129311A (en) * | 2007-09-18 | 2008-02-27 | 陈苏莉 | Creamier formulation containing turmeric and extractive of flax seed and method of producing the same |
| WO2009083612A2 (en) * | 2008-01-02 | 2009-07-09 | Groschup Martin H | Flavonoid as means for the prophylaxis and treatment of neurodegenerative and other protein folding-aberration diseases |
Non-Patent Citations (2)
| Title |
|---|
| 周秋丽: "《现代中药基础研究与临床》", 30 June 2012 * |
| 易克传等: "超声波强化逆流提取机及提取试验", 《农业机械学报》 * |
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Application publication date: 20140611 |