CN103834043A - Preparation method of methylcellulose solution - Google Patents
Preparation method of methylcellulose solution Download PDFInfo
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- CN103834043A CN103834043A CN201210476359.7A CN201210476359A CN103834043A CN 103834043 A CN103834043 A CN 103834043A CN 201210476359 A CN201210476359 A CN 201210476359A CN 103834043 A CN103834043 A CN 103834043A
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Abstract
The invention discloses a preparation method of a methylcellulose solution. The method includes: firstly adding methylcellulose into a small amount of hot water to prepare a methylcellulose mixture; and then adding a rest volume of cold water, placing the mixture in ice-water bath, conducting stirring cooling till forming a clarified viscous solution. At the initial stage of preparation, a small amount of hot water is employed to wet and disperse methylcellulose powder, and at a later stage, rapid cooling is carried out with the help of ice-water bath so as to reduce cooling time. The methylcellulose solution prepared by the method has good uniformity and stability, and the preparation time is short, the operation is simple and convenient, thus being suitable for preparation of large volume methylcellulose solution.
Description
Technical field
The present invention relates to the preparation of methocel solution, particularly relate to a kind of method of preparing fast, easily homogeneous, stable methocel solution.
Background technology
Methylcellulose gum is white or off-white color is fibrous or granulated powders, and odorless is almost insoluble in dehydrated alcohol, ether, acetone, disperses rapidly, swelling in the hot water of 80～90 DEG C, after cooling, dissolves rapidly.The aqueous solution of methylcellulose gum quite stable at normal temperatures, energy gel when high temperature, and this gel can change mutually with the height of temperature and solution.
Methocel solution has good wettability, dispersiveness, cementability, thickening property, emulsifying property, water-retentivity, film-forming properties and the opacity to grease.Institute's film forming has good toughness, flexibility and transparency.Because methocel solution belongs to non-ionic type, therefore can with other emulsifying agent compatibility, gained solution is stable in the scope of pH2～12.
In addition, methylcellulose gum also can be used as suspending agent, and as some and be insoluble to physiological saline or the solvent of the trial-product of water, is especially widely used in toxicological test, as the conventional solvent of oral administration.
At present, the compound method of methocel solution mainly contains following several:
1. hot-water process:
Two kinds of typical methods preparing methocel solution with hot-water process are as follows:
First method is in container, to put into the hot water of requirement, and is heated to about 70 DEG C; Under slowly stirring, add gradually methylcellulose gum, when beginning, methylcellulose gum floats over the surface (because methylcellulose gum is insoluble to hot water, thereby initial stage methylcellulose gum can be evenly dispersed in hot water) of water, then forms gradually a kind of mixture; Under agitation cooling this mixture.The method needs just can be cooled to for a long time room temperature for the mixture of large volume.
Second method is the water that adds aequum 1/3 or 2/3 in container, and is heated to 70 DEG C, disperses methylcellulose gum by first method, prepares hot water slurry.Then add the cold water of residual content or frozen water to hot water slurry.Cooling this mixture after stirring.The method is compared the first method time and is shortened to some extent, but will be cooled to room temperature, still needs the long period.
2. powder hybrid system: by methylcellulose gum powder particle and batching that equate or more substantial other powdery, by being dry mixed incompatible abundant dispersion, be dissolved in water afterwards, now methylcellulose gum can dissolve, and does not condense.
3. organic solvent wetting: organic solvent for methylcellulose gum (as ethanol, ethylene glycol or oil) is disperseed in advance or moistening, be then dissolved in water, methylcellulose gum also can successfully dissolve.
The problem that above-mentioned compound method exists is that, in the time of a large amount of methocel solution of preparation, preparation speed all maybe can be introduced new impurity slowly.Through retrieval, still there is no at present the reported in literature of rapid preparing large volume homogeneous, stable methocel solution.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of compound method of methocel solution, and it can prepare large volume homogeneous, stable methocel solution fast, easily.
For solving the problems of the technologies described above, the compound method of methocel solution of the present invention, step comprises:
1) methylcellulose gum is joined in hot water, be mixed with methylcellulose gum mixture;
2) add the cold water of residual volume, be placed in ice-water bath, be stirred to the viscous solution that forms clarification.
In step 1), the temperature of hot water is between 70～100 ° of C, and preferably temperature is 80～90 ° of C.The volume of hot water be the required water adding cumulative volume 1/5～1/2.
Compared with the normal compound method of methocel solution, compound method of the present invention has the following advantages and beneficial effect:
1. simple to operate, fast, for the most of methocel solutions of preparation, the time used can be saved over half in preparation.
2. in process for preparation, can not introduce other impurity, the homogeneity of the methocel solution of preparing and good stability.
Embodiment
Embodiment 1
The present embodiment is adopted and is prepared with the following method methocel solution:
Step 1, joins 2500mL water in one suitable container, and is heated to 70～100 ° of C.
Step 2, weighs 50g methylcellulose gum powder, under agitation, joins at leisure in said vesse.Then, with all pouring in said vesse after a small amount of water rinse weighing utensil.
Step 3, continues to stir, until all methylcellulose gum powder soak and are uniformly dispersed.
Step 4 under agitation, adds the cold water (amount that add be water that 7500mL deduct rinse) of temperature lower than 8 ° of C in said vesse.
Step 5, is positioned over said vesse in ice-water bath, continues stirring until the viscous solution of clarification.
Embodiment 2
The present embodiment is adopted and is prepared with the following method methocel solution:
Step 1, joins the water of about 2500mL in one suitable container, and is heated to 70～100 ° of C.
Step 2, weighs 50g methylcellulose gum powder, under agitation, joins at leisure in said vesse.Then, with all pouring in said vesse after a small amount of water rinse weighing utensil.
Step 3, continues to stir, until all methylcellulose gum powder soak and are uniformly dispersed.
Step 4, is settled to 10000mL lower than the cold water of 8 ° of C by temperature.
Step 5, is positioned over said vesse in ice-water bath, continues stirring until the viscous solution of clarification.
Concentration according to the methocel solution of the method preparation of above-described embodiment 1,2 is 0.01%～5%(w/v).When the methocel solution that obtains of preparation can leave preparation in container used or other have in the container of suitable capacity mark, the temperature of preservation is 2～8 ° of C, at this temperature, can deposit one month.
Claims (7)
1. the compound method of methocel solution, is characterized in that, step comprises:
1) methylcellulose gum is joined in hot water, be mixed with methylcellulose gum mixture;
2) add the cold water of residual volume, be placed in ice-water bath, be stirred to the viscous solution that forms clarification.
2. compound method according to claim 1, is characterized in that, step 1), and the temperature of hot water is 70～100 ° of C.
3. compound method according to claim 2, is characterized in that, step 1), and the temperature of hot water is 80～90 ° of C.
4. the compound method described in any one according to claims 1 to 3, is characterized in that, step 1), the volume of hot water be the required water adding cumulative volume 1/5～1/2.
5. compound method according to claim 1, is characterized in that step 2), the temperature of cold water is below 8 DEG C.
6. compound method according to claim 1, is characterized in that, the storage temperature of described methocel solution is 2～8 DEG C, and the shelf time at this temperature is 1 month.
7. compound method according to claim 1, is characterized in that, the concentration of described methocel solution is 0.01%～5%(w/v).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210476359.7A CN103834043A (en) | 2012-11-21 | 2012-11-21 | Preparation method of methylcellulose solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210476359.7A CN103834043A (en) | 2012-11-21 | 2012-11-21 | Preparation method of methylcellulose solution |
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| CN103834043A true CN103834043A (en) | 2014-06-04 |
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| CN201210476359.7A Pending CN103834043A (en) | 2012-11-21 | 2012-11-21 | Preparation method of methylcellulose solution |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109698078A (en) * | 2017-10-20 | 2019-04-30 | 天津大学 | Reversible overheating protection aqueous electrolyte and its preparation method and application based on Thermo-sensitive cellulose ethers hydrogel |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283805A (en) * | 2011-06-29 | 2011-12-21 | 扬子江药业集团有限公司 | Method for preparing eye drops containing non-ionic cellulose derivatives |
-
2012
- 2012-11-21 CN CN201210476359.7A patent/CN103834043A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283805A (en) * | 2011-06-29 | 2011-12-21 | 扬子江药业集团有限公司 | Method for preparing eye drops containing non-ionic cellulose derivatives |
Non-Patent Citations (1)
| Title |
|---|
| 孙雅梅等: "羟丙基甲基纤维素的溶解工艺及在滴眼剂中的应用", 《实用药物与临床》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109698078A (en) * | 2017-10-20 | 2019-04-30 | 天津大学 | Reversible overheating protection aqueous electrolyte and its preparation method and application based on Thermo-sensitive cellulose ethers hydrogel |
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Address after: No. 1318 Wuzhong District Wuzhong road in Suzhou city of Jiangsu Province in 215404 Applicant after: Suzhou medicine bright Kant's new drug development limited company Applicant after: Shanghai Yaoming Kangde New Medicine Development Co., Ltd. Address before: No. 1318 Wuzhong District Wuzhong road in Suzhou city of Jiangsu Province in 215404 Applicant before: Suzhou AppTec Co., Ltd. Applicant before: Shanghai Yaoming Kangde New Medicine Development Co., Ltd. |
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Free format text: CORRECT: APPLICANT; FROM: SUZHOU APPTEC CO., LTD. TO: SUZHOU YAOMING KANGDE NEW DRUG DEVELOPMENT CO., LTD. |
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Application publication date: 20140604 |