CN103823956A - Method and device for determination of contrast medium operation parameter and imaging equipment - Google Patents
Method and device for determination of contrast medium operation parameter and imaging equipment Download PDFInfo
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- CN103823956A CN103823956A CN201210469109.0A CN201210469109A CN103823956A CN 103823956 A CN103823956 A CN 103823956A CN 201210469109 A CN201210469109 A CN 201210469109A CN 103823956 A CN103823956 A CN 103823956A
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Abstract
The invention relates to a method and a device for determination of contrast medium operation parameter and imaging equipment. The method includes the steps of acquiring an image data set of a series of vasculatures, reconstructing a three-dimensional volumetric model of the vasculatures according to the acquired image data set, selecting a region-of-interest in the reconstructed three-dimensional volumetric model and an contrast medium input portion and a contrast medium output portion corresponding to the region-of-interest, determining flow boundary condition to the selected input portion, determining free boundary tracking condition to the selected output portion, setting the operation parameter of the contrast medium on the input portion as a preset value, performing simulation of computational fluid dynamics on blood flow and contrast medium transfer of the region-of-interest according to the determined flow boundary condition, the free boundary tracking condition and the set medium contrast operation parameter, and finally outputting results of simulation of the region-of-interest.
Description
Technical field
The application relates to Medical Devices, more specifically, relates to device and a kind of imaging device of a kind of method of definite contrast preparation operation parameter, a kind of definite contrast preparation operation parameter.
Background technology
At present, digital subtraction angiography (DSA) is considered to the goldstandard for the diagnosis and treatment of neural and vascular diseases.By opaque a certain amount of radiation contrast preparation (CA) is injected to patient artery, allow doctor to see how blood flows through blood vessel, and identify vascular constriction, aneurysm etc.
But, because excessive contrast preparation itself has certain spinoff for patient, therefore, during intervention procedure, realize for each individual patient the CA infusion protocol of optimizing and remain a challenge.First, each patient's blood vessel has the geometrical property of himself.Even corresponding vascular part anatomically, structural information concrete between each patient is also different.Secondly, each patient has specific blood flow characteristic, as mean flow rate and pulsation.Because can think that CA transports passively by blood flow in blood vessel, thus these factors may exert an influence to the distribution of CA, this and be reflected on DSA image.On the other hand, ill region may be away from injection point, makes blood and CA because complicated intracranial vessel structure is separated.This may cause CA and blood fully not to mix.Therefore the actual CA amount that, arrives ill region may be diluted widely.In addition, high velocity of blood flow and large blood vessel diameter may cause inhomogeneous CA to distribute.Therefore, may there is no suitably and accurately to illustrate actual vascular form from DSA image.On the other hand, although the short distance between low flow velocity, little blood vessel diameter and ill region and injection point can cause the completely opaque of interested vascular, the CA using may exceed the actual amount of actual needs.In addition, the excessive situation of CA also causes undesirable effects on patients.
Therefore, in the time that client need is diagnosed and treats with DSA etc., need to control the CA amount using, to can obtain correct clinical assessment and treatment decision from DSA image, and reduce the spinoff of CA to patient.
Traditionally, clinician determines injection point before operation.After this, conventionally conduit is inserted in blood vessel by femoral artery or arteria brachialis, and under X ray guiding, little by little move to inspection artery.In addition, the CA amount of injection is set to fixed value conventionally, or only classifies according to injection point (, vertebral artery, arteria carotis and sustainer etc.), typically is 8ml, 10ml and 30ml.But, in prior art, do not consider vessel geometry between each patient and the individual difference of blood flow.
Summary of the invention
In view of this, the present invention proposes a kind of method of definite contrast preparation operation parameter, can suitably and accurately determining contrast preparation operation parameter for different individual patient, thereby can in DSA image, correctly show vascular structure, and reduce the spinoff of CA to patient.The present invention is the device of a kind of definite contrast preparation operation parameter of wish proposition also, can suitably and accurately determining contrast preparation operation parameter for different individual patient, thereby can in DSA image, correctly show vascular structure, and reduce the spinoff of CA to patient.The present invention is the imaging device of a kind of device that comprises above-mentioned definite contrast preparation operation parameter of wish proposition also.
According to one embodiment of present invention, provide a kind of method of definite contrast preparation operation parameter, comprised the following steps:
A. obtain the sets of image data of a series of vascular systems;
B. according to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining;
C. in the three-D volumes model of rebuilding, select input position and the output position of area-of-interest and the contrast preparation corresponding with this area-of-interest;
D. determine flow boundary condition for the input position of selecting, and determine and follow the tracks of free boundary condition for the output position of selecting;
E. be set to predetermined value in the contrast preparation operation parameter at input position;
F. according to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation;
G. export the simulation result of area-of-interest.
According to this embodiment, doctor can select area-of-interest (for example comprising the region of suspected abnormality) from the three-dimensional model of the vascular system of reconstruction, and the input position corresponding with this area-of-interest and output position are set, flow boundary condition is determined in input position, border tracking condition is determined in output position, and the operation parameter of contrast preparation is set to initial default value (for example, normally used fixed value or the empirical value corresponding with this position).Then the blood flow of the starting condition of, utilizing these settings to area-of-interest and contrast preparation transmit carries out computational fluid dynamics (CFD) emulation.Then, can export the simulation result of area-of-interest, the such as concentration of the contrast preparation in focus region etc.Thus, doctor can be according to the simulation result of area-of-interest, directly judges that whether the concentration of contrast preparation is suitable.
Preferably, described method also comprises:
Whether the simulation result that h. judges area-of-interest meets output condition;
I. in the time that simulation result does not meet output condition, be modified in the predetermined value of the contrast preparation operation parameter at input position, and return to step f;
J. in the time that simulation result meets output condition, the indication information of current contrast preparation operation parameter is indicated in output.
According to another embodiment, the method is also according to pre-conditioned, and whether automatic decision simulation result meets output condition, and for example, judgement is through after predetermined amount of time, and whether the contrast concentration in area-of-interest reaches predetermined concentration scope.If simulation result does not meet output condition, be automatically modified in the predetermined value of the contrast preparation operation parameter at input position, and again carry out CFD simulation calculation, until simulation result meets output condition.In the time that simulation result meets output condition, can export the indication information of the current contrast preparation operation parameter of indication.The advantage of this embodiment is can be for the feature of the geometric configuration of each patient's vascular system and blood flow, calculating meets the contrast preparation operation parameter of this patient's feature, thereby can in DSA image, correctly show vascular structure, and reduce the spinoff of CA to patient.
According to this embodiment, do not need doctor's intervention, but can be according to default output condition, whether the simulation result of automatic decision area-of-interest meets default output condition, automatically judges that whether the concentration of contrast preparation is suitable.
Preferably, at least one in use CT system, MR system, ultrasonic system, 3D fluoroscopy systems and PET system obtained the sets of image data of a series of vascular systems.That is to say, can carry out imaging to patient by various imaging systems, to obtain the sets of image data of vascular system.
Preferably, the volumetric fluid of the vessel center line at the input position based on along selecting is estimated, determines the flow boundary condition at the input position of selecting, and described flow boundary condition comprises pressure, blood flow rate and/or the volume of blood flow at the input position of selection.That is to say, before carrying out CFD simulation calculation, need to test pressure, blood flow rate and/or the volume of blood flow at the input position of patient's selection, thereby can accurately determine the feature of patient's blood flow, to obtain better simulation result.
Preferably, the described output position for selecting determines that following the tracks of free boundary condition comprises:
Fluid pressure value and the fluid velocity gradient at output position are set to fixed value.
Preferably, described contrast preparation operation parameter comprises following at least one: the injection duration of the concentration of contrast preparation, the injection speed of contrast preparation and contrast preparation.That is to say, can, by controlling concentration, the injection speed of contrast preparation and the injection duration of contrast preparation one or more of contrast preparation, in DSA image, correctly show vascular structure, and reduce the spinoff of CA to patient.
Preferably, if do not reach predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, increase the concentration of described contrast preparation, if or exceeded predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, the concentration of described contrast preparation would be reduced.That is to say, the contrast concentration that can input according to simulation result adjustment input position, thus determine best contrast concentration by emulation.
Preferably, if do not reach predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, increase the injection speed of described contrast preparation, if or exceeded predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, the injection speed of described contrast preparation would be reduced.That is to say, can input according to simulation result adjustment the injection speed of the contrast preparation of position input, thereby determine the injection speed of best contrast preparation by emulation.
Preferably, if do not reach predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, increase the injection duration of described contrast preparation, if or exceeded predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, the injection duration of described contrast preparation would be reduced.That is to say, can input according to simulation result adjustment the injection duration of the contrast preparation of position input, thereby determine the injection duration of best contrast preparation by emulation.
According to another embodiment of the present invention, provide a kind of device of definite contrast preparation operation parameter, having comprised:
An acquiring unit, is configured to obtain the sets of image data of a series of vascular systems;
A reconstruction unit, is configured to according to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining;
A selected cell, is configured to select input position and the output position of area-of-interest and the contrast preparation corresponding with this area-of-interest in the three-D volumes model of rebuilding;
An input block, is configured to determine flow boundary condition for the input position of selecting, and determines and follows the tracks of free boundary condition, and be set to predetermined value in the contrast preparation operation parameter at input position for the output position of selecting;
A computing unit, is configured to according to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, and the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation;
An output unit, is configured to export the simulation result of area-of-interest.
Preferably, described device can also comprise:
A judging unit, is configured to judge whether the simulation result of area-of-interest meets output condition;
A control module, be configured in the time that simulation result does not meet output condition, control the predetermined value that described input block is modified in the contrast preparation operation parameter at input position, then control described computing unit and carry out calculating, and in the time that simulation result meets output condition, control the indication information of the current contrast preparation operation parameter of described output unit output indication.
According to another embodiment of the present invention, provide a kind of imaging device, having comprised:
An imaging device, is configured to patient to carry out imaging to obtain the sets of image data of a series of vascular systems; And
The device of any one definite contrast preparation operation parameter as above, is configured to calculate contrast preparation operation parameter according to the sets of image data of a series of vascular systems of obtaining,
Wherein, particularly, the device of described definite contrast preparation operation parameter comprises:
An acquiring unit, is configured to obtain from described imaging device the sets of image data of a series of vascular systems;
A reconstruction unit, is configured to according to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining;
A selected cell, is configured to select input position and the output position of area-of-interest and the contrast preparation corresponding with this area-of-interest in the three-D volumes model of rebuilding;
An input block, is configured to determine flow boundary condition for the input position of selecting, and determines and follows the tracks of free boundary condition, and be set to predetermined value in the contrast preparation operation parameter at input position for the output position of selecting;
A computing unit, is configured to according to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, and the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation;
An output unit, is configured to export the simulation result of area-of-interest.
Preferably, the device of described definite contrast preparation operation parameter can also comprise:
A judging unit, is configured to judge whether the simulation result of area-of-interest meets output condition;
A control module, be configured in the time that simulation result does not meet output condition, control the predetermined value that described input block is modified in the contrast preparation operation parameter at input position, then control described computing unit and carry out calculating, and in the time that simulation result meets output condition, control the indication information of the current contrast preparation operation parameter of described output unit output indication.
According to another embodiment of the present invention, provide a kind of computer program, it makes computing machine be used as in the time being performed:
An acquiring unit, is configured to obtain the sets of image data of a series of vascular systems;
A reconstruction unit, is configured to according to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining;
A selected cell, is configured to select input position and the output position of area-of-interest and the contrast preparation corresponding with this area-of-interest in the three-D volumes model of rebuilding;
An input block, is configured to determine flow boundary condition for the input position of selecting, and determines and follows the tracks of free boundary condition, and be set to predetermined value in the contrast preparation operation parameter at input position for the output position of selecting;
A computing unit, is configured to according to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, and the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation;
An output unit, is configured to export the simulation result of area-of-interest.
Preferably, described computer program also makes computing machine be used as:
A judging unit, is configured to judge whether the simulation result of area-of-interest meets output condition;
A control module, be configured in the time that simulation result does not meet output condition, control the predetermined value that described input block is modified in the contrast preparation operation parameter at input position, then control described computing unit and carry out calculating, and in the time that simulation result meets output condition, control the indication information of the current contrast preparation operation parameter of described output unit output indication.
According to another embodiment of the present invention, provide a kind of readable computer storage medium, wherein recorded executable programmed instruction, this programmed instruction makes computing machine be used as in the time being performed:
An acquiring unit, is configured to obtain the sets of image data of a series of vascular systems;
A reconstruction unit, is configured to according to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining;
A selected cell, is configured to select input position and the output position of area-of-interest and the contrast preparation corresponding with this area-of-interest in the three-D volumes model of rebuilding;
An input block, is configured to determine flow boundary condition for the input position of selecting, and determines and follows the tracks of free boundary condition, and be set to predetermined value in the contrast preparation operation parameter at input position for the output position of selecting;
A computing unit, is configured to according to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, and the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation;
An output unit, is configured to export the simulation result of area-of-interest.
Preferably, described computer program also makes computing machine be used as:
A judging unit, is configured to judge whether the simulation result of area-of-interest meets output condition;
A control module, be configured in the time that simulation result does not meet output condition, control the predetermined value that described input block is modified in the contrast preparation operation parameter at input position, then control described computing unit and carry out calculating, and in the time that simulation result meets output condition, control the indication information of the current contrast preparation operation parameter of described output unit output indication.
From above-described embodiment, can find out, because the present invention rebuilds the three-dimensional model of this patient's vascular system according to each patient's vascular image data set, thereby can be for the feature of the geometric configuration of different patients' vascular system and this patient's blood flow, each individual patient suitably and is accurately determined to contrast preparation operation parameter, thereby can in DSA image, correctly show vascular structure, and reduce the spinoff of CA to patient.
Accompanying drawing explanation
To, by describing the preferred embodiments of the present invention in detail with reference to accompanying drawing, the person of ordinary skill in the art is more clear that above-mentioned and other feature and advantage of the present invention below, in accompanying drawing:
Fig. 1 is that diagram is according to the process flow diagram of the method for first embodiment of the invention.
Fig. 2 is the schematic diagram illustrating according to the method for first embodiment of the invention.
Fig. 3 is that diagram is according to the process flow diagram of the method for second embodiment of the invention.
Fig. 4 is that diagram is according to the calcspar of the device of definite contrast preparation operation parameter of third embodiment of the invention.
Fig. 5 is that diagram is according to the calcspar of the imaging device of fourth embodiment of the invention.
Fig. 6 is the block diagram of the ios dhcp sample configuration IOS DHCP of graphics computer.
Embodiment
For making the object, technical solutions and advantages of the present invention clearer, the present invention is described in more detail by the following examples.
Fig. 1 is that diagram is according to the process flow diagram of the method for definite contrast preparation operation parameter of first embodiment of the invention.And Fig. 2 is the schematic diagram illustrating according to the method for definite contrast preparation operation parameter of first embodiment of the invention.Describe according to the method for the definite contrast preparation operation parameter for definite contrast preparation operation parameter of first embodiment of the invention below in conjunction with Fig. 1 and Fig. 2.
Comprise the following steps according to the method for definite contrast preparation operation parameter of first embodiment of the invention:
Step S101: the sets of image data of obtaining a series of vascular systems.
In this step, can obtain in several ways the sets of image data of a series of vascular systems.In one embodiment, for example, for the patient who carried out before imaging inspection, can be before injection of contrast medium, before storing, by various imaging systems, patient is carried out reading the storer of the view data that imaging obtains the sets of image data of a series of vascular systems.The imaging that can be used for the patient to carry out imaging for example includes but not limited to following: computer tomography (CT) system, magnetic resonance imaging (MRI) system, ultrasonic imaging system, 3D fluoroscopy systems and positron emission computer fault imaging (PET) system etc.That is to say, if once carried out imaging inspection before patient, can utilize the view data of patient's imaging before acquisition, thereby can reduce the number of times of patient's imaging.In addition,, while using these imaging systems to carry out imaging to patient, can inject contrast preparation to obtain better image to patient.For example, can adopt the mode such as computer tomography angiogram (CTA), dynamic CT digital flat panel angiogram (DynaCTA) to carry out imaging to obtain better view data to patient.
In another embodiment, for example, at the not emergency patients of imaging data before this patient of medical hospital, at needs fast for patient diagnoses and treat in the situation that, can first carry out Polaroid operation to patient, the sets of image data of then utilizing immediately imaging operation to obtain operates.
In addition, described " vascular system " indicated multiple vascular herein, and for example, femoral artery, arteria brachialis, vertebral artery, arteria carotis, sustainer, cardiovascular, intracranial vessel etc., have blood flow to flow through in this vascular.Or described vascular can also be bile duct etc., in this vascular by bile flow mistake.
Step S102: according to the three-D volumes model of image data set occlusal reconstruction (Reconstruction) vascular system of obtaining.
In this step, can utilize various known methods, according to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining.For example, the sectioning image that can obtain based on imaging carries out the three-dimensional reconstruction of vascular system, or can, according to general cone theory, can, by the micron order serial section image of multiple blood vessels, rebuild vascular system by calculating projected image and axis.Such method for reconstructing is well known to those skilled in the art, is not described in detail at this.
For example Fig. 2 shows the planimetric map of the three-dimensional model of the vascular system obtaining according to reconstruction image.
Step S103: in the three-D volumes model of rebuilding, select input position and the output position of area-of-interest (ROI) and the contrast preparation corresponding with this area-of-interest.
For example, as shown in Figure 2, in the three-dimensional model of rebuilding, select interested vascular (Vessel ofInterest, VOI) part, the part of the square frame part indication in Fig. 2.In this interested part, the vasculature part a that comprises possible focus.Because the image that the common imaging before the possible ill vasculature part a in the three-dimensional model of this reconstruction just utilizes obtains, may not enough accurately for judging whether it is ill vasculature part, so need to carry out further imaging inspection to it.
Now, after selected this interested blood vessel, determine the place b(angioaccess of the upstream portion of this blood vessel) as the injection point of wanting injection of contrast medium.Doctor can rule of thumb determine this injection point b.
Step S104: determine flow boundary condition for the input position of selecting, and determine and follow the tracks of free boundary condition for the output position of selecting.
In this step, determine flow boundary condition for the input position of selecting.Specifically, can based on along select input position vessel center line volumetric fluid estimate, determine input position the starting condition about blood flow.For example, in one embodiment, can be the blood pressure of determining input position, can adopt Pressure wire etc. to measure this blood pressure.
Alternately, in another embodiment, can determine the blood flow rate at input position.For example, can adopt such as magnetic resonance imaging, ultrasonic Doppler etc. to measure.Or this blood flow rate can be estimated by computing method.Computing method for example comprise Womersley method, to obtain ideal boundary blood flow rate.
Alternately, in another embodiment, can determine the volume of blood flow at input position.For example, can adopt such as ultrasonic Doppler etc. to measure.
On the other hand, in this step, determine and follow the tracks of free boundary condition for the output position of selecting.Specifically, for output position, can directly set fluid pressure value and fluid velocity gradient is fixed value, for example, can be made as constant.For example, fluid velocity gradient can be made as to 0.
Step S105: the contrast preparation operation parameter at input position is set to predetermined value.
In this step, while carrying out computational fluid dynamics (CFD) emulation for the first time, be set to predetermined value in the contrast preparation operation parameter at input position, for example, the fixed value using in prior art or the operation parameter value according to the classification of input position.For example, the initial value of supposing contrast concentration is 5%, and injection speed is 10ml/ second, and the injection duration is 5 seconds.
Step S106: according to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation.
In this step, according to the initial value of the flow boundary condition arranging in superincumbent step S104 and S105, tracking free boundary condition and contrast preparation operation parameter, the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation.
It should be noted that, in this simulation process, can show in visual mode the process of the transmission of blood flow and contrast preparation in area-of-interest, and the mode that can show with numerical value, every for example, concentration through CA in unit interval section (1 second) area-of-interest shown.
Step S107: the simulation result of output area-of-interest.
In this step, can export the simulation result of area-of-interest, the such as concentration of the contrast preparation in focus region etc.Thus, doctor can be according to the simulation result of area-of-interest, directly judges that whether the concentration of contrast preparation is suitable, that is to say, directly judges whether the concentration of contrast preparation can be clearly for showing the geometry of area-of-interest.
Specifically, as shown in Figure 2, in the time that contrast concentration is high, image ratio is darker, and in the time that contrast concentration is low, image ratio is brighter.In order to watch better the geometry of area-of-interest, need contrast concentration in suitable scope.Doctor can, according to the shading value of area-of-interest in image, directly can see image clearly.
Therefore, according to the method for definite contrast preparation operation parameter of first embodiment of the invention, doctor can judge that whether the operation parameter of contrast preparation is suitable according to simulation result, and optimize the use of contrast preparation, thereby can in DSA image, correctly show vascular structure, and reduce the spinoff of CA to patient.
< the second embodiment >
The Fig. 3 that sees reference below describes according to the method for definite contrast preparation operation parameter of second embodiment of the invention.Comprise the following steps according to the method 300 of definite contrast preparation operation parameter of second embodiment of the invention:
Step S301: the sets of image data of obtaining a series of vascular systems;
Step S302: according to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining;
Step S303: input position and the output position of selecting area-of-interest and the contrast preparation corresponding with this area-of-interest in the three-D volumes model of rebuilding;
Step S304: determine flow boundary condition for the input position of selecting, and determine and follow the tracks of free boundary condition for the output position of selecting;
Step S305: the contrast preparation operation parameter at input position is set to predetermined value;
Step S306: according to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation.
Step S301 is identical with the step S101-S 106 of the first embodiment to S306, omits its detailed description at this.
The difference of the method 100 of the method 300 of definite contrast preparation operation parameter of the second embodiment and definite contrast preparation operation parameter of the first embodiment is that this method 300 of determining contrast preparation operation parameter also comprises:
Step S307: whether the simulation result that judges area-of-interest meets output condition.
In this step, judge whether the simulation result of area-of-interest meets output condition.For example, can judge, through after predetermined amount of time, whether the contrast concentration in area-of-interest reaches predetermined concentration scope.In one embodiment, it is 2-3% that predetermined concentration scope is for example set, and judges whether the contrast concentration of area-of-interest after 10 seconds reaches the predetermined concentration scope of setting.
Step S308: in the time that simulation result does not meet output condition, be modified in the predetermined value of the contrast preparation operation parameter at input position, and return to step S306.
In this step, if simulation result does not meet output condition, illustrate that the settings of current contrast preparation operation parameter are inappropriate, need to be modified in the predetermined value of the contrast preparation operation parameter at input position, and again carry out CFD emulation.
In one embodiment, if do not reach predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, increase the concentration of described contrast preparation.In this embodiment, suppose that the contrast concentration of CFD simulation result indication area-of-interest only has 1%, the contrast concentration at input position is increased to 5%, become 10%.The incremental change of this increase can set in advance.
On the other hand, if exceed predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, reduce the concentration of described contrast preparation.
In another embodiment, if do not reach predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, increase the injection speed of described contrast preparation.In this embodiment, suppose that the contrast concentration of CFD simulation result indication area-of-interest only has 1%, the contrast-medium injection speed at input position is increased to 5ml/ second, become 15ml/ second.The incremental change of this increase can set in advance.
On the other hand, if exceed predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, reduce the injection speed of described contrast preparation.
In another embodiment, if do not reach predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, increase the injection duration of described contrast preparation.In this embodiment, suppose that the contrast concentration of CFD simulation result indication area-of-interest only has 1%, the contrast-medium injection duration at input position is increased to 5 seconds, become 10 seconds.The incremental change of this increase can set in advance.
On the other hand, if exceed predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, reduce the injection duration of described contrast preparation.
It should be noted that, can sequentially revise the injection speed of contrast concentration, contrast preparation and the operation parameter of the injection duration of contrast preparation, also the injection speed of contrast concentration, contrast preparation and the operation parameter of the injection duration of contrast preparation can be revised simultaneously, at least one can also be at random revised in the injection speed of contrast concentration, contrast preparation and the operation parameter of the injection duration of contrast preparation.
Step S309: in the time that simulation result meets output condition, the indication information of current contrast preparation operation parameter is indicated in output.
In this step, if simulation result meets output condition, can export the indication information of the current contrast preparation operation parameter of indication.For example, after the once modification of contrast concentration, if simulation result meets output condition, on display screen, automatically show indication information, indicate current contrast preparation operation parameter to meet the requirements, and show that the contrast preparation operation parameter of advising is: contrast concentration is 10%, and injection speed is 10ml/ second, and the injection duration is 5 seconds.
According to the method for definite contrast preparation operation parameter of second embodiment of the invention, can be according to default output condition, whether the simulation result of automatic decision area-of-interest meets default output condition, automatically judges that whether the concentration of contrast preparation is suitable.Therefore, doctor can optimize according to the indication information of output the use of contrast preparation, thereby can in DSA image, correctly show vascular structure, and reduces the spinoff of CA to patient.
< the 3rd embodiment >
Below, describe according to the device of definite contrast preparation operation parameter of third embodiment of the invention with reference to figure 4.Fig. 4 is that diagram is according to the calcspar of the device of definite contrast preparation operation parameter of third embodiment of the invention.
Can be any calculation element according to the device of definite contrast preparation operation parameter of the 3rd embodiment, as long as this calculation element can be carried out calculating operation.Such calculation element can be general purpose personal computer (PC), large scale computer, workstation, server etc.Such calculation element for example comprises CPU (central processing unit) (CPU), random-access memory (RAM), ROM (read-only memory) (ROM) and the memory storage such as hard disk.
As shown in Figure 4, the device 400 of determining contrast preparation operation parameter comprises:
An acquiring unit 401, is configured to obtain the sets of image data of a series of vascular systems;
A reconstruction unit 402, is configured to according to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining;
A determining unit 403, be configured to select input position and the output position of area-of-interest and the contrast preparation corresponding with this area-of-interest in the three-D volumes model of rebuilding, and determine flow boundary condition for the input position of selecting, and determine and follow the tracks of free boundary condition for the output position of selecting;
An input block 404, is configured to be set to predetermined value in the contrast preparation operation parameter at input position;
A computing unit 405, is configured to according to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, and the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation;
An output unit 406, is configured to export the simulation result of area-of-interest.
In addition the device 400 of, determining contrast preparation operation parameter can also comprise:
A judging unit 407, is configured to judge whether the simulation result of area-of-interest meets output condition;
A control module 408, be configured in the time that simulation result does not meet output condition, control the predetermined value that described input block 404 is modified in the contrast preparation operation parameter at input position, then control described computing unit and carry out calculating, and in the time that simulation result meets output condition, control the indication information of the current contrast preparation operation parameter of output unit 406 output indications.
Acquiring unit 401 for example can read from the storage unit (not shown) of the device 400 of definite contrast preparation operation parameter the view data of a series of vascular systems of having stored before.Alternately, acquiring unit 401 can be by wired or wireless mode, from various imaging devices obtain imaging or just in the view data of imaging.
The sets of image data that reconstruction unit 402 can obtain according to acquiring unit 401, rebuilds the three-D volumes model of vascular system.
Judging unit 407 can judge whether the simulation result of area-of-interest meets output condition.
Therefore, utilize according to the device of definite contrast preparation operation parameter of third embodiment of the invention, the operation parameter of the patient's of the optimization that doctor can obtain according to the calculating of the device of definite contrast preparation operation parameter contrast preparation, optimize the use of contrast preparation, thereby can in DSA image, correctly show vascular structure, and reduce the spinoff of CA to patient.
< the 4th embodiment >
Below, with reference to figure 5, the imaging device according to fourth embodiment of the invention is described.Fig. 5 is that diagram is according to the calcspar of the imaging device of fourth embodiment of the invention.
As shown in Figure 5, comprise according to the imaging device 500 of fourth embodiment of the invention:
An imaging device 501, is configured to patient to carry out imaging to obtain the sets of image data of a series of vascular systems; And
The device 500 of a definite contrast preparation operation parameter, is configured to calculate contrast preparation operation parameter according to the sets of image data of a series of vascular systems of obtaining.
The device 500 of determining contrast preparation operation parameter can be the device 400 of the definite contrast preparation operation parameter described in the 3rd embodiment, omits its detailed description at this.
Therefore, utilize according to the imaging device of fourth embodiment of the invention, doctor can carry out imaging to patient, and the operation parameter of the patient's of the optimization obtaining according to calculating contrast preparation, optimize the use of contrast preparation, thereby can in DSA image, correctly show vascular structure, and reduce the spinoff of CA to patient.
[ios dhcp sample configuration IOS DHCP of computing machine]
Above-mentioned a series of processing can be passed through software or hardware implement.In the time that these a series of processing are carried out by software, form the installation of software in computing machine.Here, computing machine for example comprises with the computing machine of specialized hardware structure and various programs is wherein installed and carries out the computing machine (as general purpose personal computer) of various functions.
Fig. 6 is the block diagram that diagram is carried out the ios dhcp sample configuration IOS DHCP of the computer hardware of above-mentioned a series of processing.
CPU (central processing unit) (CPU) 601, ROM (read-only memory) (ROM) 602 and random-access memory (RAM) 603 interconnect by the bus 604 in computing machine.
In addition, input and output interface 605 is connected to bus 604.Input block 606, output unit 607, storage unit 608, communication unit 609 and driver 610 are connected to input and output interface 605.
Input block 606 comprises keyboard, mouse, microphone etc.Output unit 607 comprises display, loudspeaker etc.Storage unit 608 comprises hard disk, nonvolatile memory etc.Communication unit 609 comprises network interface etc.Driver 610 drives removable media 611, as disk, CD, magneto-optic disk and semiconductor memory.
In above-mentioned computing machine, for example these a series of processing are carried out by CPU 601, and it makes the program of storage in storage unit 608 be loaded into RAM 603 by input and output interface 605 and bus 604, then carries out.
The program that computing machine is carried out for example can be recorded in as on the removable media 611 of encapsulation medium and provide.In addition, program can provide by wired or wireless transmission medium (as LAN (Local Area Network), the Internet and digital satellite broadcasting).
In computing machine, program can, by removable media 611 is arranged on driver 610, be installed in storage unit 608 by input and output interface 605.In addition, program can receive at communication unit 609 places by wired or wireless transmission medium, is then arranged in storage unit 608.In addition, program can be arranged in ROM 602 or storage unit 608 in advance.
Above with reference to having described each aspect of the present invention according to flowchart illustrations and/or the calcspar of the method for the embodiment of the present invention, device (system) and computer program code.Will be appreciated that flowchart illustrations and/or calcspar each and flowchart illustrations and/or calcspar each can realize by computer program instructions.The processor that these computer program instructions can offer multi-purpose computer, special purpose computer or other programmable data treating apparatus to be to produce machine, and the instruction that makes to carry out via the processor of computing machine or other programmable data treating apparatus creates the parts of the function/action of specifying for realization flow figure and/or calcspar square or multiple square.
These computer program instructions can also be stored in computer-readable medium, this computer-readable medium can instruct computing machine, other programmable data treating apparatus or other equipment with ad hoc fashion work, the instruction of storing in computer-readable medium is produced comprise the manufacturing a product of instruction of the function/action of specifying in realization flow figure and/or calcspar square or multiple square.Computer program instructions can also be loaded on computing machine, other programmable data treating apparatus or other equipment, so that sequence of operations step is carried out to produce computer implemented processing on computing machine, other programmable data treating apparatus or other equipment, make the instruction of carrying out on computing machine or other programmable data treating apparatus be provided for the processing of the function/action of specifying in realization flow figure and/or calcspar square or multiple square.
The present invention relates to a kind of method, device and imaging device of definite contrast preparation operation parameter.Said method comprising the steps of: the sets of image data of obtaining a series of vascular systems; According to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining; In the three-D volumes model of rebuilding, select input position and the output position of area-of-interest and the contrast preparation corresponding with this area-of-interest; Determine flow boundary condition for the input position of selecting, and determine and follow the tracks of free boundary condition for the output position of selecting; Contrast preparation operation parameter at input position is set to predetermined value; According to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation; And the simulation result of output area-of-interest.
Process flow diagram in accompanying drawing and the system of calcspar diagram each embodiment according to the present invention, framework in the cards, function and the operation of method and computer program product above.In this, the each square in process flow diagram or calcspar can represent module, fragment or the part of code, and it comprises one or more executable instructions of (multiple) logic function for realizing appointment.Shall also be noted that in some alternative realizations, the function representing in square can occur not according to order shown in figure.For example, according to the function relating to, in fact two pieces that illustrate continuously can substantially side by side be carried out, or each square sometimes can be carried out with reverse order.Also will note, the combination of the square in each square and calcspar and/or the flowchart illustrations of calcspar and/or flowchart illustrations can realize by carrying out special function or the system based on specialized hardware of action or the combination of specialized hardware and computer instruction.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. a method for definite contrast preparation operation parameter, comprises the following steps:
Obtain the sets of image data of a series of vascular systems;
According to the sets of image data of obtaining, rebuild the three-D volumes model of vascular system;
In three-D volumes model, select input position and the output position of area-of-interest and the contrast preparation corresponding with this area-of-interest;
Determine flow boundary condition for input position, and determine and follow the tracks of free boundary condition for output position, and be set to predetermined value in the contrast preparation operation parameter at input position;
According to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation; And
The simulation result of output area-of-interest.
2. method according to claim 1, is characterized in that, described method also comprises:
Whether the simulation result that judges area-of-interest meets output condition;
In the time that simulation result does not meet output condition, be modified in the predetermined value of the contrast preparation operation parameter at input position, and carry out computational fluid dynamics emulation and subsequent step;
In the time that simulation result meets output condition, the indication information of current contrast preparation operation parameter is indicated in output.
3. method according to claim 1, is characterized in that, at least one in use CT system, MR system, ultrasonic system, 3D fluoroscopy systems and PET system obtained the sets of image data of a series of vascular systems.
4. method according to claim 1, is characterized in that,
Describedly determine that for input position flow boundary condition comprises: the volumetric fluid of the vessel center line based on along this input position is estimated, the flow boundary condition of determining input position, described flow boundary condition comprises pressure, blood flow rate and/or the volume of blood flow of inputting position;
And/or, described for output position determine follow the tracks of free boundary condition comprise: output position fluid pressure value and fluid velocity gradient be set to fixed value.
5. method according to claim 1, is characterized in that, described contrast preparation operation parameter comprises following at least one: the injection duration of the concentration of contrast preparation, the injection speed of contrast preparation and contrast preparation.
6. method according to claim 1, is characterized in that, whether the simulation result of described definite area-of-interest meets output condition comprises: through after predetermined amount of time, determine whether the contrast concentration in area-of-interest reaches predetermined concentration scope.
7. method according to claim 6, is characterized in that, described in be modified in input position the predetermined value of contrast preparation operation parameter comprise:
If do not reach predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, increase the concentration of described contrast preparation; Or, if exceed predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, reduce the concentration of described contrast preparation; And/or,
If do not reach predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, increase the injection speed of described contrast preparation; Or, if exceed predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, reduce the injection speed of described contrast preparation; And/or,
If do not reach predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, increase the injection duration of described contrast preparation; Or, if exceed predetermined concentration scope through the contrast concentration in area-of-interest after predetermined amount of time, reduce the injection duration of described contrast preparation.
8. a device for definite contrast preparation operation parameter, comprising:
An acquiring unit, is configured to obtain the sets of image data of a series of vascular systems;
A reconstruction unit, is configured to according to the three-D volumes model of the image data set occlusal reconstruction vascular system of obtaining;
A selected cell, is configured to select input position and the output position of area-of-interest and the contrast preparation corresponding with this area-of-interest in the three-D volumes model of rebuilding;
An input block, is configured to determine flow boundary condition for input position, determines and follows the tracks of free boundary condition, and be set to predetermined value in the contrast preparation operation parameter at input position for output position;
A computing unit, is configured to according to the contrast preparation operation parameter of definite flow boundary condition, tracking free boundary condition and setting, and the blood flow to area-of-interest and contrast preparation transmit carries out computational fluid dynamics emulation; And
An output unit, is configured to export the simulation result of area-of-interest.
9. device as claimed in claim 8, also comprises:
A judging unit, is configured to judge whether the simulation result of area-of-interest meets output condition;
A control module, be configured in the time that simulation result does not meet output condition, control the predetermined value that described input block is modified in the contrast preparation operation parameter at input position, then control described computing unit and carry out calculating, and in the time that simulation result meets output condition, control the indication information of the current contrast preparation operation parameter of described output unit output indication.
10. an imaging device, comprising:
An imaging device, is configured to patient to carry out imaging to obtain the sets of image data of a series of vascular systems; And
Determine as claimed in claim 8 or 9 the device of contrast preparation operation parameter for one, be configured to calculate contrast preparation operation parameter according to the sets of image data of a series of vascular systems of obtaining, wherein, described acquiring unit is configured to obtain from described imaging device the sets of image data of a series of vascular systems.
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| WO2022228961A1 (en) * | 2021-04-26 | 2022-11-03 | Koninklijke Philips N.V. | System for improving accuracy of ultrasound-guided prediction of local bolus velocities |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105919616A (en) * | 2015-02-27 | 2016-09-07 | 西门子股份公司 | Determining the velocity of a fluid with the aid of an imaging method |
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| CN111601550A (en) * | 2017-10-09 | 2020-08-28 | 小利兰·斯坦福大学托管委员会 | Contrast agent dose reduction for medical imaging using deep learning |
| CN111601550B (en) * | 2017-10-09 | 2023-12-05 | 小利兰·斯坦福大学托管委员会 | Contrast agent reduction for medical imaging using deep learning |
| CN108815642A (en) * | 2018-04-22 | 2018-11-16 | 王连生 | A kind of opacifying injection system |
| CN112673433A (en) * | 2018-09-13 | 2021-04-16 | 皇家飞利浦有限公司 | Computing boundary conditions for virtual FFR and iFR computations based on myocardial color rendering properties |
| WO2022228961A1 (en) * | 2021-04-26 | 2022-11-03 | Koninklijke Philips N.V. | System for improving accuracy of ultrasound-guided prediction of local bolus velocities |
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| CN103823956B (en) | 2017-10-31 |
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