CN103819422A - Method of preparing chiral N-substituent-2-morpholine methanol compound - Google Patents
Method of preparing chiral N-substituent-2-morpholine methanol compound Download PDFInfo
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- CN103819422A CN103819422A CN201410101240.0A CN201410101240A CN103819422A CN 103819422 A CN103819422 A CN 103819422A CN 201410101240 A CN201410101240 A CN 201410101240A CN 103819422 A CN103819422 A CN 103819422A
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- substituent
- dimethyl ether
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- 0 *N1CC(CO)OCC1 Chemical compound *N1CC(CO)OCC1 0.000 description 1
- KICPCUVTDFJWND-UHFFFAOYSA-N OCCNCC(CCl)O Chemical compound OCCNCC(CCl)O KICPCUVTDFJWND-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention discloses a novel method of preparing a chiral N-substituent-2-morpholine methanol compound. The method comprises the following steps: by taking chiral epoxy chloropropane as an initial raw material, carrying out a reaction on chiral epoxy chloropropane and ethanol amine to generate chiral 1-chroline-3-((2-ethoxyl) amino)-2-propyl alcohol (II); protecting the compound (II) by a protective group N to obtain corresponding N-substituent-1-chroline-3-((2-ethoxyl) amino)-2-propyl alcohol (III); continuously cyclizing the compound (III) under the effect of alkaline to directly obtain a mixture of chiral N-substituent-2-morpholine methanol (I) and N-substituent-6-hydroxyl-1, 4-oxoazaane (IV); and purifying the mixture to obtain the chiral N-substituent-2-morpholine methanol (I). The method does not involve with dangerous raw materials such as lithium aluminum hydride or borane and noble metal Pd, so that the method is very high in safety. As raw materials which are low in cost and easy to get are just used, the method is short in step, simple to operate, fewer in three wastes, high in purity of a target product, and very suitable for industrialized production.
Description
Technical field
The present invention relates to fine chemical technology field, be specifically related to a kind of novel method of preparing chirality N-replacement-2-morpholine methyl alcohol compounds.
Background technology
Chirality N-replacement-2-morpholine methyl alcohol is the key intermediate of synthetic many medicines, as indeloxazine, reboxetine, viloxazine etc., and be used in the middle of new drug development by numerous scientists as construction module, therefore find a kind of low cost, simple to operate, the production technique that the three wastes are few is most important.
Existing preparation technology is as follows for chirality N-replacement-2-morpholine methyl alcohol:
The laboratory preparation method of chirality N-replacement-2-morpholine methyl alcohol has first been described in technique one, [Heterocycles, 1993,105].
The method step is tediously long, complicated operation, relates to the dangerous raw materials such as sodium periodate, lithium aluminum hydride or borine, and precious metals pd, causes that cost is high, the three wastes are many, is extremely not suitable for suitability for industrialized production.
Technique two, [J.Med.Chem1998,1934] have been introduced and have been utilized benzyl protection to obtain the method for epoxy compounds for raw material synthesis of chiral N-replacement-2-morpholine methyl alcohol.
The method step is relatively short, but raw material is not easy to obtain, cost is higher, intermediate separation difficulty, and still relates to the dangerous raw material such as lithium aluminum hydride or borine and precious metals pd, is not suitable for suitability for industrialized production.
Technique three, Granted publication number are that the Chinese invention patent of CN102212040B discloses the method for utilizing chirality glycerin chlorohydrin synthesis of chiral N-replacement-2-morpholine methyl alcohol.
The method provides a kind of scheme that is relatively more suitable for suitability for industrialized production, but the product purification of benzylamine and glycerin chlorohydrin reaction needs molecular distillation, and still relates to the dangerous raw material such as lithium aluminum hydride or borine and precious metals pd, has limited its industrial scale.
What technique four, Pfizer delivered in [JOC2008,3662] utilize chiral epichlorohydrin is prepared the technique of chirality N-replacement-2-morpholine methyl alcohol in a large number for raw material.
This processing step is simple, compares several method above, only still relates to precious metals pd, and is confirmed to be applicable to suitability for industrialized production by author with example.
Summary of the invention
In view of this, the object of the invention is the technique of Pfizer to improve, and provides a kind of safety, low cost, simple to operate, product purity is high, be applicable to the method for preparing chirality N-replacement-2-morpholine methyl alcohol compounds of suitability for industrialized production.
To achieve these goals, the invention provides following technical scheme:
The present invention prepares the method for N-replacement-2-morpholine methyl alcohol compounds, represents with following reaction formula:
In formula, R is carbobenzoxy-(Cbz), tertbutyloxycarbonyl, C
1～C
8alkyl acyl, C
1～C
8alkyl oxygen carbonyl, C
1～C
8alkyl sulphonyl, substituted benzoyl or substituted benzene alkylsulfonyl.
The present invention is take chiral epichlorohydrin as starting raw material, react the chloro-3-of 1-((2-hydroxyethyl) the amino)-2-propyl alcohol (II) that generates chirality with thanomin by it, the compound (II) of gained is protected to obtain the corresponding chloro-3-of N-replacement-1-((2-hydroxyethyl) amino)-2-propyl alcohol (III) through protecting group N, the compound (III) of gained occurs to close continuously and encircles the N-replacement-2-morpholine methyl alcohol (I) and N-replacement-6-hydroxyl-1 that directly obtain chirality under the effect of alkali, 4-oxo azepine alkane (IV) mixture, mixture obtains chirality N-replacement-2-morpholine methyl alcohol (I) through currently known methods purifying.
Concrete, the described method of preparing chirality N-replacement-2-morpholine methyl alcohol compounds comprises the steps:
(1) in reaction unit, add chiral epichlorohydrin, thanomin and solvent (A), 0～100 ℃ is reacted 1～24 hour, the concentrated compound (II) that to obtain;
Preferably, the mol ratio of described chiral epichlorohydrin and thanomin is (40: 1)～(1: 40).
Preferably, described solvent (A) is at least one in water, methyl alcohol, ethanol, propyl alcohol, Virahol, methylene dichloride, trichloromethane, tetrahydrofuran (THF), dioxane, acetonitrile, glycol dimethyl ether, diethylene glycol dimethyl ether.
(2) in reaction unit, add compound (II), N protecting group and solvent (B), 0～100 ℃ is stirred 3～5 hours, concentrates to obtain compound (III); Described N protecting group is carbobenzoxy-(Cbz), tertbutyloxycarbonyl, C
1～C
8alkyl acyl, C
1～C
8alkyl oxygen carbonyl, C
1～C
8alkyl sulphonyl, substituted benzoyl or substituted benzene alkylsulfonyl;
Preferably, described solvent (B) is at least one in methyl alcohol, ethanol, propyl alcohol, Virahol, tetrahydrofuran (THF), dioxane, acetonitrile, glycol dimethyl ether, diethylene glycol dimethyl ether.
(3) in reaction unit, add alkali and solvent (C), at 0～100 ℃, add compound (III), stir more than 2 hours, spin off solvent, add ethyl acetate and water stratification, water layer is extracted with ethyl acetate 2 times again, merge organic layer dry compound (I) and (IV) mixture, the compound (I) of purifying to obtain.
Preferably, described alkali is triethylamine, diisopropyl ethyl amine, pyridine, morpholine, sodium carbonate, salt of wormwood, sodium hydride, sodium hydroxide, potassium hydroxide, sodium methylate, sodium ethylate, sodium tert-butoxide, sodium tert-amyl alcohol, Tetramethylammonium hydroxide, at least one in tetraethyl ammonium hydroxide, TBAH.
Preferably, described solvent (C) is at least one in water, methyl alcohol, ethanol, propyl alcohol, Virahol, tetrahydrofuran (THF), dioxane, acetonitrile, glycol dimethyl ether, diethylene glycol dimethyl ether.
Compared with prior art, method provided by the invention does not relate to the dangerous raw material such as lithium aluminum hydride or borine and precious metals pd, thereby security is very high; Only used raw material cheap and easy to get, step is short, simple to operate, and the three wastes are few, and target product purity high (purity > 99%, ee% > 99%) is applicable to suitability for industrialized production very much.
Embodiment
Below in conjunction with the embodiment of the present invention, technical scheme of the present invention is described in detail, obviously, described embodiment is only the present invention's part embodiment, rather than whole embodiment.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skills obtain under the prerequisite of not making creative work, belongs to the scope of protection of the invention.
Test raw materials used reagent and all can be buied by free market, its purity is chemical pure.
Embodiment 1
(1) the chloro-3-of R-1-((2-hydroxyethyl) amino)-2-propyl alcohol (R-II) is synthetic
By 1 kilogram of R-epoxy chloropropane, 1 kilogram of thanomin, 5L dehydrated alcohol joins in 10L there-necked flask, is heated to 50 ℃ of reactions and spends the night, and is spin-dried for solvent, obtain 2 kilograms of the chloro-3-of product R-1-((2-hydroxyethyl) amino)-2-propyl alcohol (R-II), yield 100%.
(2) the chloro-3-of R-N-tertbutyloxycarbonyl-1-((2-hydroxyethyl) amino)-2-propyl alcohol (R-III) is synthetic
2 kilograms of chloro-3-of R-1-((2-hydroxyethyl) amino)-2-propyl alcohol (R-II) is dissolved in 10L anhydrous methanol, add 1.78 kilograms of tert-Butyl dicarbonates, stirring is spent the night, spin off anhydrous methanol and obtain 4.15 kilograms of the chloro-3-of product R-N-tertbutyloxycarbonyl-1-((2-hydroxyethyl) amino)-2-propyl alcohol (R-III), yield 100%.
(3) S-N-tertbutyloxycarbonyl-2-morpholine methyl alcohol (I) is synthetic
In 50L reactor, 4.15 kilograms of chloro-3-of R-N-tertbutyloxycarbonyl-1-((2-hydroxyethyl) amino)-2-propyl alcohol (R-III) is dissolved in to 20L dehydrated alcohol, add 11.1 kilograms of sodium ethylates, stir 2 hours, the concentrated ethanol of removing, add 20L ethyl acetate and 20L water stratification, water layer is used the extraction of 2 × 10L ethyl acetate again, combined ethyl acetate layer, wash with 5L saturated brine, anhydrous sodium sulfate drying, filter, concentrate to obtain S-N-tertbutyloxycarbonyl-2-morpholine methyl alcohol (I) and R-N-tertbutyloxycarbonyl-6-hydroxyl-1, 3 kilograms, 4-oxo azepine alkane (IV) mixture.Mixture is through method of purification 1.56 kilograms of white solids of S-N-tertbutyloxycarbonyl-2-morpholine methyl alcohol (I) of purifying to obtain of [JOC2008,3662] report, yield 44%.
Characterization of The Products data are as follows: mp61～64 ℃; Optically-active+20.6 (c0.2, CHCl
3);
1h NMR (399.76MHz, CDCl
3) δ 1.43 (s, 9H), 2.19 (brs, 1H), 2.64-2.79 (m, 1H), 2.82-2.99 (m, 1H), 3.42-3.60 (m, 3H), 3.60-3.67 (m, 1H), 3.73-3.94 (m, 3H).
Embodiment 2
(1) the chloro-3-of S-1-((2-hydroxyethyl) amino)-2-propyl alcohol (S-II) is synthetic
By 2 kilograms of S-epoxy chloropropane, 12 kilograms of thanomins, 10L dehydrated alcohol joins in 20L there-necked flask, being heated to 50 ℃ of reactions spends the night, be spin-dried for solvent, obtain 4 kilograms of the chloro-3-of product S-1-((2-hydroxyethyl) amino)-2-propyl alcohol (S-II), yield >100%.
(2) the chloro-3-of S-N-tertbutyloxycarbonyl-1-((2-hydroxyethyl) amino)-2-propyl alcohol (S-III) is synthetic
4 kilograms of chloro-3-of S-1-((2-hydroxyethyl) amino)-2-propyl alcohol (S-II) is dissolved in 20L anhydrous methanol, add 3.56 kilograms of tert-Butyl dicarbonates, stirring is spent the night, spin off anhydrous methanol and obtain 8.2 kilograms of the chloro-3-of product S-N-tertbutyloxycarbonyl-1-((2-hydroxyethyl) amino)-2-propyl alcohol (S-III), yield >100%.
(3) R-N-tertbutyloxycarbonyl-2-morpholine methyl alcohol (I) is synthetic
In 50L reactor, 8.2 kilograms of chloro-3-of S-N-tertbutyloxycarbonyl-1-((2-hydroxyethyl) amino)-2-propyl alcohol (S-III) is dissolved in to 40L dehydrated alcohol, add 22 kilograms of sodium ethylates, stir 2 hours, the concentrated ethanol of removing, add 40L ethyl acetate and 40L water stratification, water layer is used the extraction of 2 × 20L ethyl acetate again, combined ethyl acetate layer, wash with 10L saturated brine, anhydrous sodium sulfate drying, filter, concentrate to obtain R-N-tertbutyloxycarbonyl-2-morpholine methyl alcohol (I) and S-N-tertbutyloxycarbonyl-6-hydroxyl-1, 3 kilograms, 4-oxo azepine alkane (IV) mixture.Mixture is through method of purification 4 kilograms of white solids of R-N-tertbutyloxycarbonyl-2-morpholine methyl alcohol (I) of purifying to obtain of [JOC2008,3662] report, yield 42%.
Characterization of The Products data are as follows: mp61～64 ℃; Optically-active-20.5 (c0.2, CHCl
3); 1H NMR (399.76MHz, CDCl
3) δ 1.44 (s, 9H), 2.20 (brs, 1H), 2.65-2.80 (m, 1H), 2.83-3.00 (m, 1H), 3.43-3.61 (m, 3H), 3.61-3.68 (m, 1H), 3.74-3.95 (m, 3H).
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and in the situation that not deviating from spirit of the present invention or essential characteristic, can realize the present invention with other specific form.Therefore, no matter from which point, all should regard embodiment as exemplary, and be nonrestrictive, scope of the present invention is limited by claims rather than above-mentioned explanation, is therefore intended to all changes that drop in the implication and the scope that are equal to important document of claim to include in the present invention.
In addition, be to be understood that, although this specification sheets is described according to embodiment, but be not that each embodiment only comprises an independently technical scheme, this narrating mode of specification sheets is only for clarity sake, those skilled in the art should make specification sheets as a whole, and the technical scheme in each embodiment also can, through appropriately combined, form other embodiments that it will be appreciated by those skilled in the art that.
Claims (6)
1. a method of preparing chirality N-replacement-2-morpholine methyl alcohol compounds, is characterized in that, comprises the steps:
(1) in reaction unit, add chiral epichlorohydrin, thanomin and solvent (A), 0～100 ℃ is reacted 1～24 hour, the concentrated compound (II) that to obtain;
(2) in reaction unit, add compound (II), N protecting group and solvent (B), 0～100 ℃ is stirred 3～5 hours, concentrates to obtain compound (III); Described N protecting group R is carbobenzoxy-(Cbz), tertbutyloxycarbonyl, C
1～C
8alkyl acyl, C
1～C
8alkyl oxygen carbonyl, C
1～C
8alkyl sulphonyl, substituted benzoyl or substituted benzene alkylsulfonyl;
(3) in reaction unit, add alkali and solvent (C), at 0～100 ℃, add compound (III), stir more than 2 hours, spin off solvent, add ethyl acetate and water stratification, water layer is extracted with ethyl acetate 2 times again, merge organic layer dry compound (I) and (IV) mixture, the compound (I) of purifying to obtain
2. method according to claim 1, is characterized in that: in step (1), described chiral epichlorohydrin and the mol ratio of thanomin are (40: 1)～(1: 40).
3. method according to claim 1, it is characterized in that: in step (1), described solvent (A) is at least one in water, methyl alcohol, ethanol, propyl alcohol, Virahol, methylene dichloride, trichloromethane, tetrahydrofuran (THF), dioxane, acetonitrile, glycol dimethyl ether, diethylene glycol dimethyl ether.
4. method according to claim 1, it is characterized in that: in step (2), described solvent (B) is at least one in methyl alcohol, ethanol, propyl alcohol, Virahol, tetrahydrofuran (THF), dioxane, acetonitrile, glycol dimethyl ether, diethylene glycol dimethyl ether.
5. method according to claim 1, it is characterized in that: in step (3), described alkali is triethylamine, diisopropyl ethyl amine, pyridine, morpholine, sodium carbonate, salt of wormwood, sodium hydride, sodium hydroxide, potassium hydroxide, sodium methylate, sodium ethylate, sodium tert-butoxide, sodium tert-amyl alcohol, Tetramethylammonium hydroxide, at least one in tetraethyl ammonium hydroxide, TBAH.
6. method according to claim 1, it is characterized in that: in step (3), described solvent (C) is at least one in water, methyl alcohol, ethanol, propyl alcohol, Virahol, tetrahydrofuran (THF), dioxane, acetonitrile, glycol dimethyl ether, diethylene glycol dimethyl ether.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130274253A1 (en) * | 2010-12-28 | 2013-10-17 | Sanofi | Novel pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
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2014
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130274253A1 (en) * | 2010-12-28 | 2013-10-17 | Sanofi | Novel pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
Non-Patent Citations (3)
| Title |
|---|
| KEVIN E. HENEGAR: "Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid", 《J. ORG. CHEM.》 * |
| MATTHIAS BREUNING ET AL.: "Efficient One-Pot Synthesis of Enantiomerically Pure 2-(Hydroxymethyl)-morpholines", 《EUR. J. ORG. CHEM.》 * |
| RUDY S. BURIKS ET AL.: "Intramolecular Cyclization Products from Alkanolamines and Epichlorohydrin", 《J. ORG. CHEM.》 * |
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