CN103815980A - Device for creating rat spinal-cord blast injury model - Google Patents
Device for creating rat spinal-cord blast injury model Download PDFInfo
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- CN103815980A CN103815980A CN201410059633.XA CN201410059633A CN103815980A CN 103815980 A CN103815980 A CN 103815980A CN 201410059633 A CN201410059633 A CN 201410059633A CN 103815980 A CN103815980 A CN 103815980A
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Abstract
The invention relates to a device, for creating a rat spinal-cord blast injury model, in the field of medical experimental apparatus. The device comprises a baseplate (1), support columns (2), a blast source support rod (3) and an animal box (5). The support columns (2) are fixed on the baseplate (1), the blast source support rod (3) is mounted on the support columns (2), and the animal box (5) is mounted on the support columns (2) through an animal box support rod (4). A groove (7) is formed in the baseplate (1), and a gap (8) is formed in the groove (7). A sensor probe is arranged at the bottom of the gap (8). A groove (7) and a gap (8) corresponding to the baseplate (1) are formed in the box bottom (15) of the animal box (5). By the device, the defects that accurate blasting of target positions cannot be realized by existing spinal-cord blast injury models and experiment accuracy and overall controllability are poor are overcome; the device is simple to operate, good in actual control and capable of accurately controlling injuries of the target positions.
Description
Affiliated technical field
The present invention relates to medical experiment device field, be specially a kind of device of setting up rat spinal cord blast damage model.
Background technology
At present, existing multiple modeling hands section in the zoopery field of setting up spinal cord blast damage model, but thereby it is few directly to utilize explosive charge to produce the means of exploding in the military affairs of blast injury spinal cord simulating reality and life, most of modeling devices all can not be realized the accurate explosion at object position, cannot realize the good control of shock wave equivalent, uncontrollable due to blasting window, result blast is coarse, often with the damage of other position tissues, thereby interference experiment, even draw insecure conclusion, most of devices are not considered dissection and the physiological characteristics of laboratory animal, the accuracy of experiment and entirety are controlled poor.Desirable spinal cord blast injury model at least should possess following aspect: the explosive injury in (1) institute modeling type and war and life production has similarity: its damage model approaches the mankind as far as possible.(2) controllability of experiment: spinal cord explosive injury can accurately be adjusted damage location and degree according to actual needs, copies the blast injury model of different equivalents.(3) operability and the repeatability of experiment: duplicated model has simple to operately, and technical difficulty is little, and the repeatability of experimental result is strong.(4) experiment can reduce the damage of other organs, tissue except object position as far as possible, thereby uses as much as possible single impairment factor.But most experiment modeling device all has defect in various degree, therefore, be necessary to set up a kind of more scientific, more practical animal blast damage model.
Summary of the invention
The object of the invention is can not realize in order to overcome existing spinal cord blast injury model the accurate explosion at object position, the accuracy of experiment and the controlled poor defect of entirety, provide a kind of simple to operate, working control is good, can realize the device of setting up rat spinal cord blast damage model of the accurate control to the damage of object position.
The object of the invention is to realize by following technical proposals:
The device of setting up rat spinal cord blast damage model of the present invention, by base plate (1), be fixed on pillar (2) on base plate (1), be arranged on the explosive source pole (3) on pillar (2) and the animal box (5) that is arranged on pillar (2) by animal box pole (4) forms, it is characterized in that having on base plate (1) groove (7), in groove (7), have gap (8), bottom, gap (8) is mounted with sensor probe, for recording explosion wave numerical value; At the bottom of the box of animal box (5), on (14), have the groove (7) corresponding with base plate (1) and gap (8); On pillar (2), have brace groove (19), brace groove is equipped with slide block in (19), and slide block is connected with set screw (15), and animal box pole (4) is arranged on pillar (2) by set screw (15); Explosive source pole (3) connection metal blast frame, frame week indicates scale, settles explosive source (13) in frame, and explosive source pole (3) is arranged on pillar (2) by set screw (15).
In such scheme, in described groove (7), be mounted with gap width adjustment sheet (9), gap length adjustment sheet (10) is installed on (14) at the bottom of base plate (1) and box.
In such scheme, at the bottom of described base plate (1) and box, on (14), there is fixed strip (11), for fixing gap width adjustment sheet (9) and gap length adjustment sheet (10), fixed strip (11) is separately fixed at the bottom of base plate (1) and box on (14) by fixed screw (12); Gap length adjustment sheet (10) is L shaped.
In such scheme, the fixing point of described pillar (2) on base plate (1) is corresponding with the center line in the gap (8) in base plate (1) upper groove (7); Pillar (2) is marked with scale.
In such scheme, described animal box (5) is inverted ladder-shaped body, and lid (6) is arranged at top.
In such scheme, lid (6) and the periphery of described animal box (5) are equipped with sound insulation liner (20).
In such scheme, described animal box pole (4) is marked with scale; Groove (7) surrounding indicates scale.
Use procedure of the present invention is as follows:
Anesthetized rat is placed in the animal box of inverted trapezoidal structure, rely on animal gravity itself to realize the good agreement in its vertebra and cartridge bottom gap, and do not affect the physiologic parameters such as animal blood circulation and breathing, when experiment, lid is built, thereby reduced the blast sound to neural damages such as rat audition.By gap width adjustment sheet and gap length adjustment sheet accurate adjustment gap size.The fixed strip of fixing gap length adjustment sheet is fixing in base plate and animal box bottom, reach the object of fixing gap length adjustment sheet by rotating its subsidiary screw.Animal box is fixed on pillar.Explosive source pole is fixed on pillar, need to adjusts the distance between explosive source and animal box according to experiment.Detonate and cause Damage of Rats, set up rat spinal cord blast damage model according to shock wave numerical value and Damage of Rats situation.
Adopt the rat spinal cord blast damage model that the present invention sets up to simulate field environment completely, can utilize the blast of papery electric cap to produce shock wave, do not produce metal fragmentation.
The present invention has the following advantages: 1, simple in structure, easily manufacture, has realized the control of explosion equivalent and the accurate location at object position; Stability in the large is good, is difficult for deforming in blast; Processing ease, experiment stability and repeatability are strong.2, have can accurate adjustment gap, can accurately set blast window size, prevent other organs and tissue beyond Spinal Cord, moving horizontally of gap length adjustment sheet realized the object of damaging different spinal cord planes.3, use inverted trapezoidal to cover animal box and place rat, after rat anesthesia, do not need to fix, utilize himself gravity make rat spine can with gap good agreement, have obvious advantage compared with adopting binding or other fixing meanss in same device, reduce animal injury.4, rat lies low in animal box bottom, does not substantially exert an influence little to physiologic factors such as rat body blood circulation and breathings.5, animal box adopts and adds a cover and the design of deadener, has reduced grievous injury rat audition and other nervous system being caused because of the blast sound, reduces experiment interference.6, base plate and animal box bottom adopt identical design, and under base plate, respective distance is placed sensor probe, thereby can under same parameters, record the pressure of explosion wave; And on base plate, adopted level indicator design, the level before and after experiment can be contrasted to the fully stability in the large of evaluating system.
Therefore, the present invention has overcome existing spinal cord blast injury model and can not realize the accurate explosion at object position, the accuracy of experiment and the controlled poor defect of entirety, the device of setting up rat spinal cord blast damage model providing is simple to operate, working control is good, can realize the accurate control to the damage of object position.
Accompanying drawing explanation
Fig. 1 is schematic diagram of the present invention.
Fig. 2 is the schematic diagram of base plate of the present invention.
Fig. 3 is the schematic diagram at the bottom of animal box box of the present invention.
Fig. 4 is the schematic diagram of explosive source pole of the present invention.
Fig. 5 is the schematic diagram of pillar of the present invention.
Fig. 6 is the schematic diagram of fixed strip of the present invention and gap length adjustment sheet.
In accompanying drawing, the implication of each numeral is: 1: base plate; 2: pillar; 3: explosive source pole; 4: animal box pole; 5: animal box; 6: lid; 7: groove; 8: gap; 9: gap width adjustment sheet; 10: gap length adjustment sheet; 11: fixed strip; 12: fixed screw; 13: explosive source; 14: at the bottom of box; 15: set screw; 16: level indicator; 17: horizontal screw; 18: base plate leg; 19: brace groove; 20: sound insulation liner.
The specific embodiment
Be described in further detail the present invention below in conjunction with drawings and Examples, but the present invention is not limited only to described embodiment.
Embodiment mono-
The device of setting up rat spinal cord blast damage model of this example as shown in Figure 1, Figure 2, shown in Fig. 3, Fig. 4, Fig. 5 and Fig. 6, by base plate 1, be fixed on pillar 2 on base plate 1, by set screw 15 be arranged on the explosive source pole 3 on pillar 2, the animal box 5 being arranged on pillar 2 by set screw 15 and animal box pole 4 forms, on base plate 1, have groove 7, in groove 7, have gap 8,8 bottoms, gap are mounted with sensor probe, for recording explosion wave numerical value; At the bottom of the box of animal box 5, have the groove corresponding with base plate 17 and gap 8 on 14; On pillar 2, have brace groove 19, in brace groove 19, slide block is housed, slide block is connected with set screw 15, and animal box pole 4 is arranged on pillar 2 by set screw 15, and realizes its movement on pillar 2 and fixing; Explosive source pole 3 connection metal blast frames, frame week indicates scale, settles explosive source 13 in frame; The two ends of frame have two apertures, and the wire of explosive source is through this hole; Explosive source pole 3 is arranged on pillar 2 by set screw 15, and realizes its movement on pillar 2 and fixing.
In groove 7, be mounted with gap width adjustment sheet 9, at the bottom of base plate 1 and box, gap length adjustment sheet 10 is installed on 14, gap length adjustment sheet 10 is pushed down gap width adjustment sheet 9, at the bottom of base plate 1 and box, there is fixed strip 11 on 14, for fixing gap width adjustment sheet 9 and gap length adjustment sheet 10, fixed strip 11 is separately fixed at the bottom of base plate 1 and box on 14 by fixed screw 12, and gap length adjustment sheet 10 is L shaped.
Lid 6 and the periphery of animal box 5 are equipped with sound insulation liner 20.
Embodiment bis-
The device of setting up rat spinal cord blast damage model of this example, except not having gap width adjustment sheet 9, gap length adjustment sheet 10, fixed strip 11 and fixed screw 12, all the other are with embodiment mono-.
Embodiment tri-
The device of setting up rat spinal cord blast damage model of this example, except lid (6) and the periphery of animal box (5) do not have sound insulation liner, all the other are with embodiment mono-.
Claims (7)
1. set up the device of rat spinal cord blast damage model for one kind, by base plate (1), be fixed on pillar (2) on base plate (1), be arranged on the explosive source pole (3) on pillar (2) and the animal box (5) that is arranged on pillar (2) by animal box pole (4) forms, it is characterized in that having on base plate (1) groove (7), in groove (7), have gap (8), bottom, gap (8) is mounted with sensor probe, for recording explosion wave numerical value; At the bottom of the box of animal box (5), on (15), have the groove (7) corresponding with base plate (1) and gap (8); On pillar (2), have brace groove (20), brace groove is equipped with slide block in (20), and slide block is connected with set screw (16), and animal box pole (4) is arranged on pillar (2) by set screw (16); Explosive source pole (3) connection metal blast frame, frame week indicates scale, settles explosive source (13) in frame, and explosive source pole (3) is arranged on pillar (2) by set screw (16).
2. the device of setting up rat spinal cord blast damage model according to claim 1, is characterized in that being mounted with gap width adjustment sheet (9) in described groove (7), and gap length adjustment sheet (10) is installed on (15) at the bottom of base plate (1) and box.
3. the device of setting up rat spinal cord blast damage model according to claim 2, it is characterized in that on (15), having fixed strip (11) at the bottom of described base plate (1) and box, for fixing gap width adjustment sheet (9) and gap length adjustment sheet (10), fixed strip (11) is separately fixed at the bottom of base plate (1) and box on (15) by fixed screw (12); Gap length adjustment sheet (10) is L shaped.
4. the device of setting up rat spinal cord blast damage model according to claim 1, is characterized in that the fixing point of described pillar (2) on base plate (1) is corresponding with the center line in the gap (8) in base plate (1) upper groove (7); Pillar (2) is marked with scale.
5. the device of setting up rat spinal cord blast damage model according to claim 1, is characterized in that described animal box (5) is inverted ladder-shaped body, and lid (6) is arranged at top.
6. the device of setting up rat spinal cord blast damage model according to claim 8, is characterized in that the lid (6) of described animal box (5) and periphery are equipped with sound insulation liner (21).
7. the device of setting up rat spinal cord blast damage model according to claim 1, is characterized in that described animal box pole (4) is marked with scale; Groove (7) surrounding indicates scale.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410059633.XA CN103815980A (en) | 2013-04-23 | 2014-02-23 | Device for creating rat spinal-cord blast injury model |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310142464.1 | 2013-04-23 | ||
| CN 201310142464 CN103251461A (en) | 2013-04-23 | 2013-04-23 | Device for building of rat spinal cord explosion injury model |
| CN201410059633.XA CN103815980A (en) | 2013-04-23 | 2014-02-23 | Device for creating rat spinal-cord blast injury model |
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| Publication Number | Publication Date |
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| CN103815980A true CN103815980A (en) | 2014-05-28 |
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| CN 201310142464 Pending CN103251461A (en) | 2013-04-23 | 2013-04-23 | Device for building of rat spinal cord explosion injury model |
| CN201410059633.XA Pending CN103815980A (en) | 2013-04-23 | 2014-02-23 | Device for creating rat spinal-cord blast injury model |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201310142464 Pending CN103251461A (en) | 2013-04-23 | 2013-04-23 | Device for building of rat spinal cord explosion injury model |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117322843A (en) * | 2023-10-07 | 2024-01-02 | 中国人民解放军海军特色医学中心 | Experimental animal body injury assessment system under action of explosion shock waves |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251461A (en) * | 2013-04-23 | 2013-08-21 | 中国人民解放军成都军区总医院 | Device for building of rat spinal cord explosion injury model |
| CN109730798A (en) * | 2019-03-15 | 2019-05-10 | 中国人民解放军陆军军医大学 | Animal Wounds impregnate seawater device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201070392Y (en) * | 2007-07-18 | 2008-06-11 | 中国人民解放军第三军医大学 | Device for producing craniocerebral trauma model |
| CN102217979A (en) * | 2011-06-10 | 2011-10-19 | 中国人民解放军第四军医大学 | Device for manufacturing craniocerebral explosion injury models for small animals |
| CN102670321A (en) * | 2012-04-24 | 2012-09-19 | 中国人民解放军成都军区总医院 | Method for establishing diffuse axonal injury animal model |
| CN103251461A (en) * | 2013-04-23 | 2013-08-21 | 中国人民解放军成都军区总医院 | Device for building of rat spinal cord explosion injury model |
| CN203220453U (en) * | 2013-04-23 | 2013-10-02 | 中国人民解放军成都军区总医院 | Device for establishing rat spinal cord explosion injury model |
-
2013
- 2013-04-23 CN CN 201310142464 patent/CN103251461A/en active Pending
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2014
- 2014-02-23 CN CN201410059633.XA patent/CN103815980A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201070392Y (en) * | 2007-07-18 | 2008-06-11 | 中国人民解放军第三军医大学 | Device for producing craniocerebral trauma model |
| CN102217979A (en) * | 2011-06-10 | 2011-10-19 | 中国人民解放军第四军医大学 | Device for manufacturing craniocerebral explosion injury models for small animals |
| CN102670321A (en) * | 2012-04-24 | 2012-09-19 | 中国人民解放军成都军区总医院 | Method for establishing diffuse axonal injury animal model |
| CN103251461A (en) * | 2013-04-23 | 2013-08-21 | 中国人民解放军成都军区总医院 | Device for building of rat spinal cord explosion injury model |
| CN203220453U (en) * | 2013-04-23 | 2013-10-02 | 中国人民解放军成都军区总医院 | Device for establishing rat spinal cord explosion injury model |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117322843A (en) * | 2023-10-07 | 2024-01-02 | 中国人民解放军海军特色医学中心 | Experimental animal body injury assessment system under action of explosion shock waves |
| CN117322843B (en) * | 2023-10-07 | 2024-03-26 | 中国人民解放军海军特色医学中心 | Experimental animal body injury assessment system under action of explosion shock waves |
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| CN103251461A (en) | 2013-08-21 |
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Application publication date: 20140528 |