CN103804280A - Preparation method of donepezil HCl - Google Patents
Preparation method of donepezil HCl Download PDFInfo
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- CN103804280A CN103804280A CN201210438887.3A CN201210438887A CN103804280A CN 103804280 A CN103804280 A CN 103804280A CN 201210438887 A CN201210438887 A CN 201210438887A CN 103804280 A CN103804280 A CN 103804280A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Abstract
The invention provides a preparation method of donepezil HCl. 5, 6-dimethoxy-2-(4-piperidyl methyl)-1-indanone (C17H23NO3) or organic acid and inorganic acid salts thereof, an organic solvent, an alkaline solution, a phase transfer catalyst are added into a reactor, and benzyl bromide is dropwise added under certain temperature; and after the reaction, the reaction products are dissolved in the solvent and acidized to obtain the donepezil HCl. The preparation method has the advanategs of high selectivity, rapid response, total yield of more than 90%, simple operation, mild condition and low cost, and is easy to realize industrialized production.
Description
Technical field
The present invention relates to a kind of preparation method of E 2020.
Background technology
E 2020 is the s-generation acetylcholinesterase depressant that is used for the treatment of senile dementia of FDA approval, is used for the treatment of Alzheimer's disease.It is researched and developed successfully in 1989 by Japanese Wei Cai pharmaceutical Co. Ltd, obtains FDA approval be used for the treatment of Alzheimer in November, 1996, and in January, 1997 is first in U.S.'s listing, and in October, 1999 is in Discussion on Chinese Listed, existing oneself more than 30 country's listings in the world.Its curative effect is own by Britain, the U.S., and multiple national clinical experiments such as Japan confirm.How how croak is selectively together, and reversible noncompetitive acetylcholinesterase depressant can the degraded of acetylcholine esterase inhibition to vagusstoff, activates central cholinergic system, transmits the impaired neuronal degeneration causing thereby alleviate cholinergic.It is many that how croak has selectivity highly to neuronic second phthalein Pseudocholinesterase in brain together, and the acetylcholinesterase in digestive tube and heart is not had to significant restraining effect, with respect to first-generation acetylcholinesterase depressant tacrine, there is dosage little (5-10mg), side effect is low, long-acting (70 hours transformation period, only need take once every day), the advantages such as expense is low are that treatment is light, the more valuable medicine of moderate AD.Recently, research finds how how croak is also effective to vascular dementia together, has further expanded the indication of this medicine.
The synthetic E2020 method of bibliographical information mainly contains two large classes:
Method one: EP0711756Al is by 5,6-dimethoxy-2-(4-pyridyl methylene radical)-1-indone reacts with cylite and generates after quaternary ammonium salt, then obtain E2020 by platinum oxide catalytic hydrogenation, reaction expression is as follows:
Method two:
US2004014321Al; CN1524851A is by 5,6-dimethoxy-2-(4-pyridylmethyl)-1-indone first obtains hydride through catalytic hydrogenating reduction, then react generation E2020 with cylite, reaction expression is as follows:
。
5,6-dimethoxy-2-(4-piperidino methyl for CN200910228282)-1-indone, dehydrated alcohol, bromobenzyl, triethylamine back flow reaction under anhydrous condition, obtain E2020.With after through HCl-ethyl acetate salify, hydrochloride;
CN201110391463 is by 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone is dissolved in methylene dichloride, and under triethylamine effect, react to obtain E2020 with Benzyl Chloride, then obtain E 2020 with methyl alcohol hydrogen chloride solution salify.
Contriver finds through overtesting, the technique final step Reductive stability of described method one is very poor, mainly there are the following problems: (1) thus generate more impurity because benzyl restores to be easy to take off in process, need repeatedly refine just and can remove, cause hydrogenation yield low and unstable.(2) use platinum dioxide to make catalyzer, expensive, reclaim difficulty;
And method two, the technology providing, its shortcoming be this technique final step react with cylite the product E2020 generating while connecing benzyl can further react with cylite produce a certain amount of impurity (5), cause product purity significantly to reduce, need secondary or repeatedly refine and just can remove, cause yield not high, only 70%-75%, is shown in following reaction expression:
Therefore, provide a kind of production method of improved E2020, relevant pharmaceutical arm is extremely expected.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of E 2020.
The preparation method of a kind of E 2020 of the present invention, its step comprises:
Step 1, condensation reaction, reaction formula is as follows:
In formula, PTC is the abbreviation of phase-transfer catalyst (Phase transfer catalyst), and this reaction is phase-transfer-catalyzed reactions.
Step 2, acidifying salify, reaction formula is as follows:
In formula, substance A is 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone or 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone salt, general formula is:
HB represents organic and mineral acid.
Preparation method as above, wherein, 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone salt is 5,6-dimethoxy-2-(4-piperidino methyl)-the organic acid of 1-indone, inorganic acid salt; Wherein mineral acid is nitric acid, sulfuric acid, phosphoric acid, hydrochloric acid, Hydrogen bromide hydroiodic acid HI; Organic acid is the organic acids such as formic acid, acetic acid, propionic acid, citric acid, phenylformic acid, fumaric acid, toxilic acid.
Preparation method as above, wherein, this preparation method operates as follows: substance A, organic solvent, alkaline solution, phase-transfer catalyst are added in reactor, drip at a certain temperature cylite; After question response, reaction product is dissolved in to acidifying in certain solvent and just obtains E 2020.The mol ratio of substance A and bromobenzyl is 1:1～1:2.
Preparation method as above, wherein, solvent for use is chloroparaffin, toluene, dimethylbenzene or ethers, wherein chloroparaffin is selected from methylene dichloride, trichloromethane, 1,2 ethylene dichloride.
Preparation method as above, wherein, phase-transfer catalyst used is quaternary ammonium salt or polyoxyethylene glycol, the ratio of catalytic amount and substance A is 1:100～5:100(weight ratio).
Preparation method as above, quaternary ammonium salt is Tetrabutyl amonium bromide, hexadecyl season trimethylammonium bromide, triethyl benzyl brometo de amonio etc.; Polyoxyethylene glycol is selected from: Macrogol 200, poly(oxyethylene glycol) 400, Polyethylene Glycol-600, polyoxyethylene glycol 800, cetomacrogol 1000, Macrogol 2000.
Preparation method as above, described alkaline solution is the solution of sodium hydroxide, potassium hydroxide, or the solution of the strong base-weak acid salt such as sodium carbonate, salt of wormwood.
Preparation method as above, above-mentioned temperature of reaction is 0～40 ℃.
Preparation method as above, in above-mentioned reaction, acidifying solvent used is selected from ethyl acetate, methyl acetate, butylacetate, the ester classes such as butyl butyrate, toluene, dimethylbenzene or ethers.
Preparation method as above, acidifying salifying method used in above-mentioned reaction: the hydrogenchloride and the E2020 that utilize Acetyl Chloride 98Min. and dehydrated alcohol reaction to produce generate E 2020, and the mol ratio of Acetyl Chloride 98Min. and dehydrated alcohol is 1:1～1:30.
Beneficial effect of the present invention comprises:
1, the present invention adopts phase-transfer-catalyzed reactions, and the almost quantitative reaction of selectivity height, is swift in response, drip bromobenzyl reaction and complete, the method total recovery exceedes 90%, has easy and simple to handlely avoided anhydrous and oxygen-free reaction, condition relaxes, and temperature of reaction is upper and lower in room temperature, is easy to realize suitability for industrialized production.
2, the present invention adopts quaternary ammonium salt or polyoxyethylene glycol as catalyzer, and catalyzer is selected wide, and water is basic solution, and organic phase is chloroparaffin, toluene or ethers, and water and organic phase are practical.
3, cost of the present invention is low.
Embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated.Following embodiment and being not used in should not be interpreted as by any way to the restriction of inventing in listed claim yet.Its Raw can reference example method preparation or buying on the market.
The preparation method of a kind of E 2020 provided by the invention, comprise the steps: 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone and its esters (II) with replace cylite by phase-transfer catalysis generation condensation reaction, obtain E2020; E2020 reacts the hcl reaction producing and generates E 2020 with Acetyl Chloride 98Min. and dehydrated alcohol.
Reaction expression is as follows:
In formula, HB represents organic and mineral acid.
Wherein the mineral acid of HB representative can be nitric acid, sulfuric acid, phosphoric acid, hydrochloric acid, Hydrogen bromide hydroiodic acid HI; The organic acid of HB representative can be the organic acids such as formic acid, acetic acid, propionic acid, citric acid, phenylformic acid, fumaric acid, toxilic acid.
embodiment 1
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 39.5g, yield 95.2%.
embodiment 2
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, hexadecyl season trimethylammonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 38.1g, yield 91.8%.
embodiment 3
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), toluene 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes toluene, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 38.0g, yield 91.6%.
embodiment 4
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), isopropyl ether 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes isopropyl ether, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 38.5g, yield 92.8%.
embodiment 5
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, triethyl benzyl brometo de amonio 1.6g(5.8mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 38.7g, yield 93.3%.
embodiment 6
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, 1.6g Macrogol 200 mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 38.3g, yield 92.3%.
embodiment 7
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, 1.6g cetomacrogol 1000 mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 38.0g, yield 91.5%.
embodiment 8
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), trichloromethane 150ml, 20% potassium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 39.2g, yield 94.5%.
embodiment 9
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), trichloromethane 150ml, 20% solution of potassium carbonate 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes trichloromethane, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 38.5g, yield 92.8%.
embodiment 10
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to toluene and carries out acidifying salify.
2, acidifying salify
Toluene solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 39.0g, yield 93.9%.
embodiment 11
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to isopropyl ether and carries out acidifying salify.
2, acidifying salify
Isopropyl ether solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 38.9g, yield 93.7%.
embodiment 12
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to butyl butyrate and carries out acidifying salify.
2, acidifying salify
Butyl butyrate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 39.1g, yield 94.2%.
embodiment 13
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone 28.9g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to butyl butyrate and carries out acidifying salify.
2, acidifying salify
Butyl butyrate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 39.0g, yield 93.9%.
embodiment 14
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone vitriol 42.6g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to butyl butyrate and carries out acidifying salify.
2, acidifying salify
Butyl butyrate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 39.4g, yield 94.9%
embodiment 15
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone acetate 38.8g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to butyl butyrate and carries out acidifying salify.
2, acidifying salify
Butyl butyrate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 38.6g, yield 93.0%
embodiment 16
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone benzoate 45.0g(0.1mol), methylene dichloride 150ml, 20% sodium hydroxide solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to butyl butyrate and carries out acidifying salify.
2, acidifying salify
Butyl butyrate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 39.1g, yield 94.2%
embodiment 17
1, condensation reaction:
By (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone hydrochloride 32.5g(0.1mol), methylene dichloride 150ml, saturated sodium carbonate solution 300g, Tetrabutyl amonium bromide 1.6g(5.0mmol) mix, cool to 5 ℃, drip cylite 17.1g(0.1mol), dropwise rear stirring 30 minutes.Separate organic layer, anhydrous magnesium sulfate drying, filters out and concentratedly after siccative removes methylene dichloride, resistates is dissolved in to ethyl acetate and carries out acidifying salify.
2, acidifying salify
Ethyl acetate solution is cooled to 0～5 ℃, drips Acetyl Chloride 98Min. 25ml, dropwise, stir 1 hour.Drip again 35ml dehydrated alcohol, dropwise rear stirring 2 hours.Filter, obtain off-white color solid, wash solid three times by 90ml ethyl acetate, after being dried, obtain off-white color solid 39.2g, yield 94.4%.
In a word, the preparation method of a kind of E 2020 provided by the invention, technical process is simpler, cost is lower, purity is higher, is more conducive to method prepared by E 2020 that large-scale industrial produces.The method is characterised in that: 1, to prepare formula I be C24H29NO3 to the method, H Cl; 2, the raw material that the method is used is (II) 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone (C17H23NO3) or its organic acid, inorganic acid salt; 3, the present invention adopts phase-transfer-catalyzed reactions; 4, the present invention adopts quaternary ammonium salt or polyoxyethylene glycol as catalyzer, and water is basic solution, and organic phase is chloroparaffin, toluene or ethers, and 5, temperature of reaction of the present invention is 0 ℃～40 ℃; 6, selectivity is high, is swift in response, and the method total recovery exceedes 90%, easy and simple to handle, and condition relaxes, and cost is low, is easy to realize suitability for industrialized production.
The above, it is only exemplary embodiments of the present invention, not technical scope of the present invention is imposed any restrictions, any trickle modification, equivalent variations and modification that every foundation technical spirit of the present invention is made above enforcement, all still belong within the scope of technical scheme of the present invention.
Claims (10)
1. a preparation method for E 2020, its step comprises:
Step 1, condensation reaction, reaction formula is as follows:
Step 2, acidifying salify, reaction formula is as follows:
In formula, substance A is 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone and salt thereof, general formula is:
In formula, HB represents organic and mineral acid.
2. preparation method according to claim 1, is characterized in that 5,6-dimethoxy-2-(4-piperidino methyl)-1-indone salt is 5,6-dimethoxy-2-(4-piperidino methyl) organic acid or the inorganic acid salt of-1-indone; Wherein mineral acid is nitric acid, sulfuric acid, phosphoric acid, hydrochloric acid, Hydrogen bromide or hydroiodic acid HI; Organic acid is the organic acids such as formic acid, acetic acid, propionic acid, citric acid, phenylformic acid, fumaric acid, toxilic acid.
3. preparation method according to claim 1, is characterized in that this preparation method operates as follows: substance A, organic solvent, alkaline solution, phase-transfer catalyst are added in reactor, drip at a certain temperature cylite; After question response, reaction product is dissolved in and in solvent, carries out acidifying and just obtain E 2020;
Molar ratio 1:1～the 1:2 of substance A and bromobenzyl.
4. preparation method according to claim 3, is characterized in that solvent for use is chloroparaffin, toluene, dimethylbenzene or ethers, and wherein chloroparaffin is selected from methylene dichloride, trichloromethane, 1,2 ethylene dichloride.
5. preparation method according to claim 3, its feature is quaternary ammonium salt or polyoxyethylene glycol at phase-transfer catalyst used, the weight ratio of catalytic amount and substance A is 1:100～5:100.
6. preparation method according to claim 3, phase-transfer catalyst is quaternary ammonium salt or polyoxyethylene glycol; Quaternary ammonium salt is Tetrabutyl amonium bromide, hexadecyl season trimethylammonium bromide, triethyl benzyl brometo de amonio etc.; Polyoxyethylene glycol is selected from: Macrogol 200, poly(oxyethylene glycol) 400, Polyethylene Glycol-600, polyoxyethylene glycol 800, cetomacrogol 1000, Macrogol 2000.
7. preparation method according to claim 3, is characterized in that described alkaline solution is sodium hydroxide, potassium hydroxide, sodium carbonate, the alkaline solution of salt of wormwood or the basic solution of strong base-weak acid salt.
8. preparation method according to claim 3, is characterized in that above-mentioned temperature of reaction is 0～40 degree Celsius.
9. preparation method according to claim 3, is characterized in that in above-mentioned reaction, acidifying solvent used is selected from ethyl acetate, methyl acetate, butylacetate, the ester classes such as butyl butyrate, toluene, dimethylbenzene or ethers.
10. preparation method according to claim 1, it is characterized in that in above-mentioned reaction in acidifying salify step used: the hydrogenchloride and E2020 generation E 2020 that utilize Acetyl Chloride 98Min. and dehydrated alcohol reaction to produce, the molar ratio of Acetyl Chloride 98Min. and dehydrated alcohol is 1:1～1:30.
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| CN201210438887.3A CN103804280A (en) | 2012-11-07 | 2012-11-07 | Preparation method of donepezil HCl |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110540520A (en) * | 2019-09-12 | 2019-12-06 | 威海迪素制药有限公司 | Method for purifying donepezil |
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|---|---|---|---|---|
| CN1524851A (en) * | 2003-02-27 | 2004-09-01 | 天津药物研究院 | Technology for industrialized production of hydrochloric acid multi-donepezil |
| US20070129549A1 (en) * | 2003-03-21 | 2007-06-07 | Yatendra Kumar | Stable lamotrigine pharmaceutical compositions and processes for their preparation |
| WO2007070511A1 (en) * | 2005-12-12 | 2007-06-21 | Envirodyne Technologies, Inc. | Flow-through dip-spin coating method and system therefor |
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|---|---|---|---|---|
| CN1524851A (en) * | 2003-02-27 | 2004-09-01 | 天津药物研究院 | Technology for industrialized production of hydrochloric acid multi-donepezil |
| US20070129549A1 (en) * | 2003-03-21 | 2007-06-07 | Yatendra Kumar | Stable lamotrigine pharmaceutical compositions and processes for their preparation |
| WO2007070511A1 (en) * | 2005-12-12 | 2007-06-21 | Envirodyne Technologies, Inc. | Flow-through dip-spin coating method and system therefor |
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| SHAILENDRA KUMAR DUBEY，等: "A New Commercially Viable Synthetic Route for Donepezil Hydrochloride: Anti-Alzheimer’s Drug", 《CHEM. PHARM. BULL》, vol. 58, no. 9, 17 June 2010 (2010-06-17), pages 1157 - 1160 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110540520A (en) * | 2019-09-12 | 2019-12-06 | 威海迪素制药有限公司 | Method for purifying donepezil |
| CN110540520B (en) * | 2019-09-12 | 2022-02-08 | 迪嘉药业集团有限公司 | Method for purifying donepezil |
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