CN103793905A - Method and device for determining direction of coronal view of brain image - Google Patents
Method and device for determining direction of coronal view of brain image Download PDFInfo
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- CN103793905A CN103793905A CN201210434758.7A CN201210434758A CN103793905A CN 103793905 A CN103793905 A CN 103793905A CN 201210434758 A CN201210434758 A CN 201210434758A CN 103793905 A CN103793905 A CN 103793905A
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Abstract
The invention discloses a method and device for determining the direction of a coronal view of a brain image. The method includes: reestablishing a center sagittal plane figure according to the brain image; segmenting a plurality of brainstem regions in the center sagittal plane figure; determining the rear edge direction of the brainstem in the brainstem regions; and taking a rear edge direction of the brainstem or a direction which is parallel to the rear edge direction of the brainstem as the direction of the coronal view. The device includes a reestablishment unit which reestablishes the center sagittal plane figure according to the brain image; a segmentation unit which segments the plurality of brainstem regions in the center sagittal plane figure; a direction determination unit which determines the rear edge direction of the brainstorm in the brainstem regions; and a direction establishment unit which takes the rear edge direction of the brainstem or the direction which is parallel to the rear edge direction of the brainstem as the direction of the coronal view. Through the direction of the coronal view of the brain image, determined by the method and device and parallel to the rear edge direction of the brainstem, demands for brain imaging scanning can be better met.
Description
Technical field
The present invention relates to imaging of medical field, relate in particular to a kind of method and device of definite brain image Coronal direction.
Background technology
Computer aided medicine imaging technique has been widely used in medical diagnosis at present.Imaging of medical can pass through such as magnetic resonance imaging (Magnetic Resonance Imaging, MRI), ultrasonic scanning (Ultrosonic Scanning, US), robot calculator x-ray tomography (Electronic Computer X-ray Tomography Technique, CT), positron emission tomography scans method acquisitions such as (Positron Emission Tomography, PET).
As shown in Figure 1, conventionally imaging of medical scanning can have the scanning plane of 3 directions, is respectively: human body left and right directions is cut apart to the sagittal plane that obtains, human body fore-and-aft direction is cut apart to the coronal-plane obtaining and human body above-below direction cut apart to the transversal section obtaining.Wherein, human body left and right is cut apart and formed symmetrical two parts, this scanning plane is called center sagittal plane.Wherein, coronal scan especially has clinical meaning to diagnosis brain lesions.And, for the shape and the inner structure that make brain stem region can intactly show, be more convenient for observing brain stem, require the direction of scanning of Coronal should be parallel to brain stem back edge.
And realizing in process of the present invention, inventor finds that in prior art, all there are the following problems: brain coronal scan direction is also not parallel to brain stem back edge.Rapid scanning plan is to formulate suitable scan plan for each patient, has determined in the works this patient's direction of scanning and position.At present, the plan of brain rapid scanning is mainly formulated based on some monumented points.Fig. 2 shows definite method of existing a kind of brain coronal scan direction.Front point of contact (Anterior Commissure in the sagittal plane of center for the method, AC) with rear point of contact (Posterior Commissure, PC) line direction is as cross-section position direction, perpendicular to the direction of AC-PC line as Coronal direction.Fig. 3 shows definite method of existing another kind of head coronal scan direction.The method be with cockscomb (Crista Galli, CG) with the line of occipital bone front end (Tip ofthe Occipital Bone, TOB) as cross-section position direction, perpendicular to CG-TOB line direction as Coronal direction.But the Coronal direction definite by said method is generally all not parallel to brain stem, all there is either large or small angle α with brain stem back edge direction, be therefore unfavorable for observing complete brain stem shape.
Also have a kind of existing rapid scanning plan to utilize collection of illustrative plates to determine monumented point, also can be for determining brain scans direction, as shown in Figure 4.In figure, each point is the monumented point definite based on collection of illustrative plates, can determine fast brain Coronal direction according to these monumented points.But the prerequisite that uses the method is according to numerous a certain amount of basic datas of formerly case accumulative total, to construct the collection of illustrative plates that can meet most people scanning needs in this basic data.And, determine that just because of it basis of monumented point is the collection of illustrative plates based on most patient data, so (such as fetus) error is larger in the time that the method is applied to some especial patient.
Summary of the invention
Technical matters to be solved by this invention is to determine brain image coronal scan direction, to meet better the needs of brain imaging scanning.
In order to address the above problem, according to an aspect of the present invention, provide a kind of method of definite brain image Coronal direction, comprise the following steps:
According to brain image reconstructed center sagittal view;
In the sagittal view of described center, be partitioned into brain stem region;
In described brain stem region, determine brain stem back edge direction;
The direction of getting described brain stem back edge direction or being parallel to described brain stem back edge direction is described Coronal direction.
In one embodiment, the described brain stem region that is partitioned in the sagittal view of center comprises:
In the sagittal view of described center, in the brain stem region of correspondence, determine Seed Points;
Carry out brain stem region growing take described Seed Points as basic point, obtain described brain stem region.
In one embodiment, described definite Seed Points comprises:
In the sagittal view of described center, detect monumented point; Described monumented point is arranged near described center sagittal view corresponding brain stem region or brain stem region;
Be offset described monumented point, obtain the position of described Seed Points;
Obtain the gray-scale value of described Seed Points.
In one embodiment, described monumented point is the tie point of midbrain and pons.
In one embodiment, described detection monumented point comprises: mated and determined described monumented point by region template.
In one embodiment, the described monumented point of described skew comprises: by described monumented point, toward N location of pixels of brain stem internal direction skew, the span of described N is 1～12.
In one embodiment, the gray-scale value of the described Seed Points of described acquisition comprises:
In described brain stem region, choose K candidate point; Described candidate point from the close-by examples to those far off distributes with described monumented point in brain stem internal direction;
Obtain the gray-scale value of each candidate point, and sort by gray-scale value size increasing or decreasing;
If K is odd number, choose gray-scale value sequence and be the gray-scale value of candidate point of (K+1)/2 as the gray-scale value of described Seed Points;
If K is even number, choose gray-scale value sequence and be the gray-scale value of candidate point of K/2 or (K/2)+1 as the gray-scale value of described Seed Points.
In one embodiment, described brain stem region growing comprises: the pixel that described Seed Points is met to growth conditions around merges to the same area; Described growth conditions is: the difference of the gray-scale value of described pixel and the gray-scale value of described Seed Points is within the scope of first threshold.
In one embodiment, described first threshold span is 70 ~ 85.
In one embodiment, described in the sagittal view of center, be partitioned into brain stem region before, also comprise: described center sagittal plane is carried out to edge enhancing.
In one embodiment, adopt edge detection operator to carry out the enhancing of described edge.
In one embodiment, described edge detection operator comprises: Robert operator, Sobel operator, Prewitt operator, Kirsch operator, Laplacian operator, Gaussian-Laplacian operator and/or Canny operator.
In one embodiment, described in brain stem region determine brain stem back edge direction comprise:
Intercept the pixel data of the brain stem first half in described brain stem region;
Carry out pivot analysis, obtain described brain stem back edge direction.
In one embodiment, the pixel data of the described brain stem first half is: n pixel data of the most close human body rear side of every a line the m that starts from top, described brain stem region is capable; Described m is the positive integer between 20 ~ 30, and described n is the positive integer between 4 ~ 8.
According to a further aspect in the invention, also provide a kind of device of definite brain image Coronal direction, having comprised:
Reconstruction unit, according to brain image reconstructed center sagittal view;
Cutting unit is partitioned into brain stem region in the sagittal view of described center;
Determine direction unit, in described brain stem region, determine brain stem back edge direction;
Set up direction unit, the direction of getting described brain stem back edge direction or being parallel to described brain stem back edge direction is described Coronal direction.
In one embodiment, described cutting unit comprises:
Seed Points determining unit is determined position and the gray-scale value of Seed Points in the sagittal view of described center in corresponding brain stem region;
Region growing unit, carries out brain stem region growing take described Seed Points as basic point, obtain described brain stem region.
In one embodiment, described Seed Points determining unit comprises:
Monumented point detecting unit detects monumented point in the sagittal view of described center; Described monumented point is arranged near described center sagittal view corresponding brain stem region or brain stem region;
Acquisition unit, Seed Points position, is offset described monumented point, obtains the position of described Seed Points;
Seed Points gray-scale value obtains unit, obtains the gray-scale value of described Seed Points.
In one embodiment, described device also comprises:
Edge enhancement unit, before being partitioned into brain stem region, carries out edge enhancing to described center sagittal plane in the sagittal view of center.
In one embodiment, described definite direction unit comprises:
Interception unit, at the pixel data of the described brain stem region intercepting brain stem first half;
Pivot analysis unit, carries out pivot analysis to the pixel data of the described brain stem first half, obtains described brain stem back edge direction.
Compared with prior art, technical scheme of the present invention has the following advantages:
1, the present invention first determines brain stem direction, then based on brain stem orientation determination coronal scan direction, can guarantee that this Coronal direction is parallel with brain stem back edge direction, can meet better the needs of brain imaging scanning.
2, in possibility, utilize the same tissue feature that gray-scale value comparatively approaches in image, in brain stem region in brain imaging figure, determine Seed Points, to Seed Points, around the pixel in threshold range is carried out region growing with the gray scale difference value of Seed Points, and the brain stem region being partitioned into is more objective and accurate.
3, in possibility, intercept the right along pixel data of brain stem the first half, carry out pivot analysis, determine brain stem back edge direction, got rid of brain stem lower knuckle part to determining the impact of Coronal direction, more objective and accurate compared with prior art.
4, in possibility, by first finding comparatively significantly monumented point of visual signature in brain stem region, monumented point is adjusted toward brain stem internal direction, guarantee that Seed Points is positioned at brain stem region, and determine the gray-scale value of Seed Points by the gray scale meta numerical value of multiple pixels, the Seed Points obtaining is more accurate and reasonable.
5, in possibility, before determining Seed Points, Xian Dui center sagittal view is carried out edge increase, make the gray value differences of brain stem region and near tissue apart from more obvious, cut off brain stem region with near organize possible being connected, prevent growth and overflow, reduced the error of region growing, determined brain stem back edge direction is more accurate.
Accompanying drawing explanation
Fig. 1 is the direction of scanning schematic diagram of prior art;
Fig. 2 uses the definite Coronal direction schematic diagram of a kind of prior art;
Fig. 3 uses the definite Coronal direction schematic diagram of another kind of prior art;
Fig. 4 uses the definite monumented point schematic diagram of another kind of prior art;
Fig. 5 is the schematic flow sheet of the first embodiment of the method for definite brain image Coronal direction of the present invention;
Fig. 6 is the schematic flow sheet of the second embodiment of the method for definite brain image Coronal direction of the present invention;
Fig. 7 ~ Figure 12 is each stage result schematic diagram embodiment illustrated in fig. 6;
Figure 13 is the structural representation of the first embodiment of the device of definite brain image Coronal direction of the present invention;
Figure 14 is the structural representation of the second embodiment of the device of definite brain image Coronal direction of the present invention.
Embodiment
A lot of details are set forth in the following description so that fully understand the present invention.But the present invention can implement to be much different from alternate manner described here, and those skilled in the art can do similar popularization without prejudice to intension of the present invention in the situation that, and therefore the present invention is not subject to the restriction of following public concrete enforcement.
Secondly, the present invention utilizes schematic diagram to be described in detail, and in the time that the embodiment of the present invention is described in detail in detail, for ease of explanation, described schematic diagram is example, and it should not limit the scope of protection of the invention at this.
In order to solve the technical matters in background technology, the invention provides a kind of method of definite brain image Coronal direction.Fig. 5 is the schematic flow sheet of determining the first embodiment of the method for brain image Coronal direction.As shown in Figure 5, the present embodiment comprises the following steps:
Execution step S11, according to brain image reconstructed center sagittal view.It will be understood by those skilled in the art that existing multiple prior art can realize the reconstruction of center sagittal view, such as: Gradient Descent optimization, center line fitting process etc.Said method all can be applicable to the present invention, and the present invention does not do concrete restriction to this.
Execution step S12 is partitioned into brain stem region in the sagittal view of center.Particularly, can be by determining Seed Points in brain stem region corresponding in the sagittal view of described center.Carry out brain stem region growing take described Seed Points as basic point, obtain described brain stem region.
Described Seed Points can be determined by visual inspection, or determine by Region Matching technology for detection.The present invention does not do concrete restriction to the mode of determining Seed Points, only needs to guarantee that Seed Points is positioned at brain stem intra-zone.
Described brain stem region growing comprises: the pixel that described Seed Points is met to growth conditions around merges to the same area.This is because each neighbor pixel in a target area (as: brain stem region) in imaging of medical often has comparatively approaching like attribute, such as: intensity, gray level, texture color etc.Therefore, determine a Seed Points in target area, region growing can be according to like attribute, from the Seed Points past expansion of field around gradually, to there is the neighbor of like attribute to merge to Seed Points region with Seed Points, thereby obtain a comparatively complete target area (being partitioned into brain stem region).Particularly, the like attribute that the present embodiment is selected is gray-scale value.
Determine whether that the neighbor for having like attribute can determine by the threshold value of setting area growth conditions, that is: when the difference of the property value that certain property value of neighbor is corresponding with Seed Points is less than or equal to this threshold value, think that this neighbor and Seed Points have like attribute, can merge to same target area in the time of region growing.Particularly, the threshold value of region growing condition can arrange according to different application.The applicant is through many experiments, and the preferred threshold value that draws brain stem region growing condition is 70 ~ 85, merges to Seed Points region by being less than or equal to 70 ~ 85 neighbor with the difference of Seed Points gray-scale value that is:, obtains described brain stem region.Preferably threshold value 70 ~ 85 both can avoid the growth causing because threshold value setting is excessive to overflow, and the brain stem region of the formation of can avoiding again grow because threshold value setting is too small is too small, affects the accuracy of follow-up definite brain stem back edge direction.
It will be understood by those skilled in the art that and can also use additive method in the sagittal view of center, to be partitioned into brain stem region, such as: connected domain method, template matching method, watershed algorithm etc., the present invention does not do concrete restriction to this.
Execution step S13 determines brain stem back edge direction in brain stem region.Particularly, can be by intercept the pixel data of the brain stem first half in described brain stem region; Described pixel data is carried out to pivot analysis, obtain described brain stem back edge direction.
Because brain stem region and brain stem material object have similarity in form, the right of its first half is along all comparatively smooth, Lower Half is sweep, therefore the pixel data that the present embodiment only intercepts the brain stem first half carries out pivot analysis, determine brain stem back edge direction, can avoid on the one hand Lower Half sweep to determining the interference of brain stem back edge direction, can reduce on the other hand unnecessary data calculated amount, accelerate arithmetic speed.Particularly, show through many experiments result statistics, start to intercept 20 ~ 30 row pixels from top, brain stem region, substantially can cover the first half comprehensively, in these row pixels, intercept again 4 ~ 8 pixels of the most close human body rear side of every a line, substantially can cover the region of pressing close to the right edge of brain stem of the first half comprehensively.
By pivot analysis, can, at the prerequisite of the not sacrificing accuracy low dimension that declines, can effectively find out topmost element and structure in data, remove noise and redundancy, by original complex data dimensionality reduction, disclose and be hidden in complex data simple structure behind.In the present embodiment, based on the pixel data of the brain stem region first half is carried out to pivot analysis, can determine brain stem back edge direction.
Execution step S14, the direction of getting brain stem back edge direction or being parallel to brain stem back edge direction is Coronal direction.Particularly, can be based on brain stem back edge direction, take brain stem back edge direction itself or be parallel to brain stem back edge direction and with described brain stem back edge direction distance multiple parallel directions not etc. as Coronal direction.
It will be understood by those skilled in the art that the technical program can adopt several data analytical approach to determine brain stem back edge direction, such as: pivot analysis, border tracing or Wavelet Transform etc.In the present embodiment, adopt pca method, but the present invention does not do concrete restriction to this.
The present embodiment is by determining brain stem back edge direction, thereby determine brain coronal scan direction, can guarantee that this Coronal direction is parallel with brain stem back edge direction, can meet better the needs of brain imaging scanning, observe better brain stem shape, improve correctness and the promptness of brain lesions clinical diagnosis.
Fig. 6 is the schematic flow sheet of the second embodiment of the method for definite brain image Coronal direction of the present invention.Different from last embodiment, the present embodiment has specifically illustrated the step of determining Seed Points by monumented point, and center sagittal plane is carried out to the step of edge increase.As shown in Figure 6, the present embodiment comprises the following steps:
Execution step S21, according to brain image reconstructed center sagittal view.Concrete mode describes in detail in last embodiment, repeats no more herein.
Execution step S22, carries out edge enhancing to center sagittal plane.As previously mentioned, although the each pixel of same organization internal has comparatively approaching like attribute conventionally, but complicated annexation between tissue and tissue during due to actual scanning imaging, other that are connected with this tissue are organized in the pixel of junction, may also have like attribute with this tissue.That these belong to its hetero-organization but there is the pixel of like attribute with this tissue, in subsequent region growings process, can cause growth to overflow, may cause final definite brain stem back edge direction to occur error.Particularly, in the present embodiment, adopt edge detection operator to carry out edge enhancing to described center sagittal view, make the most significant operative gap of image local Strength Changes more obvious, cut off brain stem region with near organize presumable connection.
It will be understood by those skilled in the art that existing multiple edge detection operator can be used for edge enhance operation, such as: Robert operator based on single order differential, Sobel operator, Prewitt operator, Kirsch operator etc.; Laplacian operator based on second-order differential, Gaussian-Laplacian operator, Canny operator etc.The combination of above-mentioned any operator or operator all can be applicable to the present invention.
Preferably, use Sobel operator based on single order differential, or Laplacian operator based on second-order differential.Because several operators based on single order differential are all with directivity (being horizontal edge, vertical edge or oblique 45 degree edges etc.), applicant is through repeatedly testing discovery: the situation that growth is overflowed mainly occurs in the marginal position of vertical direction, therefore preferably adopts the Sobel operator that detects vertical edge.In addition, Laplacian operator also can be used for the rim detection of vertical direction, there is no too big difference through check Laplacian operator and Sobel operator in effect.And other Second Order Differential Operator is compared with Laplacian operator, there is the inferior adaptability of the reasons such as the single or calculated amount of direction is larger.
Execution step S23, in the sagittal view of center, detects monumented point; Described monumented point is arranged near center sagittal view corresponding brain stem region or brain stem region.
Different from a upper embodiment, the present embodiment is not directly determined Seed Points, but first determines a monumented point in brain stem region, determines Seed Points according to monumented point.Because monumented point often has outstanding visual signature, therefore determine that monumented point is more convenient and accurate in Seed Points.Meanwhile, because needs are guaranteed Seed Points and are positioned at brain stem region, so the selection of monumented point also needs to consider the position relationship in itself and brain stem region.Particularly, monumented point can be positioned at brain stem region, or considers for the precision of images, suitably relaxes near brain stem region.Near described, drop in brain stem region and be limited described monumented point is offset to position after some pixels.
In the present embodiment, select midbrain-pons point of contact (Midbrain-Pons Junction, MPJ) be monumented point, this point is positioned at the top of brain stem left margin depression, conventionally naked eyes are distinguishable, also the mode such as accessible region territory template matches is determined midbrain-pons point of contact (MPJ), and the present invention does not do concrete restriction to the mode that detects monumented point.In other embodiments, also can select other monumented points, such as: midbrain coboundary, pons-medulla oblongata tie point etc.
Execution step S24, drift marker point, the position of acquisition Seed Points.Because the monumented point-midbrain in the present embodiment-pons point of contact (MPJ) is positioned on the border of brain stem and surrounding tissue, for guaranteeing that Seed Points is positioned at brain stem region, monumented point is offset to several location of pixels toward brain stem internal direction, obtain the position of Seed Points.Position relationship and the image resolution ratio of considering monumented point and brain stem region, the location of pixels of skew is advisable with 1～12.
Execution step S25, the gray-scale value of acquisition Seed Points.Too small or excessive in order to prevent the gray-scale value of the indivedual pixels of brain stem fringe region, with the comparison standard of range of influence growth conditions, can select the gray average of multiple pixels in brain stem region, as the gray-scale value of Seed Points, to reduce error.Particularly, can in brain stem region, choose several candidate points.These candidate points, from described monumented point, from the close-by examples to those far off distribute in brain stem internal direction.Obtain the gray-scale value of each candidate point, and sort by gray-scale value size increasing or decreasing.Get the gray-scale value of pixel of median as the gray-scale value of Seed Points.That is: choose K candidate point, if K is odd number, choose gray-scale value sequence and be the gray-scale value of candidate point of (K+1)/2 as the gray-scale value of described Seed Points; If K is even number, choose gray-scale value sequence and be the gray-scale value of candidate point of K/2 or (K/2)+1 as the gray-scale value of described Seed Points.
In the present embodiment, in brain stem intra-zone direction, select 5 candidate seed points.These 5 candidate seed points are respectively 1,3,5,7,9 pixel with the distance that described MPJ is ordered.Obtain gray-scale value the sequence of 5 candidate seed points.Choose the gray-scale value of the candidate seed point that comes the 3rd as the gray-scale value of Seed Points (Seed).
Execution step S26, carries out brain stem region growing take Seed Points as basic point, obtain brain stem region.In the present embodiment, growth conditions threshold value is 75.Concrete mode describes in detail in last embodiment, repeats no more herein.
Perform step S27, in brain stem region, intercept the pixel data of the brain stem first half.In the present embodiment, 6 pixels of the most close human body rear side of every a line 25 row that intercepting brain stem region starts from top, for pivot analysis.
Execution step S28, carries out pivot analysis, obtains brain stem back edge direction.Concrete mode describes in detail in last embodiment, repeats no more herein.
Execution step S29, the direction of getting brain stem back edge direction or being parallel to brain stem back edge direction is Coronal direction.Concrete mode describes in detail in last embodiment, repeats no more herein.
In the present embodiment, before determining Seed Points, Xian Dui center sagittal view is carried out edge increase, make the gray value differences of brain stem region and near tissue apart from more obvious, cut off brain stem region with near organize possible being connected, prevent growth and overflow, reduced the error of region growing, determined brain stem back edge direction is more accurate.On the other hand, by first finding comparatively significantly monumented point MPJ of visual signature in brain stem region, monumented point is adjusted toward brain stem internal direction, guarantee that Seed Points is positioned at brain stem region, and determine the gray-scale value of Seed Points by the gray scale meta numerical value of multiple pixels, the Seed Points obtaining is more accurate and reasonable.
Below in conjunction with accompanying drawing, the second embodiment is described further.
Fig. 7 ~ Figure 12 is the result schematic diagram in each stage of second embodiment of the invention.
Shown in Fig. 7 is the center sagittal view obtaining after brain image is rebuild in the present embodiment.In the sagittal view of described center, vertically irregular portion is divided into brain stem region 1.On the top of brain stem left margin recess, the position that is scissors mouth shape is monumented point MPJ(midbrain-pons point of contact of the present embodiment, Midbrain-Pons Junction).In the present embodiment, mate and determine described monumented point by region template.
Then, adopt Sobel operator to carry out edge enhancing to described center sagittal view.Shown in Fig. 8 is that edge strengthens Hou center sagittal view.As shown in Figure 8, compared to Fig. 7, the edge of the each tissue of Fig. 8 deutocerebral region is cut apart more clearly.
Shown in Fig. 9 is candidate seed point and final definite Seed Points.As shown in Figure 9, the present embodiment is chosen in 5 points that on the x, y axle of brain stem internal direction, range mark point MPJ is respectively 1,3,5,7,9 pixel as candidate seed point, obtain gray-scale value the sequence of 5 candidate seed points, choose gray-scale value sequence and be the candidate seed point of the 3rd (being meta numerical value) as definite Seed Points seed, that is: with described monumented point MPJ on x, y axle all toward brain stem internal blas the candidate seed point of 5 pixels.The position of described Seed Points seed is the position of this candidate seed point, the gray-scale value that the gray-scale value of described Seed Points seed is this candidate seed point.
Then, take Seed Points seed as basic point, carry out brain stem region growing, obtain brain stem region.In the present embodiment, the first threshold in growth conditions is set as to 75, that is: is merged together being less than or equal to 75 neighbor pixel with the difference of Seed Points seed gray-scale value, finally form brain stem region.Shown in Figure 10 is the brain stem region obtaining after region growing.
Then,, in the brain stem region being partitioned into, intercept the pixel data of the brain stem first half.In the present embodiment, intercept 6 pixels of the most close human body rear side of every a line 25 row that start from top, brain stem region, for pivot analysis.Figure 11 shows the brain stem first half pixel data intercepting out.
Then, 25 × 6 pixel datas that intercept are carried out to pivot analysis, obtain described brain stem back edge direction.Rectilinear direction is brain stem back edge direction definite after pivot analysis as shown in figure 12.
Finally, determine that described brain Coronal direction is described brain stem back edge direction or the direction parallel with described brain stem back edge direction.
It should be noted that, the picture of the present embodiment based on 256 × 256, for other size pictures, without departing from the spirit and scope of the present invention, when doing a little modification and perfect, therefore protection scope of the present invention is worked as with being as the criterion that claims were defined.
It should be noted that, by the description of above embodiment, those skilled in the art can be well understood to partly or entirely can realizing by software and in conjunction with essential general hardware platform of the application.Based on such understanding, the part that the application's technical scheme contributes to prior art in essence in other words can embody with the form of software product, this computer software product can comprise the one or more machine readable medias that store machine-executable instruction on it, and these instructions can make these one or more machines carry out executable operations according to embodiments of the invention in the time being carried out by one or more machines such as such as computing machine, computer network or other electronic equipments.Machine readable media can comprise, but be not limited to floppy disk, CD, CD-ROM(compact-disc-ROM (read-only memory)), magneto-optic disk, ROM(ROM (read-only memory)), RAM(random access memory), EPROM(Erasable Programmable Read Only Memory EPROM), EEPROM(Electrically Erasable Read Only Memory), magnetic or optical card, flash memory or be suitable for the medium/machine readable media of the other types of storing machine-executable instruction.
The application can be used in numerous general or special purpose computingasystem environment or configuration.For example: personal computer, server computer, handheld device or portable set, plate equipment, multicomputer system, system, set top box, programmable consumer-elcetronics devices, network PC, small-size computer, mainframe computer based on microprocessor, comprise the distributed computing environment of above any system or equipment etc.
The application can describe in the general context of the computer executable instructions of being carried out by computing machine, for example program module.Usually, program module comprises and carries out particular task or realize routine, program, object, assembly, data structure of particular abstract data type etc.Also can in distributed computing environment, put into practice the application, in these distributed computing environment, be executed the task by the teleprocessing equipment being connected by communication network.In distributed computing environment, program module can be arranged in the local and remote computer-readable storage medium including memory device.
The present invention also provides a kind of device of definite brain image Coronal direction.Figure 13 is the structural representation of determining the first embodiment of the device of brain image Coronal direction.As shown in figure 13, the present embodiment comprises:
Reconstruction unit U11, for according to the brain location scanning image obtaining, rebuilds described center sagittal view;
The cutting unit U12 being connected with described reconstruction unit U11, for being partitioned into brain stem region in described center sagittal view;
The definite direction unit U13 being connected with described cutting unit U12, for always determining brain stem back edge direction in described brain stem region.
Setting up direction unit U14, is described Coronal direction for the direction of getting described brain stem back edge direction or being parallel to described brain stem back edge direction.
Figure 14 is the structural representation of the second embodiment of the device of definite brain image Coronal direction of the present invention.As shown in figure 14, the present embodiment comprises:
Reconstruction unit U11, for according to the brain location scanning image obtaining, rebuilds described center sagittal view;
The edge enhancement unit U11 ' being connected with described reconstruction unit U11, before being partitioned into brain stem region in center sagittal view, carries out edge enhancing to described center sagittal plane.
Described cutting unit U12 comprises: the Seed Points determining unit U121 being connected with described edge enhancement unit U11 ', and for determine position and the gray-scale value of Seed Points in brain stem region corresponding to described center sagittal view.And the region growing unit U122 being connected with described Seed Points determining unit U121, for carry out brain stem region growing take described Seed Points as basic point, obtain described brain stem region.
Described Seed Points determining unit U121 also further comprises: the monumented point detecting unit (not shown) being connected with described edge enhancement unit U11 ', for detecting monumented point in described center sagittal view; Described monumented point is arranged near described center sagittal view corresponding brain stem region or brain stem region.And acquisition unit, the Seed Points position (not shown) being connected with described monumented point detecting unit, for being offset described monumented point, obtain the position of described Seed Points.And the Seed Points gray-scale value being connected with acquisition unit, described Seed Points position acquisition unit (not shown), for obtaining the gray-scale value of described Seed Points.
Described definite direction unit U13 comprises: the interception unit U131 being connected with described region growing unit U122, and for intercept the pixel data of the brain stem first half in described brain stem region.And the pivot analysis unit U132 being connected with described interception unit U131, for the pixel data of the described brain stem first half is carried out to pivot analysis, obtain described brain stem back edge direction.
What be connected with described pivot analysis unit U132 sets up direction unit U14, for the pixel data of the described brain stem region binary map first half is carried out to pivot analysis, obtains brain stem back edge direction.
It should be noted that, it will be appreciated by those skilled in the art that, above-mentioned part assembly can be such as programmable logic array (Programmable Array Logic, PAL), generic array logic (Generic Array Logic, GAL), field programmable gate array (Field-Programmable Gate Array, FPGA), CPLD (Complex Programmable Logic Device, one or more in programmable logic device (PLD) such as CPLD), but the present invention does not do concrete restriction to this.
The present invention first determines brain stem direction, then based on brain stem orientation determination coronal scan direction, can guarantee that this Coronal direction is parallel with brain stem back edge direction, can meet better the needs of brain imaging scanning.
The present invention has also utilized the same tissue feature that gray-scale value comparatively approaches in image, in brain stem region in brain imaging figure, determine Seed Points, to Seed Points, around the pixel in threshold range is carried out region growing with the gray scale difference value of Seed Points, and the brain stem region being partitioned into is more objective and accurate.
The present invention also, by intercepting the right along pixel data of brain stem the first half, carries out pivot analysis, determines brain stem back edge direction, has got rid of brain stem lower knuckle part to determining the impact of Coronal direction, more objective and accurate compared with prior art.
The present invention is also by first finding comparatively significantly monumented point of visual signature in brain stem region, monumented point is adjusted toward brain stem internal direction, guarantee that Seed Points is positioned at brain stem region, and determine the gray-scale value of Seed Points by the gray scale meta numerical value of multiple pixels, the Seed Points obtaining is more accurate and reasonable.
The present invention is before determining Seed Points, Xian Dui center sagittal view is carried out edge increase, make the gray value differences of brain stem region and near tissue apart from more obvious, cut off brain stem region with near organize possible being connected, preventing growth overflows, reduced the error of region growing, determined brain stem back edge direction is more accurate.
Although the present invention with preferred embodiment openly as above; but it is not for limiting the present invention; any those skilled in the art without departing from the spirit and scope of the present invention; can utilize method and the technology contents of above-mentioned announcement to make possible variation and modification to technical solution of the present invention; therefore; every content that does not depart from technical solution of the present invention; any simple modification, equivalent variations and the modification above embodiment done according to technical spirit of the present invention, all belong to the protection domain of technical solution of the present invention.
Claims (19)
1. a method for definite brain image Coronal direction, is characterized in that, comprises the following steps:
According to brain image reconstructed center sagittal view;
In the sagittal view of described center, be partitioned into brain stem region;
In described brain stem region, determine brain stem back edge direction;
The direction of getting described brain stem back edge direction or being parallel to described brain stem back edge direction is described Coronal direction.
2. the method for definite brain image Coronal direction according to claim 1, is characterized in that, the described brain stem region that is partitioned in the sagittal view of center comprises:
In the sagittal view of described center, in the brain stem region of correspondence, determine Seed Points;
Carry out brain stem region growing take described Seed Points as basic point, obtain described brain stem region.
3. the method for definite brain image Coronal direction according to claim 2, is characterized in that, described definite Seed Points comprises:
In the sagittal view of described center, detect monumented point; Described monumented point is arranged near described center sagittal view corresponding brain stem region or brain stem region;
Be offset described monumented point, obtain the position of described Seed Points;
Obtain the gray-scale value of described Seed Points.
4. the method for definite brain image Coronal direction according to claim 3, is characterized in that, described monumented point is the tie point of midbrain and pons.
5. the method for definite brain image Coronal direction according to claim 3, is characterized in that, described detection monumented point comprises: mated and determined described monumented point by region template.
6. the method for definite brain image Coronal direction according to claim 3, is characterized in that, the described monumented point of described skew comprises: by described monumented point, toward N location of pixels of brain stem internal direction skew, the span of described N is 1～12.
7. the method for definite brain image Coronal direction according to claim 3, is characterized in that, the gray-scale value of the described Seed Points of described acquisition comprises:
In described brain stem region, choose K candidate point; Described candidate point from the close-by examples to those far off distributes with described monumented point in brain stem internal direction;
Obtain the gray-scale value of each candidate point, and sort by gray-scale value size increasing or decreasing;
If K is odd number, choose gray-scale value sequence and be the gray-scale value of candidate point of (K+1)/2 as the gray-scale value of described Seed Points;
If K is even number, choose gray-scale value sequence and be the gray-scale value of candidate point of K/2 or (K/2)+1 as the gray-scale value of described Seed Points.
8. the method for definite brain image Coronal direction according to claim 2, is characterized in that, described brain stem region growing comprises: the pixel that described Seed Points is met to growth conditions around merges to the same area; Described growth conditions is: the difference of the gray-scale value of described pixel and the gray-scale value of described Seed Points is within the scope of first threshold.
9. the method for definite brain image Coronal direction according to claim 8, is characterized in that, described first threshold span is 70 ~ 85.
10. the method for definite brain image Coronal direction according to claim 1, is characterized in that, described in the sagittal view of center, be partitioned into brain stem region before, also comprise: described center sagittal plane is carried out to edge enhancing.
The method of 11. definite brain image Coronal directions according to claim 10, is characterized in that, adopts edge detection operator to carry out the enhancing of described edge.
The method of 12. definite brain image Coronal directions according to claim 11, it is characterized in that, described edge detection operator comprises: Robert operator, Sobel operator, Prewitt operator, Kirsch operator, Laplacian operator, Gaussian-Laplacian operator and/or Canny operator.
The method of 13. definite brain image Coronal directions according to claim 1, is characterized in that, described in brain stem region determine brain stem back edge direction comprise:
Intercept the pixel data of the brain stem first half in described brain stem region;
Carry out pivot analysis, obtain described brain stem back edge direction.
The method of 14. definite brain image Coronal directions according to claim 13, is characterized in that, the pixel data of the described brain stem first half is: n pixel data of the most close human body rear side of every a line the m that starts from top, described brain stem region is capable; Described m is the positive integer between 20 ~ 30, and described n is the positive integer between 4 ~ 8.
The device of 15. 1 kinds of definite brain image Coronal directions, is characterized in that, comprising:
Reconstruction unit, according to brain image reconstructed center sagittal view;
Cutting unit is partitioned into brain stem region in the sagittal view of described center;
Determine direction unit, in described brain stem region, determine brain stem back edge direction;
Set up direction unit, the direction of getting described brain stem back edge direction or being parallel to described brain stem back edge direction is described Coronal direction.
The device of 16. definite brain image Coronal directions according to claim 15, is characterized in that, described cutting unit comprises:
Seed Points determining unit is determined position and the gray-scale value of Seed Points in the sagittal view of described center in corresponding brain stem region;
Region growing unit, carries out brain stem region growing take described Seed Points as basic point, obtain described brain stem region.
The device of 17. definite brain image Coronal directions according to claim 16, is characterized in that, described Seed Points determining unit comprises:
Monumented point detecting unit detects monumented point in the sagittal view of described center; Described monumented point is arranged near described center sagittal view corresponding brain stem region or brain stem region;
Acquisition unit, Seed Points position, is offset described monumented point, obtains the position of described Seed Points;
Seed Points gray-scale value obtains unit, obtains the gray-scale value of described Seed Points.
The device of 18. definite brain image Coronal directions according to claim 15, is characterized in that, described device also comprises:
Edge enhancement unit, before being partitioned into brain stem region, carries out edge enhancing to described center sagittal plane in the sagittal view of center.
The device of 19. definite brain image Coronal directions according to claim 15, is characterized in that, described definite direction unit comprises:
Interception unit, at the pixel data of the described brain stem region intercepting brain stem first half;
Pivot analysis unit, carries out pivot analysis to the pixel data of the described brain stem first half, obtains described brain stem back edge direction.
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