CN103787015B - A kind of culture packing instrument worm drive close heap orifice plate fast access device - Google Patents

Abstract

The utility model relates to a fast access device for a close-packed orifice plate driven by a screw drive of a culture medium dispensing instrument, which belongs to the technical field of culture medium dispensing equipment. The device includes a base, a driver, an orifice box, a driving shaft, a driven shaft, a first transmission mechanism, a second transmission mechanism, a third transmission mechanism, a fourth transmission mechanism, a driving screw and a driven screw. The device of the invention adopts a driver, a transmission mechanism, a gear mechanism, a double-screw mechanism and the like to comprehensively realize the storage and access functions of the orifice plate. The device uses a driver to drive the driving screw and the driven screw to cooperate through the first gear, the second gear, the driving wheel, the driven wheel and the transmission member to realize the access of the bottom orifice plate; the orifice plate box is used to realize the storage of the orifice plate. The device is used in the culture medium dispensing instrument, has good compatibility, and can operate orifice plates of different specifications; the mechanical structure is simple, and the requirements for processing accuracy and installation accuracy are low; only one driver is needed, and the control system is simple; the orifice plate is placed in the hole Packed tightly in the box, the space utilization rate is high.

Description

A fast access device for densely packed orifice plate with screw drive for medium packing instrument

technical field

The invention relates to a fast access device for close-packed orifice plates of a medium packing instrument, belonging to the technical field of medium packing equipment.

Background technique

The culture medium dispenser is a necessary device in drug screening and microbial culture, which can efficiently dispense a large number of samples with similar properties and the same operation into well plates. Orifice plates mainly include micro-well plates and deep-well plates, which are commonly used medical, biological and chemical experimental equipment, including 24-well plates, 48-well plates, 96-well plates and 384-well plates. When the reagents are less or more expensive, the orifice plate becomes an ideal laboratory consumable because the volume of each well is on the order of ml. Compared with the manual dispensing method, the use of the medium dispensing instrument reduces the labor intensity of the operator, and improves the dispensing efficiency and accuracy.

The medium dispensing instrument mainly includes: two access devices, one is used to store unpacked orifice plate stacks and take out the bottom orifice plate; the other is used to store the dispensed orifice plate stacks and Orifice plates temporarily placed on the handling unit are stored in the well plate stack; peristaltic pumps and conduits are used to transfer reagents; handling units are used to move the manipulated orifice plates between the storage unit and the dispensing station .

The access device of the medium dispensing device is the focus of the design of the medium dispensing device, and the improvement of efficiency, stability and space utilization is the difficulty in the design of the access device. In recent years, a lot of progress has been made in the research on the access device of the medium dispenser. As an important part of the access device, the well plate cassette is mainly used to store well plate stacks. According to the stacking form of the orifice plate in the orifice box, the access device is divided into a densely packed orifice plate type and a sparsely arranged orifice plate type.

The traditional orifice plate access device only needs one driver, but its structure is complicated, and it requires high processing accuracy and installation accuracy. For example, the patent US6099230 proposes a sorting orifice access device, which mainly includes a motor and two transmission mechanisms. The transmission mechanism has the same height as the orifice box, which results in a bulky and complex structure of the whole device. The top and bottom of the orifice box are respectively equipped with a driving wheel and a driven wheel, which are connected by transmission parts; the transmission parts are equipped with equidistant teeth, which are used to support the orifice plates and separate them from each other. The space between the orifice plates reduces the space efficiency of the device. By controlling the steering of the motor, the two transmission parts can coordinately realize the storage and withdrawal of the orifice plate. When the motor is turned on, the orifice plate is driven downward by the two transmission parts. When the teeth fixed on the transmission parts go around the wheel, the orifice plate is released, realizing the transfer from the orifice box to the handling device; when the motor reverses , the two transmission parts move the orifice plate from the handling device to the orifice plate box.

The traditional close-packed orifice plate access device requires at least two drivers, and the mechanical structure is simple, but the control difficulty increases. Many mature products use close-packed orifice plate quick access devices. When the bottom plate is removed from the cassette, one drive is used to grab the upper plate stack and the other is used to move the bottom plate. Because the orifice plates are closely arranged and there is no redundant space, the space utilization rate is high. However, compared with the traditional sparse orifice plate type, the number of drivers used in the densely packed orifice plate type increases the complexity of the control system.

Contents of the invention

The purpose of the present invention is to provide a fast access device for densely-packed orifice plates in a medium packing instrument, which is designed to store densely-packed orifice plates and realize the bottom hole Efficient access to boards. The device can stably separate and take out the bottom orifice plate from the orifice plate stack, and then move the upper orifice plate stack down by one orifice plate height, and also move the upper orifice plate stack up by one orifice plate height, and then the bottom layer Well plates are deposited into well plate stacks. The device is used in the culture medium dispensing instrument, has good compatibility, and can operate orifice plates of different specifications; the mechanical structure is simple, and the requirements for machining accuracy and installation accuracy are low; only one driver is needed, and the control system is simple; the orifice plate is placed in the hole Packed tightly in the box, the space utilization rate is high.

Technical scheme of the present invention is as follows:

The present invention provides a fast access device for densely packed orifice plates with screw drive for a culture medium dispensing instrument, comprising a base, a driver and an orifice box; the driver is fixedly installed in the base, and the orifice box is set on the base On the seat, at least one orifice plate is accommodated in the orifice plate box, and it is characterized in that: the device also includes an orifice plate screw lifting mechanism, and the lifting mechanism includes a driving shaft, a driven shaft, a first transmission mechanism, a second transmission mechanism, a second transmission mechanism, Three transmission mechanisms, a fourth transmission mechanism, a driving screw and a driven screw; the driving shaft and the driven shaft are respectively movably sleeved in the base; the driving screw is connected to the output shaft of the driver through the first transmission mechanism; The driving shaft is connected with the output shaft of the driver through the second transmission mechanism; the driven shaft is connected with the driving shaft through the third transmission mechanism; the driven screw is connected with the driven shaft through the fourth transmission mechanism; the orifice plate The center line of the box, the axis of the driving screw and the axis of the driven screw are parallel to each other, the direction is vertical and coplanar; the orifice plate is placed between the driving screw and the driven screw, and the flange of the orifice is slidingly embedded in the adjacent part of the driving screw. Between the two adjacent teeth of the driven screw and the adjacent teeth of the driven screw, and the bottom plane of the orifice plate remains horizontal; assuming that the height of the orifice plate is h, the axial lengths of the threaded parts of the driving screw and the driven screw are both H, and satisfy H≥h; assuming that the flange height of the orifice plate is h ₁ , the pitches of the driving screw and the driven screw are both P, and P>h ₁ is satisfied.

A fast access device for a medium-packing instrument with a spiral drive close-packed orifice plate according to the present invention is characterized in that: the third transmission mechanism includes a driving wheel, a driven wheel and a transmission member; the driving wheel, the driven wheel, and the The driving wheel is respectively fixedly sleeved on the driving shaft and the driven shaft, and the transmission part is connected to the driving wheel and the driven wheel, and the driving wheel, the driven wheel and the transmission part cooperate to form a transmission relationship; the transmission part adopts a transmission belt, a chain or a rope The driving wheel adopts a pulley, a sprocket or a rope pulley accordingly, and the driven pulley adopts a pulley, a sprocket or a rope pulley accordingly, and the driving pulley, a driven pulley and a transmission part cooperate to form a belt, a chain or a Rope transmission relationship; the first transmission mechanism and the fourth transmission mechanism adopt direct transmission, or adopt belt, chain and rope transmission.

The present invention relates to a fast access device for a medium packer with spiral drive close-packed orifice plate, which is characterized in that: when the helical directions of the driving screw and the driven screw are opposite, the rotation directions of the two screws are opposite; The second transmission mechanism includes a first gear and a second gear; the first gear is fixedly sleeved on the output shaft of the driver, the second gear is fixedly sleeved on the drive shaft, and the first gear and the second gear are fixedly sleeved on the drive shaft. The gears are meshed; when the helical directions of the driving screw and the driven screw are the same, the rotation directions of the two screws are the same; the second transmission mechanism cooperates to form a belt, chain or rope transmission relationship.

The present invention relates to a fast access device for a medium packer with screw drive densely packed orifice plates, which is characterized in that: the driver adopts a motor, an air cylinder or a hydraulic cylinder.

The medium dispensing instrument adopting the screw-driven close-packed orifice fast access device provided by the present invention is characterized in that: it includes a vehicle frame, a medium dispensing instrument, a spiral-driven close-packed orifice quick access device, a handling device, and a conduit rack, peristaltic pump, and conduit; the screw-driven close-packed orifice plate quick access device, handling device, jacket frame, and peristaltic pump of the culture medium dispensing instrument are respectively fixed and installed on the frame; one end of the conduit is movably sleeved on On the jacket, the other end of the catheter is placed in the culture medium, and the middle part of the catheter is movably sleeved in the peristaltic pump; the handling device includes a motor, a transmission mechanism and a trolley.

Compared with the prior art, the present invention has the following advantages and outstanding effects:

The device of the invention adopts a driver, a transmission mechanism, a gear mechanism, a double-screw mechanism and the like to comprehensively realize the storage and access functions of the orifice plate. The device uses a driver to drive the driving screw and the driven screw to cooperate through the first gear, the second gear, the driving wheel, the driven wheel and the transmission member to realize the access of the bottom orifice plate; the orifice plate box is used to realize the storage of the orifice plate. The device is used in the culture medium dispensing instrument, has good compatibility, and can operate orifice plates of different specifications; the mechanical structure is simple, and the requirements for machining accuracy and installation accuracy are low; only one driver is needed, and the control system is simple; the orifice plate is placed in the hole Packed tightly in the box, the space utilization rate is high.

Description of drawings

Fig. 1 is a front view of an embodiment of the screw drive close-packed orifice plate fast access device provided by the present invention (in order to show the screw and the deep orifice plate, a part of the base and the orifice plate box are expressed by dotted lines ).

Figure 2 is a schematic diagram of the present invention.

Fig. 3 is a top view of the present invention (in order to show the screw, the orifice box part is not drawn).

Fig. 4 is a perspective view of the present invention.

Figure 5 is an exploded view of the present invention.

Figure 6(a), Figure 6(b) and Figure 6(c) are schematic diagrams of the working process of the present invention.

Fig. 7 is a perspective view of a culture medium dispensing apparatus using a screw drive close-packed orifice plate quick access device provided by the present invention (the conduit is not shown).

Fig. 8 is a top view of the medium filling device.

Fig. 9 is a schematic diagram of the structure of the medium filling device.

Figure 10(a), Figure 10(b), Figure 10(c), Figure 10(d), Figure 10(e) and Figure 10(f) are schematic diagrams of the working process of the medium filling device.

In the figure: 1-base, 2-driver, 3-well plate box,

4-driving shaft, 5-driven shaft, 6-first transmission mechanism,

7-second transmission mechanism, 8-third transmission mechanism, 9-fourth transmission mechanism,

10-driving screw, 11-driven screw, 12-orifice plate,

13-frame, 14-jacket, 15-peristaltic pump,

16-car, 71-first gear, 72-second gear,

81-driving wheel, 82-driven wheel, 83-transmission member.

detailed description

The specific structure, working principle and working process of the present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

A kind of embodiment of the fast access device of a kind of culture medium dispensing instrument designed by the present invention is screw-driven close-packed orifice plate, as shown in Fig. 1, Fig. 2, Fig. 3, Fig. 4 and Fig. 5, including base 1, Driver 2 and orifice box 3; the driver 2 is fixedly installed in the base 1, the orifice box 3 is arranged on the base 1, at least one orifice 12 is accommodated in the orifice box, and the device also includes a hole Plate screw lifting mechanism, the lifting mechanism includes a driving shaft 4, a driven shaft 5, a first transmission mechanism 6, a second transmission mechanism 7, a third transmission mechanism 8, a fourth transmission mechanism 9, a driving screw 10 and a driven screw 11 The driving shaft 4 and the driven shaft 5 are respectively movably sleeved in the base 1; the driving screw 10 is connected to the output shaft of the driver 2 through the first transmission mechanism 6; the driving shaft 4 is connected through the second transmission mechanism 7 It is connected with the output shaft of the driver 2; the driven shaft 5 is connected with the driving shaft 4 through the third transmission mechanism 8; the driven screw 11 is connected with the driven shaft 5 through the fourth transmission mechanism 9; the orifice box 3 The center line, the axis of the driving screw 10 and the axis of the driven screw 11 are parallel to each other, the direction is vertical and coplanar; the orifice 12 is placed between the driving screw 10 and the driven screw 11, and the flange of the orifice 12 is slidingly embedded Between the adjacent two teeth of the driving screw 10 and the adjacent two teeth of the driven screw 11, and the bottom plane of the orifice plate 10 remains horizontal; if the height of the orifice 12 is h, the driving screw 10 and the driven screw 11 thread The axial length of the part is H, and satisfies H≥h (in Fig. 2); suppose the flange height of the orifice plate 12 is h ₁ , the pitches of the driving screw 10 and the driven screw 11 are both P, and P>h ₁ is satisfied.

According to the present invention, a screw-driven close-packed orifice plate quick access device for a culture medium packaging instrument, the third transmission mechanism 8 includes a driving wheel 81, a driven wheel 82 and a transmission member 83; the driving wheel 81, The driven wheel 82 is fixedly sleeved on the driving shaft 4 and the driven shaft 5 respectively, and the transmission member 83 is connected to the driving wheel 81 and the driven wheel 82, and the driving wheel 81, the driven wheel 82 and the transmission member 83 cooperate to form a transmission relationship; The transmission part adopts a transmission belt, a chain or a rope, the driving wheel adopts a pulley, a sprocket or a rope pulley, and the driven wheel adopts a pulley, a sprocket or a rope pulley accordingly. Wheels, driven wheels and transmission parts cooperate to form a belt, chain or rope transmission relationship; the first transmission mechanism and the fourth transmission mechanism adopt direct transmission or belt, chain and rope transmission.

In this embodiment, in the third transmission mechanism 8, the transmission member 83 adopts a transmission belt, the driving pulley 81 adopts a pulley correspondingly, and the driven pulley 82 adopts a pulley correspondingly, and the driving pulley 81, slave The driving wheel 82 cooperates with the transmission member 83 to form a belt transmission relationship; the first transmission mechanism 6 and the fourth transmission mechanism 9 adopt direct transmission.

In this embodiment, the helical directions of the driving screw 10 and the driven screw 11 are opposite, and the rotation directions of the two screws are opposite; the second transmission mechanism 7 includes a first gear 71 and a second gear 72; The first gear 71 is fixedly sleeved on the output shaft of the driver 2 , the second gear 72 is fixedly sleeved on the drive shaft 4 , and the first gear 71 is meshed with the second gear 72 .

The screw-driven close-packed orifice plate rapid access device of the present invention uses a motor, an air cylinder or a hydraulic cylinder as the driver. In this embodiment, the driver 2 is a motor.

The culture medium dispensing instrument that adopts the screw drive close-packed orifice plate quick access device provided by the present invention, as shown in Figure 7 and Figure 8, includes a vehicle frame 13, a culture medium dispensing instrument spiral drive close-packed orifice plate quick access device, handling device, jacket 14, peristaltic pump 15 and conduit; the fast access device, handling device, jacket 14 and peristaltic pump 15 of the medium packing instrument screw drive close-packed orifice plate are fixedly installed on the vehicle frame 13 respectively One end of the conduit is movably sleeved on the jacket 14, the other end of the conduit is placed in the culture medium, and the middle part of the conduit is movably sleeved in the peristaltic pump 15; the handling device includes a motor, a transmission Bodies and trolleys16.

The working principle of device of the present invention, in conjunction with accompanying drawing, is described as follows:

The device of the present invention can be used for taking out and depositing the orifice plate 12 . Stack the unpacked orifice plates 12 into the orifice plate box 3, as shown in Figure 6(a), the bottom surface of the bottom orifice plate 12 (marked by the shaded part) is in contact with the driving screw 10 and the driven screw 11 . Start the motor, the motor drives the first gear 71 and the driving screw 10 to rotate (in Fig. 1); at the same time, the second gear 72 meshed with the first gear 71 rotates in the opposite direction, and then drives the coaxial driving wheel 81 to rotate; Under the action of the transmission member 83 , the driven wheel 82 rotates in the same direction as that of the driving wheel 81 , thereby driving the driven screw 11 to rotate in a direction opposite to that of the driving screw 10 . The driving screw 10 and the driven screw 11 have the same size and opposite directions of rotation, and the pitch P of the two screws is greater than the height h ₁ of the flange of the orifice plate, P>h ₁ , that is, the flange of the orifice plate can be placed in two adjacent screws. Therefore, with the rotation of the screws, the two screws synergistically drive the bottom orifice plate 12 to descend along the helical line, as shown in Figure 6(b). When the bottom orifice plate 12 moves to the end of the helix and is about to be released, the driving screw 10 and the driven screw 11 support the flange of the B orifice plate 12, and then support the upper orifice plate stack. After the bottom orifice plate 12 leaves the driving screw 10 and the driven screw 11, it falls onto the trolley 16 placed under the orifice box 3, as shown in Figure 6(c), so that the device realizes the removal of the orifice plate 12. When the motor reverses, contrary to the process of taking out the orifice plate, the motor driving screw 10 and driven screw 11 cooperate to store the finished orifice plate 12 from the trolley 16 into the orifice plate box 3, thereby realizing the orifice plate 12 deposit.

In order to ensure the stability of the orifice plate 12 taken out, that is, to reduce vibration and impact, and when the bottom orifice plate 12 is about to leave the two screws, the upper orifice plate stack can be stably supported, the shaft of the threaded part of the driving screw 10 and the driven screw 11 The vertical length H and the height h of the orifice plate 11 need to satisfy H≥h. If H<h, when the bottom orifice plate 11 is released, the upper orifice plate stack needs to freely fall to the top of the driving screw 10 and the driven screw 11, causing vibration, reducing the life of the screw and orifice plate and the stability of the system.

The device of the present invention can be used in but not limited to the technical field of medium packaging equipment. By rationally designing the size parameters of the driving screw 10 and the driven screw 11 , the device of the present invention can operate other objects whose shape is similar to the orifice plate 12 . As long as the target object has a flange, the twin-screw will drive it up and down, and then the access of the target object will be realized.

The culture medium dispensing apparatus adopting the quick access device of the screw drive close-packed orifice plate includes two quick access devices of the screw drive close-packed orifice plate: input and output (referred to as the input device and the output device), which are respectively used for the storage of the orifice plate. in and out (in Figure 9). The working process is as follows: put the unpacked orifice plate 12 into the orifice box 3 of the input device, as shown in Figure 10(a); start the motor of the handling device, and move the trolley 16 to the bottom of the output device, as shown in Figure 10(a) 10(b); drive the driver 2 of the output device, and the bottom orifice plate 12 (indicated by the shaded part) is taken out to the trolley 16 (in Fig. 10(c)); the trolley 16 drives the orifice plate 12 to move to the sub-assembly station , the peristaltic pump 15 works, and the culture solution or reagent is dispensed into the orifice plate 12 (in Figure 10(d)); after the dispensing is completed, the orifice plate 12 is moved below the input device (in Figure 10(e) ); start the driver 2 of the input device, and the orifice plate 12 that has been subpackaged is stored in the orifice box 3, as shown in Figure 10 (f); when the orifice box 3 is filled with the orifice plate 12 that has been subpackaged , the experimenter can conveniently lift the orifice box 3 away.

The device of the invention adopts a driver, a transmission mechanism, a gear mechanism, a double-screw mechanism and the like to comprehensively realize the storage and access functions of the orifice plate. The device can stably separate and take out the bottom orifice plate from the orifice plate stack, and then move the upper orifice plate stack down by one orifice plate height, and also move the upper orifice plate stack up by one orifice plate height, and then the bottom layer Well plates are deposited into well plate stacks. The device uses a driver to drive the driving screw and the driven screw to cooperate with each other through the first gear, the second gear, the driving wheel, the driven wheel, and the transmission member to realize the access of the bottom orifice plate; the orifice plate box is used to realize the storage of the orifice plate. The device is used in the culture medium dispensing instrument, has good compatibility, and can operate orifice plates of different specifications; the mechanical structure is simple, and the requirements for processing accuracy and installation accuracy are low; only one driver is needed, and the control system is simple; the orifice plate is placed in the hole Packed tightly in the box, the space utilization rate is high.

Claims (3)

1. A fast access device for medium-packing instrument screw drive close-packed orifice plate, comprising a base (1), a driver (2) and an orifice box (3); the driver is fixedly installed in the base, and the The orifice box is arranged on the base, and at least one orifice plate (12) is accommodated in the orifice box, and it is characterized in that: the device also includes an orifice plate screw lifting mechanism, and the lifting mechanism includes a driving shaft (4), a driven Shaft (5), first transmission mechanism (6), second transmission mechanism (7), third transmission mechanism (8), fourth transmission mechanism (9), driving screw (10) and driven screw (11); The driving shaft and the driven shaft are movably sleeved in the base respectively; the driving screw is connected with the output shaft of the driver through the first transmission mechanism; the driving shaft is connected with the output shaft of the driver through the second transmission mechanism; The driven shaft is connected with the driving shaft through the third transmission mechanism; the driven screw is connected with the driven shaft through the fourth transmission mechanism; the centerline of the orifice box, the axis of the driving screw and the axis of the driven screw are parallel to each other, The direction is vertical and coplanar; the orifice plate is placed between the driving screw and the driven screw, and the flange of the orifice is slidingly embedded between the two adjacent teeth of the driving screw and the two adjacent teeth of the driven screw, and Keep the bottom plane of the orifice plate horizontal; set the height of the orifice plate to be h, the axial lengths of the threaded parts of the driving screw and the driven screw are both H, and satisfy H≥h; set the flange height of the orifice plate to be h ₁ , The pitches of the driving screw and the driven screw are both P, and satisfy P>h ₁ ; The third transmission mechanism (8) includes a driving wheel (81), a driven wheel (82) and a transmission member (83); the driving wheel and the driven wheel are respectively fixedly sleeved on the driving shaft and the driven shaft, so The transmission part connects the driving wheel and the driven wheel, and the driving wheel, the driven wheel and the transmission part cooperate to form a transmission relationship; the transmission part adopts a transmission belt, a chain or a rope, and the driving wheel adopts a pulley, a sprocket or a rope accordingly The driven wheel adopts a pulley, a sprocket or a rope wheel accordingly, and the driving wheel, the driven wheel and the transmission member cooperate to form a belt, chain or rope transmission relationship; the first transmission mechanism and the fourth transmission mechanism The mechanism adopts direct transmission, or belt, chain and rope transmission. 2. A fast access device for a medium-packing instrument with spiral drive close-packed orifice plate as claimed in claim 1, characterized in that: when the winding direction of the driving screw and the driven screw helix are the same, the two screws The rotation direction is the same, and the second transmission mechanism cooperates to form a belt, chain or rope transmission relationship; when the winding directions of the driving screw and the driven screw helix are opposite, the rotation directions of the two screws are opposite, and the second transmission mechanism ( 7) It includes a first gear (71) and a second gear (72), the first gear is fixedly sleeved on the output shaft of the driver, the second gear is fixedly sleeved on the drive shaft, and the first gear and The second gear meshes. 3. A fast access device for a medium packing apparatus with screw drive close-packed orifice plate according to claim 1, characterized in that: the driver adopts a motor, an air cylinder or a hydraulic cylinder.