CN103784975A - Function of IRF (Interferon Regulatory Factor) 7 in atherosclerosis and application of inhibitor of IRF7 - Google Patents
Function of IRF (Interferon Regulatory Factor) 7 in atherosclerosis and application of inhibitor of IRF7 Download PDFInfo
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- CN103784975A CN103784975A CN201410031612.7A CN201410031612A CN103784975A CN 103784975 A CN103784975 A CN 103784975A CN 201410031612 A CN201410031612 A CN 201410031612A CN 103784975 A CN103784975 A CN 103784975A
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- irf7
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Abstract
Description
Claims (7)
- Application in the medicine that 1.IRF7 forms at screening inhibition Aortic Plaque as drug targets.
- 2.IRF7 is the application in the medicine of screening treatment atheromatosis as drug targets.
- Application in the medicine that the inhibitor of 3.IRF7 forms at preparation inhibition Aortic Plaque.
- 4. suppress the medicine that Aortic Plaque forms, it is characterized in that: the inhibitor that comprises IRF7.
- The application of the inhibitor of 5.IRF7 in the medicine of preparation treatment atheromatosis.
- 6. a medicine for the treatment of atheromatosis, is characterized in that: the inhibitor that comprises IRF7.
- 7. according to the medicine described in the application described in claim 3 or 5 or claim 4 and 6, the inhibitor that it is characterized in that described IRF7 is the one in siRNA, the rna interference vector of IRF7 gene or the antibody of IRF7 of IRF7 gene.
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CN201410031612.7A CN103784975B (en) | 2014-01-23 | 2014-01-23 | Function of IRF (Interferon Regulatory Factor) 7 in atherosclerosis and application of inhibitor of IRF7 |
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CN201410031612.7A CN103784975B (en) | 2014-01-23 | 2014-01-23 | Function of IRF (Interferon Regulatory Factor) 7 in atherosclerosis and application of inhibitor of IRF7 |
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CN103784975A true CN103784975A (en) | 2014-05-14 |
CN103784975B CN103784975B (en) | 2015-07-15 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104258419A (en) * | 2014-09-29 | 2015-01-07 | 武汉大学 | Applications of interferon regulatory factor 1 gene in treatment of atherosclerosis |
CN114557318A (en) * | 2022-03-28 | 2022-05-31 | 中山大学 | Non-alcoholic steatohepatitis mouse model construction method based on PEDF/LDLR double gene knockout and application |
-
2014
- 2014-01-23 CN CN201410031612.7A patent/CN103784975B/en active Active
Non-Patent Citations (3)
Title |
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QIMINGLIANG ET AL.: "negative regulation of irf7 activation by activating transcription factor 4 suggests a cross-regulation between the ifn responses and the cellular integrated stress responses", 《THE JOURNAL OF IMMUNOLOGY》, 8 December 2010 (2010-12-08) * |
吴丹等: "炎症体研究进展", 《中国细胞生物学学报》, vol. 35, no. 10, 31 December 2013 (2013-12-31) * |
陈煌峰等: "toll样受体4与冠状动脉粥样硬化关系的研究进展", 《J CLIN CARDIOL》, vol. 24, no. 5, 31 May 2008 (2008-05-31) * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104258419A (en) * | 2014-09-29 | 2015-01-07 | 武汉大学 | Applications of interferon regulatory factor 1 gene in treatment of atherosclerosis |
CN114557318A (en) * | 2022-03-28 | 2022-05-31 | 中山大学 | Non-alcoholic steatohepatitis mouse model construction method based on PEDF/LDLR double gene knockout and application |
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CN103784975B (en) | 2015-07-15 |
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Effective date of registration: 20191122 Address after: 430040 No.1, floor 1, No.17, eleven village, Changqing Garden, Dongxihu District, Wuhan City, Hubei Province (18) Patentee after: Wuhan Dafeng Biotechnology Co., Ltd Address before: 430072 Hubei Province, Wuhan city Wuchang District of Wuhan University Luojiashan Patentee before: WuHan University |
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Effective date of registration: 20191218 Address after: 430014 3119, floor 3, building 9, Guanggu science and technology port, 18 huashiyuan North Road, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee after: Wuhan linyijia Gene Technology Co., Ltd Address before: 430040 No.1, floor 1, No.17, eleven village, Changqing Garden, Dongxihu District, Wuhan City, Hubei Province (18) Patentee before: Wuhan Dafeng Biotechnology Co., Ltd |
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Address after: 430076 room 002, 16 / F, building D2, phase III, software new town, No. 8, Huacheng Avenue, Wuhan East Lake New Technology Development Zone, Wuhan, Hubei Province Patentee after: Wuhan Huikang Gene Technology Co.,Ltd. Address before: Room 3119, 3 / F, building 9, Guanggu science and technology harbor, 18 huashiyuan North Road, Donghu New Technology Development Zone, Wuhan City, Hubei Province, 430014 Patentee before: Wuhan linyijia Gene Technology Co.,Ltd. |
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