CN103782159B - Method and device for coupling a light beam into a foil - Google Patents
Method and device for coupling a light beam into a foil Download PDFInfo
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- CN103782159B CN103782159B CN201280043175.XA CN201280043175A CN103782159B CN 103782159 B CN103782159 B CN 103782159B CN 201280043175 A CN201280043175 A CN 201280043175A CN 103782159 B CN103782159 B CN 103782159B
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- light beam
- transparent components
- optical device
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- 238000000034 method Methods 0.000 title claims abstract description 21
- 230000008878 coupling Effects 0.000 title claims description 13
- 238000010168 coupling process Methods 0.000 title claims description 13
- 238000005859 coupling reaction Methods 0.000 title claims description 13
- 239000011888 foil Substances 0.000 title abstract description 5
- 230000003287 optical effect Effects 0.000 claims abstract description 40
- 201000009310 astigmatism Diseases 0.000 claims description 19
- 239000000523 sample Substances 0.000 claims description 8
- 238000004458 analytical method Methods 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 2
- 238000004186 food analysis Methods 0.000 claims description 2
- 238000004374 forensic analysis Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 241000219739 Lens Species 0.000 description 10
- 210000000695 crystalline len Anatomy 0.000 description 10
- 238000001514 detection method Methods 0.000 description 8
- 238000013461 design Methods 0.000 description 6
- 239000002105 nanoparticle Substances 0.000 description 6
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- 238000001746 injection moulding Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 239000006249 magnetic particle Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000012491 analyte Substances 0.000 description 1
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- 230000007423 decrease Effects 0.000 description 1
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Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
- G02B6/0011—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being planar or of plate-like form
- G02B6/0013—Means for improving the coupling-in of light from the light source into the light guide
- G02B6/0023—Means for improving the coupling-in of light from the light source into the light guide provided by one optical element, or plurality thereof, placed between the light guide and the light source, or around the light source
- G02B6/003—Lens or lenticular sheet or layer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/02—Details
- G01J1/04—Optical or mechanical part supplementary adjustable parts
- G01J1/0407—Optical elements not provided otherwise, e.g. manifolds, windows, holograms, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
Abstract
The invention relates to a method and an optical device (150) in which a light beam (L) is coupled into a transparent component, for example into a foil (110). The incoupling is achieved by astigmatically focusing a light beam (L) onto an oblong entrance window (W) of the foil (110), wherein a focal line (Fx) of the light beam (L) is oriented along the axis (x) of extension of the entrance window (W). Preferably, a second focal line (Fy) of the light beam (L) is disposed inside the transparent component (110) below a region of interest (112).
Description
Technical field
The present invention relates to being used for coupling the beam in transparent components, especially it is coupled in the planar module of such as paper tinsel,
Method and optical device.
Background technology
Wo2009/016533a2 discloses for being optically inspected in box (cartridge), especially for passing through
The detection to magnetic-particle for the frustrated total internal reflection (ftir), microelectronic sensor device.Box include for light and with respect to
The plane of box has the entrance and exit window of certain tilt degree.
Content of the invention
It is an object of the invention to provide allow light to planar transparent assembly effectively enter coupling (incoupling) and
The component that can cost-effectively realize.
This purpose is passed through according to the method for claim 1 and 2, optical device according to claim 3 and according to right
Require 13 purposes realizing.It has been disclosed in the dependent claims preferred embodiment.
The method of the present invention allows that light beam enters coupling to transparent components, and light beam can pass through described transparent components, institute
State assembly and there is rectangle or ellipse (oblong) entrance window, described entrance window has given outrigger shaft.Entrance window
True form quite any, however, it will be typically rectangle (or at least including rectangle region), have along described window
Length and the width less than described length that described outrigger shaft extends.Typical aspect ratio (i.e. length and the width of entrance window
Between ratio) scope between about 20:1 and 3:2.
The method includes the astigmatism to entrance window for the light beam and focuses on so that focal line (focal line) (typically two
The first focal line in focal line) along entrance window axle extend.
In this context, term " astigmatism focusing " means the focusing of (for example symmetrical) light beam so that even theoretical
On, it is not that all rays of light beam meet in identical focal point.But, there is at least one 1 dimension that the ray of light beam passes through
Line segment (hereinafter referred to as " focal line ").Generally, it is capable of identify that and incline towards each other (typically vertical) and be somebody's turn to do along two that optical axis interval is opened
Focal line.
Additionally, the extension along (first) focal line of the axle of entrance window should mean the axle of (first) focal line and entrance window
Between less than about 45 ° of angle, preferably less than 20 °.It is highly preferred that focal line and the axle of entrance window be substantially parallel (wherein,
Tolerance with regard to orientation depends on the true form of focal line, by the height entering to couple na and first and second focal length and entrance window
Limit.
After being coupled into light using the first focal line in planar wave assembly, using total internal reflection along optical axis in component internal
Guide this light.As a result, by component internal at the position of the second focal line, from entrance window macroscopic view with a distance from place, cause high intensity
Region, this distance is given by the difference between two focal lengths of optics of astigmatism device.These features are main and have away from assembly
The thin optical module (such as box) of the sections of sensors of edge several millimeters is related.
The invention still further relates to optical device, this optical device include two primary clusterings it may be assumed that
The transparent components with rectangle or elliptical inlet window can be arranged in this appearance by a) receiving space (or support)
Receive space (or support) place, or have rectangle or elliptical inlet window transparent components be arranged in this receiving space (or
Frame) place.In the first scenario (" can by ... be arranged in "), transparent components will be typically from and are not belonging to handing over of optical device
The element changing.In the latter case (" being arranged in "), transparent components can forever be laid at receiving space and can regard
Part for optical device.
B) focusing optics, for light beam astigmatism being focused to the entrance window of the transparent components at receiving space,
So that (preferably first) focal line is along the axle extension of entrance window.
Methods described and optical device are the related embodiment of the present invention.The explanation providing to one of these embodiments and limit
Fixed is also effective therefore for other embodiments.
Methods described and optical device have the advantage that they allow using rectangle or elliptical inlet window, all
Light beam to planar transparent assembly enter coupling, it is available typically even for the simple shape of transparent components.By making
Focused on the astigmatism of light beam, and make focal line along the axle extension of described window, most preferably make use of the rectangle of this entrance window or ellipse
Round-shaped.Which give the other focus characteristic with regard to light beam, especially with regard to the second focal line, freedom, such as following more detailed
Carefully explain.
Below, the various embodiments of the present invention related to said method and optical device will be described.
It has been noted that the light beam that astigmatism focuses on generally includes the second focal line.In a preferred embodiment of the invention, by optics
Design parameter is chosen so as to the second focal line and is arranged on inside transparent components.This is allowed in described transparent components and is internally generated convergence
The area of all light.
Generally, as long as providing rectangle or elliptical inlet window, then transparent components can have any 3D shape.This
Outward, the guided-wave conditions for total internal reflection are preferably met.In a preferred embodiment, transparent components be (transparent) plate of material or
Piece, thus have the form that can be most readily achieved.Particularly, transparent components can be paper tinsel, and preferably thickness is at about 50 μm
And the paper tinsel between 1000 μm.This paper tinsel for example can be utilized to be effectively realized wherein can provide sample to be used for optics investigation once
Property box.
The design of transparent components and focusing optics preferably makes at least one of light beam or light beam penetrate
At least total internal reflection is once inside transparent components for line.In this way, light beam or part thereof can be inside transparent components
Propagate without loss, and thus reach the target area away from entrance window.Preferably, light beam is for example in two apparent surfaces
Locate total internal reflection for several times, thus as propagated in the waveguide.
If the na belonging to the first focal line is less than maximum namaxIt is ensured that the total internal reflection within transparent components, thus
As waveguide, then for example it is capable of previous designs.This maximum is it can be assumed that be:
ncomponentFor the refractive index of transparent components, and nsurroundingFor the surrounding medium of transparent components, (for example, air exists
Lower and water upper, in this case, nsurrounding=nwater) largest refractive index.
According to another embodiment, transparent components include the surface with search coverage, and light beam is complete at this search coverage
Internal reflection (after entering transparent components).This allows the generation using the evanescent waves being caused by total internal reflection, for example, be used for leaning on
The illumination of the finite region near reflex surface.Thus, the target element of sample for example can be detected by frustrated total internal reflection.
Most preferably, above-mentioned second focal line of the light beam that astigmatism focuses on can be arranged at search coverage so that all light of light beam
Reach this region, wherein, the second focal line is preferably perpendicular to search coverage orientation.
Astigmatism in order to realize light beam focuses on, and focusing optics can include astigmat, such as cylindrical lenss.
Any source can be derived from, for example originating from ambient light in the light beam principle that astigmatism focuses on.Most preferably, however, optics
Equipment includes (technology) light source for controllably generating light beam.Light source can optionally be provided with for light beam
The laser instrument of some optics being collimated or light emitting diode (led).The na of the light beam focusing on should be sufficiently small, preferably
Ground is less than the na of previous definitionmax, to meet the condition for total internal reflection.
When intending to measure or during detection process, generally increase photo-detector, for detecting the light leaving transparent components.
This light can particularly be derived from coupled to the light beam in transparent components, i.e. it can (for example reflecting or scattering by this light beam
) photon or (such as fluorescence) photon inducted by this light beam constitute.Detector can include detecting the light of given spectrum
Any suitably single sensor or multiple sensor, such as photodiode, light resistance, light cell, ccd chip or photoelectricity
Multiplier tube.
According to the further development of previous embodiment, provide evaluation unit, for photo-detector signal process and
Evaluate.Evaluation unit can for example pass through dedicated electronic hardware, have the Digital data processing hardware of related software or the two
Combination realizing.
It is furthermore possible to also provide magnetic field generating (for example, permanent magnet or electromagnet), for transparent components internal and/or
Magnetic field is generated in the space adjacent with this transparent components.Using this magnetic field, for example, manipulate in the sample of transparent components
The target element magnetically marking is possible.
The invention still further relates to above-mentioned optical device divides for molecular diagnosis, biological sample analysises, chemical sample analysis, food
Analysis and/or the purposes of forensic analysis.Can be for example by means of the magnetic bead being directly or indirectly attached to target molecule or fluorescent grain
To complete molecular diagnosis.
Brief description
According to embodiment described below, these and other aspects of the invention will be apparent from, and with reference to these enforcements
Example is illustrated to these and other aspects of the invention.
In figure:
Fig. 1 is schematically illustrated with perspective view and utilizes globe lenss, in light beam to paper tinsel enter coupling；
Fig. 2 shows the top view of the equipment of Fig. 1；
Fig. 3 schematically illustrates wherein light beam astigmatism with perspective view and is coupled to the optical device in paper tinsel；
Fig. 4 shows the top view of the equipment of Fig. 3；
Fig. 5 illustrates the geometric parameter for calculating；
Fig. 6 shows the focal length of the function as numerical aperture and the diagram of beam diameter；
Fig. 7 is the perspective example of the light beam that astigmatism focuses on；
Fig. 8 includes the formula of the derivation for design parameter.
Similar reference number refers to same or similar assembly in figure.
Specific embodiment
Wo2009/016533a2(passes through to quote to be incorporated into the application) optical detection based on superparamagnetic nanoparticle
Describe immunoassay biological sensing technology.Here, the magnetic properties of nano-particle are used for: (i) accelerate analyte towards detection
The diffusion process on surface；And (ii) allow for magnetic wash step, wherein, from detection before carrying out optical detection
Section extracts unconjugated nano-particle.For detecting, it is possible to use frustrated total internal reflection.In addition it is possible to use to from combination
The details in a play not acted out on stage, but told through dialogues of the scattered light of the substrate of nano-particle detects, and also referred to as single pearl detects.
In the technology mentioned, using disposable plastic injection molding box, this box includes for example: blood filter；For blood
Slurry comprises buffer components and nano-particle towards the miniflow matter jet pipe of detecting chamber conveying, described detecting chamber；Optical window, for coupling
It is incorporated into the exciting light needed for total internal reflection and be coupled out the ftir bundle detecting for frustrated total internal reflection (ftir) or be used for details in a play not acted out on stage, but told through dialogues
The scattered light of the nano-particle of combination detecting.
If the box based on paper tinsel can be used, it is desired, because this allows roll-to-roll (roll-to- parallel in a large number
Roll) manufacture, and thereby eliminate the needs to relatively costly injection molding technology.Towards the optical box face based on paper tinsel
The problem faced be create evanescent field needed for light enter coupling.Known injection molding is box-packed to have entrance and exit window
Mouthful, need the assembly of complexity, non-flat forms.
Therefore, problem to be solved is: how to couple light into paper tinsel base internal,
(i) so that evanescent field is created at the position of detecting chamber,
(ii) there is at the speckle of good location fully high intensity, and
Need not such as grating or prism additional labyrinth.
Main target is the standard null white light paper tinsel using no additional grating, prism or waveguiding structure.When light beam is focused on
During to paper tinsel inside, focusing optics must observe two fundamental rules: (i) the optical speckle at foil edge should be than paper tinsel
Thickness h is little, and the numerical aperture of the light beam (ii) focusing on should sufficiently small so that entering the light of coupling at the bottom of paper tinsel and top surface
Experiences total internal reflection.
Fig. 1 and 2 illustrates aforementioned when utilizing the globe lenss 51 being used for focusing to light beam l in planar transparent paper tinsel 10 to realize
What happens during approach.Paper tinsel 10(or its sub-district) side constitute there is long outrigger shaft (x-axis) and width h(in y direction
On) rectangle or elliptical inlet window w.With a tight waist it is located at the edge of paper tinsel 10 and from this point f forward, Shu Zaici dissipates, and draws
Play the intensity decreases in the region 12 interested of setting at a certain distance in the edge away from paper tinsel 10.
In order to solve this it is meant that:
(i) by focusing on the edge of paper tinsel by all optically coupling to paper tinsel inside；And
(ii) create focus still at region interested,
Propose the optics of astigmatism device using such as cylindrical lenss.
Fig. 3 schematically shows the optical device 150 according to this idea.This optical device 150 includes two main groups
Part it may be assumed that
- transparent components, realize (in Fig. 1 and 2) by astrafoil 110 here.Generally, this paper tinsel will be commutative (disposable)
Assembly or box, using this assembly or box, using the teaching of the invention it is possible to provide sample to be studied and this assembly or box are lost after a single use
Abandon.Optical device 150 therefore typically only includes the support for this paper tinsel or box 110 or receiving space, and box itself constitute with
The separate independent component of optical device.
- focusing optics, to be realized by astigmat 151 here.
Fig. 3 further indicates the light source 152 for generating collimation (parallel) light beam being focused into light beam l by lens 151 astigmatism.
Astigmat 151 focuses on incoming directional light so that creating at the lens respectively position of z=fx and z=fy
Two focal line fx and fy.The first focal line fx at fx is orientated in xz plane, and it can have certain length lx, but its height hy
Clearly little than paper tinsel thickness h.As a result, it is possible to be optically coupled to all inside paper tinsel 110, and if numerical aperture (na) is enough
Little, then by total internal reflection, all light are transported to inside paper tinsel 110.The second focal line fy at fy is orientated, preferably in x/y plane
Ground along y-axis, has certain length ly and the width hx of nax and nay within paper tinsel and astigmatism distance | fy-fx | management and control.Although this
Focal line points in the y-direction, but all light is still limited in paper tinsel 110 and this focal line passes through total internal reflection and " folds into it certainly
Oneself " on.As top view, Fig. 4 shows such that it is able to all light of light beam l are delivered to region 112 interested.
Fig. 3 also schematically shows the photo-detector 153 of the detection of the light for leaving paper tinsel 110.By this photo-detector
153 signal transmission is used for processing to assessment unit 154 and assesses, such as with regard to being attached to the sample in region 112 interested
Target element amount.Additionally, indicating the magnetic field generating 155 being arranged in paper tinsel below 110.This allows to generate magnetic field, utilizes
This magnetic field, can manipulate the magnetic-particle of the sample interior of paper tinsel more than 110.
Fig. 5 illustrates to work as to be made as applying by the size entering to couple geometry proposing and is used for the several of optics of astigmatism device
During what optics formula, the definition of geometry variable used below.Design parameter be astigmat 151 focal length fx and fy and
The diameter a of incoming bundle.Experiment constraint (i), (ii) and is (iii) given by following: (i) be used for the bar of the total internal reflection within paper tinsel
Part；(ii) from the position with a tight waist of foil edge measurement, (in the case, the half of paper tinsel, paper tinsel has width w)；And (iii) when
When entering paper tinsel, the width of the focal line at fx.
Design parameter: fx, fy and a
Constraint:
(i) naxShould be fully little, enable to realize tir:na inside paper tinselx<natir.Refractive index n of given paper tinsel, with
And refractive index n of the direct material (can be the thin layer of optical cement) on the top of paper tinselt, then maximum allowable enter Coupled Numerical hole
Footpath natirIt is equal to:
(ii) the focal line fx at fx should be with the coincident of box.
(iii), due to refraction, the focal line fy at fy is by the inside amount of movement δ fy in box.This amount is given by that (n is
The refractive index of paper tinsel):
δ fy=(n-1) (fy-fx).
The second focal line fy at fy is preferably provided at the center (i.e. in sensor regions 112) of box；Given box width w,
This leads to
Fy+ δ fy-fx=w/2 or fy-fx=w/ (2 n).
For the different detection section of the inside separate a certain many apart from xd in the x-direction of illumination box, dissipate accordingly
The diameter of optical lens can be less than this value xd.In true application, enter coupled lens and be preferably placed near box entrance window
Place, leads to certain maximum corresponding of lx.At fx, length lx of the first focal line should have certain maximum: lx=lmax.This leads
Cause equation (1) and (2) reproducing in Fig. 8.Two equatioies of combination lead to the equation (3) of Fig. 8.This is substituted into equation (2), this leads to
The final group of equation illustrating of the diameter a of focal length fx, fy of description optics of astigmatism device and incoming bundle.
It should be noted that generally, optics of astigmatism device numerical aperture in the x and y direction is without the need for identical: nax(exists
Inlet angle (entrance angle) at fx in yz plane) determined by the condition for total internal reflection；Nay(i.e., in xz plane
Inlet angle at middle fy) determine the last width of the speckle of focusing at the fy of position.
Be coupled into all light to be at inlet face in position fx, bundle na in y-direction should fully big so that line
The height of focus fx is less than the thickness h of box:
1.22λ/nay<h；nay>1.22λ/h.
Another implements requirement can be the little beam diameter of appropriateness, enabling (in the x direction) adjacent one another are dispose
More multi beam, thus creates many speckles in the inside of paper tinsel.For the biosensor application with more than one reading speckle, this
Can be favourable (for example, in the case that multicell and/or many speckles are multiplexed).
For numerical value example, it can be assumed that values below:
- should be a=1mm for the representative value of beam diameter.
- it is w=8mm for the representative value of box/paper tinsel width.
- paper tinsel refractive index is n=1.51.
- glue refractive index is nt=1.4.
This leads to for natir=0.54 maximum.
Fig. 6 illustrates focal length fx, fy of the function as entrance nax and beam diameter a(for above parameter and the first focal line
Length lx=0.6mm).
According to this, it is able to conclude that focal length fy=4.4mm, fx=1.8mm and the lens of beam diameter a=1.0mm are allowed
The maximum being 0.28 in the porch of box enters to couple na.The width of the first focal line in the case of this is lx=600 μm.
In order to study the quality of this optical system further, perform ray tracing (raytrace) using these parameters and imitate
Very.Fig. 7 illustrates the 3d layout (not shown total internal reflection) of the optics geometry of this emulation.
In order to experimentally verify invention, construct the plastic optics box being made up of optical grade pmma paper tinsel.Using ball and cylinder
The combination of lens is by optical coupling so far the tir layer of box.Camera viewing monitors to enter to couple scattering of light at the bottom side of tir layer
Box top.Can be clearly viewed scattered light instruction using scattering optics in tir layer within enter to couple light
Focusing.
Although in pattern and middle detailed example described above and describe the present invention, this example and description are considered as
Exemplary or exemplary rather than restricted；The present invention is not restricted to disclosed embodiment.Those skilled in the art are in reality
When trampling the invention claimed, according to the research of pattern, description and appended claim it is to be understood that and implementing to public affairs
Other changes of the embodiment opened.In the claims, word " inclusion " is not excluded for other elements or step, and indefinite article
"a" or "an" is not excluded for multiple.The pure fact that certain measure is recorded in mutually different dependent claims does not indicate not
Can be advantageously using the combination of these measures.Any reference markss in claim are not construed as limiting scope.
Claims (13)
1. one kind is for being coupled to light beam (l) in the transparent components (110) with entrance window (w) extending along axle (x)
Method, methods described includes focusing to described light beam (l) astigmatism on described entrance window (w) by astigmat (151), makes
:
The focal line (fx) of-light beam (l) extends along the x-axis of described entrance window (w),
Second focal line (fy) of-light beam (l) extends along y-axis and is arranged on described transparent components (110) inside, wherein said y
Axle is orthogonal to described x-axis,
- described light beam (l) in the internal at least total internal reflection of described transparent components (110) once,
Wherein, described transparent components (110) include the surface (111) with search coverage (112),
It is characterized in that, the second focal line (fy) is arranged on described search coverage (112) place.
2. a kind of optical device (150), comprising:
A) receiving space, has and is arranged in institute along the rectangle of x-axis extension or the transparent components (110) of elliptical inlet window (w)
State at receiving space or can be arranged at described receiving space；
B) focusing optics (151), for by light beam (l) astigmatism focus to described entrance window (w) upper so that light beam (l)
Focal line (fx) extend along the described x-axis of described entrance window (w), second focal line (fy) of light beam (l) extends along y-axis and sets
Put internal in described transparent components (110), wherein said y-axis is orthogonal to described x-axis.
3. method according to claim 1, or optical device according to claim 2 (150),
It is characterized in that, described transparent components (110) are plate of material or piece.
4. method according to claim 3 or optical device (150),
It is characterized in that, described transparent components (110) are paper tinsels between 50 μm and 1000 μm for the thickness.
5. optical device (150) according to claim 2,
It is characterized in that, described light beam (l) is in the internal at least total internal reflection of described transparent components (110) once.
6. optical device (150) according to claim 2,
It is characterized in that, provide astigmat (151), for the focusing of described light beam (l).
7. method according to claim 1,
It is characterized in that, provide light source (152), for generating described light beam (l).
8. method according to claim 1, or optical device according to claim 2 (150),
It is characterized in that, provide photo-detector (153), for detecting the light leaving described transparent components (110).
9. method according to claim 8 or optical device (150),
It is characterized in that, described photo-detector (153) is provided for detecting the light being derived from the described light beam (l) into coupling.
10. method according to claim 8 or optical device (150),
It is characterized in that, provide assessment unit (154), for processing the signal of described photo-detector (153).
11. methods according to claim 1, or optical device according to claim 2 (150),
It is characterized in that, provide magnetic field generating (155), for described transparent components (110) are internal and/or neighbouring generation magnetic
?.
12. optical devices (150) according to claim 2,
It is characterized in that, provide light source (152), for generating described light beam (l).
13. optical devices according to claim 2 to 6 and any one of 8 to 11 are used for molecular diagnosis, biological sample
The purposes of analysis, chemical sample analysis, food analysis and/or forensic analysis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161531122P | 2011-09-06 | 2011-09-06 | |
| US61/531,122 | 2011-09-06 | ||
| PCT/IB2012/054540 WO2013035028A1 (en) | 2011-09-06 | 2012-09-03 | Method and device for coupling a light beam into a foil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103782159A CN103782159A (en) | 2014-05-07 |
| CN103782159B true CN103782159B (en) | 2017-01-18 |
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ID=47049334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280043175.XA Expired - Fee Related CN103782159B (en) | 2011-09-06 | 2012-09-03 | Method and device for coupling a light beam into a foil |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140217267A1 (en) |
| EP (1) | EP2745100A1 (en) |
| JP (1) | JP6046723B2 (en) |
| CN (1) | CN103782159B (en) |
| BR (1) | BR112014004892A2 (en) |
| IN (1) | IN2014CN01633A (en) |
| RU (1) | RU2014113337A (en) |
| WO (1) | WO2013035028A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014195204A1 (en) * | 2013-06-03 | 2014-12-11 | Ventana Medical Systems, Inc. | Fluorescence imaging system for tissue detection |
| GB2549298B (en) * | 2016-04-12 | 2022-02-02 | Univ I Tromsoe Norges Arktiske Univ | Super-resolution imaging |
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| US4810658A (en) * | 1984-06-13 | 1989-03-07 | Ares-Serono Research & Development | Photometric instruments, their use in methods of optical analysis, and ancillary devices therefor |
| US5677196A (en) * | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US6384912B2 (en) * | 1996-11-18 | 2002-05-07 | Novartis Ag | Measuring device and the use thereof |
| DE102007033124A1 (en) * | 2007-07-16 | 2009-01-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for optical detection of substances in fluid or gaseous medium, comprises a carrier with molecules for the recognition of the substances to be detected that are immobilized on a surface of the carrier or in the carrier |
| WO2009016533A3 (en) * | 2007-07-31 | 2009-08-06 | Koninkl Philips Electronics Nv | Microelectronic sensor device with a modulated light source |
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| JP3261362B2 (en) * | 1998-05-28 | 2002-02-25 | 株式会社アドバンテスト | Surface condition measuring method and device |
| JP3345590B2 (en) * | 1998-07-16 | 2002-11-18 | 株式会社アドバンテスト | Substrate processing method and apparatus |
| DE10002566A1 (en) * | 2000-01-21 | 2001-08-02 | Fraunhofer Ges Forschung | Method and device for determining the melting point and / or the binding constant of substances such. B. DNA sequences in a sample |
| US6850659B2 (en) * | 2001-06-04 | 2005-02-01 | Agility Communicatioins, Inc. | Grin lens based astigmatism correcting optical coupler |
| US20070084989A1 (en) * | 2003-09-22 | 2007-04-19 | Koninklijke Philips Electronics N.V. | Light guide touch screen |
| KR20100063969A (en) * | 2008-12-04 | 2010-06-14 | 삼성전자주식회사 | System and method for information input using a touch input device |
| JP2010210378A (en) * | 2009-03-10 | 2010-09-24 | Fujifilm Corp | Sensing method and sensing kit to be used of the same |
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2012
- 2012-09-03 WO PCT/IB2012/054540 patent/WO2013035028A1/en active Application Filing
- 2012-09-03 RU RU2014113337/28A patent/RU2014113337A/en not_active Application Discontinuation
- 2012-09-03 CN CN201280043175.XA patent/CN103782159B/en not_active Expired - Fee Related
- 2012-09-03 BR BR112014004892A patent/BR112014004892A2/en not_active IP Right Cessation
- 2012-09-03 JP JP2014529107A patent/JP6046723B2/en not_active Expired - Fee Related
- 2012-09-03 IN IN1633CHN2014 patent/IN2014CN01633A/en unknown
- 2012-09-03 EP EP12775550.2A patent/EP2745100A1/en not_active Withdrawn
- 2012-09-03 US US14/342,045 patent/US20140217267A1/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810658A (en) * | 1984-06-13 | 1989-03-07 | Ares-Serono Research & Development | Photometric instruments, their use in methods of optical analysis, and ancillary devices therefor |
| US5677196A (en) * | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US6384912B2 (en) * | 1996-11-18 | 2002-05-07 | Novartis Ag | Measuring device and the use thereof |
| DE102007033124A1 (en) * | 2007-07-16 | 2009-01-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for optical detection of substances in fluid or gaseous medium, comprises a carrier with molecules for the recognition of the substances to be detected that are immobilized on a surface of the carrier or in the carrier |
| WO2009016533A3 (en) * | 2007-07-31 | 2009-08-06 | Koninkl Philips Electronics Nv | Microelectronic sensor device with a modulated light source |
| CN101779117A (en) * | 2007-07-31 | 2010-07-14 | 皇家飞利浦电子股份有限公司 | Microelectronic sensor device with a light source |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013035028A1 (en) | 2013-03-14 |
| RU2014113337A (en) | 2015-10-20 |
| BR112014004892A2 (en) | 2017-03-21 |
| US20140217267A1 (en) | 2014-08-07 |
| JP2014525592A (en) | 2014-09-29 |
| JP6046723B2 (en) | 2016-12-21 |
| CN103782159A (en) | 2014-05-07 |
| IN2014CN01633A (en) | 2015-05-08 |
| EP2745100A1 (en) | 2014-06-25 |
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