CN103779170B - A kind of electrospray ion source device - Google Patents
A kind of electrospray ion source device Download PDFInfo
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- CN103779170B CN103779170B CN201410063639.4A CN201410063639A CN103779170B CN 103779170 B CN103779170 B CN 103779170B CN 201410063639 A CN201410063639 A CN 201410063639A CN 103779170 B CN103779170 B CN 103779170B
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Abstract
The present invention relates to a kind of electrospray ion source device, it comprises insulating carrier, conductive electrode, high voltage source, determinand drop, tool interface system, described insulating carrier is provided with a tip portion corresponding with tool interface system, described determinand drop drips and covers on tip portion surface, described conductive electrode one end contacts with determinand drop, the other end is connected with high voltage source by wire, charged determinand drop forms highfield at tip portion and tool interface system, determinand drop forms electron spray under electric field action, realizes the ionization of determinand. Described insulating carrier tip portion is provided with the wedge angle of 30 ~ 150 °. Apparatus of the present invention are simple in structure, and cost is low, are easy to build and operate; Adopt this ion gun can be to the material Real-Time Monitoring in solution; Fluid sample is without processing, even there is the solution of suspended particulate also can direct-detection.
Description
Technical field
The present invention relates to a kind of ion source device, be specifically related to a kind of drop electrospray ion source device of insulating materials as carrier that adopt.
Background technology
Ion gun is the critical component of the analytical instrument such as mass spectrograph or ionic migration spectrometer, and ionogenic ionization principle and Ionization Efficiency directly affect application, the sensitivity etc. of instrument. At present, in the time adopting mass spectral analysis fluid sample, electron spray ionisation source (ESI) is most widely used general, ESI technology is reported used as mass ion source by professor JohnFenn of Yale university etc. for 1984 first, and is applied to protein analysis. The liquid droplet charged that this technology utilizes highfield that capillary is flowed out, after the evaporation of drop solvent, surface area dwindles, and surface charge density constantly increases, and drop explosion is less charged drop, finally forms single electric charge or multiple-charged ion. On the basis of electron spray ionisation (ESI), in conjunction with other ionization techniques, researcher has also worked out desorb electron spray ionisation (DESI), electron spray extraction ionization (EESI), paper substrate electron spray ionisation (PSI) etc. Desorption electrospray ionization (DESI) develops on ESI basis, within 2004, the Cooks of Purdue Univ-West Lafayette USA teach problem group has been reported DESI mass-spectrometric technique, DESI can under atmospheric pressure analyze various body surfaces, is one of focus of current Mass Spectra. DESI adopts the sprayer unit that is similar to ESI to produce ion, then produces determinand ion by these ions and determinand effect, and then ion is introduced in mass spectrograph and detected. Electron spray extraction ionization (EESI) is the Novel ion technology growing up on the basis of ESI and DESI technology inheriting, and is also a member in open type ionization technique family. EESI technology, the earliest for the direct ionization of complicated substrate fluid sample, has realized the fluid sample that contains complicated substrate very like a cork in continuous, real-time, on-line mass spectroscopy analysis without in sample pretreatment situation. Paper substrate electron spray technology adopts the scraps of paper as the carrier of testing sample, testing sample is placed on the scraps of paper or is dissolved in solvent to be added drop-wise on the scraps of paper, makes containing the scraps of paper of testing sample moisteningly, on the wetting scraps of paper, applies high voltage, can be by analyte ions.
Above-mentioned these are ionization mode under atmospheric pressure, all have advantages of separately, and have certain application. But every kind of ion gun all can have the limitation of oneself, as ESI structure relative complex, generally need to adopt syringe pump, assist gas etc., owing to adopting capillary pipe spray, so can not have impurity in sample; The sensitivity of DESI and EESI is lower, and the field of practical application is at present also little, and is difficult to directly to fluid sample analysis; PSI adopts the mode of Direct spraying, but due to the carrier that adopts the scraps of paper as spraying, poor stability, holds the yielding scraps of paper and bring a lot of uncertainties to analysis.
Summary of the invention
To be solved by this invention is in order to overcome the deficiencies in the prior art, provides a kind of simple in structure, is easy to build and operate, and without sample pre-treatments, can carry out the simple and easy electrospray ion source device detecting in real time to determinand.
The technical scheme that the present invention solves the problems of the technologies described above employing is:
A kind of electrospray ion source device, it is characterized in that: comprise insulating carrier, conductive electrode, high voltage source, determinand drop, tool interface system, described insulating carrier is provided with a tip portion corresponding with tool interface system, described determinand drop drips and covers on tip portion surface, described conductive electrode one end contacts with determinand drop, the other end is connected with high voltage source by wire, charged determinand drop forms highfield at tip portion and tool interface system, determinand drop forms electron spray under electric field action, realizes the ionization of determinand.
Insulating carrier tip portion of the present invention is provided with the wedge angle of 30 ~ 150 °.
Conductive electrode of the present invention is the wire that is fixed on insulating carrier upper surface. Also can be the layer of metal film of electroplating at insulating carrier upper surface.
When the present invention uses, conductive electrode is fixed on insulating carrier surface, and determinand drop drips on insulating carrier, covers wedge angle, and contacts with conductive electrode, and the conductive electrode other end is connected with high voltage source by wire. In the time opening high voltage source, high pressure is added on determinand drop by conductive electrode, charged drop forms highfield at the tip portion of sharp corner and the tool interface system of mass spectrum or ion mobility spectrometry, most advanced and sophisticated liquid forms spraying under electric field action, produce electron spray phenomenon, realize the ionization of determinand, finally enter mass spectrum or ion mobility spectrometry detector carries out analyzing and testing. This ion source device is simple in structure, cost is low, be easy to build and operate, and in the situation that loading high pressure, can adopt liquid getting device directly to drip solution to be measured; Adopt this ion gun can be to the material Real-Time Monitoring in solution; Fluid sample is without processing, even there is the solution of suspended particulate (solid impurity) also can direct-detection. This ion source device in conjunction with mass spectrum and Ion mobility spectrometry will study at chemical reaction mechanism (to intermediate Real-Time Monitoring), biological sample analysis, the on-the-spot aspect such as quick plays an important role.
Brief description of the drawings
Below in conjunction with accompanying drawing, the present invention will be further described.
Fig. 1 is a kind of structural representation of the present invention.
Fig. 2 is another kind of structural representation of the present invention.
Number in the figure is: 1. high voltage source, 2. wire, 3. conductive electrode, 4. insulating carrier, 5. determinand drop, 6. tool interface system.
Detailed description of the invention
From Fig. 1, Fig. 2, can find out, a kind of electrospray ion source device, it comprises insulating carrier 4, conductive electrode 3, high voltage source 1, determinand drop 5, tool interface system 6 etc. Described insulating carrier 4 is provided with a tip portion corresponding with tool interface system 6, described determinand drop 5 drips and covers on the tip portion surface of insulating carrier 4, described conductive electrode 3 one end contact with determinand drop 5, the other end is connected with high voltage source 1 by wire 2, charged determinand drop 5 forms highfield with tool interface system 6 on insulating carrier 4 tip portions, determinand drop 5 forms electron spray under electric field action, realizes the ionization of determinand.
Insulating carrier 4 tip portions of the present invention are provided with the wedge angle of 30 ~ 150 °. Determinand drop 5 drips on insulating carrier 4, and covers tip portion.
Conductive electrode 3 of the present invention is the wires that are fixed on insulating carrier 4 upper surfaces, as shown in Figure 1. Drop electrospray ion source device shown in Fig. 1, described conductive electrode 3 is for being fixed on the wire on insulating carrier surface, determinand drop 5 drips at insulating carrier 4 tip portions, and cover tip portion, and determinand drop 5 contacts with wire, the wire other end is connected with high voltage source 1 by wire 2. In the time opening high voltage source 1, high voltage source 1 is added to voltage on determinand drop 5 by wire 2 and wire, charged drop forms highfield at the tool interface system 6 of tip portion and mass spectrum or ion mobility spectrometry, most advanced and sophisticated liquid forms spraying under electric field action, produce electron spray phenomenon, realize the ionization of determinand, finally enter mass spectrum or ion mobility spectrometry detector carries out analyzing and testing.
Conductive electrode 3 of the present invention can be also the layer of metal film of electroplating at insulating carrier 4 upper surfaces, as shown in Figure 2. Drop electrospray ion source device shown in Fig. 2, described conductive electrode 3 is for electroplating the metallic film on insulating carrier 4 surfaces, and plated film does not cover the wedge angle position of insulating carrier 4; Determinand drop 5 drips on insulating carrier 4, and covers the most advanced and sophisticated position of its wedge angle; One side of metallic film contacts with determinand drop 5, and opposite side also joins by wire 2 and high voltage source 1. In the time that drop esi ion source is worked, high voltage source 1 is added to voltage on determinand drop 5 by wire 2 and metallic film, charged drop forms highfield at the tool interface system 6 of tip portion and mass spectrum or ion mobility spectrometry, most advanced and sophisticated liquid forms spraying under electric field action, produce electron spray phenomenon, realize the ionization of determinand, finally enter mass spectrum or ion mobility spectrometry detector carries out analyzing and testing.
Ion source device of the present invention is simple in structure, cost is low, be easy to build and operate, and in the situation that loading high pressure, can adopt liquid getting device directly to drip solution to be measured; Adopt this ion gun can be to the material Real-Time Monitoring in solution; Fluid sample is without processing, even there is the solution of suspended particulate (solid impurity) also can direct-detection. This ion source device in conjunction with mass spectrum and Ion mobility spectrometry will study at chemical reaction mechanism (to intermediate Real-Time Monitoring), biological sample analysis, the on-the-spot aspect such as quick plays an important role.
Claims (1)
1. an electrospray ion source device, it is characterized in that: comprise insulating carrier, conductive electrode, high voltage source, determinand drop, tool interface system, described insulating carrier is provided with a tip portion corresponding with tool interface system, described determinand drop drips and covers on tip portion surface, described conductive electrode one end contacts with determinand drop, the other end is connected with high voltage source by wire, charged determinand drop forms highfield at tip portion and tool interface system, determinand drop forms electron spray under electric field action, realizes the ionization of determinand; Described insulating carrier tip portion is provided with the wedge angle of 30 ~ 150 °; Described conductive electrode is to be fixed on the wire of insulating carrier upper surface or to electroplate the layer of metal film at insulating carrier upper surface.
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| CN201410063639.4A CN103779170B (en) | 2014-02-25 | 2014-02-25 | A kind of electrospray ion source device |
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| CN201410063639.4A CN103779170B (en) | 2014-02-25 | 2014-02-25 | A kind of electrospray ion source device |
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| CN103779170A CN103779170A (en) | 2014-05-07 |
| CN103779170B true CN103779170B (en) | 2016-05-25 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105470097B (en) * | 2015-12-09 | 2018-02-09 | 清华大学 | A kind of interlayer electrospray ionization source device and ioning method |
| CN105895494B (en) * | 2016-06-29 | 2017-12-12 | 哈尔滨工业大学（威海） | A kind of mass ions source device |
| CN106442695A (en) * | 2016-10-09 | 2017-02-22 | 苏州微木智能系统有限公司 | Ion source and ion mobility spectrometer |
| CN106841706B (en) * | 2017-03-31 | 2023-06-27 | 中国工程物理研究院电子工程研究所 | Ion source test fixture |
| CN108680619B (en) * | 2018-04-03 | 2023-12-26 | 哈尔滨工业大学（威海） | Electrochemical-mass spectrum combined device and application method thereof |
| CN110060916A (en) * | 2019-04-09 | 2019-07-26 | 武汉大学 | A kind of mass spectrometer for the online photochemical reaction research of high-throughput drop |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102629544A (en) * | 2012-04-09 | 2012-08-08 | 中国科学院化学研究所 | Internal standard ion source device for quality correction |
| CN102636553A (en) * | 2012-03-23 | 2012-08-15 | 哈尔滨工业大学（威海） | Paper-based electrospray ion mobility spectrometry analysis method |
| CN102637574A (en) * | 2012-04-12 | 2012-08-15 | 清华大学 | Paper-base electrospray ion source device for mass spectrum analysis on continuous droplets |
Family Cites Families (1)
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|---|---|---|---|---|
| US7763848B2 (en) * | 2005-01-18 | 2010-07-27 | Phoenix S&T, Inc. | Apparatus and method for controlling an electrostatically induced liquid spray |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102636553A (en) * | 2012-03-23 | 2012-08-15 | 哈尔滨工业大学（威海） | Paper-based electrospray ion mobility spectrometry analysis method |
| CN102629544A (en) * | 2012-04-09 | 2012-08-08 | 中国科学院化学研究所 | Internal standard ion source device for quality correction |
| CN102637574A (en) * | 2012-04-12 | 2012-08-15 | 清华大学 | Paper-base electrospray ion source device for mass spectrum analysis on continuous droplets |
Non-Patent Citations (2)
| Title |
|---|
| 《Development, Characterization, and Application of Paper Spray Ionization》;Jiangjiang Liu 等;《Analytical Chemistry》;20100315;第82卷(第6期);正文第2463-2471页 * |
| 《常压电离源-纸喷雾电离技术及应用》;张智平 等;《分析化学》;20140131;第42卷(第1期);正文第145-152页 * |
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