CN103773631B - A kind of scavenging solution of blood coagulation analyzer - Google Patents
A kind of scavenging solution of blood coagulation analyzer Download PDFInfo
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- CN103773631B CN103773631B CN201410048373.6A CN201410048373A CN103773631B CN 103773631 B CN103773631 B CN 103773631B CN 201410048373 A CN201410048373 A CN 201410048373A CN 103773631 B CN103773631 B CN 103773631B
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- scavenging solution
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- clorox
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- 230000002000 scavenging effect Effects 0.000 title claims abstract description 93
- 230000023555 blood coagulation Effects 0.000 title claims abstract description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 44
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000004140 cleaning Methods 0.000 claims abstract description 17
- CDMADVZSLOHIFP-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane;decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 CDMADVZSLOHIFP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 12
- JDRIHSRRXBVHRY-UHFFFAOYSA-N B(O)(O)Cl.[Na] Chemical compound B(O)(O)Cl.[Na] JDRIHSRRXBVHRY-UHFFFAOYSA-N 0.000 claims abstract description 7
- -1 EDTA-K 2 Chemical compound 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 87
- 238000000034 method Methods 0.000 claims description 16
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- 239000012528 membrane Substances 0.000 claims description 7
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 6
- 239000004327 boric acid Substances 0.000 claims description 6
- 238000001471 micro-filtration Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 208000007536 Thrombosis Diseases 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 3
- 238000005374 membrane filtration Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 7
- 238000011161 development Methods 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 238000002425 crystallisation Methods 0.000 abstract description 4
- 230000008025 crystallization Effects 0.000 abstract description 4
- 238000002474 experimental method Methods 0.000 abstract description 4
- 238000001556 precipitation Methods 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 230000010165 autogamy Effects 0.000 description 4
- 238000013016 damping Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 3
- 239000003513 alkali Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000003245 working effect Effects 0.000 description 2
- 108091005658 Basic proteases Proteins 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010931 ester hydrolysis Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000005121 nitriding Methods 0.000 description 1
- 238000006053 organic reaction Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of scavenging solution of blood coagulation analyzer.A kind of scavenging solution for cleaning blood coagulation analyzer provided by the invention, by sodium-chlor, boric acid, sodium tetraborate decahydrate, EDTA-K
2, clorox, sodium hydroxide, Sumizyme MP and water composition; Wherein sodium-chlor, boric acid, sodium tetraborate decahydrate, EDTA-K
2, clorox, sodium hydroxide, Sumizyme MP proportioning be 0.574g:0.09g:0.018g:0.018g:1.0g:0.001g:0.1g.Experiment of the present invention proves, the scavenging solution appearance colorless of the present invention's development is transparent, physical and chemical index stable performance, and through between the usage period of half a year, all have no crystallization, precipitation, muddiness, every physical and chemical index all shows stable; And scavenging solution is with low cost, and formulatory agents is easily purchased, in physical and chemical index, stability, cleaning performance and practical effect, meet or exceed original-pack scavenging solution CA? CLEAN? I, its good stability, validity period is long, and cleaning performance is good.
Description
Technical field
The present invention relates to a kind of scavenging solution, particularly a kind of scavenging solution of blood coagulation analyzer.
Background technology
Scavenging solution is blood coagulation analyzer routine use and the reagent in safeguarding, it reaches by cleaning blood coagulation analyzer counting pipeline, counting cell, colorimetric pool and gem hole etc. the object keeping instrument performance to stablize and extend instrument work-ing life.Under scavenging solution effect, the dirts such as blood clot are sufficiently solubilized, and rinse through diluent, thus reach the object of cleaning blood coagulation analyzer counting piping system.
SYSMEXCA-500 blood coagulation analyzer etc. is applied widely at home, and scavenging solution day consumption is comparatively large, and original-pack scavenging solution used is CACLEANI, expensive, complete dependence on import.Domestic scholars is many to the development of Biochemical Analyzer scavenging solution substitute products, rarely has bibliographical information to cross blood coagulation analyzer scavenging solution development status.Have manufacturer production to substitute scavenging solution even if domestic at present, but result of use is not good, easily produces crystallization after main unlatching, huge negative impact is caused to instrument count section, pipeline.
Summary of the invention
An object of the present invention is to provide a kind of scavenging solution for cleaning blood coagulation analyzer.
Scavenging solution provided by the invention, by sodium-chlor, boric acid, sodium tetraborate decahydrate, EDTA-K
2, clorox, sodium hydroxide, Sumizyme MP and water composition; Wherein sodium-chlor, boric acid, sodium tetraborate decahydrate, EDTA-K
2, clorox, sodium hydroxide, Sumizyme MP mass ratio be 0.564-0.584:0.08-0.10:0.008-0.028:0.008-0.028:0.9-1.1:0. 001:0.08-0.12.
In above-mentioned scavenging solution, described sodium-chlor, described boric acid, described sodium tetraborate decahydrate, described EDTA-K
2, described clorox, described sodium hydroxide, described Sumizyme MP proportioning be 0.574g:0.09g:0.018g:0.018g:1.0g:0.001g:0.1g.
In above-mentioned scavenging solution, the final concentration of described sodium-chlor in described scavenging solution is 98.1mmol/L;
The final concentration of described boric acid in described scavenging solution is 14.5mmol/L;
The final concentration of described sodium tetraborate decahydrate in described scavenging solution is 0.47mmol/L;
Described EDTA-K
2final concentration in described scavenging solution is 0.48mmol/L;
The final concentration of described clorox in described scavenging solution is 134.4mmol/L;
The final concentration of described sodium hydroxide in described scavenging solution is 250mmol/L;
The final concentration of described Sumizyme MP in described scavenging solution is 1g/L.
The Rate activity of above-mentioned Sumizyme MP is 200000u/g.
In above-mentioned scavenging solution, the pH value of described scavenging solution is 12.40.
In above-mentioned scavenging solution, described clorox is analytical pure clorox, and described water is deionized water;
The pH value of described deionized water is specially 7.
Another object of the present invention is to provide the method that preparation is above-mentioned scavenging solution.
Method provided by the invention, each material mixes by the consumption in scavenging solution described in comprising the steps: according to the method described above, namely obtains scavenging solution.
In aforesaid method, after described mixing, also comprise the steps: that the mixed solution described mixing obtained is through membrane filtration, collect filtrate and obtain scavenging solution.
In aforesaid method, before described filtration, also comprise the steps: that by described mixed solution adjust pH be 12.40.
The aperture of described microfiltration membrane is 0.2-0.4 micron, and the aperture of described microfiltration membrane is specially 0.22 micron.
In aforesaid method, described clorox is analytical pure clorox, and described water is deionized water;
The pH value of described deionized water is specially 7.
The application that above-mentioned scavenging solution cleans in the product of blood clot or blood coagulation analyzer cleaning in preparation is also the scope of protection of the invention.
Or the application of above-mentioned scavenging solution in cleaning blood clot or blood coagulation analyzer cleaning is also the scope of protection of the invention
Experiment of the present invention proves, scavenging solution provided by the invention, its major ingredient is clorox, clorox be a kind of efficient, wide spectrum, safety powerful sterilizing, kill the virus medicament, it is fine with the affinity of water, can with water arbitrarily than dissolving each other, sterilisation effect is good, and operational safety is easy to use, be easy to store, to environment toxicological harmless; In configuration scavenging solution damping fluid used, sodium-chlor can improve and maintain osmotic pressure, and boric acid, as pH value regulator, also has antibacterial rot-resistant effect, and can improve heat-resisting, the properties of transparency of glasswork, improves physical strength, extends the work-ing life of instrument pipeline; EDTA-K
2be excellent sequestrant, complexing agent, be mainly used in water softening, can each metal ion species effectively in chelating, complexing hard water, for washing composition etc.; Sodium hydroxide is a kind of extremely conventional alkali, in the absorption agent of the sewage-treating agent of general application, fundamental analysis reagent, preparation analysis standard alkali lye, a small amount of carbonic acid gas and moisture, acid and sodium salt manufacture, manufacture the reagent of other hydroxyl-containing ion, all important use is had in papermaking, printing and dyeing, wastewater treatment, plating, chemical industry probing, the good catalyst of sodium hydroxide or many organic reactions, wherein most typical is ester hydrolysis reaction; Sumizyme MP makes the 2709 withered grass bar microorganisms that educate by submerged fermentation, extraction and refining a kind of proteolytic ferment through bacterial protoplast mutafacient system, belong to the crisp outer high alkaline proteases of a kind of Serine, it can generate polypeptide or amino acid by hydrolyze protein molecules peptide chain, there is the ability of stronger decomposing protein, Sumizyme MP is detergent additive popular in the market, washing soil removability can be increased substantially, especially to protein dirts such as bloodstain, sweat stain, milk stain, oil stains, there is unique washing effect.
In addition, the present invention is adopt the modern techniquies such as micro-filtration Ultra filtration membrane, spraying dry or vacuum lyophilization in the production technique of scavenging solution, is widely used in food, medical treatment, brewages, silk, the industry such as process hides.
Through experiment proof, the scavenging solution appearance colorless of the present invention's development is transparent, physical and chemical index stable performance, and through between the usage period of half a year, all have no crystallization, precipitation, muddiness, every physical and chemical index all shows stable; And scavenging solution is with low cost, and formulatory agents is easily purchased, and in physical and chemical index, stability, cleaning performance and practical effect, meet or exceed original-pack scavenging solution CACLEANI, its good stability, validity period is long, and cleaning performance is good; Meeting " People's Republic of China's pharmaceutical industries standard " YY/T0456.1-2003 standard-required that State Food and Drug Administration issues, is that one can replace original-pack scavenging solution entirely, in applying clinical inspection work.
Embodiment
The experimental technique used in following embodiment if no special instructions, is ordinary method.
Material used in following embodiment, reagent etc., if no special instructions, all can obtain from commercial channels.
In following embodiment, portion of material used is as follows:
SYSMEXCA-500 blood coagulation analyzer is purchased from Japanese SYSMEX company; PHS-3E acidometer is purchased from Shanghai Lei Ci company; SYSMEXCACLEANI scavenging solution is purchased from Japanese SYSMEX company.
The preparation of the scavenging solution of embodiment 1, blood coagulation analyzer
1, damping fluid
Precise sodium-chlor 6.38g, boric acid 1.00g, sodium tetraborate decahydrate 0.20g, EDTA-K
20.20g, by above-mentioned solute dissolves in deionized water (pH value=7.0), with deionized water constant volume to 1L; Rear 0.22 micrometer Millipore filter membrane negative pressure leaching is dissolved in abundant mixing, collects filtrate and is damping fluid.
2, scavenging solution
Measure above-mentioned damping fluid 180ml, add 20ml10% analytical pure clorox (mass percentage), add 1mg sodium hydroxide, 0.6g Sumizyme MP (Beijing extensive and profound in meaning star biotechnology responsibility company limited again, catalog number 01-132,200000u/g), with some scaling methods, pH value is adjusted to 12.40 with the potassium primary phosphate of pH6.86 and Sodium phosphate dibasic standard buffer solution, with 0.22 micrometer Millipore filter membrane negative pressure leaching, collect filtrate and be scavenging solution, packing 4 DEG C is preserved and is used (chemical reagent is purchased from Guangzhou Ding Guo biotech firm).
Above-mentioned scavenging solution is by sodium-chlor, boric acid, sodium tetraborate decahydrate, EDTA-K
2, clorox, sodium hydroxide, Sumizyme MP and deionized water composition; Wherein sodium-chlor, boric acid, sodium tetraborate decahydrate, EDTA-K
2, clorox, sodium hydroxide, Sumizyme MP mass ratio be 0.574g:0.09g:0.018g:0.018g:1.0g:0.001g:0.1g;
The final concentration of sodium-chlor in described scavenging solution is 98.1mmol/L; The final concentration of boric acid in described scavenging solution is 14.5mmol/L; The final concentration of sodium tetraborate decahydrate in described scavenging solution is 0.47mmol/L; EDTA-K
2final concentration in described scavenging solution is 0.48mmol/L; The final concentration of clorox in described scavenging solution is 134.4mmol/L; The final concentration of sodium hydroxide in described scavenging solution is 250mmol/L; The final concentration of Sumizyme MP in described scavenging solution is 1g/L.
The application of embodiment 2, scavenging solution
The scavenging solution effect assessment of above-mentioned development is as follows:
Get instrument original-pack scavenging solution SYSMEXCACLEANI respectively, prepare latter 1 day, 15,30,60 development scavenging solution carry out washing test, stability test, result of use evaluation test.
1, washing test
Rate measuring method is cleaned according to " People's Republic of China's pharmaceutical industries standard " YY/T0456.1-2003; Nitrogen content ratio in protein is measured in the blood plasma soaked through scavenging solution in nitrogen content in protein and the blood plasma that soaked without scavenging solution with triumphant formula nitriding, for evaluating the cleaning performance of scavenging solution, result display autogamy scavenging solution meets or exceeds original-pack scavenging solution in clean rate, and reach required by " People's Republic of China's pharmaceutical industries standard " YY/T0456.1-2003 be not less than 90% standard.(see table 1).
Table 1 is cleaned rate for original-pack scavenging solution and autogamy scavenging solution and is contrasted
2, stability test
Leave and take at random preparation latter 1 day, 15,30,60 bus install from preparation each five bottles of scavenging solution, outward appearance, crystallization and grumeleuse is carried out and pH value mean value compares with original-pack scavenging solution CACLEANI, it is clear, transparent that preparation scavenging solution and original-pack scavenging solution CACLEANI are outward appearance, nodeless mesh and grumeleuse, what PH met " People's Republic of China's pharmaceutical industries standard " required by YY/T0456.1-2003 be less than 0.5 standard (the results are shown in Table 2).
Table 2 is that original-pack scavenging solution and autogamy scavenging solution stability contrast
3, result of use evaluation test
Under identical working conditions, what install with preparation latter 1 day, 15,30,60 bus respectively carries out pin cleaning, testing pipes cleaning from preparation scavenging solution and original-pack scavenging solution CACLEANI to SYSMEXCA-500 blood coagulation analyzer, use siemens's blood coagulation quality control product (lot number: 528117) detect respectively again, in table 3, determination data after result display instrument uses different scavenging solution has high correlation, no significant difference (P>0.05).
The original-pack scavenging solution of table 3 and autogamy scavenging solution contrast the impact of measurement result
Claims (9)
1. for cleaning a scavenging solution for blood coagulation analyzer, by sodium-chlor, boric acid, sodium tetraborate decahydrate, EDTA-K
2, clorox, sodium hydroxide, Sumizyme MP and water composition;
The final concentration of described sodium-chlor in described scavenging solution is 98.1mmol/L;
The final concentration of described boric acid in described scavenging solution is 14.5mmol/L;
The final concentration of described sodium tetraborate decahydrate in described scavenging solution is 0.47mmol/L;
Described EDTA-K
2final concentration in described scavenging solution is 0.48mmol/L;
The final concentration of described clorox in described scavenging solution is 134.4mmol/L;
The final concentration of described sodium hydroxide in described scavenging solution is 250mmol/L;
The final concentration of described Sumizyme MP in described scavenging solution is 1g/L.
2. scavenging solution according to claim 1, is characterized in that: the pH value of described scavenging solution is 12.40.
3. scavenging solution according to claim 1 and 2, is characterized in that: described clorox is analytical pure clorox, and described water is deionized water; The pH value of described deionized water is 7.
4. prepare a method for arbitrary described scavenging solution in claim 1-3, comprise the steps: according to the consumption in scavenging solution described in claim 1, each material to be mixed, namely obtain scavenging solution.
5. method according to claim 4, is characterized in that: after described mixing, also comprise the steps: that the mixed solution described mixing obtained is through membrane filtration, collects filtrate and obtains scavenging solution.
6. method according to claim 5, is characterized in that: the aperture of described microfiltration membrane is 0.2-0.4 micron.
7. method according to claim 6, is characterized in that: the aperture of described microfiltration membrane is 0.22 micron.
8., according to described method arbitrary in claim 4-7, it is characterized in that: described clorox is analytical pure clorox, described water is deionized water; The pH value of described deionized water is 7.
9. the application of the arbitrary described scavenging solution of claim 1-3 in cleaning blood clot or blood coagulation analyzer cleaning.
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| CN106635440A (en) * | 2016-12-19 | 2017-05-10 | 青岛古高生物科技有限公司 | Cleaning liquid of blood coagulation analysis instrument |
| CN106987462A (en) * | 2017-03-29 | 2017-07-28 | 苏州康铭诚业医用科技有限公司 | A kind of compound stabilizer of Biochemical Analyzer cleaning fluid |
| CN108913376B (en) * | 2018-05-30 | 2020-11-24 | 武汉华大医学检验所有限公司 | Reagent for cleaning sequencing chip and preparation method and application thereof |
| CN110964602B (en) * | 2019-10-23 | 2021-10-29 | 北京鑫骥金诺医疗器械有限公司 | Cleaning fluid composition for bacterial resistance counting, preparation method and application thereof |
| CN111793528A (en) * | 2020-07-27 | 2020-10-20 | 郑州兰森生物技术有限公司 | Antibacterial phosphorus-free cleaning agent and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1548510A (en) * | 2003-05-09 | 2004-11-24 | 上海捷瑞医用试剂有限公司 | Cleaner for hemocyte analyzer and its prepn |
| CN101819199A (en) * | 2010-05-08 | 2010-09-01 | 桂林市朗道诊断用品有限公司 | Reagent for hemocyte analyzers |
| CN103131547A (en) * | 2011-11-24 | 2013-06-05 | 杨军 | Washing liquid for disinfecting and removing peculiar smell in service institutions for the aged |
| CN103275823A (en) * | 2013-05-29 | 2013-09-04 | 苏州康和顺医疗技术有限公司 | Cleanser for full-automatic biochemical analyzer and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548510A (en) * | 2003-05-09 | 2004-11-24 | 上海捷瑞医用试剂有限公司 | Cleaner for hemocyte analyzer and its prepn |
| CN101819199A (en) * | 2010-05-08 | 2010-09-01 | 桂林市朗道诊断用品有限公司 | Reagent for hemocyte analyzers |
| CN103131547A (en) * | 2011-11-24 | 2013-06-05 | 杨军 | Washing liquid for disinfecting and removing peculiar smell in service institutions for the aged |
| CN103275823A (en) * | 2013-05-29 | 2013-09-04 | 苏州康和顺医疗技术有限公司 | Cleanser for full-automatic biochemical analyzer and preparation method thereof |
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