CN103751756B - 一种治疗胃下垂的中药组合物及其在制备治疗胃下垂的药物中的应用 - Google Patents
一种治疗胃下垂的中药组合物及其在制备治疗胃下垂的药物中的应用 Download PDFInfo
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Abstract
本发明涉及一种治疗胃下垂中药组合物及其应用，该组合物由如下重量份的中药材原料制备而成：五倍子20-30份、白术8-16份、苍术8-16份、韭菜籽23-35份、干姜8-16份、红参8-16份、黄芪18-30份、山药50-80份、陈皮23-35份。本发明涉及的中药组合物治疗胃下垂的疗效显著，尤其是该药结合质子泵抑制剂治疗胃下垂疗效更为显著，同时能减少该病复发，疗效较为稳定。
Description
技术领域
本发明属于中药技术领域，具体而言，涉及一种治疗胃病的药物，尤其涉及一种治疗胃下垂的中药组合物及其应用。
背景技术
胃下垂源于消化无力，吸收不良，胃体因无力下垂，呈瀑布形，患者多形体消瘦，时见消化不良，有时便溏或有完谷不化表现。神疲体倦，面色萎黄，少气无力，舌淡苔白，脉细而无力。胃下垂是消化系统的常见病、多发病，临床西医治疗往往效果欠佳，且复发率高。
中医认为该病为中气下陷所致，由于中气不足，无力托举脏器而下垂；中气不足而至消化吸收功能不良；气虚气滞而气机运化不畅，营养吸收不良。脾气虚，久则影响肝气的疏泄，致内脏中气血不能正常运行和流动，由于不能正常的运化和流动，营养的代谢就不能正常，脏器得不到正常的营养，就会无力而下垂；下垂的脏器，又会进一步的加重气血运行的不畅，两者相互影响，最终形成胃下垂。
发明内容
本发明的目的在于通过对传统中药药理进行研究后重新组方，提供了一种疗效好、见效快，毒副作用小的治疗胃下垂的中药组合物及医药用途。
本发明的目的是这样实现的：
一种治疗胃下垂的中药组合物，由如下重量份的中药材原料制备而成：五倍子20-30份、白术8-16份、苍术8-16份、韭菜籽23-35份、干姜8-16份、红参8-16份、黄芪18-30份、山药50-80份、陈皮23-35份。
优选地，如上所述治疗胃下垂的中药组合物，它由如下重量份的中药材原料制备而成：五倍子24-26份、白术10-12份、苍术10-12份、韭菜籽28-30份、干姜10-12份、红参10-12份、黄芪23-25份、山药58-63份、陈皮28-30份。
在本发明一个最优选的实施例中，如上所述治疗胃下垂的中药组合物，它由如下重量份的中药材原料制备而成：五倍子25份、白术11份、苍术11份、韭菜籽28份、干姜11份、红参11份、黄芪24份、山药60份、陈皮28份。
进一步优选地，如上所述的治疗胃下垂的中药组合物，它为口服制剂，包括片剂、胶囊剂、颗粒剂和口服液。
通过大量试验研究发现，由上述中药材原料组成的药物组合物在治疗胃下垂患者方面具有显著的疗效。因此，本发明的第二个目的在于提供一种医药新用途，即上述的中药组合物在制备治疗胃下垂的药物中的应用。
根据中医药史料记载，上述中药材原料具有如下功能主治和来源：
五倍子：敛肺；止汗；涩肠；固精；止血；解毒；主治：肺虚久咳；自汗盗汗；久痢久泻；脱肛；遗精；白浊；各种出血；痈肿疮疖；本发明选用漆树科植物盐肤木（RhuschinensisMill.）树上寄生倍蚜科昆虫角倍蚜或倍蛋蚜后形成的虫瘿；
白术：健脾益气，燥湿利水，止汗，安胎；用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安；选用菊科植物白术AtractylodesmacrocephalaKoidz.的干燥根茎；
苍术：燥湿健脾，祛风散寒，明目；用于脘腹胀满，泄泻水肿，脚气痿躄，风湿痹痛，风寒感冒，夜盲；选用菊科植物茅苍术的根茎；
韭菜籽：温补肝肾，壮阳固精，暖腰膝；用于阳痿、遗精、白带白淫，遗尿，小便频数、腰膝酸软、冷痛等；选用百合科植物韭菜AlliumtuberosumRottler的干燥成熟种子；
干姜：温中散寒，回阳通脉，燥湿消痰，温肺化饮；主治脘腹冷痛；呕吐；泄泻，亡阳厥逆；寒饮喘咳；寒湿痹痛；选用姜科植物姜ZingiberofficinaleRosc.的干燥根茎；
红参：能大补元气，固脱生津，安神，可以用来治劳伤虚损，食少，倦怠，反胃吐食，大便滑泄，虚咳喘促，自汗暴脱，惊悸，健忘，眩晕头痛，阳痿，尿频，消渴，妇女崩漏，小儿慢惊，及久虚不复，一切气血津液不足之证；
黄芪：有益气固表、敛汗固脱、托疮生肌、利水消肿之功效；用于治疗气虚乏力，中气下陷，久泻脱肛，便血崩漏，表虚自汗，痈疽难溃，久溃不敛，血虚萎黄，内热消渴，慢性肾炎，蛋白尿，糖尿病等；
山药：补脾养胃，生津益肺，补肾涩精；用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴；选用薯蓣科植物薯蓣DioscoreaoppositaThunb.的干燥根茎；
陈皮：具有理气健脾，调中，燥湿，化痰的作用；主治脾胃气滞之脘腹胀满或疼痛、消化不良；湿浊阻中之胸闷腹胀、纳呆便溏；痰湿壅肺之咳嗽气喘；选用为芸香科植物橘及其栽培变种的干燥成熟果皮。
将上述各中药材制备成本发明的复方制剂的制备方法，包括如下步骤：称取上述五倍子、白术、苍术、韭菜籽、干姜、红参、黄芪、山药和陈皮，洗净去杂，加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮二次，第一次加总药材8-10倍量的水，煎煮2h，取煎液，滤过，第二次加总药材6-8倍量的水，煎煮1h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.10的浓缩液；将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含2.5-3.0g生药量，再加入0.2%的山梨酸钾，搅拌均匀，置0-5℃低温冷藏24h，将冷藏液滤过，得口服液。
与现有技术相比，本发明涉及的中药组合物治疗胃下垂的疗效显著，尤其是该药结合质子泵抑制剂治疗胃下垂疗效更为显著，同时能减少该病复发，疗效较为稳定。
具体实施方式
以下是本发明的具体实施例，对本发明的技术方案做进一步作描述，但是本发明的保护范围并不限于这些实施例。凡是不背离本发明构思的改变或等同替代均包括在本发明的保护范围之内。
实施例1
生药处方：五倍子2.5kg、白术1.1kg、苍术1.1kg、韭菜籽2.8kg、干姜1.1kg、红参1.1kg、黄芪2.4kg、山药6.0kg、陈皮2.8kg。
制备方法：称取上述中药材，洗净去杂，加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮二次，第一次加总药材8倍量的水，煎煮2h，取煎液，滤过，第二次加总药材8倍量的水，煎煮1h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.10的浓缩液；将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含2.5g生药量，再加入0.2%的山梨酸钾，搅拌均匀，置5℃低温冷藏24h，将冷藏液滤过，得口服液。
实施例2
生药处方：五倍子3kg、白术0.8kg、苍术1kg、韭菜籽3kg、干姜0.8kg、红参1.3kg、黄芪2.8kg、山药5kg、陈皮3.5kg。
制备方法：称取上述中药材，洗净去杂，加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮二次，第一次加总药材10倍量的水，煎煮2h，取煎液，滤过，第二次加总药材8倍量的水，煎煮1h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.10的浓缩液；将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含2.5g生药量，再加入0.2%的山梨酸钾，搅拌均匀，置0℃低温冷藏24h，将冷藏液滤过，得口服液。
实施例3
生药处方：五倍子2.4kg、白术1.5kg、苍术1.5kg、韭菜籽3.5kg、干姜1.6kg、红参0.8kg、黄芪2kg、山药7.2kg、陈皮2.3kg。
制备方法：称取上述中药材，洗净去杂，加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮二次，第一次加总药材8倍量的水，煎煮2h，取煎液，滤过，第二次加总药材6倍量的水，煎煮1h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.10的浓缩液；将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含3.0g生药量，再加入0.2%的山梨酸钾，搅拌均匀，置0℃低温冷藏24h，将冷藏液滤过，得口服液。
临床应用例
65例经确诊的胃下垂患者，临床表现以“胃脘部胀满、餐后加重”为主，且无“胃脘部疼痛”表现，经过上消化道钡餐造影证实有胃下垂。其中男性28例，女性37例，最小年龄30岁，最大年龄78岁，患者平均年龄为57.2±5.8岁。6O例患者被随机分成试验组（33例）和对照组（32例）。两组患者年龄、性别构成、病程等基本情况经均衡性检验，无显著性差异，具有可比性。对照组患者采用生理盐水100mL+泮托拉唑钠40mg静滴，1天1次，连续1周。试验组患者在对照组用药的基础上给予本发明实施例1制备的中药口服液，早、晚各服30mL，连续1周。治疗结束后，观察比较两组患者治疗后临床症状改善情况及病情复发情况，其中病情复发包括两种情况：痊愈患者1个月后再次出现胃脘胀满，好转患者1个月后症状加重或回到治疗前状态。按照以下标准评定各组疗效：
痊愈：胃脘胀满症状完全消除，饮食正常；好转：胃脘胀满症状明显减轻，饮食基本正常，但进餐后仍有轻度胃脘饱胀；无效：胃脘胀满症状无改善。
试验结果具体参见表1、表2。从表1可见，试验组总有效率明显高于对照组，分别为90.91%和53.13%。从表2可见，试验组病情复发明显少于对照组。
表1试验组与对照组疗效统计结果
表2两组治疗1个月后复发情况统计
Claims (3)
1.一种治疗胃下垂的中药组合物，其特征在于：所述的中药组合物由如下重量份的中药材原料制备而成：五倍子25份、白术11份、苍术11份、韭菜籽28份、干姜11份、红参11份、黄芪24份、山药60份、陈皮28份。
2.根据权利要求1所述的治疗胃下垂的中药组合物，其特征在于：所述的中药组合物为片剂、胶囊剂、颗粒剂或口服液。
3.权利要求1或2所述的中药组合物在制备治疗胃下垂的药物中的应用。
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