CN103751670A - 辅助肺癌化疗的中药组合物 - Google Patents
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Abstract
本发明涉及一种辅助肺癌化疗的中药组合物，由下述重量配比的原料制成：玉米叶20-100g，苏叶10-50g，桑叶15-60g，侧柏叶20-80g，七叶一枝花10-50g，沙参20-50g，仙鹤草20-120g，麦冬10-45g，百部10-50g。诸药配伍，共奏祛痰散结、润肺清心之效，化疗期间服用，对肺癌化疗患者康复疗效确切，治愈率高，减轻患者痛苦，愈后不易复发。
Description
技术领域
本发明属于中药领域，具体涉及一种辅助肺癌化疗的中药组合物。
背景技术
肺癌是发病率和死亡率增长最快，对人群健康和生命威胁最大的恶性肿瘤之一。近50年来许多国家都报道肺癌的发病率和死亡率均明显增高，男性肺癌发病率和死亡率均占所有恶性肿瘤的第一位，女性发病率占第二位，死亡率占第二位。肺癌的病因至今尚不完全明确，大量资料表明，长期大量吸烟与肺癌的发生有非常密切的关系。
肺癌的临床表现比较复杂，症状和体征的有无、轻重以及出现的早晚，取决于肿瘤发生部位、病理类型、有无转移及有无并发症，以及患者的反应程度和耐受性的差异。肺癌早期症状常较轻微，甚至可无任何不适。中央型肺癌症状出现早且重，周围型肺癌症状出现晚且较轻，甚至无症状，常在体检时被发现。肺癌的症状大致分为：局部症状、全身症状、肺外症状、浸润和转移症状。
化疗是肺癌的主要治疗方法，90％以上的肺癌需要接受化疗治疗。化疗对小细胞肺癌的疗效无论早期或晚期均较肯定，甚至有约1％的早期小细胞肺癌通过化疗治愈。化疗也是治疗非小细胞肺癌的主要手段，化疗治疗非小细胞肺癌的肿瘤缓解率为40％～50％。化疗一般不能治愈非小细胞肺癌，只能延长患者生存和改善生活质量。化疗除能杀死肿瘤细胞外，对人体正常细胞也有损害，因此化疗需要在肿瘤专科医生指导下进行。近年化疗在肺癌中的作用已不再限于不能手术的晚期肺癌患者，而常作为全身治疗列入肺癌的综合治疗方案。化疗会抑制骨髓造血系统，主要是白细胞和血小板的下降，可以应用粒细胞集落刺激因子和血小板刺激因子治疗。
发明内容
为了解决化疗不能完全治愈肺癌，给肺癌患者带来极大痛苦的问题，本发明的目的在于提供一种辅助肺癌化疗的中药组合物，与化疗相结合，提高肺癌的治愈率，减轻患者痛苦。
本发明解决其技术问题所采用的技术方案是：辅助肺癌化疗的中药组合物，由下述重量配比的原料制成：玉米叶20-100g，苏叶10-50g，桑叶15-60g，侧柏叶20-80g，七叶一枝花10-50g，沙参20-50g，仙鹤草20-120g，麦冬10-45g，百部10-50g。
优选的，辅助肺癌化疗的中药组合物，由下述重量配比的原料制成：玉米叶80g，苏叶40g，桑叶40g，侧柏叶40g，七叶一枝花30g，沙参30g，仙鹤草80g，麦冬25g，百部30g。
用法：水煎服，每日1副，每天2次。
本发明各中原料药的药理活性如下：
玉米叶，性甘，平，归脾、胃经，经现代科学研究，含有抗癌作用的多糖类物质，动物实验证明，它可抑制癌瘤生长，尤其是对肺癌有效，以新鲜的为最佳。
苏叶，辛、微温，归脾、肺经，具有散寒解表，宣肺止咳，理气和中，安胎，解毒的功效。《纲目》：行气宽中，消痰利肺，和血，温中，止痛，定喘，安胎。《本草逢原》：能散血脉之邪。
桑叶，味苦、甘、性寒，归肺、肝经，具有降气化痰、断痰丝化顽痰、清肺气、降肺火、通调水道、祛痰散结之功用。桑叶能预防癌细胞生成，提高人体免疫力，主要功能成分是DNJ、类黄酮、桑素、γ-氨基丁酸及维生素，能抑制染色体突变和基因突变。
侧柏叶，性寒、味苦，归心、肝、大肠经，侧柏叶煎剂能明显缩短出血时间及凝血时间，其止血有效成分为槲皮素和鞣质。此外，尚有镇咳、祛痰、平喘、镇静等作用。《医林纂要》：泄肺逆，泻心火，平肝热，清血分之热。
七叶一枝花，苦、凉，归心、肝、肺、胃、大肠经，败毒抗癌、消肿止痛、清热定惊、镇咳平喘。
沙参，味甘、微苦，性微寒，归肺、胃经，沙参具有滋阴生津、清热凉血之功，配合放化疗用于肿瘤患者，尤其是对晚期肿瘤病人血枯阴亏、肺阴虚之肺癌、消化道肿瘤术后气阴两虚或因放疗而伤阴引起的津枯液燥者，具有较好的疗效。
仙鹤草，苦、凉，归胃、肝、脾、肺、大肠经，败毒抗癌、凉血止血、养伤退肿。
麦冬，甘、微苦，微寒，归心、肺、胃经，养阴生津，润肺清心。用于肺燥干咳，阴虚痨嗽，喉痹咽痛，津伤口渴，内热消渴，心烦失眠，肠燥便秘。《名医别录》：疗身重目黄，心下支满，虚劳客热，口干烦渴，止呕吐，愈痿蹶，强阴益精，消谷调中，保神，定肺气，安五脏，令人肥健。
百部，性味甘、苦，微温，归肺经，润肺下气止咳，杀虫。《滇南本草》：润肺，治肺热咳嗽；消痰定喘，止虚痨咳嗽，杀虫。
本发明具有以下有益效果：诸药配伍，共奏祛痰散结、润肺清心之效，化疗期间服用，对肺癌化疗患者康复疗效确切，治愈率高，减轻患者痛苦，愈后不易复发。
具体实施方式
以下是本发明的具体实施例，对本发明的技术方案做进一步描述，但是本发明的保护范围并不限于这些实施例。凡是不背离本发明构思的改变或等同替代均包括在本发明的保护范围之内。
实施例1
辅助肺癌化疗的中药组合物，由下述重量配比的原料制成：玉米叶20g，苏叶30g，桑叶30g，侧柏叶20g，七叶一枝花40g，沙参50g，仙鹤草120g，麦冬10g，百部10g。
实施例2
辅助肺癌化疗的中药组合物，由下述重量配比的原料制成：玉米叶50g，苏叶10g，桑叶15g，侧柏叶80g，七叶一枝花50g，沙参20g，仙鹤草40g，麦冬30g，百部50g。
实施例3
辅助肺癌化疗的中药组合物，由下述重量配比的原料制成：玉米叶80g，苏叶40g，桑叶40g，侧柏叶40g，七叶一枝花30g，沙参30g，仙鹤草80g，麦冬25g，百部30g。
实施例4
辅助肺癌化疗的中药组合物，由下述重量配比的原料制成：玉米叶100g，苏叶50g，桑叶60g，侧柏叶60g，七叶一枝花10g，沙参40g，仙鹤草20g，麦冬45g，百部20g。
方中，玉米叶性甘，平，归脾、胃经，经现代科学研究，含有抗癌作用的多糖类物质，动物实验，它可抑制癌瘤生长，尤其是对肺癌有效，以新鲜的为最佳。苏叶有解表散寒、抑菌解毒、镇咳化痰之功效。桑叶具有降气化痰、断痰丝化顽痰、清肺气、降肺火、通调水道、祛痰散结之功用。侧柏叶凉血、止血、止咳。七叶一枝花败毒抗癌、消肿止痛、清热定惊、镇咳平喘。沙参养阴清肺。仙鹤草败毒抗癌、凉血止血、养伤退肿。麦冬养阴生津，润肺清心。百部润肺止咳。
利用本发明的中药组合物对59例肺癌患者辅助化疗治疗，治愈32例，有效20例，无效7例，随访至今，最长者8年未复发。
典型病例1：李**，男，农民，65岁。2008年2月经省级医院诊断为肺癌，在西医化疗的同时，配以此方治疗，1个月后检查，癌细胞钙化，未见转移。继服2个月，至今未见复发。
典型病例2：崔**，男，52岁，咳嗽、胸闷、呼吸困难、吐痰带血丝、身体消瘦两个月，于2010年3月经医院CT检查诊断为右肺中心型肺癌，西医化疗的同时服用本发明的中药，一个半月后症状明显改善，继续服用两个月CT复查肿瘤基本消失，为巩固疗效，嘱其继续服用一个月，随访至今未复发。
Claims (2)
1.辅助肺癌化疗的中药组合物，其特征在于，由下述重量配比的原料制成：玉米叶20-100g，苏叶10-50g，桑叶15-60g，侧柏叶20-80g，七叶一枝花10-50g，沙参20-50g，仙鹤草20-120g，麦冬10-45g，百部10-50g。
2.如权利要求1所述的辅助肺癌化疗的中药组合物，其特征在于，由下述重量配比的原料制成：玉米叶80g，苏叶40g，桑叶40g，侧柏叶40g，七叶一枝花30g，沙参30g，仙鹤草80g，麦冬25g，百部30g。
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| 刘亚娴: "以肺癌为例谈肿瘤的中医、中西医结合治疗合并", 《第四届中医药继续教育高峰论坛暨中华中医药学会继续教育分会换届选举会议论文集》 * |
| 闫瑢玓: "《肺抑瘤合剂治疗肺癌及对小鼠Lewis肺癌cyclinD1表达影响的临床和实验研究》", 《中国优秀博硕士学位论文全文数据库（硕士） 医药卫生科技辑》 * |
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