CN103751280A - Pharmaceutical composition for treating psoriasis - Google Patents
Pharmaceutical composition for treating psoriasis Download PDFInfo
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- CN103751280A CN103751280A CN201110309644.5A CN201110309644A CN103751280A CN 103751280 A CN103751280 A CN 103751280A CN 201110309644 A CN201110309644 A CN 201110309644A CN 103751280 A CN103751280 A CN 103751280A
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Abstract
A pharmaceutical composition for treating psoriasis and neurodermatitis comprises 1.25-16 parts of long-noded pit viper and 5-30 parts of szechwan Chinaberry fruit or Azadirachta indica, which are leached with an alcohol or ester solvent to obtain a leaching medicinal liquid for external administration. The alcohol solvent employs ethanol, isopropanol, butanol or liquor, and the pharmaceutical composition is leached in the alcohol solvent for more than three days for external administration. 10-100 parts of Tripterygium wilfordii and 10-100 parts of honeysuckle are added to prepare a liniment or an application. The leaching component obtained by the invention can be added into a hydrogel matrix to prepare a facial cleanser, a facial mask and an external application drug. The pharmaceutical composition provided by the invention has the advanategs of small side effects in the treatment of psoriasis and neurodermatitis, low cost, convenient application and simple preparation process.
Description
Invention field
The present invention relates to a kind of Chinese medicine constituent, especially a kind of antipsoriatics thing constituent.
Background technology
Psoriasis claims again psoriasis, is a kind of common chronic inflammatory disease dermatoses.Psoriasis has the feature of intractable and recurrent, and its skin lesion feature is on red pimple or speckle, to be covered with multilamellar silvery white squama, has obvious seasonality, and most of patients state of an illness spring, increase the weight of winter, and alleviate summer.Psoriasis is divided four classes, and one is homeliness type.
Two is Folium Styracis Suberifoliae type.Three is pustular type.Four is joint type.Whole nation total prevalence rate is 0.72%o, and sickness rate is on the rise nearly ten years.Think relevant with industrial pollution and working environment.Though psoriasis does not directly affect life, but healthy and physical and mental health are had a direct impact.The main cause active oxygen of psoriasis, is harmful product of body metabolism, is impregnated in blood cell interstitial, causes human body environment pollution, the change of the pure matter of blood.Occur that heat in blood, blood are dry, blood stasis, accumulate stagnant resistance and too much cause pestilent toxicity to be sent out in skin.Outbreak repeatedly all the year round, the course of disease is delayed with the passing of time hematozemia wound essence, failure of skin and muscle to be nourished, uninteresting pruritus, the insomnia of overtaxing one's nerves, wrecks health.Psoriasis due to large stretch of skin lesion and desquamation irksome.Affect society and family relation, so psoriatic's psychological problem is painful.Most of treatments can only be alleviated for the moment, can not thoroughly cure, and the toxic and side effects of Western medicine allows psoriatic's health make the matter worse simultaneously.Its pathogeny, the traditional Chinese medical science is thought: the traditional Chinese medical science thinks that psoriasis is many because of feelings will internal injury, obstruction of QI, heat lies prostrate in nutrient blood, and because of eating and drinking without temperance, surfeit raw meat is sent out food, taste are become estranged, functional activity of QI being not smooth, strongly fragrant heat-transformation of a specified duration, wind-engaging pyretic toxicity is evil and fall ill repeatedly, if disease for a long time or outbreak repeatedly, cloudy blood is consumed, qi-blood disharmony, failure of skin and muscle to be nourished, the raw wind of dryness-transformation, and suffer from this disease.
The Chinese medicine adopting at present or Western medicine all just play the effect that slows down or temporarily cure, once stop can recurring again with Ji, the medicine that can not effect a radical cure temporarily, and these products overwhelming majority is with chemical reagent, the Antibiotics of Western medicine or hormones are main, this series products is desirable effect in for the moment only often, but keep away unavoidable recurrence (bounce-back), once recurrence not only increases the weight of than original symptom, the more important thing is that more refractory is treated, even if some medicine has certain curative effect to part ordinary " psoriasis " patient, but cannot make illing skin recover as usual, to patient, cause mental pressure.
In Chinese medicine, have the oral drugs such as a part Yin Kangtai, BAICAO silver tinea is clean, curative effect still awaits improving.
Neurodermatitis has another name called chronic simple lichen.The traditional Chinese medical science is called neurodermatitis or stubborn dermatitis is a kind of common chronic dermatosis, and take skin lichenification and violent pruritus is feature.During onset, pars affecta skin often only has pruritus and occurs without erythra.After often scratching or rubbing, just occur that foxtail millet gruel is to Semen phaseoli radiati size to pimple, last slightly for a long time, because pimple increases day by day, intensive fusion, forms that dermatoglyph is deepened and the patch of the typical lichenification that cutaneous ridge swells.
Summary of the invention
The invention provides a kind of antipsoriatics compositions, a kind of externally-applied medicinal composition is especially provided, there is outstanding curative effect, have no side effect, cost is low, use conveniently, preparation technology is simply used for the treatment of the pharmaceutical composition of psoriasis and neurodermatitis.
The present invention is achieved in that this medicine comprises following component: Agkistrodon 1.25-16 part, Fructus Toosendan (or seed of Azadirachta indica, lower with) 5-30 part, form its basic composition, and soak medicinal liquid molten or that leach and put on the skin, apply for external.Especially adopt alcohols or esters solvent to soak molten, leach medicinal liquid.
Better formula is Agkistrodon 2-10 part, Fructus Toosendan (or seed of Azadirachta indica) 15-25 part.
Improvement of the present invention is: in said components, add Radix Tripterygii Wilfordii and/or Flos Lonicerae, the addition of Radix Tripterygii Wilfordii, Flos Lonicerae is: Radix Tripterygii Wilfordii 10-100 part, Flos Lonicerae 10-100 part.Alcohols solvent adopts ethanol, isopropyl alcohol, n-butyl alcohol, also can adopt Chinese liquor, and above-mentioned constituent is dipped in 200-2500 part alcohols solvent more than three days, three days i.e. pharmaceutically acceptable (external) afterwards.
Agkistrodon is that Viperidae animal snakelet etc. is removed all of internal organs.Wind-damp dispelling, saturating muscles and bones,, arresting convulsion is jerked.Can grind into powder and take 1-1.5g, enter decoction 2-log, also can infusing drugs in wine.Gas is special, sour in the mouth, hardship.Toosendanin chemical composition is containing Toosendanin (toosendanin), alkaloid, kaempferol, resin, tannin.Seed of Azadirachta indica is higher containing chinaberry element and alkaloidal ratio.Chinaberry nature and flavor are cold in nature, bitter in the mouth.Function cures mainly soothing liver-QI, promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Psoriatic morbidity and immunity have very important relation.It is that epidermal cell proliferation accelerates that psoriasic important pathophysiological becomes, and makes epidermis cell substitute time shorten, and the normal epidermis replacement time is about 26-28 days, and the epidermal replacement time of psoriatic lesion is 3-4 days.Thereby the maturation of epidermis cell is interfered, and causing epidermis histology, bar biochemical and keratinization is random, produces silvery white squama, and micro-filament forms the phenomenons such as decline and keratohyalin granule minimizing.CAMP in epidermis cell (CAMP) level reduces and ring one phosphoric acid glycosides (CGMP) level increases, and impels epidermis cell training to grow; In psoriatic's blood and in skin, the polyamines that extracts is apparently higher than normally, and therefore the variation of psoriatic pathogeny and polyamines and serine protease increase certain relation.Agkistrodon and chinaberry extractum are effective to this.
The present invention is prepared into liniment or application external by said components.The method for making of application is to be added on hydrogel matrix, makes the external drug of topical application, and the time of contact skin is long, and effect is better.The kind of hydrogel matrix is a lot: if the aqueous acrylamide acid copolymer through crosslinked is carbomer, aqueous resin of thickening, also can adopt the hydrogel after sodium alginate, agar, gelatin dissolve.Pharmaceutical compositions soaks molten more than three days external in alcohols solvent.
Alcohols solvent of the present invention adopts ethanol, n-butyl alcohol, isopropyl alcohol, Chinese liquor 500-2500 part, weight ratio optimal proportion: Chinese liquor 1000-2000 part, Agkistrodon 4-8 part, Fructus Toosendan 15-25 part.Separately can add Radix Tripterygii Wilfordii, Flos Lonicerae has better effect.
The addition of Radix Tripterygii Wilfordii, Flos Lonicerae is: Radix Tripterygii Wilfordii 10-100 part, Flos Lonicerae 10-100 part, be prepared into liniment or application type.Prescription component is added on and in hydrogel matrix, makes Cleansing Foam, facial film, the external drug of topical application.
The present invention is to treatment psoriasis and neurodermatitis toxic and side effects is little, cost is low, use convenience, and preparation is simple.
The specific embodiment:
Example one Guo, female, 28 years old, suffers from " psoriasis " approximately 1 year.The first visit time is: on February 9th, 2003, first visit symptom is very to itch in back, and the position shape of very itching is as not of uniform size in copper coin, close-packed arrays, and edge takes on a red color, xerosis cutis peeling.Adopt medicine of the present invention (liniment), coating affected part is one week continuously, and condition of illness disappears completely, the same with normal skin.On February 1st, 2004, pay a return visit this patient, do not send out so far.
Example two Chens, female, 29 years old.The first visit time is: on April 20th, 2003, first visit symptom is on shank, to be about 10 centimetres, wide approximately 4 centimetres, erose disease sites, epidermis is dried peeling, and spy itches, after hardening epidermis is taken off, expose pink soft textive, after affected part is dry, epidermis hardening again, change are itched.Adopt medicine of the present invention (application), continuous use, after 3 days, greatly takes a turn for the better, but elimination completely of gargalesthesia continues to use drug application after 15 days with advising, and above-mentioned symptom disappears completely, and the colour of skin is normally as good as.On May 2nd, 2004, specially interview this patient, do not send out so far.
Similar above-mentioned example accumulation has hundreds of example, and cure rate is more than 80%, and after curing, 100% without recurrence.Neurodermatitis example
Example three Chens, female, 29 years old.The first visit time is: on March 9th, 2004, first visit symptom has irregular pattern spy to itch for long on back of the body breast and lower limb, epidermis is somewhat hard, scratched brokenly and dropped down yellow fluid and infect other position, spurging, recently spy itches, and is diagnosed as neurodermatitis, and taking Radix Tripterygii Wilfordii symptom has alleviation, adopt medicine of the present invention (liniment), continuous use is (put affected part four to six every day, first puts outer ring on the skin) after 2 days, greatly takes a turn for the better, but gargalesthesia is not eliminated completely, with advising, continue with drug application after 10 days, symptom disappears completely, and the colour of skin is with normal the same.
Claims (8)
1. an antipsoriatics thing constituent, is characterized in that forming with following ratio, and Agkistrodon 1.25-16 part, Fructus Toosendan or seed of Azadirachta indica 5-30 part are soaked molten, leaching medicinal liquid external with alcohols or esters solvent.
2. according to claim] described antipsoriatics thing constituent, it is characterized in that Agkistrodon 2-10 part, Fructus Toosendan or seed of Azadirachta indica 15-25 part.
3. antipsoriatics thing constituent according to claim 1, is characterized in that separately adding Radix Tripterygii Wilfordii 10-100 part.
4. antipsoriatics thing constituent according to claim 1, is characterized in that separately adding Flos Lonicerae 10-100 part.
5. antipsoriatics thing constituent according to claim 1 and 2, is characterized in that being prepared into liniment or application type.
6. according to claim 3 or 4 antipsoriatics thing constituents, it is characterized in that being prepared into liniment or application type.
7. antipsoriatics thing constituent according to claim 1 and 2, is characterized in that alcohols solvent adopts ethanol, isopropyl alcohol, n-butyl alcohol or Chinese liquor, and pharmaceutical compositions soaks molten more than three days external in alcohols solvent.
8. antipsoriatics thing constituent according to claim 1 and 2, is characterized in that Chinese liquor 1000-2000 part, Agkistrodon 4-8 part, Fructus Toosendan 15-25 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110309644.5A CN103751280A (en) | 2011-10-13 | 2011-10-13 | Pharmaceutical composition for treating psoriasis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110309644.5A CN103751280A (en) | 2011-10-13 | 2011-10-13 | Pharmaceutical composition for treating psoriasis |
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| CN103751280A true CN103751280A (en) | 2014-04-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617024A (en) * | 2016-02-22 | 2016-06-01 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof |
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2011
- 2011-10-13 CN CN201110309644.5A patent/CN103751280A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617024A (en) * | 2016-02-22 | 2016-06-01 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof |
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Application publication date: 20140430 |