CN103750816B - Taking graphene mesh as sensing element carries out to intraocular pressure the method that high sensitivity measures in real time - Google Patents
Taking graphene mesh as sensing element carries out to intraocular pressure the method that high sensitivity measures in real time Download PDFInfo
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- CN103750816B CN103750816B CN201410014258.7A CN201410014258A CN103750816B CN 103750816 B CN103750816 B CN 103750816B CN 201410014258 A CN201410014258 A CN 201410014258A CN 103750816 B CN103750816 B CN 103750816B
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 77
- 229910021389 graphene Inorganic materials 0.000 title claims abstract description 77
- 230000004410 intraocular pressure Effects 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 title claims abstract description 32
- 230000035945 sensitivity Effects 0.000 title claims abstract description 15
- 210000005252 bulbus oculi Anatomy 0.000 claims abstract description 12
- 230000006698 induction Effects 0.000 claims description 16
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 13
- 229910052802 copper Inorganic materials 0.000 claims description 13
- 239000010949 copper Substances 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 12
- 238000012545 processing Methods 0.000 claims description 9
- 238000012546 transfer Methods 0.000 claims description 9
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 8
- 238000003672 processing method Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 229910052786 argon Inorganic materials 0.000 claims description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 4
- 238000005229 chemical vapour deposition Methods 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 2
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- 239000011521 glass Substances 0.000 claims description 2
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 208000010412 Glaucoma Diseases 0.000 abstract description 7
- 238000005452 bending Methods 0.000 abstract description 7
- 238000001514 detection method Methods 0.000 abstract description 7
- 238000012544 monitoring process Methods 0.000 abstract description 3
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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Abstract
The present invention proposes a kind of highly sensitive tonometry method can measuring intraocular pressure in real time, is by a kind of method measuring intraocular pressure based on graphene mesh conductive characteristic.It is attached on contact lens by sensing element graphene mesh, and by the direct contact lens of those who are investigated, obtained the intraocular pressure information of those who are investigated by the detection system be connected with sensing element.Real-Time Monitoring varieties of intraocular pressure is convenient in the present invention, is applicable to the detection of eyeball tension of glaucoma patient, simplifies intraocular pressure measuring process.Because graphene mesh is to bending hypersensitivity, improve the sensitivity of tonometry.
Description
Technical field
The present invention is a kind of method of real-time tonometry; Particularly with a kind of checkout equipment based on graphene mesh conductive characteristic, by sensing element is invested contact lens, after the direct contact lens of those who are investigated, obtained the method for the intraocular pressure information of those who are investigated by the detection system be connected with sensing element.
Background technology
Graphene mesh is the material with good mechanical properties and electrology characteristic.Compared with single-layer graphene, it has structural intergrity and the mechanical property of height; Compared with multi-layer graphene, it has better breathability and water penetration; The reaction of its pressure and pulling force to external world, for exponentially to rise, is applicable to being applied to high sensitivity device.Conductive channel in graphene mesh is netted, and along with graphene mesh is stretched, crack appears in conductive channel, when the part of conductive channel is split, resistance can be caused to rise, when whole disconnection of conductive channel, electronics then can be hindered to pass through, cause graphene mesh monolithic conductive ability to decline.When graphene mesh is attached to contact lens substrate, due to the elasticity of substrate, the crack of graphene mesh has restorability.
Intraocular pressure and intraocular pressure, refer to the tolerant counterpressure applied wall of eyeball of ophthalmic.The scope that the intraocular pressure of normal person is stabilized in normal intraocular tension is 10 ~ 21mmHg, to maintain the normal morphology of eyeball, ensure that refractive media plays maximum optical property simultaneously.Intraocular pressure increases the depression that optic disc appearance can be caused large and dark, infringement visual performance.
Glaucoma is because pathologic is high, the retinal nerve fiber infringement that intraocular pressure causes and a kind of oculopathy of defect of visual field.Glaucoma is the ophthalmic of second-biggest-in-the-world blinding, is a kind of irreversible gradual ophthalmic nerve disease.Glaucoma standard test regularly arrives ophthalmologists outpatient service to use tonometer to detect intraocular pressure (IOP).But the early stage intraocular pressure of glaucoma is also unstable, a few hours intraocular pressures only may be had within one day to raise, thus be difficult to control intraocular pressure situation and therefore measure 24 hours Diurnal IOP curves and contribute to diagnosis and treatment.Meanwhile, for severe glaucoma patient, the intraocular pressure situation understanding oneself in real time also contributes to glaucomatous detection and treatment.Therefore need to operate simple and easy, to measure accurate, practicable real-time detection tonometer.
Current detection of eyeball tension method mainly contains and refers to survey method and tonometer measurement method.Wherein, refer to that survey method is comparatively rough, and need examiner to have abundant detection experience.Tonometer mainly contains pressure-sinking type, planishing type two kinds according to measuring principle difference, although than referring to that survey method is directly perceived, accurately, mostly need the use knowledge of specialty.And there is the lower shortcoming of accuracy in Portable tenonometer.Therefore need to have easy to operate, to measure accurate feature metering system concurrently
Now widely used tonometer cannot detect mostly in real time.STMicw Electronics develops a unique sensor being embedded in contact lens in 2010, utilize an embedded micro strain gauge within a period of time, (be generally 24 hours) continuously monitoring eyes curvature.But this kind of product is not high due to the precision of sensing element, need in contact lens, embed amplification chip and carry out amplifying signal, reduce noise, therefore, this kind of product structure is complicated and cost is higher.
The present invention uses graphene mesh as sensing element, measures intraocular pressure by contact lens, can not only measure in real time, also improves the sensitivity of measurement.No longer need amplifying signal, reduce noise, reduce complexity and cost.In addition, because graphene mesh also has good light transmission, therefore after detected person's contact lens, on seeing that thing impact is very little.
Summary of the invention
The object of this invention is to provide a kind of is sensing element with graphene mesh, has high sensitivity characteristic, intraocular pressure is carried out to the measuring method measured in real time.
Technical program of the present invention lies in providing a kind of and the method that high sensitivity measures in real time is carried out to intraocular pressure.
Taking graphene mesh as sensing element carries out to intraocular pressure the method that high sensitivity measures in real time, and step is as follows:
(1) graphene mesh and integrated chip are sticked on contact lens, and be worn on eyeball;
(2) by the power transfer module collection energy in integrated chip, using graphene mesh as induction module, graphene mesh applies suitable voltage, and obtain the electric current of corresponding size; Described voltage, current value feed back to data acquisition module;
(3) voltage and current value are transferred in extraneous processing module by wireless transport module by data acquisition module;
(4) voltage obtained is compared from the current-voltage correlation of induction module under different intraocular pressure stored in current relationship and processing module, intraocular pressure numerical value can be drawn.
The invention has the beneficial effects as follows: utilize the adhesiveness of graphene mesh conductive capability to bending sensitivity and Graphene and contact lens to produce tonometry device, simplify intraocular pressure measuring process.Because graphene mesh is to bending hypersensitivity, the arrangement increases the sensitivity of tonometry.Real-Time Monitoring varieties of intraocular pressure is convenient in the present invention, is applicable to the detection of eyeball tension of glaucoma patient.
Accompanying drawing explanation
Fig. 1 is graphene mesh high sensitivity measuring instrument for intraocular pressure circuit theory diagrams.
Fig. 2 is the instrumentation plan of graphene mesh high sensitivity measuring instrument for intraocular pressure.
Fig. 3 is use principle figure of the present invention.
In figure: 1. induction module, 2. voltage output module, 3. data acquisition module, 4. power transfer module, 5. wireless transport module, 6. data processing module, 7. graphene mesh, 8. contact lens, 9. integrated chip, 10. conductive electrode, 11. eyeballs, 12. intraocular pressures increase processes, and 13. graphene meshs are stretched process.
Detailed description of the invention
The invention provides that a kind of to take graphene mesh as sensing element carry out to intraocular pressure the method that high sensitivity measures in real time, its step is as follows:
(1) graphene mesh and integrated chip are sticked on contact lens, and be worn on eyeball;
(2) by the power transfer module collection energy in integrated chip, using graphene mesh as induction module, graphene mesh applies suitable voltage, and obtain the electric current of corresponding size; Described voltage, current value feed back to data acquisition module;
(3) voltage and current value are transferred in extraneous processing module by wireless transport module by data acquisition module;
(4) voltage obtained is compared from the current-voltage correlation of induction module under different intraocular pressure stored in current relationship and processing module, intraocular pressure numerical value can be drawn.
In described step (1), the processing method of graphene mesh is:
A) be that 80 ~ 120 object copper mesh carry out cutting by specification, copper mesh size is 3 × 5 to 8 × 10cm
2, with guarantee to put into chemical vapor deposition apparatus boiler tube and can at follow-up b) process fully reacts; To pass into flow be 800 ~ 1200mL/min argon and flow is 50 ~ 80mL/min hydrogen; Furnace tubing simultaneously;
B), when temperature reaches 900-1100 DEG C in boiler tube, pass into argon flow amount and become 150 ~ 300mL/min and methane gas stream quantitative change is 10 ~ 20mL/min; Through 15 ~ 30 minutes, long good multi-layer graphene on copper mesh; Be cooled to room temperature, take out the long copper mesh having multi-layer graphene;
C) configure the liquor ferri trichloridi of 0.5 ~ 2mol/L and the hydrochloric acid solution of 0.5 ~ 2mol/L, and be mixedly configured into corrosive liquid;
D) copper mesh of multi-layer graphene is had to put into processing method c described length) corrosive liquid of configuration corrodes, until by clean for the copper mesh corrosion of being wrapped up by graphene mesh, form pure graphene mesh;
E) after etching, accept graphene mesh with ferrum net, put into deionized water and leave standstill about 10 ~ 30min, the corrosive liquid that rinsing graphene mesh speckles with;
F) processing method e is repeated), until rinse the corrosive liquid that graphene mesh speckles with completely.
Each conditional parameter for reference only above, suitably can adjust change in the actual course of processing according to the thickness of the graphene mesh wanting to process and electrology characteristic.
Integrated chip 9 in described step (1) comprises voltage output module 2, data acquisition module 3, power transfer module 4 and wireless transport module 5; Integrated chip 9 has following function: the output of energy acquisition, voltage, current detecting, data wireless transmission.
In described step (1); method graphene mesh being adhered to contact lens is: make graphene mesh float in deionized water; with tweezers, contact lens is pulled out from protection liquid; and accept the graphene mesh in deionized water with contact lens fast; after moisture natural evaporation; graphene mesh just sticks on contact lens, now contact lens can be put into protection liquid, with the character of remain undetected glasses and graphene mesh.
Fig. 1 is graphene mesh high sensitivity measuring instrument for intraocular pressure circuit theory diagrams.Voltage output module 2, data acquisition module 3, power transfer module 4 and wireless transport module 5 are integrated into integrated chip 9 in Fig. 2, are distributed in the symmetric position of contact lens both sides.In FIG, stick to graphene mesh on contact lens as induction module 1, induction module 1 is connected with voltage output module 2 and data acquisition module 3, after voltage output module 2 supplies energy by power transfer module 4, apply voltage to induction module 1, be generally 5V; Voltage on it, current value are fed back to data acquisition module 3 by induction module 1.The voltage of induction module 1 and current data are transferred in extraneous analysis and processing module 6 by wireless transport module 5 by data acquisition module 3.
Use of the present invention and measuring principle are by shown in Fig. 2 and Fig. 3.In fig. 2, graphene mesh 7 and integrated chip 9 are attached on contact lens 8.During test, contact lens 8 is worn on eyeball 11.The conductive electrode 10 of graphene mesh 7 both sides simultaneously as the input and output side of graphene mesh 7, by control and the process of integrated chip 9, detects electric current to graphene mesh 7 applied voltage.
In the present example illustrated in fig. 3, along with eyeball 11 intraocular pressure increases process 12, contact lens 8 bending curvature is reduced, graphene mesh 7 realizes being stretched process 13, thus resistance becomes large.
Above solution principle is as follows:
When people's intraocular pressure increases, eyeball can be expanded, and cornea bending curvature reduces;
Because contact lens fits in cornea, the reduction of cornea bending curvature can make contact lens bending curvature change thereupon, and contact lens is stretched, and in like manner, graphene mesh is also stretched with contact lens;
Conductive channel in graphene mesh is netted, and along with graphene mesh is stretched, crack appears in conductive channel, when the part of conductive channel is split, resistance can be caused to rise, and causes graphene mesh monolithic conductive ability to decline.
Claims (7)
1. being sensing element with graphene mesh carries out to intraocular pressure the method that high sensitivity measures in real time, and its step is as follows:
(1) graphene mesh and integrated chip are sticked on contact lens, and be worn on eyeball; Integrated chip comprises voltage output module, data acquisition module, power transfer module and wireless transport module;
(2) by the power transfer module collection energy in integrated chip, using graphene mesh as induction module, graphene mesh applies suitable voltage, and obtain the electric current of corresponding size; Described voltage, current value feed back to data acquisition module;
(3) voltage and current value are transferred in extraneous processing module by wireless transport module by data acquisition module;
(4) voltage obtained is compared from the current-voltage correlation of induction module under different intraocular pressure stored in current relationship and processing module, intraocular pressure numerical value can be drawn.
2. method according to claim 1, is characterized in that, in described step (1), the processing method of graphene mesh is:
A) copper mesh is put into the boiler tube of chemical vapor deposition apparatus; To pass into flow be 800 ~ 1200mL/min argon and flow is 50 ~ 80mL/min hydrogen; Furnace tubing simultaneously;
B), when temperature reaches 900-1100 DEG C in boiler tube, pass into argon flow amount and become 150 ~ 300mL/min and methane gas stream quantitative change is 10 ~ 20mL/min; Through 15 ~ 30 minutes, long good multi-layer graphene on copper mesh; Be cooled to room temperature, take out the long copper mesh having multi-layer graphene;
C) configure the liquor ferri trichloridi of 0.5 ~ 2mol/L and the hydrochloric acid solution of 0.5 ~ 2mol/L, and be mixedly configured into corrosive liquid;
D) copper mesh of multi-layer graphene is had to put into processing method c described length) corrosive liquid of configuration corrodes, until by clean for the copper mesh corrosion of being wrapped up by graphene mesh, form pure graphene mesh;
E) after etching, accept graphene mesh with ferrum net, put into deionized water and leave standstill 10 ~ 30min, the corrosive liquid that rinsing graphene mesh speckles with;
F) processing method e is repeated), until rinse the corrosive liquid that graphene mesh speckles with completely.
3. method according to claim 1 and 2; it is characterized in that; in described step (1); method graphene mesh being adhered to contact lens is: make graphene mesh float in deionized water; with tweezers, contact lens is pulled out from protection liquid; and accept the graphene mesh in deionized water with contact lens fast; after moisture natural evaporation; graphene mesh just sticks on contact lens; now contact lens can be put into protection liquid, with the character of remain undetected glasses and graphene mesh.
4. method according to claim 1, is characterized in that, in described step (1), integrated chip is distributed in the symmetric position of contact lens both sides.
5. method according to claim 1, is characterized in that, in described step (2), induction module is connected with voltage output module and data acquisition module, and voltage output module applies voltage to induction module after supplying energy by power transfer module; Voltage on it, current value are fed back to data acquisition module by induction module.
6. method according to claim 2, is characterized in that, the processing method of described step (1) graphene mesh is a) in step: be that 80 ~ 120 object copper mesh carry out cutting by specification, copper mesh size is 3 × 5 to 8 × 10cm
2, put into chemical vapor deposition apparatus boiler tube and can at follow-up b) step fully reacts.
7. method according to claim 5, is characterized in that, in described step (2), voltage output module applies voltage to induction module and is generally 5V.
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EP2979622A1 (en) * | 2014-07-31 | 2016-02-03 | Ophtimalia | Passive sensing means for a contact lens |
CN106681022A (en) * | 2015-11-06 | 2017-05-17 | 林惠花 | Graphene contact lens |
GB2556920A (en) * | 2016-11-25 | 2018-06-13 | Univ Liverpool | Method and apparatus for determining properties of an eye |
CN106859591A (en) * | 2017-02-23 | 2017-06-20 | 首都医科大学附属北京同仁医院 | Micro-wound implanting type sclera interlayer intraocular pressure real-time monitoring chip and detection of eyeball tension system |
CN110200586A (en) * | 2019-04-04 | 2019-09-06 | 清华大学 | A kind of intraocular pressure monitoring sensor |
CN110604561B (en) * | 2019-06-19 | 2021-05-18 | 北京大学 | Hydrogel-based electronic device and preparation method and application thereof |
CN110604560B (en) * | 2019-06-19 | 2021-08-24 | 北京大学 | Method for connecting electronic material and hydrogel substrate |
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CN101861119A (en) * | 2007-10-19 | 2010-10-13 | 森思迈德股份公司 | Intraocular pressure monitoring device |
CN102583349A (en) * | 2012-02-24 | 2012-07-18 | 东南大学 | Method for preparing graphene mesh |
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EP2852318B1 (en) * | 2012-05-21 | 2016-10-12 | Sensimed SA | Intraocular pressure measuring and/or monitoring system with inertial and/or environmental sensor |
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CN101861119A (en) * | 2007-10-19 | 2010-10-13 | 森思迈德股份公司 | Intraocular pressure monitoring device |
CN103458775A (en) * | 2011-04-07 | 2013-12-18 | 森思迈德有限公司 | Device and method for detecting ophtalmic and/or brain diseases |
CN102583349A (en) * | 2012-02-24 | 2012-07-18 | 东南大学 | Method for preparing graphene mesh |
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