CN103745907A - Sampling vacuum interface of chromatography mass spectrometer - Google Patents
Sampling vacuum interface of chromatography mass spectrometer Download PDFInfo
- Publication number
- CN103745907A CN103745907A CN201310755171.0A CN201310755171A CN103745907A CN 103745907 A CN103745907 A CN 103745907A CN 201310755171 A CN201310755171 A CN 201310755171A CN 103745907 A CN103745907 A CN 103745907A
- Authority
- CN
- China
- Prior art keywords
- cone
- sampling
- axis
- vacuum interface
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention relates to a sampling vacuum interface of a chromatography mass spectrometer. The sampling vacuum interface comprises a sampling cone and an extracting cone, and is characterized in that the abaxial design is adopted between the axis of the extracting cone and the axis of the sampling cone, and an angle between the two axes is not equal to 90DEG. The sampling vacuum interface has the advantages of less ion loss, small vacuum load, small noise interface of neutral particles and the like.
Description
Technical field
The present invention relates to a kind of vacuum interface, especially a kind of chromatograph-mass spectrometer sampling vacuum interface.
Background technology
Vacuum interface in liquid chromatography mass combined instrument is used for ion transfer that atmospheric pressure ionizationion the is produced mass analyzer to high vacuum.Because air pressure is transitioned into high vacuum region (1E-3～1E-4Torr) from atmospheric pressure region, the sudden change of air pressure makes the loss of whole system intermediate ion bundle mainly concentrate on this region, the design of vacuum interface can form the baric area (about 2Torr) of a transition between atmospheric pressure region and high vacuum region, this design can reduce the loss of ion beam and the vacuum loading of high vacuum region, so the design of vacuum interface directly has influence on the most critical index sensitivity of instrument.
The design of vacuum interface at present mainly contains two kinds: the one, and capillary design, use capillary by ion from importing high vacuum region, atmospheric pressure region, the major defect of this design is that capillary easily results in blockage, the 2nd, and bipyramid sampling Design, extraction cone is positioned at quiet district or the diffusion region after sampling cone.The sampling of quiet district can obtain maximum sampling efficiency, but because space between extraction cone and sampling cone is less, can not form effective pressure buffer district, can cause very large vacuum loading to extraction cone high vacuum region below, in order to maintain vacuum degree, the molecular pump that must use large pumping speed, causes the remarkable increase of instrument cost.
Refer to Fig. 1, tradition sampling after quiet district, in the mode of diffusion region sampling, for extraction cone 1 is vertical with the axis of sampling cone 2, extracts axis of cone line 10 and is 90 ° with sampling cone axis 20.Although this sample mode is less on the high vacuum region impact after extraction cone, because entering extraction cone from sampling cone, ion needs 90 ° of deflections, so losses of ions is larger.
Summary of the invention
In order to solve above-mentioned deficiency of the prior art, the invention provides the loss chromatograph-mass spectrometer sampling vacuum interface of minimizing ion that a kind ofly reduces vacuum loading to high vacuum region, can avoid the noise jamming of neutral particle simultaneously.
For achieving the above object, the present invention adopts following technical scheme:
A chromatograph-mass spectrometer sampling vacuum interface, comprises sampling cone and extraction cone, is characterized in:
Between described extraction axis of cone line and described sampling cone axis, adopt from the angle between axle design and two axis and be not equal to 90 degree.
As preferably, described extraction axis of cone line is parallel with described sampling cone axis.
As preferably, the distance between described extraction axis of cone line and described sampling cone axis is 0.5～5mm.
As preferably, along on sampling cone axis direction, the distance of described extraction cone cone mouth and described sampling cone cone mouth is 10～40mm.
As preferably, described extraction cone and described sampling cone axes intersect.
As preferably, described extraction cone cone mouth is extracting on axis of cone line or sampling cone axis when different from described sampling cone cone mouth.
As preferably, the distance of described extraction cone cone mouth and described sampling cone axis is 0.5～5mm
As preferably, along on sampling cone axis direction, the distance of described extraction cone cone mouth and described sampling cone cone mouth is 10～40mm.
The present invention compared with prior art has following beneficial effect:
The present invention adopts bipyramid sampling Design, and extraction cone is sampled in diffusion region, can reduce the vacuum loading to high vacuum region; Extraction axis of cone line or deflection certain angle (be less than 90 °) parallel with sampling cone axis, be offset certain parallel distance, when avoiding the noise jamming of neutral particle, while also having avoided ion to enter extraction cone from sampling cone, flight path deflection is 90 °, has reduced the loss of ion like this.
Accompanying drawing explanation
Fig. 1 samples and extracts the vacuum interface structural representation of boring while being 90 ° with sampling cone after quiet district;
Fig. 2 is vacuum interface structural representation in embodiment 1;
Fig. 3 is the vacuum interface structure ion trajectory schematic diagram that emulation obtains while being Fig. 2;
Fig. 4 is the vacuum interface structure ion trajectory schematic diagram that emulation obtains while being Fig. 1;
Vacuum interface structural representation in Fig. 5 embodiment 2.
Embodiment
Embodiment 1
A chromatograph-mass spectrometer sampling vacuum interface, comprises sampling cone and extraction cone, adopts from the angle between axle design and two axis and be not equal to 90 degree between described extraction axis of cone line and described sampling cone axis.
Preferably, described extraction axis of cone line is parallel with described sampling cone axis.
Preferably, the distance between described extraction axis of cone line and described sampling cone axis is 0.5～5mm.
Preferably, along on sampling cone axis direction, the distance of described extraction cone cone mouth and described sampling cone cone mouth is 10～20mm.
Refer to Fig. 2, for a kind of structure of vacuum interface in this patent, extract axis of cone line 201 parallel with sampling cone axis 101 in figure, distance between the two can be optimized (scope is within the scope of several millimeters) by experiment.
On extraction cone 21 and sampling cone 11, all load direct voltage, between two cones, form electrical potential difference like this, contribute to ion to transfer to extraction cone 21 from sampling cone 11, can be according to the designing requirement of instrument itself in experiment along the distance on sampling cone axis direction between two cone cone mouths, as vacuum degree, efficiency of transmission etc. are optimized.
The present embodiment also provide experimental simulation according to the ion transfer effect from axle condition of the present embodiment.Physical simulation condition is: along in sampling cone axis 101 directions, described extraction cone cone mouth 211 is 15mm with the distance of described sampling cone cone mouth 111; Distance between extraction axis of cone line 201 and sampling cone axis 10 is 2mm.Simulate effect is shown in Fig. 3.
Ion transfer effect when the present embodiment also provides traditional extraction cone of experimental simulation and sampling cone to be 90 °.Physical simulation condition is identical with the simulated conditions of Fig. 3, and along in sampling cone axis 101 directions, described extraction cone cone mouth 211 is 15mm with the distance of described sampling cone cone mouth 111; Distance between extraction axis of cone line 201 and sampling cone axis 101 is 2mm.Simulate effect is shown in Fig. 4.
Visible, under the identical prerequisite of simulated conditions, high 30% left and right of efficiency of transmission when the present embodiment is 90 ° from the efficiency of transmission of axle construction than the extraction cone of 90 ° of tradition and sampling cone, has obviously reduced the loss of ion.
Meanwhile, the mode of sampling in diffusion region can reduce the vacuum loading to high vacuum region, can avoid the noise jamming of neutral particle simultaneously.
A chromatograph-mass spectrometer sampling vacuum interface, different from the vacuum interface described in embodiment 1:
Described extraction axis of cone line and described sampling cone axes intersect, angle is θ.Described extraction cone cone mouth and described sampling cone cone mouth can, simultaneously on extraction axis of cone line or sampling cone axis, also can extract on axis of cone line or sampling cone axis during difference.
Preferably, the distance of described extraction cone cone mouth and described sampling cone axis is 1～3mm.
Preferably, along on sampling cone axis direction, the distance of described extraction cone cone mouth and described sampling cone cone mouth is 10～20mm.
Referring to Fig. 6, is a kind of structure of vacuum interface in this patent, extracts axis of cone line 201 and intersect with sampling cone axis 101 in figure.
Two axis of cone lines are at an angle after θ, also can improve the ion transmission efficiency between two cones, but also can bring the difficulty in structural design, change the structure of passage between two cones, so also can affect the barometric gradient between two cones, and then the air pressure of the high vacuum region after impact extraction cone, can in experiment, for different angles, carry out contrast experiment, obtain optimum angle value.The present embodiment is 2mm and along on sampling cone axis direction in the distance of described extraction cone cone mouth and described sampling cone axis, and when the distance that cone mouth and described sampling cone cone mouth are bored in described extraction is 20mm, θ is 130 degree.
Above-mentioned execution mode should not be construed as limiting the scope of the invention.Key of the present invention is: by designing from axle, reduced from sampling cone to the losses of ions extraction cone, the mode of sampling in diffusion region can reduce the vacuum loading to high vacuum region, can avoid again the noise jamming of neutral particle.In the situation that not departing from spirit of the present invention, within any type of change that the present invention is made all should fall into protection scope of the present invention.
Claims (7)
1. a chromatograph-mass spectrometer sampling vacuum interface, comprises sampling cone and extraction cone, it is characterized in that:
Between described extraction axis of cone line and described sampling cone axis, adopt from the angle between axle design and two axis and be not equal to 90 degree.
2. vacuum interface according to claim 1, is characterized in that: described extraction axis of cone line is parallel with described sampling cone axis.
3. vacuum interface according to claim 2, is characterized in that: the distance between described extraction axis of cone line and described sampling cone axis is 0.5～5mm.
4. vacuum interface according to claim 1, is characterized in that: described extraction axis of cone line and described sampling cone axes intersect.
5. vacuum interface according to claim 4, is characterized in that: described extraction cone cone mouth is extracting on axis of cone line or sampling cone axis when different from described sampling cone cone mouth.
6. vacuum interface according to claim 4, is characterized in that: the distance of described extraction cone cone mouth and described sampling cone axis is 0.5～5mm.
7. according to the arbitrary described vacuum interface of claim 2～5, it is characterized in that: along on sampling cone axis direction, the distance of described extraction cone cone mouth and described sampling cone cone mouth is 10～40mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310755171.0A CN103745907A (en) | 2013-12-23 | 2013-12-23 | Sampling vacuum interface of chromatography mass spectrometer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310755171.0A CN103745907A (en) | 2013-12-23 | 2013-12-23 | Sampling vacuum interface of chromatography mass spectrometer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103745907A true CN103745907A (en) | 2014-04-23 |
Family
ID=50502919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310755171.0A Pending CN103745907A (en) | 2013-12-23 | 2013-12-23 | Sampling vacuum interface of chromatography mass spectrometer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103745907A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2476340B (en) * | 2009-12-17 | 2016-06-22 | Agilent Technologies Inc | Ion funnel for mass spectrometry |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5793039A (en) * | 1995-02-27 | 1998-08-11 | Hitachi Ltd. | Mass spectrometer, skimmer cone assembly, skimmer cone and its manufacturing method |
| US6630665B2 (en) * | 2000-10-03 | 2003-10-07 | Mds Inc. | Device and method preventing ion source gases from entering reaction/collision cells in mass spectrometry |
| CN1672238A (en) * | 2002-07-31 | 2005-09-21 | 美国瓦里安澳大利亚有限公司 | Mass spectrographic analysis equipment and method |
| CN102103969A (en) * | 2009-12-17 | 2011-06-22 | 安捷伦科技有限公司 | Ion funnel for mass spectrometry |
| CN203746792U (en) * | 2013-12-23 | 2014-07-30 | 聚光科技(杭州)股份有限公司 | Chromatography-mass spectrometer sampling vacuum interface |
-
2013
- 2013-12-23 CN CN201310755171.0A patent/CN103745907A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5793039A (en) * | 1995-02-27 | 1998-08-11 | Hitachi Ltd. | Mass spectrometer, skimmer cone assembly, skimmer cone and its manufacturing method |
| US6630665B2 (en) * | 2000-10-03 | 2003-10-07 | Mds Inc. | Device and method preventing ion source gases from entering reaction/collision cells in mass spectrometry |
| CN1672238A (en) * | 2002-07-31 | 2005-09-21 | 美国瓦里安澳大利亚有限公司 | Mass spectrographic analysis equipment and method |
| CN102103969A (en) * | 2009-12-17 | 2011-06-22 | 安捷伦科技有限公司 | Ion funnel for mass spectrometry |
| CN203746792U (en) * | 2013-12-23 | 2014-07-30 | 聚光科技(杭州)股份有限公司 | Chromatography-mass spectrometer sampling vacuum interface |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2476340B (en) * | 2009-12-17 | 2016-06-22 | Agilent Technologies Inc | Ion funnel for mass spectrometry |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN203746792U (en) | Chromatography-mass spectrometer sampling vacuum interface | |
| CN103745907A (en) | Sampling vacuum interface of chromatography mass spectrometer | |
| CN203405748U (en) | Gas sample introduction flow control system of mass spectrometer | |
| CN101599407B (en) | Array type microfaraday cage | |
| CN104597156A (en) | Two-column system gas chromatograph | |
| Fang et al. | Butterfly community structure and diversity in Qinling National Botanical Garden, China | |
| CN204405611U (en) | Dual column system gas chromatograph | |
| CN202837255U (en) | Gas circuit structure of adsorption instrument | |
| CN105783903A (en) | Fiber-optic gyroscope data acquisition system based on USB | |
| CN106287052A (en) | A kind of novel exhaust pipe connector | |
| CN210607180U (en) | Inductively coupled plasma mass spectrometry interface device | |
| CN202550378U (en) | Isolating switch device for GIS (gas insulated switchgear) combined electrical appliance | |
| Accettura | Ultra-high vacuum characterization of advanced materials for future particle accelerators | |
| CN202268323U (en) | Ion transference tube | |
| CN204334774U (en) | The allotter circuit of multi output end | |
| CN202947902U (en) | Push-pull closed pulverized coal sampler | |
| CN102983053B (en) | A kind of ion reception device | |
| CN202905129U (en) | Combined Chinese vertical bamboo flute | |
| CN206564157U (en) | A kind of branch's insulator | |
| Słomińska et al. | Soxhlet extraction and new developments such as soxtec in: Comprehansive Sampling and Sample Preparation | |
| CN204241495U (en) | A kind of head space instrument is automatically fixed time and determines the dual-purpose sampling air-channel system of volume | |
| CN204255700U (en) | For the sampling probe of kiln tail CO gas analyzing apparatus | |
| CN106821141A (en) | A kind of novel dust collector | |
| CN204973988U (en) | Multi -functional centrifugal connecting pipe | |
| CN204515410U (en) | A kind of vehicle-mounted Sensor Network data analysis facilities of bus Network Based |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140423 |