CN103735261A - Brain electricity monitoring sedation depth close loop control injection pump device - Google Patents
Brain electricity monitoring sedation depth close loop control injection pump device Download PDFInfo
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- CN103735261A CN103735261A CN201410001522.3A CN201410001522A CN103735261A CN 103735261 A CN103735261 A CN 103735261A CN 201410001522 A CN201410001522 A CN 201410001522A CN 103735261 A CN103735261 A CN 103735261A
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Abstract
The invention relates to a brain electricity monitoring sedation depth close loop control injection pump device. The brain electricity monitoring sedation depth close loop control injection pump device comprises a brain electricity data gathering module and an injection module host machine which are integrated in the same device, wherein the brain electricity data gathering module is used to gather original brain electricity signals of a human body and convert the original brain electricity signals into a quantized data index which can monitor the sedation depth, and the injection module host machine is connected with the brain electricity data gathering module, and used to confirm sedation drug administration parameter information according to the quantized data index and control sedation drug injection doses according to the sedation drug administration parameter information. The brain electricity monitoring sedation depth close loop control injection pump device achieves integration of brain electricity monitoring technology and injection pump technology, uses the brain electricity monitoring sedation depth to perform close loop control, achieves individualized drug administration and accurate drug use, avoids clinic harm generated due to deep or shallow anesthesia or sedation, and avoids negative effects brought to a patient, which are generated due to large or small doses.
Description
Technical field
The present invention relates to a kind of anesthesia (calmness) medicine intravenous injection (or infusion) automaton, be specifically related to a kind of eeg monitoring sedation depth closed loop control syringe pump apparatus, belong to anesthesiology technical field.
Background technology
How applying more accurately downern enforcement anesthesia is the problem that clinical vein anesthesia faces.In recent years, such as brain Bispectral index (Bispectral Index, BIS), and Auditory Evoked Potential Index (Auditory Evoked Potential Index, AEPindex, AEPI), NCT (Narcotren index anesthesia/brain electricity consciousness depth monitoring system), anesthesia entropy (EEG spectral entropy), CSI(cerebral State Index) can react brain mind composition and instruct and better use the custodial care facility of downern more and more in clinical practice, doctor is according to the dosage of brain electricity index manual adjustments syringe pump.
Because syringe pump and monitor are all products independently, and at present in the world the approved brain electricity monitor (such as BIS) authenticating by U.S. FDA be all external product.Because there is certain difficulty in technology more complicated, the exploitation of the general index of this brain electricity double frequency, so, the current domestic syringe pump producer that has, utilizing third party's monitor is the reserved communication interface of other designated equipment, in the syringe pump that monitoring data receiver is produced to oneself, by data the brain Bispectral index going out from numerous monitoring extracting data, and control syringe pump automatic chemical feeding as leading indicator, with this, realize closed loop administration injection.
But above-mentioned syringe pump prior art is not a complete product.Can only say on syringe pump with a data communication interface.If user wants to use closed loop drug administration by injection function, must possess the condition that has monitor.In addition, there is very big clinical risk in technology application: anesthesia monitor is all multi-parameter monitoring equipment, not only has data of brain Bispectral index, also has many other monitoring data, such as: heart rate, blood pressure, pulse oxygen etc.Monitor is the reserved communication interface of other designated equipment, it is not the data-interface for using to non-designated third party device, the data of transmission also can be carried out different technical finesses for its different designated equipment, monitor manufacturer can not guarantee the accuracy of its data on non-designated third party device, if receive these data and as Main Basis or the index of equipment administration, produce so possibly error, so-called " least bit leading to great error of difference ", severe patient can cause malpractice, because narcotics is all to belong to the great medicine of hazardness, excessive administration risk is very big.
Summary of the invention
Provide hereinafter about brief overview of the present invention, to the basic comprehension about some aspect of the present invention is provided.Should be appreciated that this general introduction is not about exhaustive general introduction of the present invention.It is not that intention is determined key of the present invention or pith, and nor is it intended to limit the scope of the present invention.Its object is only that the form of simplifying provides some concept, usings this as the preorder in greater detail of discussing after a while.
The invention provides a kind of eeg monitoring sedation depth closed loop control syringe pump apparatus, in order to realize the automatic chemical feeding closed loop control of downern, reduce administration risk.
A kind of eeg monitoring sedation depth closed loop control syringe pump apparatus provided by the invention, comprising:
Be integrated in brain electric data collecting module and injection module main frame in same device;
Described brain electric data collecting module for gather the original EEG signals of human body and be translated into can sedation depth monitoring quantized data index;
Described injection module main frame is connected with described brain electric data collecting module, for determining downern administration parameter information according to described quantized data index, carries out downern injection dose control according to described administration parameter information.
Eeg monitoring sedation depth closed loop control syringe pump apparatus provided by the invention, install and self be integrated with brain electric data collecting module and injection module main frame, it is a complete product facility with the automatic chemical feeding closed loop control function of downern, realize integrated by eeg monitoring technology and syringe pump technology, and used eeg monitoring sedation depth to carry out closed loop control.Because injection module main frame in device carries out the eeg data that downern is injected dose automatic chemical feeding closed loop control institute foundation, directly to be gathered by the integrated brain electric data collecting module of same device, therefore got rid of because third party device disturbs the error causing to the human body initial data gathering, reduced administration risk, individual administration, accurately medication have been realized, avoid the mistake of anesthesia (calmness) degree of depth dark or cross the clinical harm of shallow generation, and avoided the excessive or too small negative interaction bringing to patient of dose.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, to the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skills, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
One of theory diagram of the eeg monitoring sedation depth closed loop control syringe pump apparatus that Fig. 1 provides for the embodiment of the present invention;
Two of the theory diagram of the eeg monitoring sedation depth closed loop control syringe pump apparatus that Fig. 2 provides for the embodiment of the present invention;
The control method schematic diagram that Fig. 3 is eeg monitoring sedation depth closed loop control syringe pump apparatus that the embodiment of the present invention is provided.
The specific embodiment
For making object, technical scheme and the advantage of the embodiment of the present invention clearer, below in conjunction with the accompanying drawing in the embodiment of the present invention, technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, rather than whole embodiment.The element of describing in an accompanying drawing of the present invention or a kind of embodiment and feature can combine with element and feature shown in one or more other accompanying drawing or embodiment.It should be noted that for purposes of clarity, in accompanying drawing and explanation, omitted expression and the description of unrelated to the invention, parts known to persons of ordinary skill in the art and processing.Embodiment based in the present invention, the every other embodiment that those of ordinary skills obtain under the prerequisite of not paying creative work, belongs to the scope of protection of the invention.
Common anesthesia is body weight, the age rough estimate tranquilizer dosage with patient, and in art, by blood pressure, heart rate, judge the depth of anesthesia (calmness), and blood pressure, heart rate are subject to the impact that operation stimulates, the degree of depth that can not accurately reflect anesthesia (calmness), therefore, in anaesthesia process, doctor's experience has played decisive action to a great extent.And due to individual variation, the adult of same body weight, reaction to the same anesthetic and sedative drugs thing of Isodose also may vary, even if veteran doctor also cannot make different patients reach desirable depth of anesthesia, thereby be born for the instrument and equipment of special monitoring anesthesia (calmness) degree of depth.
The instrument monitoring of anesthesia (calmness) degree of depth has experienced and studies widely and attempt, as plethysmogram, frontalis electricity, skin resistance, lower esophageal contractility, heart rate variability, original electroencephalogram with bring out current potential etc.By continuous clinical verification, above-mentioned most methods is owing to cannot reflecting well that anesthesia (calmness) degree of depth or interference factor are too much, and (or needing further perfect) is gradually eliminated.Only have the derivation index according to original electroencephalogram---brain Bispectral index (Bispectral Index, BIS), and Auditory Evoked Potential Index (Auditory Evoked Potential Index, AEPindex, AEPI), NCT (Narcotren index anesthesia/brain electricity consciousness depth monitoring system), anesthesia entropy (EEG spectral entropy), CSI(cerebral State Index) become the application indexes more likely of monitoring anesthesia (calmness) degree of depth, be used widely gradually clinically.
Brain Bispectral index (Bispectral Index, BIS), refer to and measure the linear composition (frequency and power) of electroencephalogram, be parsed into again the non-linear relation (position phase and harmonic wave) between partial wave, the various EEG signals that can represent different level of sedation are picked out, carry out standardization and digitized processing, be finally converted into a kind of simple quantizating index.The size of brain Bispectral index value and calm, consciousness, memory height correlation, not only closely related with normal physiological sleep, the sedation degree in Depth of Anesthesia, has higher specificity and sensitivity well.At present, this index is as the index that detects sedation depth of anaesthesia, in clinical middle extensive use.Coordinate intravenous anesthesia infusion apparatus (as syringe pump), the calm dosage of manual control, can reach good anesthesia sedation effect simultaneously.
In surgery anesthesia process, medical personnel only rely on manpower can not accomplish that carrying out that again can be real-time manually adjusted dosage in the fluctuation of Real Time Observation brain Bispectral index; Therefore, medical personnel need to a kind ofly both can detect brain Bispectral index in real time, can automatically control according to the fluctuation of brain Bispectral index the infusion apparatus (syringe pump) of dosage again.
Yet, because by human body directly obtain brain Bispectral index technology more complicated, there is certain difficulty; So, current some infusion apparatus (as syringe pump) producer, in a disguised form utilizing third party's anesthesia monitor is the reserved communication interface of other designated equipment, in the syringe pump that monitoring data receiver is produced to oneself, by going out brain Bispectral index from numerous monitoring extracting data, and control syringe pump automatic chemical feeding as leading indicator, with this, realize the object of closed loop administration.
But, because anesthesia monitor belongs to comprehensive anesthesia monitoring equipment, brain Bispectral index is one of its numerous monitoring data, monitor is the reserved communication interface of other designated equipment, its effect is not data-interface open, that use to non-designated third party device, and the data of transmission also can be carried out different technical finesses for different designated equipments; Anesthesia monitor manufacturer can not guarantee the accuracy of its data on non-designated third party device, if receive these data and as Main Basis or the index of equipment administration, produce so possibly error, so-called " least bit leading to great error of difference ", severe patient can cause malpractice.
As mentioned above, although brain Bispectral index (BIS) index as the index that detects sedation depth of anaesthesia, the sedation depth in Depth of Anesthesia well, and being widely used in clinical; But because approach or mode that collection is obtained are improper, not only can not accomplish accurate closed loop administration, also can produce serious problem, even jeopardize patient's life.
The present invention, in order to overcome above-mentioned defect, provides a kind of complete product equipment that is integrated with brain electric data collecting module and injection module main frame, i.e. eeg monitoring sedation depth closed loop control syringe pump apparatus.Because injection module main frame in device carries out the eeg data that downern is injected dose administration closed loop control institute foundation, directly to be gathered by the integrated brain electric data collecting module of same device, therefore got rid of because third party device disturbs the error causing to the human body initial data gathering, reduced administration risk.Below in conjunction with accompanying drawing, technical scheme of the present invention is described in detail.
The theory diagram of the eeg monitoring sedation depth closed loop control syringe pump apparatus that Fig. 1 provides for the embodiment of the present invention.As shown in Figure 1, the eeg monitoring sedation depth closed loop control syringe pump apparatus 1 that the present embodiment provides comprises: brain electric data collecting module 11 and injection module main frame 12.
Brain electric data collecting module 11 for gather the original EEG signals of human body of human body (as patient) and be translated into can sedation depth monitoring quantized data index.Wherein, the original EEG signals abundant information of human body, can include but not limited to following one or more: brain wave spectrum, frequency, power, the frontalis signal of telecommunication, human body impedance, quantized data index that can sedation depth monitoring can include but not limited to following one or more: BIS(Bispectral Index, brain Bispectral index), AEPI (Auditory Evoked Potential Index, AEPindex, Auditory Evoked Potential Index), NCT (Narcotren index anesthesia/brain electricity consciousness depth monitoring system), anesthesia entropy (EEG spectral entropy), CSI(cerebral State Index) quantitative EEG (quantitative EEG), edge frequency spectrum (SpectralEdge Frequency), meta frequency spectrum (mean power frequency) etc. comes from brain electricity, be used for monitoring the quantized data index of sedation depth of anaesthesia (the consciousness degree of depth).By the original EEG signals of above-mentioned human body carry out analytical calculation be converted into above one or more can sedation depth monitoring the technology of quantized data index, be prior art, the present invention does not repeat them here.
Injection module main frame 12 is connected with brain electric data collecting module 11, for determining downern administration parameter information according to the described quantized data index of brain electric data collecting module 11 outputs, carries out downern injection dose control according to described administration parameter information.The implementation of injection module main frame of the present invention is very flexible, for example: injection module main frame can regulate the speed of injectable drug and with this speed constant speed, inject after adjusting according to described administration parameter information.Or injection module main frame can also regulate target level (being target blood drug level) according to described administration parameter information, constant by regulating the target level of injectable drug to maintain target blood drug level.Administration parameter information can include but not limited to following one or more: dosage, injection speed, TCI target level.
The eeg monitoring sedation depth closed loop control syringe pump apparatus that the present embodiment provides is integrated with brain electric data collecting module and injection module main frame, brain electric data collecting module directly gathers the original EEG signals of human body and is converted into the quantized data index that can monitor sedation depth, this quantized data index is sent to injection module main frame, the situation of change of this quantized data index of injection module host supervision is also carried out downern injection dose according to testing result and is controlled, using this eeg monitoring sedation depth closed loop control syringe pump apparatus human body to be carried out in the process of eeg monitoring thus, can realize the automatic chemical feeding closed loop control of downern, avoided the mistake of anesthesia (calmness) degree of depth dark or cross the clinical harm of shallow generation, avoid the excessive negative interaction bringing to patient of dose, realize individual administration, accurately administration, and the quantized data index of automatic chemical feeding closed loop control institute foundation is to be provided by the integrated brain electric data collecting module of same device, therefore, got rid of because third party device disturbs to the original EEG signals of the human body gathering the error causing, reduced administration risk.
(1), in technique scheme, the optional structure of brain electric data collecting module 11 as shown in Figure 2, comprising: the brain electric transducer 111, human body cable 112, data conversion module 113 and the main frame cable 114 that connect successively, concrete:
Brain electric transducer 111 is connected with human body cable 112, for gathering the original EEG signals of human body.Brain electric transducer can be but is not limited to brain electrode sheet, and during use, brain electrode sheet is attached to human body brain, by electrode points, gathers the primitive organism signal of telecommunication (being the original EEG signals of human body) that human body brain produces.
Adopt this technical scheme, injection module main frame can directly obtain the original EEG signals of human body from installing integrated brain electric data collecting module, and the quantity of information of the original EEG signals of human body is abundant, can meet the administration demand for control of injection module main frame.This technical scheme is controlled required information without obtain administration by third party device, has got rid of thus because third party device disturbs to the original EEG signals of the human body gathering the error causing, and has reduced administration risk.
(2), in technique scheme, the optional structure of injection module main frame 12 as shown in Figure 2, comprising: data monitoring analysis module 121 and drug administration by injection control module 122 are concrete:
Data monitoring analysis module 121 is connected with brain electric data collecting module 11, and the situation of change of the described quantized data index sending for monitor cerebral electric data collecting module 11 is adjusted downern administration parameter information according to monitoring result.
Drug administration by injection control module 122 is connected with data monitoring analysis module 121, for carry out the administration of downern according to described downern administration parameter information, controls.
Further, injection module main frame 12 also can comprise man-machine interaction display module 123.Man-machine interaction display module 123 is connected with described drug administration by injection control module with described data monitoring analysis module respectively, be used for adopting figure and/or written form to show following one or more information, the original EEG signals of described human body, described quantized data index, described downern administration parameter information.
(21) in an optional implementation, data monitoring analysis module 121 can further comprise: analyze submodule 1211, monitoring submodule 1212 and output sub-module 1213.
Described monitoring submodule 1212 is connected with described brain electric data collecting module 11, for monitoring the situation of change of the quantizating index data of described brain electric data collecting module 11 outputs.
Described analysis submodule 1211 is connected with described output sub-module 1213 with described monitoring submodule 1212 respectively, for adjusting downern administration parameter information and export to described output sub-module 1213 according to the monitoring result of described monitoring submodule 1212.
Described output sub-module 1213 is connected with described drug administration by injection control module 122 with described analysis submodule 1211 respectively, for described downern administration parameter information is processed into corresponding drug administration information and sends to described drug administration by injection control module 122.
In technique scheme, described quantized data index comprise following one or more: BIS, AEPI, NCT, anesthesia entropy, CSI, quantitatively EEG, edge frequency spectrum.Described analysis submodule 1211 can be adjusted downern administration parameter information and export to described output sub-module 1213 according to the monitoring result of above-mentioned one or more quantized data indexs.For example: monitoring submodule 1212 is for the variation of quantized data index (as BIS) described in Real-Time Monitoring.Analyzing submodule 1211 compares the value of described quantized data index (as BIS) and predetermined upper limit value or predetermined lower bound value (reservation threshold) to analyze with adjustment downern administration parameter information.For example: when BIS sedation depth changes higher than capping threshold values, illustrate that current sedation depth is inadequate, should increase dose; When sedation depth changes lower than lower limit threshold values, illustrate that current sedation depth is excessively dark, should reduce dosage.Simultaneously, according to the changing value of the associated BIS value of sedation depth, adopt special algorithm calculate the final increasing dose of downern or subtract dose, and according to the instruction of result of calculation output increase and decrease medicine, for example: when BIS surpasses predetermined upper limit value, to output sub-module 1213 outputs, increase medicine instruction; When BIS surpasses predetermined lower bound value, to output sub-module 1213 outputs, subtract medicine instruction.
Preferably, analyzing submodule 1211 also can be used for determining original electroencephalogram (EEG) data and/or electromyogram (EMG) data according to the original EEG signals of described human body, the monitoring result of comprehensive described quantized data index situation of change and described original EEG data and/or electromyographic data, adjust downern administration parameter information.For example: in the technical program, when brain Bispectral index (BIS) reaches pre-set threshold value, analyze submodule 1211 and can in conjunction with the vibration frequency of current EMG relative strength index and/or EEG curve, carry out comprehensive analysis simultaneously, determine the accuracy that BIS value changes, thereby reach the object of the current human body sedation depth of correct judgement.Particularly, human body is very complicated physiological system, BIS changes may there is interference, for fear of simple BIS, change the erroneous judgement that causes administration, BIS is judged in conjunction with EEG, EMG first judge whether BIS surpasses pre-set threshold value, if surpassed, in conjunction with the relative strength index of EMG and/or the vibration frequency of EEG curve, further judge, whether the variation of seeing thus BIS is caused when the interference of forebrain consciousness situation by frontalis electrical activity or human body.Generally speaking, EMG index is lower shows that frontalis electrical activity is more weak, less to the interference of BIS; Index is higher shows that frontalis electrical activity is stronger, also larger to the interference of BIS; The frequency fluctuation of EEG curve illustrate sooner when forebrain consciousness more clear-headed, also larger to the interference of BIS; Frequency fluctuation illustrate more gently when forebrain consciousness fuzzyyer, also less to the interference of BIS.BIS carries out the step of comprehensive judgement in conjunction with EEG, EMG, can be judged by operative site medical worker, to this, data monitoring analysis module of the present invention also can comprise controlling alarm unit (not shown), this controlling alarm unit is connected with brain electric data collecting module, for monitoring the variation of described brain Bispectral index, when the value of described brain Bispectral index surpasses predetermined threshold (predetermined upper limit value or predetermined lower bound value), output alarm information is also interrupted described drug administration by injection control module and is carried out administration control.The control instruction that described drug administration by injection control module can be accepted medical worker at warning intercourse is determined as increased medicine, subtracting the actual administration controls such as medicine.Further, for fear of described drug administration by injection control module, can not get for a long time feedback and incur loss through delay administration and control, impact operation is carried out smoothly, and data monitoring analysis module of the present invention also comprises time delay control unit (not shown).Time delay control unit is connected with described drug administration by injection control module with described alarm unit respectively, for when described alarm unit output alarm information, start computation delay, if do not receive the external command of adjusting administration parameter and carrying out administration between time delay,, after time delay finishes, control described drug administration by injection control module and recover administration according to former setting administration parameter.
Described output sub-module 1213 is connected with drug administration by injection control module 122 with analysis submodule 1211 respectively, for described downern administration parameter information is processed into corresponding drug administration information and sends to drug administration by injection control module 122.The target control of might as well take injection describes as example: output sub-module 1213 is for according to increasing, subtract medicine instruction, changing value according to sedation depth of anaesthesia, drug parameters is calculated, determined the target level that finally increases, subtracts downern, and output to drug administration by injection control module.
(22) in an optional implementation, drug administration by injection control module 122 comprises: syringe thrust unit 1221 and step motor control module 1222.
Step motor control module 1222 is connected with syringe thrust unit 1221 with data monitoring analysis module 121 respectively, for the downern administration parameter information injector-actuated thrust unit 1221 sending according to data monitoring analysis module 121.For example: administration parameter information can include but not limited to dosage and/or injection speed; Step motor control module 1222 comprises motor and control circuit, realizes the accurate speed governing of motor by control circuit, for controlling actual injection speed and the dosage of syringe pump.
(23) in an optional implementation, man-machine interaction display module 123 comprises: LCD MODULE 1231 and the touch-control module 1232 being connected with LCD MODULE 1231.
Touch-control module 1232 is controlled LCD MODULE 1231 according to the touch information receiving.For example: touch-control module 1232, for the operation that taps of graphical functional keys in response screen, completes the various functions of design in advance, realizes more simple man-machine interaction mode.
The control method schematic diagram that Fig. 3 is eeg monitoring sedation depth closed loop control syringe pump apparatus that the embodiment of the present invention is provided.As shown in Figure 3, the control method of eeg monitoring sedation depth closed loop control syringe pump apparatus comprises: brain electric data collecting module gather patient's the original EEG signals of human body and be translated into can sedation depth monitoring quantized data index, and send described quantized data index to injection module main frame; Injection module main frame carries out Real-Time Monitoring and analysis to described quantized data index, according to the injection dose of monitoring and analysis result control downern, to realize the administration of human body (as patient) closed loop automatic injection.In Fig. 3, solid line loop is the route signal of closed loop drug administration by injection, concrete, for example:
Brain electric data collecting module is obtained patient's the original EEG signals of human body by brain electric transducer.For example: the brain electric transducer by brain Bispectral index acquisition module directly gathers the original EEG signals of human body, and after data conversion module carries out filtering, amplification and computing etc. and processes, obtain can sedation depth monitoring the crucial eeg data of quantized data index (as BIS value etc.).
Data monitoring analysis module is monitored the situation of change of described quantized data index, according to monitoring result, adjusts downern administration parameter information.For example: data monitoring submodule carries out Real-Time Monitoring by monitoring submodule to the situation of change of described quantized data index, by analyzing submodule, described quantized data index is analyzed, the described quantized data index real-time monitoring is synchronizeed to relative analysis with predetermined threshold (upper and lower marginal value), when being about to meet or exceed default upper and lower marginal value, carry out alarm, and determine whether to increase, subtract administration according to relative analysis result, to adjust the administration parameter information of downern.Data monitoring analysis module also can be by man-machine interaction display module, the information such as the original EEG signals of described human body, described quantized data index, described downern administration parameter information are shown to figure and textual form on the display screen of man-machine interaction display module, and can to data parameters, operate by touch-control interface.
The administration parameter informations such as the dosage after drug administration by injection control module is adjusted according to data monitoring analysis module, injection speed, carry out the actual administration of downern and control.
Technical scheme provided by the invention, by being attached to the brain electric transducer of human body brain, gather the original EEG signals of human body, based on the original EEG signals of human body, directly obtain as eeg datas such as brain Bispectral indexes, got rid of because third party device disturbs the error causing to initial data; And can effectively monitor the sedation depth of anaesthesia of In surgery patient, and according to the variation of sedation depth of anaesthesia, automatically control the consumption of downern, solve because of the inaccurate problem of different individual patient difference administration.Further, the present invention also can by described quantized data index (as BIS) in conjunction with based on as described in the original EEG signals of human body original electroencephalogram (EEG) and/or the electromyogram (EMG) determined comprehensively analyze, determine and monitor the variation of sedation depth of anaesthesia, accurate Calculation and control dosage, reaches the object of closed loop automatic chemical feeding; Thereby changed in common surgery anesthesia, rely on and manually cannot accurately judge the situation of individual patient difference, improved the safety in anaesthesia process, there is good society and using value.
In the various embodiments described above of the present invention, the sequence number of embodiment and/or sequencing are only convenient to describe, and do not represent the quality of embodiment.Description to each embodiment all emphasizes particularly on different fields, and there is no the part of detailed description in certain embodiment, can be referring to the associated description of other embodiment.
One of ordinary skill in the art will appreciate that: all or part of step that realizes said method embodiment can complete by the relevant hardware of programmed instruction, aforesaid program can be stored in a computer read/write memory medium, this program, when carrying out, is carried out the step that comprises said method embodiment; And aforesaid storage medium comprises: various media that can be program code stored such as read only memory (Read-Only Memory is called for short ROM), random access memory (Random Access Memory is called for short RAM), magnetic disc or CDs.
In the embodiment such as apparatus and method of the present invention, obviously, each parts or each step reconfigure after can decomposing, combine and/or decomposing.These decomposition and/or reconfigure and should be considered as equivalents of the present invention.Simultaneously, in the above in the description of the specific embodiment of the invention, the feature of describing and/or illustrating for a kind of embodiment can be used in same or similar mode in one or more other embodiment, combined with the feature in other embodiment, or substitute the feature in other embodiment.
Should emphasize, term " comprises/comprises " existence that refers to feature, key element, step or assembly while using herein, but does not get rid of the existence of one or more further feature, key element, step or assembly or add.
Finally it should be noted that: although described above the present invention and advantage thereof in detail, be to be understood that in the situation that do not exceed the spirit and scope of the present invention that limited by appended claim and can carry out various changes, alternative and conversion.And scope of the present invention is not limited only to the specific embodiment of the described process of description, equipment, means, method and step.One of ordinary skilled in the art will readily appreciate that from disclosure of the present invention, can use carry out with the essentially identical function of corresponding embodiment described herein or obtain process, equipment, means, method or step result essentially identical with it, that existing and will be developed future according to the present invention.Therefore, appended claim is intended to comprise such process, equipment, means, method or step in their scope.
Claims (10)
1. an eeg monitoring sedation depth closed loop control syringe pump apparatus, is characterized in that, comprising:
Be integrated in brain electric data collecting module and injection module main frame in same device;
Described brain electric data collecting module for gather the original EEG signals of human body and be translated into can sedation depth monitoring quantized data index;
Described injection module main frame is connected with described brain electric data collecting module, for determining downern administration parameter information according to described quantized data index, carries out downern injection dose control according to described administration parameter information.
2. eeg monitoring sedation depth closed loop control syringe pump apparatus according to claim 1, is characterized in that,
Described brain electric data collecting module comprises: the brain electric transducer, human body cable, data conversion module and the main frame cable that connect successively;
Described human body cable is for sending to described data conversion module by the original EEG signals of human body of described brain electric transducer collection;
Described data conversion module for the original EEG Processing of described human body is converted into can sedation depth monitoring quantized data index, and described quantized data index sends to described injection module main frame through described main frame cable.
3. eeg monitoring sedation depth closed loop control syringe pump apparatus according to claim 1 and 2, is characterized in that, described injection module main frame comprises: data monitoring analysis module and drug administration by injection control module;
Described data monitoring analysis module is connected with described brain electric data collecting module, for monitoring the situation of change of described quantized data index, according to monitoring result, adjusts downern administration parameter information;
Described drug administration by injection control module is connected with described data monitoring analysis module, for carry out the administration of downern according to described downern administration parameter information, controls.
4. eeg monitoring sedation depth closed loop control syringe pump apparatus according to claim 3, is characterized in that, described data monitoring analysis module comprises: monitoring submodule, analysis submodule and output sub-module;
Described monitoring submodule is connected with described brain electric data collecting module, for monitoring the situation of change of the quantizating index data of described brain electric data collecting module output;
Described analysis submodule is connected with described output sub-module with described monitoring submodule respectively, for adjusting downern administration parameter information and export to described output sub-module according to the monitoring result of described monitoring submodule;
Described output sub-module is connected with described drug administration by injection control module with described analysis submodule respectively, for described downern administration parameter information is processed into corresponding drug administration information and sends to described drug administration by injection control module.
5. eeg monitoring sedation depth closed loop control syringe pump apparatus according to claim 3, is characterized in that, described drug administration by injection control module comprises: syringe thrust unit and step motor control module; Described syringe thrust unit is for carrying out the injection of downern;
Described step motor control module is connected with described syringe thrust unit with described data monitoring analysis module respectively, for driving described syringe thrust unit according to described downern administration parameter information.
6. eeg monitoring sedation depth closed loop control syringe pump apparatus according to claim 3, is characterized in that, also comprises: man-machine interaction display module;
Described man-machine interaction display module is connected with described drug administration by injection control module with described data monitoring analysis module respectively, for adopting figure and/or written form to show following one or more information: the original EEG signals of described human body, described quantized data index, described downern administration parameter information.
7. eeg monitoring sedation depth closed loop control syringe pump apparatus according to claim 6, is characterized in that, described man-machine interaction display module comprises LCD MODULE and the touch-control module being connected with described LCD MODULE.
8. eeg monitoring sedation depth closed loop control syringe pump apparatus according to claim 3, is characterized in that,
The original EEG signals of described human body comprise following one or more: brain wave spectrum, frequency, power, the frontalis signal of telecommunication, human body impedance; And/or,
Described quantized data index comprise following one or more: BIS, AEPI, NCT, anesthesia entropy, CSI, quantitatively EEG, edge frequency spectrum; And/or,
Described data monitoring analysis module is connected with described brain electric data collecting module, also for determining original EEG data and/or electromyographic data according to the original EEG signals of described human body, the monitoring result of comprehensive described quantized data index situation of change and described original EEG data and/or electromyographic data, adjust downern administration parameter information.
9. eeg monitoring sedation depth closed loop control syringe pump apparatus according to claim 3, is characterized in that, described data monitoring analysis module comprises:
Controlling alarm unit, be connected with described brain electric data collecting module, for monitoring the variation of described quantized data index, when described quantized data refers to that target value surpasses predetermined threshold, output alarm information is also interrupted described drug administration by injection control module and is carried out administration control.
10. eeg monitoring sedation depth closed loop control syringe pump apparatus according to claim 9, is characterized in that, described data monitoring analysis module also comprises:
Time delay control unit, be connected with described drug administration by injection control module with described alarm unit respectively, for when described alarm unit output alarm information, start computation delay, if do not receive the external command of adjusting administration parameter and carrying out administration between time delay,, after time delay finishes, control described drug administration by injection control module and recover administration according to former setting administration parameter.
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| CN201410001522.3A CN103735261B (en) | 2013-12-05 | 2014-01-02 | Eeg monitoring sedation depth closed-loop control syringe pump apparatus |
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| CN201410001522.3A Active CN103735261B (en) | 2013-12-05 | 2014-01-02 | Eeg monitoring sedation depth closed-loop control syringe pump apparatus |
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| CN103735261B (en) | 2016-08-24 |
| CN203749411U (en) | 2014-08-06 |
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