CN103705973A - Photoinduced hyperchromic yellow intraocular lens device and preparation method thereof - Google Patents
Photoinduced hyperchromic yellow intraocular lens device and preparation method thereof Download PDFInfo
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- CN103705973A CN103705973A CN201310583451.8A CN201310583451A CN103705973A CN 103705973 A CN103705973 A CN 103705973A CN 201310583451 A CN201310583451 A CN 201310583451A CN 103705973 A CN103705973 A CN 103705973A
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Abstract
The invention belongs to the field of medical appliances, and particularly relates to a photoinduced hyperchromic yellow intraocular lens device, an optical body thereof is prepared from polyacrylate polymer, and polymerization monomers of the polymer comprise (a) at least one acrylate or methacrylate monomer; (b) one or non or more than one styrene derivative monomer; (c) at least one crosslinking agent; (d) at least one ultraviolet absorbent; (e) at least one blue ray absorbent; and (f) at least one photoinduced hyperchromic agent. The invention also provides a preparation method of the photoinduced hyperchromic yellow intraocular lens device, and the method comprises the following steps: a, providing an intraocular lens containing no photoinduced hyperchromic agent; b, immersing the finished-product intraocular lens obtained from the step a into a hot photoinduced hyperchromic agent solution so as to penetrate photoinduced hyperchromic agent molecules throughout the whole polymer network; and c, drying the immersed intraocular lens prepared by the step b for removal of a solvent.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to a kind of photic yellow intraocular lens device that can be hyperchromic and preparation method thereof.
Background technology
Intraocular lens device, have another name called intraocular lens, the ophthalmic cataract geode that has been widely used in replacement cataract patient removes the intraocular lens of rear implantation, worldwide there are every year about 20,000,000 people to carry out cataract implant surgery, wherein, the annual approximately 3,000,000 routine cataract implant surgeries of the U.S..India approximately has 6,500,000 people to do cataract transplant operation every year.China also has 1,000,000 people of surpassing to do cataract transplant operation now, and in the speed increase with annual 25 to 30 percent left and right of this numeral, the annual cataract transplant operation of China will be over 7,000,000 person-times afterwards to estimate 5-10.Ultraviolet is very large to humans and animals eye injury, and therefore people, when preparing intraocular lens device, can add ultraviolet absorber, conventionally to absorb major part or whole ultraviolet conventionally.We know, ultraviolet wave band is 200 to 400nm, and the light-wave band of shortwave blue light is 400-470nm, and shortwave blue light has very large injury to human and animal's class eyes equally, be this injury for ultraviolet, slightly smaller.Therefore, since 2000, ophthalmology worker starts to consider that shortwave blue light is to the amphiblestroid injury of ophthalmic, and AlconLaboratoriesInc. has pushed the ACRYSOF Natural crystalline lens of buff to world intraocular lens market after 2003, and has obtained ophthalmology worker's extensive approval.Then AMO has also released its crystalline lens.This crystalline lens, by 400 to the 410nm large portions of blue light short-wave band or all absorptions, stops its shortwave blue light to arrive the amphiblestroid probability of its ophthalmic like this, reduces the degeneration of ophthalmic retinal pigment epithelium, and causes making the maculopathy of its age-dependent.
Summary of the invention
The object of this invention is to provide a kind of photic yellow intraocular lens device that can be hyperchromic, under the outdoor strong sunlight environment of this intraocular lens, hyperchromic to buff, effectively reduce its daylight to amphiblestroid injury in human eye; Once get back to its indoor weak light environment, its lens devices will be adjusted to light yellow automatically, and not affect people's driveability, also can effectively sponge part blue light simultaneously, reduce its blue light to the amphiblestroid impact of ophthalmic.
For achieving the above object, the invention provides a kind of photic yellow intraocular lens device that can be hyperchromic, its optical bodies is made by the polyacrylate polymers being cross-linked, and the polymerization single polymerization monomer of this polymer comprises:
(a), at least one acrylate or methacrylate monomer;
(b), have without or more than one styrene derivative monomer;
(c), at least one cross-linking agent;
(d), at least one ultraviolet absorber;
(e), at least one blue-light absorbers;
(f), at least one photic toner;
The glass transition temperature of described intraocular lens device is room temperature or lower, and the transmitance of hyperchromic front shortwave blue light when 400-470nm be higher than 85%, the visible ray more than 550nm, and the transmitance of light is higher than 90%; After hyperchromic, when 400-470nm wave band, transmitance must not be higher than 65 %, and its transmitance of light wave more than 550nm is greater than 90%.
Preferably, described acrylate or methacrylate monomer are:
(1) alkyl acrylate, alkyl methacrylate, wherein alkyl is C
1-8 straight or branched alkyl; Or
(2) acrylic acid phenylalkyl ester or methacrylic acid phenylalkyl ester, described phenylalkyl is Ph (CH
2)
n-, n=1-8; Or
(3) acrylic acid phenoxyalkyl ester or methacrylic acid phenoxyalkyl ester, described phenoxyalkyl is PhO (CH
2)
n-, n=1-8; Or
(4) acrylic acid hydroxy alkyl ester or hydroxyalkyl methacrylate, wherein alkyl is C
1-8straight or branched alkyl.
The concept of acrylic acid hydroxy alkyl ester or hydroxyalkyl methacrylate is known, can be referring to the associated description of description in CN102471225A, and its concrete representation example is 3-acryloxy-2-HPMA, also referred to as GAMA.
Preferably, described styrene derivative monomer is selected from styrene, 4-methyl styrene, 3-methyl styrene, 3,4-dimethyl styrene, 3-alkoxystyrene, 4-alkoxystyrene, one or more in the styrene that 3,4-dialkoxy styrene and 4-dimethylamino replace.
Preferably, described cross-linking agent is selected from ethylene glycol diacrylate, Ethylene glycol dimethacrylate, diacrylate propylene glycol ester, dimethyl allene acid propylene glycol ester, diacrylate butanediol ester, tetramethylene dimethacrylate, 1,4-divinylbenzene and 2-methyl isophthalic acid, one or more in 4-divinylbenzene.
Preferably, described photic toner is the dye composition that photic enhancing absorbs blue ray intensity, is selected from diarylethene, spiro-pyrans class, naphthopyrans class, azobenzene with one or more in spirooxazine compounds.The example of spiro-pyrans comprises 1 ', 3 '-dihydro-1 ', 3 ', 3 '-trimethyl-6-nitro spiral shell [2H-1-.alpha.-5:6-benzopyran-2, the example of 2 '-(2H)-indole] ， Luo oxazine comprises 1,3-dihydro-1,3,3-trimethyl-spiral shell [2H-indole-2,3 '-[3H] luxuriant and rich with fragrance [9,10-b] (Isosorbide-5-Nitrae) oxazine].
Preferably, described blue-light absorbers is polymerizable azo-compound, and the azo-compound of saying is here the substituted-phenyl azobenzene compound (I) that can absorb blue ray: 1-aryl-3-alkyl-4-vinyl benzene azo group-5-hydroxypyrazoles.The polymerizable functional group of substituted-phenyl azobenzene compound (I) is acryloyl group, methacryl group, acrylamide group, methacryl amine groups, Ethenylbenzene group, propylene phenyl group or methyl ethylene phenyl group.
Preferably, described ultraviolet absorber is polymerizable type benzotriazole compound or polymerizable type Benzophenones compound, can be also as the kind described in patent CN200580016948.5.
preferably, photic yellow intraocular lens device that can be hyperchromic of the present invention, is intraocular lens, or the property implanted glasses for the myopia intraocular lens.
Preferably, the consumption of described ultraviolet absorber is the 0.1-5.0% of described optical bodies quality.
The present invention also provide a kind of photic can be hyperchromic
yellowthe preparation method of intraocular lens device, the method comprises the following step:
A. various monomers, cross-linking agent, ultraviolet absorber, blue-light absorbers and radical initiator are made to uniform mixed liquor;
B. remove the air in mixed liquor, under inert atmosphere, mixed liquor is transferred in preprepared lamellar mould; Under heating condition, be made into 5.0-11.0 inch long, 5.0-11.0 inch is wide, thick
degreeflaky material for 1.5-3.0 millimeters thick;
C. described flaky material is cut into circular coarse-grain sheet;
D. the extractable matter in coarse-grain sheet is removed in extraction, then the dry coarse-grain sheet having extracted;
E. machine cuts is prepared into the butterfly-shaped wafer with optical surface;
F. after polishing, butterfly-shaped wafer engraving is prepared into various types of yellow intraocular lens devices.
The present invention also provides
a kind of preparation method of photic yellow intraocular lens device that can be hyperchromic, the method comprises the steps:
A., the yellow intraocular lens that does not contain photochromic agent is provided;
B. the yellow intraocular lens of the finished product that derives from step a is immersed in the photochromic agent solution of heat, thereby makes the described slight swelling of yellow intraocular lens, so that photochromic molecules is infiltrated in whole described polymer network; And
C. the yellow intraocular lens through dipping that prepared by drying steps b, thus remove all solvents.
Beneficial effect of the present invention is as follows:
The invention provides a kind of photic yellow intraocular lens device that can be hyperchromic, this yellow intraocular lens device is when the low light level or indoor environment, its lens devices is light yellow, and do not affect people's driveability, also can effectively sponge part blue light, reduce its blue light to the amphiblestroid impact of ophthalmic simultaneously; High light environment is next automatically hyperchromic to buff, effectively reduces its high light to amphiblestroid injury in human eye.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1: do not contain the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into ultraviolet absorber 2-(2 '-hydroxyl-3 ' of 0.015mol, 5 '-bis-tertiary phenyl)-5-chlorination benzotriazole, the azodiisobutyronitrile of 0.18mol, 1-phenyl-3-methyl-4-vinyl benzene azo group-5-hydroxypyrazoles of 0.0007mol, 2.16mol 4-ethoxybenzene ethylene, the methacrylic acid stearyl of 2.5mol, the acrylic acid 2-phenylethylester of 8.0mol, the diacrylate ethylene glycol diester of 0.65mol, and the Hydroxypropyl methacrylate of 0.27mol.Be accompanied by stirring, remove after the air in solution, under nitrogen, transfer in mould.Then at 120 ℃, make block roughage, be then cut into the circular coarse-grain sheet of our required size.With the circular coarse-grain sheet of methanol extraction at least 48 hours, then 85 ℃ dry except desolventizing, make the good coarse-grain sheet material of extraction.In the time of 25 ℃, index of refraction is that the coarse-grain sheet of thick ℃ of 1.545,0.8mm is 393nm while having 10% transmitance, and transmitance when transmitance when transmitance during 450nm is greater than 70%, 500nm is greater than 90%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then this butterfly-shaped coarse-grain sheet is inserted in a polishing medium preparing in advance, at low temperatures, carries out polishing, and then engraving is prepared into our needed product.
Embodiment 2: do not contain the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into the ultraviolet absorber ESCALOL 567 of 0.02mol, the azodiisobutyronitrile of 0.013mol, 1-phenyl-3-ethyl-4-vinyl benzene azo group-5-hydroxypyrazoles of 0.0015mol, the 4-ethoxybenzene ethylene of 1.85mol, the lauryl methacrylate of 2.1mol, the acrylic acid 2-phenylethylester of 8.6mol, the diacrylate propylene glycol ester of 0.46mol.Be accompanied by stirring, remove after air, at 50 ℃, make block roughage forward mould under nitrogen in, then cut into the circular coarse-grain sheet of our required size.With methanol or ethanol kind solvent, extract circular coarse-grain sheet at least 48 hours, then dry except desolventizing at suitable temperature ℃, make the good coarse-grain sheet material of extraction.In the time of 25 ℃, index of refraction is that the coarse-grain sheet of thick ℃ of 1.550,0.8mm is 395nm while having 10% transmitance, and transmitance when transmitance when transmitance during 450nm is greater than 65%, 500nm is greater than 90%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then this butterfly-shaped coarse-grain sheet is inserted in a polishing medium preparing in advance, at low temperatures, carries out polishing, and then engraving is prepared into our needed product.
Embodiment 3: do not contain the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into the ultraviolet absorber Octabenzone of 0.01mol, the azodiisobutyronitrile of 0.020mol, the 1-(4-aminomethyl phenyl of 0.0003mol)-3-methyl-4-vinyl benzene azo group-5-hydroxypyrazoles, the 4-ethoxybenzene ethylene of 1.45mol, the acrylic acid stearyl of 2.0mol, the acrylic acid 2-phenoxy group ethyl ester of 7.5mol, the tetramethylene dimethacrylate of 0.60mol.Be accompanied by stirring, remove after air, at high temperature make block roughage forward mould under nitrogen in, then cut into the circular coarse-grain sheet of my required size.With the circular coarse-grain sheet of alcohol extraction at least 48 hours, then dry except desolventizing at 30 ℃, make the good coarse-grain sheet material of extraction.In the time of 25 ℃, index of refraction is that the coarse-grain sheet of thick ℃ of 1.545,0.8mm is 390nm while having 10% transmitance, and transmitance when transmitance when transmitance during 450nm is greater than 75%, 500nm is greater than 90%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then this butterfly-shaped coarse-grain sheet is inserted in a polishing medium preparing in advance, at low temperatures, carries out polishing, and then engraving is prepared into our needed product.
Example 4: photic can hyperchromic light yellow lenticular preparation
In a wide mouthed bottle, add in the aphthopyrans and appropriate methanol of appropriate amount, stir until azo-compound blue light toner is all dissolved in methanol, put into the good coarse-grain sheet material of appropriate extraction and permeate more than at least 72 hours in solution, be then dried and be prepared into photic light yellow coarse crystalline body that can be hyperchromic.
Before lens material that embodiment 1 obtains is hyperchromic, in the time of 25 ℃, index of refraction is 1.545, the coarse-grain sheet that 0.8mm is thick ℃ transmitance when 402nm is 10%, transmitance when transmitance when transmitance during 450nm is greater than 45%, 500nm is greater than 88%, 550nm is greater than 95%, after hyperchromic, in the time of 25 ℃, index of refraction is that the coarse-grain sheet of thick ℃ of 1.545,0.8mm transmitance when transmitance is 10%, 450nm during at 402nm is greater than 30%, transmitance when transmitance during 500nm is greater than 80%, 550nm is greater than 95%.
Before lens material that embodiment 2 obtains is hyperchromic, in the time of 25 ℃, index of refraction is that the transmitance of the transmitance of the coarse-grain sheet of thick ℃ of 1.545,0.8mm transmitance when transmitance is 10%, 450nm during at 402nm while being greater than 40%, 500nm while being greater than 75%, 550nm is greater than 95%.After hyperchromic, in the time of 25 ℃, index of refraction is that the transmitance of the transmitance of the coarse-grain sheet of thick ℃ of 1.545,0.8mm transmitance when transmitance is 10%, 450nm when 402nm while being greater than 25%, 500nm while being greater than 65%, 550nm is greater than 95%.
Before lens material that embodiment 3 obtains is hyperchromic, in the time of 25 ℃, index of refraction is that the transmitance of the transmitance of the coarse-grain sheet of thick ℃ of 1.545,0.8mm transmitance when transmitance is 10%, 450nm during at 402nm while being greater than 50%, 500nm while being greater than 90%, 550nm is greater than 95%.After hyperchromic, in the time of 25 ℃, index of refraction is that the coarse-grain sheet of thick ℃ of 1.545,0.8mm is 402nm while having 10% transmitance, and transmitance when transmitance when transmitance during 450nm is greater than 40%, 500nm is greater than 85%, 550nm is greater than 95%.
Embodiment 5: contain the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into ultraviolet absorber 2-(2 '-hydroxyl-3 ' of 0.015mol, 5 '-bis-tertiary phenyl)-5-chlorination benzotriazole, the azodiisobutyronitrile of 0.017mol, 1-phenyl-3-methyl-4-vinyl benzene azo group-5-hydroxypyrazoles of 0.0007mol, the polymerisable aphthopyrans of 0.0025mol, the 4-ethoxybenzene ethylene of 2.16mol, the methacrylic acid stearyl of 2.5mol, the acrylic acid 2-phenylethylester of 8.0mol, the diacrylate ethylene glycol diester of 0.65mol, and the Hydroxypropyl methacrylate of 0.27mol.Be accompanied by stirring, remove after air, at high temperature make block roughage in forwarding mould under nitrogen, then chromium plating becomes the circular coarse-grain sheet of my required size.With alcohols solvent, extract circular coarse-grain sheet at least 48 hours, then dry except desolventizing at 65 ℃, make the good coarse-grain sheet material of extraction.Before hyperchromic, in the time of 25 ℃, index of refraction is that the transmitance of the transmitance of the coarse-grain sheet of thick ℃ of 1.545,0.8mm transmitance when transmitance is 10%, 450nm during at 402nm while being greater than 45%, 500nm while being greater than 88%, 550nm is greater than 95%; After hyperchromic, in the time of 25 ℃, index of refraction is that the coarse-grain sheet of thick ℃ of 1.545,0.8mm is 405nm while having 10% transmitance, and transmitance when transmitance when transmitance during 450nm is greater than 30%, 500nm is greater than 80%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then this butterfly-shaped coarse-grain sheet is inserted in a polishing medium preparing in advance, at low temperatures, carries out polishing, and then engraving is prepared into our needed product.
Example 6: contain the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into the ultraviolet absorber ESCALOL 567 of 0.01mol, the azodiisobutyronitrile of 0.013mol, 1-phenyl-3-ethyl-4-vinyl benzene azo group-5-hydroxypyrazoles of 0.0015mol, the polymerisable methacrylic acid aphthopyrans ester of 0.004mol, the 4-ethoxybenzene ethylene of 1.85mol, the lauryl methacrylate of 2.1mol, the acrylic acid 2-phenylethylester of 8.6mol, the dimethyl allene acid propylene glycol ester of 0.46mol.Be accompanied by stirring, remove after air, at 80 ℃, make block roughage forward mould under nitrogen in, then cut into the circular coarse-grain sheet of my required size.With alcohols solvent, extract circular coarse-grain sheet at least 48 hours, then at 30-85 ℃, be dried except desolventizing, make the good coarse-grain sheet material of extraction.Before hyperchromic, in the time of 25 ℃, index of refraction is that the transmitance of the transmitance of the coarse-grain sheet of thick ℃ of 1.550,0.8mm transmitance when transmitance is 10%, 450nm during at 402nm while being greater than 35%, 500nm while being greater than 75%, 550nm is greater than 95%; After hyperchromic, in the time of 25 ℃, index of refraction is that the coarse-grain sheet of thick ℃ of 1.545,0.8mm is 407nm while having 10% transmitance, and transmitance when transmitance when transmitance during 450nm is greater than 25%, 500nm is greater than 65%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then this butterfly-shaped coarse-grain sheet is inserted in a polishing medium preparing in advance, at low temperatures, carries out polishing, and then engraving is prepared into our needed product.
Example 7: contain the preparation of the light yellow lens material of photic toner
In the round-bottomed bottle of three necks, put into the ultraviolet absorber Octabenzone of 0.02mol, the azodiisobutyronitrile of 0.020mol, the 1-(4-chlorphenyl of 0.0003mol)-3-methyl-4-vinyl benzene azo group-5-hydroxypyrazoles, the polymerisable even methacrylic acid aphthopyrans ester of 0.002mol, the 4-ethoxybenzene ethylene of 1.45mol, the acrylic acid stearyl of 2.0mol, the acrylic acid 2-phenoxy group ethyl ester of 7.5mol, the tetramethylene dimethacrylate of 0.60mol.Be accompanied by stirring, remove after air, at 120 ℃, make block roughage forward mould under nitrogen in, then cut into the circular coarse-grain sheet of required size.With the circular coarse-grain sheet of alcohol extraction at least 48 hours, then dry except desolventizing at 75 ℃, make the good coarse-grain sheet material of extraction.Before hyperchromic, in the time of 25 ℃, index of refraction is that the transmitance of the transmitance of the coarse-grain sheet of thick ℃ of 1.545,0.8mm transmitance when transmitance is 10%, 450nm during at 402nm while being greater than 50%, 500nm while being greater than 90%, 550nm is greater than 95%.After hyperchromic, in the time of 25 ℃, index of refraction is that the coarse-grain sheet of thick ℃ of 1.545,0.8mm is 402nm while having 10% transmitance, and transmitance when transmitance when transmitance during 450nm is greater than 40%, 500nm is greater than 85%, 550nm is greater than 95%.Machine cuts is prepared into the butterfly-shaped coarse-grain sheet with optical surface, then this butterfly-shaped coarse-grain sheet is inserted in a polishing medium preparing in advance, at low temperatures, carries out polishing, and then engraving is prepared into our needed product.
All documents that the present invention mentions are all quoted as a reference in this application, just as each piece of document, are quoted as a reference separately.
Should be appreciated that above narration is only example and illustrative for the present invention who is set forth as claim, is not limited it.According to disclosed herein content of the present invention, other embodiment of the present invention is apparent for a person skilled in the art.Should be noted that this description and embodiment only should be regarded as example, actual range of the present invention is determined by claim.
Claims (10)
1. photic yellow intraocular lens device that can be hyperchromic, its optical bodies is made by the polyacrylate polymers being cross-linked, and the polymerization single polymerization monomer of this polymer comprises:
(a), at least one acrylate or methacrylate monomer;
(b), have without or more than one styrene derivative monomer;
(c), at least one cross-linking agent;
(d), at least one ultraviolet absorber;
(e), at least one blue-light absorbers;
(f), at least one photic toner;
The glassy transition temperature of described intraocular lens device is room temperature or lower, and the transmitance of hyperchromic front shortwave blue light when 400-450nm be higher than 85%, the visible ray more than 550nm, and the transmitance of light is higher than 90%; After hyperchromic, when 400-450nm wave band, transmitance must not be greater than 90% higher than its transmitance of light wave more than 65%, 550nm.
2. photic yellow intraocular lens device that can be hyperchromic as claimed in claim 1, is characterized in that described acrylate or methacrylate monomer are
(1) alkyl acrylate, alkyl methacrylate, wherein alkyl is C
1-8straight or branched alkyl; Or
(2) acrylic acid phenylalkyl ester or methacrylic acid phenylalkyl ester, described phenylalkyl is Ph (CH
2)
n-, n=1-8; Or
(3) acrylic acid phenoxyalkyl ester or methacrylic acid phenoxyalkyl ester, described phenoxyalkyl is PhO (CH
2)
n-, n=1-8; Or
(4) acrylic acid hydroxy alkyl ester or hydroxyalkyl methacrylate, wherein alkyl is C
1-8straight or branched alkyl.
3. photic yellow intraocular lens device that can be hyperchromic as claimed in claim 1, it is characterized in that described styrene derivative monomer is selected from styrene, 4-methyl styrene, 3-methyl styrene, 3,4-dimethyl styrene, 3-alkoxystyrene, 4-alkoxystyrene, one or more in the styrene that 3,4-dialkoxy styrene and 4-dimethylamino replace.
4. photic yellow intraocular lens device that can be hyperchromic as claimed in claim 1, it is characterized in that described cross-linking agent is selected from ethylene glycol diacrylate, Ethylene glycol dimethacrylate, diacrylate propylene glycol ester, dimethyl allene acid propylene glycol ester, diacrylate butanediol ester, tetramethylene dimethacrylate, divinylbenzene and 2-methyl isophthalic acid, one or more in 4-divinylbenzene.
5. photic yellow intraocular lens device that can be hyperchromic as claimed in claim 1, it is characterized in that described photic toner is the dye composition that photic enhancing absorbs blue ray intensity, is selected from diarylethene, spiro-pyrans class, naphthopyrans class, azobenzene with one or more in spirooxazine compounds.
6. photic yellow intraocular lens device that can be hyperchromic as claimed in claim 1, is characterized in that described blue-light absorbers is polymerizable azo-compound, and the azo-compound of saying is here the azo-compound that can absorb blue ray; The polymerizable functional group of azo-compound is acryloyl group, methacryl group, acrylamide group, methacryl amine groups, Ethenylbenzene group, propylene phenyl group or methyl ethylene phenyl group.
7. photic yellow intraocular lens device that can be hyperchromic as claimed in claim 1, is characterized in that described ultraviolet absorber is polymerizable type benzotriazole compound or polymerizable type Benzophenones compound.
8. photic yellow intraocular lens device that can be hyperchromic as claimed in claim 1, is intraocular lens, or the property implanted glasses for the myopia intraocular lens.
9. a preparation method of preparing photic yellow intraocular lens device that can be hyperchromic as claimed in claim 1, the method comprises the following step:
A. various monomers, cross-linking agent, ultraviolet absorber, blue-light absorbers and radical initiator are made to uniform mixed liquor;
B. remove the air in mixed liquor, under inert atmosphere, mixed liquor is transferred in preprepared lamellar mould; Under heating condition, be made into 5.0-11.0 inch long, 5.0-11.0 inch is wide, and thick ℃ is the flaky material of 1.5-3.0 millimeters thick;
C. described flaky material is cut into circular coarse-grain sheet;
D. the extractable matter in coarse-grain sheet is removed in extraction, then the dry coarse-grain sheet having extracted;
E. machine cuts is prepared into the butterfly-shaped wafer with optical surface;
F. after polishing, butterfly-shaped wafer engraving is prepared into various types of intraocular lens devices.
10. a preparation method of preparing photic yellow intraocular lens device that can be hyperchromic as claimed in claim 1, the method comprises the following step:
A., the intraocular lens that does not contain photochromic agent is provided;
B. the finished product intraocular lens that derives from step a is immersed in the photochromic agent solution of heat, thereby makes the described slight swelling of intraocular lens, so that photochromic molecules is infiltrated in whole described polymer network; And
C. the intraocular lens through dipping that prepared by drying steps b, thus remove all solvents.
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| WO2014201956A1 (en) * | 2013-06-17 | 2014-12-24 | 无锡蕾明视康科技有限公司 | Implantable myopia lens and preparation method therefor |
| CN104693646A (en) * | 2015-03-16 | 2015-06-10 | 南京工业大学 | Transparent plasticized PVC (Polyvinyl Chloride) functional film and preparation method |
| CN106800376A (en) * | 2016-12-29 | 2017-06-06 | 武汉华星光电技术有限公司 | One kind filter blue light resists dizzy hand-set lid and preparation method thereof |
| CN108474888A (en) * | 2015-11-25 | 2018-08-31 | 株式会社晶姿 | Optical component |
| CN109503758A (en) * | 2018-11-20 | 2019-03-22 | 华东师范大学 | A kind of photochromic polyacrylamide supramolecular hydrogel and preparation method |
| CN113527567A (en) * | 2021-07-26 | 2021-10-22 | 康小林 | Hydrophobic non-glare high refractive index ophthalmic polymeric materials |
| TWI776064B (en) * | 2018-06-01 | 2022-09-01 | 大陸商上海富吉醫療器械有限公司 | Polymer material and intraocular lens |
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| WO2014201956A1 (en) * | 2013-06-17 | 2014-12-24 | 无锡蕾明视康科技有限公司 | Implantable myopia lens and preparation method therefor |
| CN104693646A (en) * | 2015-03-16 | 2015-06-10 | 南京工业大学 | Transparent plasticized PVC (Polyvinyl Chloride) functional film and preparation method |
| CN108474888A (en) * | 2015-11-25 | 2018-08-31 | 株式会社晶姿 | Optical component |
| CN108474888B (en) * | 2015-11-25 | 2021-02-12 | 睛姿控股公司 | Optical component |
| CN106800376A (en) * | 2016-12-29 | 2017-06-06 | 武汉华星光电技术有限公司 | One kind filter blue light resists dizzy hand-set lid and preparation method thereof |
| TWI776064B (en) * | 2018-06-01 | 2022-09-01 | 大陸商上海富吉醫療器械有限公司 | Polymer material and intraocular lens |
| CN109503758A (en) * | 2018-11-20 | 2019-03-22 | 华东师范大学 | A kind of photochromic polyacrylamide supramolecular hydrogel and preparation method |
| CN109503758B (en) * | 2018-11-20 | 2019-11-15 | 华东师范大学 | A kind of photochromic polyacrylamide supramolecular hydrogel and preparation method |
| CN113527567A (en) * | 2021-07-26 | 2021-10-22 | 康小林 | Hydrophobic non-glare high refractive index ophthalmic polymeric materials |
| CN113527567B (en) * | 2021-07-26 | 2023-01-24 | 康小林 | Hydrophobic non-glare high refractive index ophthalmic polymeric materials |
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