CN103690589A - Medicinal preparation containing albizia flower total flavone - Google Patents
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Abstract
The invention provides a medicinal preparation containing albizia flower total flavone and medical application. The albizia flower total flavone contains the following components in percentage by weight: 41-50 percent of quercitrin, 0.1-10 percent of quercetin, 0.1-5 percent of kaempferide, 0.1-2 percent of quercetin-3-0-alpha-L-arabinoside, and quercetin-3-0-alpha-L-arabinoside. The invention also discloses a method for preparing the albizia flower total flavone medicinal preparation with high dissolution rate, as well as application of the albizia flower total flavone and medical preparation thereof serving as basic active substances in preparing a medicine for treating depression.
Description
Technical field:
The invention belongs to medical technical field, be specifically related to a kind of pharmaceutical preparation that contains total flavonoids in albizia julibrissin durazz.
Background technology:
Flos Albiziae is dry inflorescence or the alabastrum of leguminous plant Herba Albiziae (Albizziajulibrissin Durazz.), is conventional Chinese medicine, and the flat bitter in the mouth of property, has QI regulating by alleviation of mental depression, and the active effect of calming the nerves has been recorded in one of 2010 editions Chinese Pharmacopoeia.The main chemical compositions of Flos Albiziae comprises flavonoid, triterpene and glycosides compound thereof, alkaloid, polysaccharide and organic acid etc.Modern pharmacology experiment shows that the contained chemical composition of Flos Albiziae has multiple pharmacological effect, as tranquilizing soporific antidepressant, and immunologic function adjusting and antioxidation etc.Some disclosed documents have been reported the pharmacological action of Flos Albiziae crude extract, prove that it has certain antidepressant effect.
Inventor is by separated to the extraction of Flos Albiziae, and multiple pharmacological model carries out medicine efficacy screening research, finds that total flavonoids in albizia julibrissin durazz is the material base of Flos Albiziae Cure of depression.Chemical research shows that total flavonoids in albizia julibrissin durazz composition is higher with component contents such as Quercitroside, kaempferide and Quercetins.The extract that different extracting method obtains is owing to comprising different flavone compounds, different content, and its pharmacology, the property of medicine exist very big-difference.Therefore, guaranteeing under the prerequisite of drug effect, improving as far as possible total flavones constituent in the content, the particularly content of antidepressant activity composition Quercitroside of extractive total flavone and clear and definite extract is technological difficulties.Through personal practice and checking repeatedly, inventor is optimized and verifies the extraction and separation process of Flos Albiziae, improved key technology point, main pharmacodynamics composition Determination of Quercitrin in total flavonoids in albizia julibrissin durazz has been stabilized between 41-50%, higher than the 0-40% having been reported, the simultaneously clear and definite content of the flavonoid main components such as Quercetin, kaempferide, Quercetin-3-O-α-L-arabinose glycosides, kaempferol-3-O-α-L-arabinose glycosides, has defined the total flavonoids in albizia julibrissin durazz of the present patent application jointly.
At present Lee that has of research total flavonoids in albizia julibrissin durazz extract does the Preliminary screening research > > document at equality < < Chinese medicine Flos Albiziae antidepressant activity position and application for a patent for invention " preparation method of total flavonoids in albizia julibrissin durazz and pharmaceutical composition thereof " that application number is 201010601551.5 etc.
Lee makes equality, and (Lee makes equality, 2006:17) in document, the antidepressant effect at the petroleum ether of Flos Albiziae ethanol extract and water extract and ethyl acetate extraction position is screened, think that nonpolarity element and middle polarity composition may be the active substance of Flos Albiziae antidepressant effect.Although this research is screened the effective site of Flos Albiziae, its main component is not identified and assay.Meanwhile, Lee do to mention in equality document " Flos Albiziae (pulverizing) 60g is got in 2.1.2 Flos Albiziae ethanol extract and the preparation that respectively extracts position thereof, with 95% alcohol reflux 3 times, 1h/ time, filtered while hot, merging filtrate, is evaporated to dryly, is diluted with water to 200mL.In long-term practice, inventor finds that this technical scheme has improper part, first must avoid " filtered while hot ", reason be while hot time in extracting solution each constituent dissolubility larger, constituent is naturally more, by the non-skill of " filtration " while hot, can remove the composition of petroleum ether part greatly, when having guaranteed to contain the Quercitroside of high level in total flavonoids in albizia julibrissin durazz, saved again the step of petroleum ether extraction; Secondly after " being evaporated to dry ", the scheme of thin up there will be two kinds of adverse consequencess again: one, be evaporated to dry after again thin up can not dissolve completely at all, its two, have a strong impact on effect of extracting.
Application number is to propose in 201010601551.5 application for a patent for invention, and the main component of total flavonoids in albizia julibrissin durazz has Quercetin (0-40%), Quercitroside (0-40%), kaempferide (0-5%), isorhamnetin (0-5%) and isoquercitrin, kaempferide-3-0-rhamnoside and other flavanol compound derivants.Whether, though this patent has been introduced the content of flavonoid main component in Flos Albiziae, the minimum of each composition is all 0, contain and uncertain, and scope is wide, itself and Flos Albiziae crude extract effectively cannot be distinguished.In addition, claim 3. (2) think filtrate should " ... be concentrated into without alcohol taste ... ", concentrated degree that inventor is further clear and definite, be concentrated into raw medicinal herbs 4:1-5:1 (mL:g), relative density (1.02-1.03,35 ℃), now effect of extracting is optimum.
Through experimental study, find, the total flavonoids in albizia julibrissin durazz that contains 41-50% Quercitroside, has great advantage compared with other Flos Albiziae crude extracts at aspects such as outward appearance, curative effect and stability.Be embodied in and be different from Flos Albiziae crude extract poor fluidity, the be clamminess shortcoming of easy in bulk of humidity, this product is yellow green dried powder, and good fluidity, without caking phenomenon, without sharp aroma.Significantly reduced mice when oral sense of discomfort as vomiting, abdominal distention, the back of a bow etc., and reduce mouse tail suspension dead time and forced swimming dead time, improve the depressive state of mice.Through influence factor's the effects, total flavonoids in albizia julibrissin durazz is placed in respectively the violent condition such as high temperature, illumination, 75% humidity after lower 5 days, 10 days, and weightening finish, Quercitroside and general flavone content variation all, in ± 5%, have good stability.
Antidepressants are psychoactive drugs of the various depressive disorders of current treatment, can efficient solution remove depressive mood and the anxiety of following, anxiety and somatization.Be widely used in now clinically, the antidepressants of determined curative effect, generally generally acknowledge and can be divided into two large classes.The classical antidepressants of the first generation: comprise oxidase inhibitor (Monoamine Oxidase Inhibitor, MAOIs) and tricyclic antidepressant (Tricyclic Antidepressant, TCAs).Second filial generation novel antidepressant: comprise selectivity 5-HT reuptake inhibitor (Selective Serotonin Reuptake Inhibitor, SSRIs), selectivity 5-HT and NE reuptake inhibitor (Serotonin Noradrenaline Reuptake Inhibitor, SNRIs) and plant antidepressants etc.Traditional MAOIs, TCAs antidepressant effect are remarkable, but taking dose is large, side effect is strong, and the appearance of novel antidepressant has made up the deficiency of this quasi drugs, but in fact, because antidepressants need long-term taking, its untoward reaction that cannot ignore makes Most patients be difficult to adhere to medication.Chinese patent medicine preparation is compared with chemosynthesis antidepressants, has the advantages such as relatively little, the many target spot of side effect, many effects.Therefore, from Flos Albiziae, extract and obtain total flavonoids in albizia julibrissin durazz, for the treatment of depression, there is good DEVELOPMENT PROSPECT.
The total pyrite of Flos Albiziae can be mixed by proper proportion with one or more pharmaceutically acceptable carriers or excipient, make the pharmaceutical composition of the different dosage form that is applicable to use clinically.For example said compositions can be configured to can be for oral administration tablet, capsule, and the spray, aerosol, the ointment that are applicable to topical, or can supply the injection of intravenous, intramuscular intraperitoneal, the drug administration by injection such as subcutaneous.But the clinical characters of considering depression needs Long-term taking medicine, comparatively suitable with oral solid formulation.For oral solid formulation, dissolution is an important quality investigation index, because the bioavailability of dissolution and oral solid formulation is closely related, also directly affects the curative effect of medicine.Due to total flavonoids in albizia julibrissin durazz extract soluble,very slightly in water, degree of scatter is poor, and meets water and be easily clamminess, and while preparing solid preparation, need solve the poor problem of dissolution by preparation technique.Inventor is by fluidizer, disintegrating agent, the lubricant of screening variety classes and ratio, and preparation method, obtain a kind of total flavonoids in albizia julibrissin durazz preparation of high-dissolution, can effectively improve in total flavonoids in albizia julibrissin durazz extract effective ingredient at the dissolution of intestinal juice, make effective substance more than the dissolubility of simulated intestinal fluid is brought up to 60min50% from initial 60min15.2%, thereby increase the absorption of Flos Albiziae antidepressant effective ingredient in human body, improve bioavailability, increase curative effect.This pharmaceutical preparation can be used for preparation but is not limited to prepare hard capsule, granule, drop pill, tablet, constant product quality, and drug absorption is good, and is easy to preparation, is applicable to suitability for industrialized production.
Summary of the invention:
The object of this invention is to provide a kind of total flavonoids in albizia julibrissin durazz; Second object of the present invention is to provide a kind of pharmaceutical preparation with the total flavonoids in albizia julibrissin durazz of high-dissolution; The 3rd object of the present invention is to provide take the antidepressant drug that total flavonoids in albizia julibrissin durazz and pharmaceutical preparation thereof is primary activity material.
Total flavonoids in albizia julibrissin durazz of the present invention, mainly contains Quercitroside 41-50%.
Total flavonoids in albizia julibrissin durazz of the present invention, also contains Quercetin 0.1-10%, kaempferide 0.1-5%, Quercetin-3-0-α-L-arabinose glycosides 0.1-2%, kaempferol-3-0-α-L-arabinose glycosides 0.1-2%.
Total flavonoids in albizia julibrissin durazz of the present invention is to take Flos Albiziae as raw material, through the extraction with aqueous solution of alcohol, then the extract obtaining through ethyl acetate extraction.Preparation method is as follows:
(1) 50% ethanol of dry Flos Albiziae doubly being measured with 10-12, twice of heating and refluxing extraction;
(2) merge extractive liquid,, filters, and filtrate recycling ethanol is also equivalent to raw medicinal herbs 4:1-5:1 (mL/g) to being concentrated into, relative density (1.02-1.03,35 ℃);
(3) standing, filter, filtrate adds 1-3 and doubly measures ethyl acetate extracting twice;
(4) combining extraction liquid, reclaims ethyl acetate and is concentrated into thick paste, and drying under reduced pressure, is ground into fine powder.
The invention provides following technical scheme: a kind of total flavonoids in albizia julibrissin durazz pharmaceutical preparation of high-dissolution, comprises the component of following ratio:
The present invention also provides a kind of method of preparing high-dissolution total flavonoids in albizia julibrissin durazz preparation, preparation method is that total flavonoids in albizia julibrissin durazz and mixed with excipients is even, wet method or dry granulation, dry, granulate, add mixed with excipients evenly to obtain granule, this granule can be used for preparing tablet, capsule and granule.
Following experimental example is used for further illustrating the present invention but is not limited to the present invention.
In [experimental example 1] total flavonoids in albizia julibrissin durazz, Determination of Quercitrin is measured
The content assaying method of Quercitroside is:
Precision takes the about 15mg of Quercitroside, puts in 25mL measuring bottle, adds dissolve with ethanol and is diluted to scale, shakes up; Precision measures 1mL, puts in 10mL measuring bottle, adds Diluted Alcohol and is diluted to scale, shakes up, and obtains reference substance solution.
Get total flavonoids in albizia julibrissin durazz 15mg, accurately weighed, put in 100mL measuring bottle, add dissolve with ethanol and be diluted to scale, shake up, filter, get subsequent filtrate, obtain test liquid.
Mobile phase: take acetonitrile as mobile phase A, take 0.1% phosphoric acid solution as Mobile phase B, the regulation according to the form below is carried out gradient elution
Detect wavelength: 256nm
Flow velocity: 1.0ml/min
Chromatographic column: Dikma Diamonsil5 μ m C184.6 * 250mm
Column temperature: 30 ℃
Sample size: 10 μ L
Obtaining Determination of Quercitrin in total flavonoids in albizia julibrissin durazz is 41.3%.
[experimental example 2] illumination, high temperature, the impact of high humidity environment on total flavonoids in albizia julibrissin durazz weight
Get total flavonoids in albizia julibrissin durazz, 280mg/ part, totally 36 parts, be divided into 6 groups, 6 parts every group, be placed in respectively 60 ℃ of high temperature, illumination, high humidity 75% condition lower 5 days, 10 days.In the time of the 0th day, 5 days, 10 days, weigh total flavonoids in albizia julibrissin durazz weight.The results are shown in Table 1.
Influence factor-the weightening finish of table 1 total flavonoids in albizia julibrissin durazz
From result, different time high temperature, illumination and 75% humidity environment, have good stability on the impact of total flavonoids in albizia julibrissin durazz weight in ± 5%.
[experimental example 3] illumination, high temperature, the impact of high humidity environment on Determination of Quercitrin in total flavonoids in albizia julibrissin durazz
Get total flavonoids in albizia julibrissin durazz, 280mg/ part, totally 36 parts, be divided into 6 groups, 6 parts every group, be placed in respectively 60 ℃ of high temperature, illumination, high humidity 75% condition lower 5 days, 10 days.Determination of Quercitrin measured total flavonoids in albizia julibrissin durazz in the time of the 0th day, 5 days, 10 days in.
Determination of Quercitrin assay method is as described in experimental example 1.Result is as shown in table 2.
Table 2 total flavonoids in albizia julibrissin durazz influence factor-Determination of Quercitrin
From result, after the violent condition such as illumination in 5 days, 10 days, high temperature (60 ℃), high humidity (75%), in total flavonoids in albizia julibrissin durazz, Determination of Quercitrin was compared with 0 day, did not have notable difference, and explanation has good stability, and effective ingredient is not made significant difference.
[experimental example 4] illumination, high temperature, the impact of high humidity environment on flavones content in total flavonoids in albizia julibrissin durazz
Get total flavonoids in albizia julibrissin durazz, 280mg/ part, totally 36 parts, be divided into 6 groups, 6 parts every group, be placed in respectively 60 ℃ of high temperature, illumination, high humidity 75% condition lower 5 days, 10 days.General flavone content measured total flavonoids in albizia julibrissin durazz in the time of the 0th day, 5 days, 10 days in.
The content assaying method of total flavones is:
Precision takes the about 20mg of Quercitroside reference substance, puts in 100mL measuring bottle, adds ethanol 20mL and dissolves, then be diluted with water to scale, shakes up and obtain reference substance solution.
Precision measures reference substance solution 1mL, 2mL, 3mL, 4mL, 5mL, 6mL, put respectively in 25mL measuring bottle, respectively add water to 6mL, add 10% sodium nitrite solution 1mL, make to mix, place 6min, add 15% aluminum nitrate solution 1mL, shake up, place 6min, add 6% sodium hydroxide test solution 10mL, add water to again scale, shake up, place 10min, take corresponding reagent as blank, according to ultraviolet visible spectrophotometry, at 510nm wavelength place, measure absorbance, take absorbance as vertical coordinate, concentration is abscissa, drawing standard curve.
Get total flavonoids in albizia julibrissin durazz 0.09g, accurately weighed, precision adds ethanol 25mL to make to dissolve, and precision measures 5mL, puts in 25mL measuring bottle, is diluted with water to scale, shakes up, as need testing solution.Precision measures need testing solution 2mL, puts in 25mL measuring bottle, and the preparation method of sighting target directrix curve from " add water to 6mL ", is measured absorbance in accordance with the law, and precision measures need testing solution 2mL simultaneously, puts in 25mL measuring bottle, adds water to scale, shakes up, as blank solution.The amount of reading Quercitroside in test sample from standard curve, calculates, and obtains.
The results are shown in Table 3.
Table 3 total flavonoids in albizia julibrissin durazz influence factor-general flavone content
From result, after the violent condition such as illumination in 5 days, 10 days, high temperature (60 ℃), high humidity (75%), in total flavonoids in albizia julibrissin durazz, general flavone content was compared with 0 day, did not have notable difference, and explanation has good stability, and effective ingredient is not made significant difference.
[experimental example 5] Tail suspension test
Select 50 of male mouse of kunming, by body weight, be divided at random 5 groups, be respectively model control group, positive drug matched group (fluoxetine, 20mg/kg), low/medium/high dosage group (50.2mg/kg, 172mg/kg of total flavonoids in albizia julibrissin durazz, 344mg/kg), 10 every group.Each organize gastric infusion or etc. capacity distilled water, every day 1 time, continuously 7d.After last administration 1h, mouse tail end 2cm place is fixed on rubber plaster on horizontal brandreth, the about 5cm of its head destage face, hangs both sides and separates animal sight line with plate.Observe 6min, record the accumulative total dead time (s) of mice in rear 4min.Judge motionless standard: mice stops struggling, and health is vertical upside down shape, transfixion aloft.Experimental situation is kept quite, and light is soft, reduces the interference to animal.Experimental result is in Table 4.
The impact of table 4 total flavonoids in albizia julibrissin durazz on the Tail suspension test dead time
Note: with matched group comparison, * P<0.05
Experimental result demonstration, sub-chronic giving, after middle and high dosage total flavonoids in albizia julibrissin durazz, can significantly be shortened the mouse tail suspension dead time, shows that total flavonoids in albizia julibrissin durazz has antidepressant effect on this model.
The experiment of [experimental example 6] mice forced swimming
Select 50 of male mouse of kunming, by body weight, be divided at random 5 groups, be respectively model control group, and positive drug matched group (fluoxetine, 20mg/kg), low/medium/high dosage group of FAF (50.2mg/kg, 172mg/kg, 344mg/kg), 10 every group.Each organize gastric infusion or etc. capacity distilled water, every day 1 time, continuously 7d.After last administration 1h, mice is inserted separately to high 30cm, diameter 14cm, depth of water 10cm (with mice rear solid end just may and cylinder bottom, but can not body support be as the criterion), in the circular glass cylinder that water temperature is 25 ℃, observe 6min, the accumulative total dead time (s) after record in 4min.Judge motionless standard: mice is floating state in water, stop struggling or only have tiny limb motion to keep head to keep afloat.Experimental situation is kept quite, and keeps the water in glass jar as clear as crystal, reduces the interference to animal.Experimental result is in Table 5.
The impact of table 5 total flavonoids in albizia julibrissin durazz on the mice forced swimming dead time
Note: with matched group comparison, * P<0.05
Experimental result demonstration, sub-chronic giving after high dose total flavonoids in albizia julibrissin durazz, can significantly shorten mice non-swimming time, shows that total flavonoids in albizia julibrissin durazz has antidepressant effect on this model.
The dissolution determination of [experimental example 7] total flavonoids in albizia julibrissin durazz hard capsule preparation
Preparation method: the total flavonoids in albizia julibrissin durazz extract of recipe quantity is mixed homogeneously with fluidizer, disintegrating agent is added to said mixture; 20 order wet granulations, 50 ℃ of oven dry, granulate; Disintegrating agent is added and dries rear mixture; Lubricant is added to said mixture, and mix homogeneously, incapsulates, and obtains.
Total flavonoids in albizia julibrissin durazz extract under made capsule and content uniformity item is carried out to dissolution determination.
Condition determination: according to dissolution method (two appendix X C the second methods of Chinese Pharmacopoeia version in 2010), pH7.6 phosphate buffer (containing the 0.01% polyoxyethylene sorbitan monoleate) 900mL of take is solvent, rotating speed 65rpm, operation in accordance with the law, sampling and measuring when 60 minutes and 180 minutes respectively, result is as shown in table 6.
Table 6 dissolution determination result
The specific embodiment:
The preparation of [embodiment 1] total flavonoids in albizia julibrissin durazz
Take dry Flos Albiziae 1kg, with 12 times, measure 50% ethanol extractions 2 times, be followed successively by 1.5h, 1h, merge extractive liquid,, filters, 60-70 ℃ is evaporated to 1/10 volume, 1 times of amount ethyl acetate extraction 3 times, combined ethyl acetate extract, 60-70 ℃ of concentrating under reduced pressure, drying under reduced pressure, obtains total flavonoids in albizia julibrissin durazz 39g.
The prescription of [embodiment 2] total flavonoids in albizia julibrissin durazz capsule preparations forms and preparation
Preparation method: the total flavonoids in albizia julibrissin durazz extract of recipe quantity is mixed homogeneously with fluidizer, disintegrating agent is added to said mixture; 20 order wet granulations, 60 ℃ of oven dry, granulate; Disintegrating agent is added and dries rear mixture; Lubricant is added to said mixture, and mix homogeneously, incapsulates, and obtains.
The prescription of [embodiment 3] total flavonoids in albizia julibrissin durazz capsule preparations forms and preparation
Preparation method: the total flavonoids in albizia julibrissin durazz extract of recipe quantity is mixed homogeneously with fluidizer, disintegrating agent is added to said mixture; 20 order wet granulations, 50 ℃ of oven dry, granulate; Disintegrating agent is added and dries rear mixture; Lubricant is added to said mixture, and mix homogeneously, incapsulates, and obtains.
[embodiment 4] dissolution determination result
Embodiment 2,3 made capsules are carried out to dissolution determination.
Condition determination: according to dissolution method (two appendix X C the second methods of Chinese Pharmacopoeia version in 2010), pH7.6 phosphate buffer (containing the 0.01% polyoxyethylene sorbitan monoleate) 900ml of take is solvent, rotating speed 65rpm, operation in accordance with the law, sampling and measuring when 60 minutes and 180 minutes respectively, result is as shown in table 1.
Table 1 dissolution determination result
The prescription of [embodiment 5] total flavonoids in albizia julibrissin durazz drop pill forms and preparation
Preparation method: polyethylene glycol 6000 and PLURONICS F87 are put to 70-85 ℃ of heating, and stir into molten condition, get recipe quantity total flavonoids in albizia julibrissin durazz, flavoring agent, divided 60 mesh sieves, add wherein, be stirred to medicinal liquid color and luster homogeneous, without block, select water dropper to splash in liquid coolant by every ball 30-35mg, dripping becomes ball, centrifugal deoiling, dry sieve ball, obtains.
The prescription of [embodiment 6] total flavonoids in albizia julibrissin durazz soft capsule forms and preparation
Preparation method: the total flavonoids in albizia julibrissin durazz extract of recipe quantity is suspended in PEG400, standby.Prepare softgel shell colloid, pelleting, sizing is dry, obtains.
Claims (9)
1. contain a pharmaceutical preparation for total flavonoids in albizia julibrissin durazz, its principal character is, in described total flavonoids in albizia julibrissin durazz, to contain 41-50% Quercitroside.
2. the pharmaceutical preparation of total flavonoids in albizia julibrissin durazz as claimed in claim 1, another feature is that described total flavonoids in albizia julibrissin durazz also contains 0.1-10% Quercetin, 0.1-5% kaempferide, 0.1-2% Quercetin-3-O-α-L-arabinose glycosides, 0.1-2% kaempferol-3-O-α-L-arabinose glycosides.
3. the pharmaceutical preparation of total flavonoids in albizia julibrissin durazz as claimed in claim 1, another feature is mixed and is formed mutually with the pharmaceutically acceptable carrier of total flavonoids in albizia julibrissin durazz claimed in claim 2 and one or more and/or excipient by the claims 1.
4. the pharmaceutical preparation as described in claim 1-3, another feature is total flavonoids in albizia julibrissin durazz and carrier or the excipient described in the claims 1-3, following ratio, consists of:
。
5. the pharmaceutical preparation as described in claim 1-4, another feature is that described fluidizer is selected from micropowder silica gel, micropowder silica gel and their mixture, described disintegrating agent is selected from microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch sodium and their mixture, and described lubricant is selected from magnesium stearate, calcium stearate, Macrogol 4000, polyethylene glycol 6000, hydrogenated vegetable oil, magnesium laurylsulfate and their mixture.
6. the pharmaceutical preparation as described in claim 1-5, another feature is that preparation method is that total flavonoids in albizia julibrissin durazz and mixed with excipients is even, adopts wet method or dry granulation, granulate, additional other mixed with excipients are even, obtain medicine single-size.
7. the drug particles as described in claim 1-6, can be used for preparation but is not limited to prepare hard capsule, granule, tablet.
8. the pharmaceutical preparation as described in claim 1-3, another feature is can be used for preparation but be not limited to prepare soft capsule, drop pill and liquid preparation.
9. the pharmaceutical preparation as described in claim 1-8, the application in the medicine for the preparation of Cure of depression.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104042720A (en) * | 2014-07-08 | 2014-09-17 | 河南中医学院 | Traditional Chinese medicine for preventing and treating diabetes with depression and application of traditional Chinese medicine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210738A (en) * | 2010-12-23 | 2011-10-12 | 北京双鹭药业股份有限公司 | Preparation method of total flavonoids in albizia julibrissin durazz and medicinal composition thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102210738A (en) * | 2010-12-23 | 2011-10-12 | 北京双鹭药业股份有限公司 | Preparation method of total flavonoids in albizia julibrissin durazz and medicinal composition thereof |
Non-Patent Citations (2)
| Title |
|---|
| 康健等: "正交试验法优选合欢花提取工艺的研究", 《中成药》 * |
| 施学丽等: "合欢花的研究进展", 《中国民族医药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042720A (en) * | 2014-07-08 | 2014-09-17 | 河南中医学院 | Traditional Chinese medicine for preventing and treating diabetes with depression and application of traditional Chinese medicine |
| CN104042720B (en) * | 2014-07-08 | 2016-03-30 | 河南中医学院 | There is the Chinese medicine and application thereof of preventing and treating diabetes complicated depression |
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