CN103664752A - Synthesis process for ibuprofen piconol - Google Patents
Synthesis process for ibuprofen piconol Download PDFInfo
- Publication number
- CN103664752A CN103664752A CN201410000761.7A CN201410000761A CN103664752A CN 103664752 A CN103664752 A CN 103664752A CN 201410000761 A CN201410000761 A CN 201410000761A CN 103664752 A CN103664752 A CN 103664752A
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- Prior art keywords
- ibuprofen
- ibuprofen piconol
- synthetic method
- piconol
- catalyzer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention discloses a synthesis process for ibuprofen piconol. Ibuprofen and 2-(Hydroxymethyl)pyridine react under the action of condensing agent and catalyst, so that the ibuprofen piconol is produced. Compared with the prior art, the process route is advanced, the process conditions are reasonable, the usage of thionyl chloride and other poisonous and harmful reagents is avoided, moreover, the synthesis process is easy and safe to operate and easy to control, the problems after the reaction process in the conventional process, such as troublesome post-processing and severe three-waste pollution, are avoided from the source, and the synthesis process is environment-friendly and has great implementation value and social and economic benefits.
Description
Technical field
The present invention relates to medicine invention field, relate to the preparation method of a kind of chemosynthesis of medicinal compound, particularly Ibuprofen piconol.
Background technology
Ibuprofen BP/EP is aryl alkanoic acid compounds, is one of antipyretic anti-inflammatory analgesic of current turnout and usage quantity maximum.Ibuprofen piconol is the derivative of Ibuprofen BP/EP, belong to the dermatological treatment externally applied agent of non_steroidal anti_inflammatory drug, chemistry (±)-(Alpha-Methyl-4-(2-methyl-propyl)-toluylic acid-2-picolyl ester by name, it is the external application NSAID (non-steroidal anti-inflammatory drug) of Japanese Hisamitsu Pharmaceutical Co., Inc. exploitation, within 1984, in Japan, go on the market first, trade(brand)name Vesicum, cures mainly acute eczema, contact dermatitis, atopic dermatitis, chronic eczema, vinasse sample dermatitis, Perioral Dermatitis, zoster, acne, infantile eczema etc.Ibuprofen piconol has stronger analgesia and anti-inflammatory action, there is no the various toxic actions of topical corticosteroids medicine, has wide range of applications, and toxic side effect is minimum, develops this product and has obvious economic and social benefit.
At present the predominating path of Ibuprofen piconol be take Ibuprofen BP/EP as starting raw material with exactlying, carries out acyl chloride reaction, then under the existence of alkaline catalysts, carry out esterification generation Ibuprofen piconol (GB1573322, US4150137) with the acyl chlorinating agent such as sulfur oxychloride.This is conventional esterification route.The main drawback of the method is complicated operation, total recovery is low, in reaction, used a large amount of disagreeableness as raw materials such as sulfur oxychloride, triethylamine or pyridines to environment, from reaction process, can see the value and the measure that there is no recycling, produce a large amount of hydrogenchloride and sulfur dioxide gas, cause environmental pollution, make manufacturer aspect cost and environmental protection, all have larger pressure.
Summary of the invention
The object of the invention is to overcome in prior art and prepare Ibuprofen piconol complex process, the deficiency that yield is not good, provides a kind of synthetic method of Ibuprofen piconol.
The technical solution used in the present invention is as follows:
A kind of synthetic method of Ibuprofen piconol, Ibuprofen BP/EP and 2-4-hydroxymethylpiperidine are in organic solvent, under room temperature condition, under the effect of condensing agent and catalyzer, esterification 1-24 hour, filters, filtrate is extremely neutral with 5wt% sodium hydrogen carbonate solution, purified water washing, dry, underpressure distillation, obtains Ibuprofen piconol.
Further, described organic solvent is selected from following one or more mixture: methylene dichloride, dimethyl formamide, ethyl acetate, toluene, acetone, tetrahydrofuran (THF), butanone, trichloromethane, trichloroethane, cyclopentanone, cyclohexanone, isopropyl ether, normal hexane.
Further, described condensing agent is selected from following one or more mixture: N, N'-dicyclohexylcarbodiimide (DCC), 1-(3-dimethylamino-propyl)-3-ethyl-carbodiimide and hydrochloride (EDC) thereof, N, N'-DIC (DIC),, the agent of DCC-1-hydroxybenzotriazole (HOBt) coupling condenser; Described catalyzer is DMAP (DMAP).
Further, described catalyzer is DMAP.
Further, in described synthetic method, the mol ratio of the consumption of Ibuprofen BP/EP used, 2-4-hydroxymethylpiperidine, condensing agent and catalyzer is as follows: Ibuprofen BP/EP: 2-4-hydroxymethylpiperidine: condensing agent: catalyzer is 0.8-1.1:1.2:1-1.2:0.05-0.1.
Further, in described synthetic method, consumption of organic solvent is 8-10 doubly (organic solvent ml/ raw material g).
Further, described reaction is carried out 2-12 hour at 20 ~ 25 degrees Celsius.
compared with prior art, the invention has the beneficial effects as follows: operational path is advanced, processing condition are reasonable, avoided using the halogenating agents such as sulfur oxychloride that produce a large amount of toxic and harmfuls, and two-step reaction becomes single step reaction, easy to operate and safe, reaction yield is high, and reaction conditions is easy to control, the equal recovery of solvent and dehydrating condensation agent, the problems such as traditional technology reaction process aftertreatment trouble, three-waste pollution be serious from source, have been eliminated, environmentally friendly, quantity of three wastes is few, has larger implementary value and economic results in society.
Embodiment
Below in conjunction with embodiment, foregoing invention content of the present invention is described in further detail.But this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following embodiment.Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, make various replacements and change, all should comprise within the scope of the invention.
Embodiment 1
In the dry there-necked flask of 5000ml, add 206g Ibuprofen BP/EP and 2500m1 methylene dichloride, stirring and dissolving, add 109g 2-4-hydroxymethylpiperidine, 206g N, N'-dicyclohexylcarbodiimide and 4.0g DMAP, temperature control 20-25 degree stirs 12h, separate out a large amount of white crystals, filter, appropriate washed with dichloromethane, merge washing filtrate, use successively the Na of 500ml 5wt%
2cO
3, 1000ml is washed to neutrality, anhydrous Na
2sO
4dry, vacuum distillation recovered solvent, then rectifying obtains 276g Ibuprofen piconol (171-173 ℃/0.133kPa), yield 94%.
Embodiment 2
In the dry there-necked flask of 5000ml, add 197g Ibuprofen BP/EP and 2500m1 acetone, stirring and dissolving, add 123g 2-4-hydroxymethylpiperidine, 199g N, N'-dicyclohexylcarbodiimide and 4.3g DMAP, temperature control 20-25 degree stirs 12h, separate out a large amount of white crystals, filter, appropriate washed with dichloromethane, merge washing filtrate, use successively the Na of 600ml 5wt%
2cO
3, 800ml is washed to neutrality, anhydrous Na
2sO
4dry, vacuum distillation recovered solvent, then rectifying obtains 276g Ibuprofen piconol (171-173 ℃/0.133kPa), yield 94%.
Claims (7)
1. a synthetic method for Ibuprofen piconol, is characterized in that, by Ibuprofen BP/EP and 2-4-hydroxymethylpiperidine, under the effect of condensing agent and catalyzer, reaction generates Ibuprofen piconol.
2. according to the synthetic method of the Ibuprofen piconol described in claim 1, it is characterized in that, by Ibuprofen BP/EP, 2-4-hydroxymethylpiperidine in organic solvent, under room temperature condition, esterification 1-24 hour under the effect of condensing agent and catalyzer, filters, filtrate is extremely neutral with 5wt% sodium hydrogen carbonate solution, purified water washing, dry, underpressure distillation, gained is Ibuprofen piconol.
3. the synthetic method of Ibuprofen piconol according to claim 1, it is characterized in that, described organic solvent is selected from one of following or two or more mixture wherein: methylene dichloride, dimethyl formamide, ethyl acetate, toluene, acetone, tetrahydrofuran (THF), butanone, trichloromethane, trichloroethane, cyclopentanone, cyclohexanone, isopropyl ether, normal hexane.
4. the synthetic method of Ibuprofen piconol according to claim 1, it is characterized in that, described condensing agent is one of following or two or more mixture: N wherein, N'-dicyclohexylcarbodiimide, 1-(3-dimethylamino-propyl)-3-ethyl-carbodiimide and hydrochloride thereof, N, N'-DIC, hydroxybenzotriazole;
Described catalyzer is DMAP.
5. the synthetic method of Ibuprofen piconol according to claim 1, it is characterized in that, in described method, the consumption of Ibuprofen BP/EP used, 2-4-hydroxymethylpiperidine, condensing agent and catalyzer is in molar ratio: Ibuprofen BP/EP: 2-4-hydroxymethylpiperidine: condensing agent: catalyzer=0.8-1.1:1.2:1-1.2:0.05-0.1.
6. according to the synthetic method of the Ibuprofen piconol described in claim 1, it is characterized in that, the 8-10 that the consumption of organic solvent of using in reaction process is raw material times, organic solvent ml/ raw material g.
7. according to the synthetic method of the Ibuprofen piconol described in claim 6, it is characterized in that, organic solvent reclaims, and drying is reused after processing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410000761.7A CN103664752A (en) | 2014-01-02 | 2014-01-02 | Synthesis process for ibuprofen piconol |
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| CN201410000761.7A CN103664752A (en) | 2014-01-02 | 2014-01-02 | Synthesis process for ibuprofen piconol |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105985283A (en) * | 2015-01-30 | 2016-10-05 | 安徽省新星药物开发有限责任公司 | Synthesis method for Pimeprofen |
| CN107805219A (en) * | 2017-12-26 | 2018-03-16 | 荆门医药工业技术研究院 | It is a kind of that the method that Ibuprofen Piconol is reclaimed in waste material is produced from Ibuprofen Piconol |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102304081A (en) * | 2011-05-25 | 2012-01-04 | 湖南医药工业研究所 | Green synthesis method for ibuprofen piconol and medicinal preparation thereof |
-
2014
- 2014-01-02 CN CN201410000761.7A patent/CN103664752A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102304081A (en) * | 2011-05-25 | 2012-01-04 | 湖南医药工业研究所 | Green synthesis method for ibuprofen piconol and medicinal preparation thereof |
Non-Patent Citations (4)
| Title |
|---|
| 丁盈红，等: "水杨酸苯酯的合成新方法研究", 《山西化工》, vol. 22, no. 2, 31 May 2002 (2002-05-31), pages 10 - 12 * |
| 佘志刚，等: "DMAP催化合成苯甲酸苯酯的研究", 《化学试剂》, vol. 23, no. 2, 31 December 2001 (2001-12-31) * |
| 向玲，等: "酰氯法合成布洛芬吡甲酯工艺的改进", 《华西药学杂志》, vol. 21, no. 2, 31 December 2006 (2006-12-31), pages 178 - 179 * |
| 许友: "水杨酸甲酯的合成新方法", 《精细石油化工进展》, vol. 11, no. 4, 30 April 2010 (2010-04-30), pages 42 - 45 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105985283A (en) * | 2015-01-30 | 2016-10-05 | 安徽省新星药物开发有限责任公司 | Synthesis method for Pimeprofen |
| CN105985283B (en) * | 2015-01-30 | 2018-08-24 | 安徽省新星药物开发有限责任公司 | A kind of synthetic method of Ibuprofen piconol |
| CN107805219A (en) * | 2017-12-26 | 2018-03-16 | 荆门医药工业技术研究院 | It is a kind of that the method that Ibuprofen Piconol is reclaimed in waste material is produced from Ibuprofen Piconol |
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Application publication date: 20140326 |