CN103664681A - Preparation method of N-[2-(3,4-dimethoxy phenyl)-2-oxo-ethyl]-2-(3,4,5-trimethoxy phenyl) acetamide - Google Patents
Preparation method of N-[2-(3,4-dimethoxy phenyl)-2-oxo-ethyl]-2-(3,4,5-trimethoxy phenyl) acetamide Download PDFInfo
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- CN103664681A CN103664681A CN201210345222.8A CN201210345222A CN103664681A CN 103664681 A CN103664681 A CN 103664681A CN 201210345222 A CN201210345222 A CN 201210345222A CN 103664681 A CN103664681 A CN 103664681A
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Abstract
The invention discloses a preparation method of N-[2-(3,4-dimethoxy phenyl)-2-oxo-ethyl]-2-(3,4,5-trimethoxy phenyl) acetamide. The preparation method comprises the following steps: (1) adding 3,4,5-dimethoxy-1-aminoacetyl phenyl hydrobromide, 3,4,5-trimethoxy phenylacetate, DMAP (dimethylaminopyridine) and anhydrous dichloromethane in a reaction flask, cooling to 0 DEG.C, adding EDCI.HCl under the nitrogen protection, stirring to react for 30 minutes, and then warming to room temperature, and continuously stirring to react for 24 hours; (2) orderly washing by using 2.0mol/L hydrochloric acid, a saturated sodium bicarbonate solution and a saturated saline solution, drying by using anhydrous sodium sulfate, removing the solvent through reduced pressure evaporation, and recrystallizing residue by using dichloromethane-ethyl acetate to obtain the N-[2-(3,4-dimethoxy phenyl)-2-oxo-ethyl]-2-(3,4,5-trimethoxy phenyl) acetamide. The preparation method has the advantages that the method is simple and convenient, and the yield can achieve 76%.
Description
Technical field
The invention belongs to organic chemical synthesis technical field, be specifically related to a kind of N-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl] preparation method of-2-(3,4,5-trimethoxyphenyl) ethanamide.
Background technology
Combretastatin (Combretastatins) is the natural product with anticancer activity that separation obtains from South Africa shrub (Combretum caffrum), it is by suppressing tubulin polymerization, optionally stop blood to flow to tumour, cause death of neoplastic cells, thereby reach anticancer object.In this class natural product, the activity of Combretastatin A4 (CA-4) is the highest, and kinds of tumors is had to strong restraining effect.Due to the poorly water-soluble of CA-4, bioavailability is low, therefore changes its phosphorylated into water miscible phosphate disodium salt predrug (CA-4P), and its anti-tumor in vivo activity improves greatly.CA4P has entered the clinical study stage three phases.But CA-4 has the shortcoming for the E-configuration without antitumour activity from Z-configurational isomerization.For fixing Z-configuration, for bibliographical information, five yuan of fragrant heterocycles such as imidazoles, oxazole, thiazole, pyrazoles, triazole and furazan replace the ethylene linkage in CA-4 molecules in recent years.In these CA-4 analogues, the Anticancer Activity in vitro of some compounds and CA-4 are quite even higher than CA-4.The ethylene linkage that replaces CA-4 with suitable rigidity alicyclic ring, also can reach the fixedly object of Z-configuration.The ring butyramide of the use such as Niamh alicyclic ring replaces the IC of the synthetic CA-4 analogue of the ethylene linkage of CA-4 to MCF-7 tumour cell
50value reaches 10nmolL
-1level, the derivative after the ethylene linkage of the maleinamide replacement CA-4 of the use such as Dannhardt alicyclic ring is as tumour cell microtubule polymerization inhibitor, IC
50value also reaches nmole level level.But less with the CA-4 analogue bibliographical information of unit centered by alicyclic ring.
In order to study rigidity alicyclic ring, replace on CA-4 analogue that ethylene linkage builds and aromatic ring substituting group on bioactive impact, applicant has synthesized the CA-4 analogue of unit centered by a series of new alicyclic rings, 3,4-diaryl pyrrole-2,5-diketone and 3,4-diaryl pyrrole-2-ketone.Therefore, need a kind of N-[2-of special design (3,4-Dimethoxyphenyl)-2-oxoethyl]-2-(3,4,5-trimethoxyphenyl) ethanamide.In actual fabrication process, change bromide into primary amine, conventional method is Gabriel synthesis method.But in Gabriel reaction, need just can obtain primary amine with hydrazine hydrate hydrazinolysis, and carbonyl in reactant is easy and hydrazine condensation causes lower yield.
Summary of the invention
For solving the problems of the technologies described above, the object of the present invention is to provide a kind of N-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-2-(3,4,5-trimethoxyphenyl) preparation method of ethanamide, the method not only method for making is easy, and productive rate is higher.
The present invention solves the problems of the technologies described above taked technical scheme: a kind of N-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-2-(3,4,5-trimethoxyphenyl) preparation method of ethanamide, it is characterized in that comprising the steps: that (1) adds 3 in reaction flask, 4-dimethoxy-1-glycyl benzene hydrobromate, 3,4,5-trimethoxy toluylic acid, DMAP and anhydrous methylene chloride, be cooled to 0 ℃, under nitrogen protection, add EDCIHCl, after stirring reaction 30min, rise to room temperature, continue stirring reaction 24h; (2) use successively 2.0mol/L hydrochloric acid, saturated sodium bicarbonate solution, saturated common salt water washing, anhydrous sodium sulfate drying, pressure reducing and steaming solvent, methylene dichloride-re-crystallizing in ethyl acetate for residue, obtain N-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-2-(3,4,5-trimethoxyphenyl) ethanamide.
As preferably; described 3; 4-dimethoxy-1-glycyl benzene hydrobromate consumption is 0.5g, described 3; 4; 5-trimethoxy toluylic acid consumption is that 0.41g, described DMAP consumption are that 0.55g, described anhydrous methylene chloride consumption are 35mL; described EDCIHCl consumption is 0.38g, and described hydrochloric acid, saturated sodium bicarbonate solution, saturated common salt water consumption are 50mL.
Technique of the present invention is simple, and easily, productive rate is higher in preparation.Preparation method's of the present invention N-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl] productive rate of-2-(3,4,5-trimethoxyphenyl) ethanamide can reach more than 76%.
Embodiment
Below in conjunction with embodiment, to of the present invention, be further elaborated.
Embodiment 1: in reaction flask, add 0.5g 3; 4-dimethoxy-1-glycyl benzene hydrobromate, 0.41G 3,4,5-trimethoxy toluylic acid, 0.55g DMAP and 35mL anhydrous methylene chloride; be cooled to 0 ℃, under nitrogen protection, add 0.38gEDCIHCl.After stirring reaction 30min, rise to room temperature, continue stirring reaction 24h.Then use successively 50mL 2.0mol/L hydrochloric acid, 50mL saturated sodium bicarbonate solution, the water washing of 50mL saturated common salt, anhydrous sodium sulfate drying.Pressure reducing and steaming solvent, residue obtains compound N-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-2-(3 of 0.55g (1.36mmol) by methylene dichloride-re-crystallizing in ethyl acetate, 4,5-trimethoxyphenyl) ethanamide, white solid, productive rate 76%.
Though it is pointed out that above-described embodiment is to the present invention's detailed text description of contrasting, these text descriptions are the simple description to mentality of designing of the present invention just, rather than the restriction to thinking of the present invention.Any combination, increase or modification that is no more than mentality of designing of the present invention, all falls within the scope of protection of the present invention.
Claims (2)
1. a N-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl] preparation method of-2-(3,4,5-trimethoxyphenyl) ethanamide, it is characterized in that comprising the steps: that (1) adds 3 in reaction flask, 4-dimethoxy-1-glycyl benzene hydrobromate, 3,4,5-trimethoxy toluylic acid, DMAP and anhydrous methylene chloride, be cooled to 0 ℃, under nitrogen protection, add EDCIHCl, after stirring reaction 30min, rise to room temperature, continue stirring reaction 24h; (2) use successively 2.0mol/L hydrochloric acid, saturated sodium bicarbonate solution, saturated common salt water washing, anhydrous sodium sulfate drying, pressure reducing and steaming solvent, methylene dichloride-re-crystallizing in ethyl acetate for residue, obtain N-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-2-(3,4,5-trimethoxyphenyl) ethanamide.
2. N-[2-(3 according to claim 1; 4-Dimethoxyphenyl)-2-oxoethyl]-2-(3; 4; 5-trimethoxyphenyl) preparation method of ethanamide; it is characterized in that: described 3; 4-dimethoxy-1-glycyl benzene hydrobromate consumption is 0.5g, described 3; 4; 5-trimethoxy toluylic acid consumption is that 0.41g, described DMAP consumption are that 0.55g, described anhydrous methylene chloride consumption are 35mL; described EDCIHCl consumption is 0.38g, and described hydrochloric acid, saturated sodium bicarbonate solution, saturated common salt water consumption are 50mL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210345222.8A CN103664681A (en) | 2012-09-18 | 2012-09-18 | Preparation method of N-[2-(3,4-dimethoxy phenyl)-2-oxo-ethyl]-2-(3,4,5-trimethoxy phenyl) acetamide |
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| CN201210345222.8A CN103664681A (en) | 2012-09-18 | 2012-09-18 | Preparation method of N-[2-(3,4-dimethoxy phenyl)-2-oxo-ethyl]-2-(3,4,5-trimethoxy phenyl) acetamide |
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| CN103664681A true CN103664681A (en) | 2014-03-26 |
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| CN201210345222.8A Pending CN103664681A (en) | 2012-09-18 | 2012-09-18 | Preparation method of N-[2-(3,4-dimethoxy phenyl)-2-oxo-ethyl]-2-(3,4,5-trimethoxy phenyl) acetamide |
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2012
- 2012-09-18 CN CN201210345222.8A patent/CN103664681A/en active Pending
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Application publication date: 20140326 |