CN103638008A - Application of Artoxanthochromane in skin cancer treatment drugs - Google Patents
Application of Artoxanthochromane in skin cancer treatment drugs Download PDFInfo
- Publication number
- CN103638008A CN103638008A CN201310634100.5A CN201310634100A CN103638008A CN 103638008 A CN103638008 A CN 103638008A CN 201310634100 A CN201310634100 A CN 201310634100A CN 103638008 A CN103638008 A CN 103638008A
- Authority
- CN
- China
- Prior art keywords
- artoxanthochromane
- application
- skin cancer
- drugs
- cancer treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VHDAXQOBUDDCHU-VXKWHMMOSA-N artoxanthochromane Natural products CC1(C)[C@H]([C@@H](Oc2cc(O)ccc12)c3ccc(O)cc3O)c4cc(O)cc(O)c4 VHDAXQOBUDDCHU-VXKWHMMOSA-N 0.000 title claims abstract description 22
- 201000000849 skin cancer Diseases 0.000 title claims abstract description 18
- 239000003814 drug Substances 0.000 title claims abstract description 16
- 229940079593 drug Drugs 0.000 title abstract description 8
- 208000000453 Skin Neoplasms Diseases 0.000 title abstract description 7
- 201000008261 skin carcinoma Diseases 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 abstract description 11
- 230000012010 growth Effects 0.000 abstract description 7
- 102100027833 14-3-3 protein sigma Human genes 0.000 abstract description 6
- 101100107350 Homo sapiens SFN gene Proteins 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 230000000259 anti-tumor effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- 239000003560 cancer drug Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 8
- 241001438988 Artocarpus xanthocarpus Species 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- The application of 1.Artoxanthochromane in treatment skin carcinoma medicine, described compd A rtoxanthochromane structure is as shown in formula I:Formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310634100.5A CN103638008B (en) | 2013-12-02 | 2013-12-02 | The application of Artoxanthochromane in treatment skin carcinoma medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310634100.5A CN103638008B (en) | 2013-12-02 | 2013-12-02 | The application of Artoxanthochromane in treatment skin carcinoma medicine |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103638008A true CN103638008A (en) | 2014-03-19 |
CN103638008B CN103638008B (en) | 2015-09-16 |
Family
ID=50243384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310634100.5A Active CN103638008B (en) | 2013-12-02 | 2013-12-02 | The application of Artoxanthochromane in treatment skin carcinoma medicine |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103638008B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9701655B2 (en) | 2014-02-07 | 2017-07-11 | Novogen Limited | Functionalised benzopyran compounds and use thereof |
-
2013
- 2013-12-02 CN CN201310634100.5A patent/CN103638008B/en active Active
Non-Patent Citations (2)
Title |
---|
HORNG-HUEY KO等: "a novel monoterpene-stilbene adduct with a 4,4-dimethyl-2,3-diphenylchromane skeleton from artocarpus xanthocarpus", 《CHEMISTRY & BIODIVERSITY》, vol. 10, no. 7, 12 July 2013 (2013-07-12), pages 1269 - 1275 * |
崔剑 等: "自由基生物抗氧化与疾病", 《清华大学学报 自然科学版》, vol. 40, no. 6, 31 December 2000 (2000-12-31), pages 9 - 12 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9701655B2 (en) | 2014-02-07 | 2017-07-11 | Novogen Limited | Functionalised benzopyran compounds and use thereof |
US10370349B2 (en) | 2014-02-07 | 2019-08-06 | Kazia Therapeutics Limited | Functionalised benzopyran compounds and use thereof |
Also Published As
Publication number | Publication date |
---|---|
CN103638008B (en) | 2015-09-16 |
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Address after: 225300 Jiangsu province Taizhou Gaogang Xu Zhuang Street Minghe Village No. 53 Patentee after: Liu Yanjiao Address before: 235000 Anhui Province, Huaibei City Xiangshan District Anhui Hengyuan coal Limited by Share Ltd dormitory Patentee before: Liu Yanjiao |
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