CN103613683A - Method for extracting sodium alginate from gulfweed - Google Patents
Method for extracting sodium alginate from gulfweed Download PDFInfo
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- CN103613683A CN103613683A CN201310621839.2A CN201310621839A CN103613683A CN 103613683 A CN103613683 A CN 103613683A CN 201310621839 A CN201310621839 A CN 201310621839A CN 103613683 A CN103613683 A CN 103613683A
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- sodium alginate
- calcium
- nacl solution
- solution
- sargassun
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Abstract
The invention relates to a method for extracting sodium alginate from gulfweed, belonging to the technical field of marine organism extraction. The method comprises the following steps: (1) immersing: (2) digesting; (3) precipitating calcium, wherein HCl, which accounts for 11% of the total raw material, is added into a CaCl2 solution to ensure the pH value of the colloidal liquid in the calcium precipitation process is 6.0-7.0, and 25ml of 10% CaCl2 solution is added to every liter of colloidal liquid; and (4) ion exchange: adding a calcium alginate gel into 6 times by volume of NaCl solution, stirring at normal temperature for 60 minutes, filtering out the NaCl solution to complete the primary exchange, and repeating the process 5-6 times, wherein the waste NaCl solution can be regenerated for repeated use, and the obtained sodium alginate is bleached by H2O2 and dried to obtain the finished product. The gulfweed is used as the raw material to produce the high-viscosity sodium alginate by the ion exchange method; and the yield is 23.7%. and the product viscosity is greater than 1300 mPa.s. The method is expected to generate huge economic benefit and social benefit when being applied to industrial production.
Description
Technical field
The invention belongs to marine organisms extractive technique field, particularly a kind of from sargassun the method for sodium alginate extraction.
Background technology
Sodium alginate has just been taken in American Pharmacopeia as far back as 1938.Lalgine is at 1963 annual income British Pharmacopoeias.Lalgine is water insoluble, but put into water, can expand.Therefore, traditionally, sodium alginate is as the tackiness agent of tablet, and Lalgine is as the disintegrating agent of fast-release tablet.Yet sodium alginate depends on the amount of putting in prescription on the impact of tablet character, and in some cases, sodium alginate can promote the disintegration of tablet.Sodium alginate can add in the process of granulating, rather than the form with powder adds after granulation, and making processes is simpler like this.Compare with using starch, made physical strength in blocks is larger.
Sodium alginate is also for suspension, gel with take the production of the emulsifiable concentrates that fat and oils is matrix.Sodium alginate, for some liquid medicines, can strengthen viscosity, improves the suspension of solid.Protanal Ester SD-LB can improve the stability of emulsion.Controlled release drug transmission system accounts for very consequence in health care.Water soluble drug particulate time before separation from gluey medium will minimize to guarantee that drug loading is maximum.Yet this is unimportant to water-insoluble drug.They find that the release of medicine is relevant with the solvability of medicine used.
Sargassun is the torrid zone and temperate zone perennial algae, and aboundresources, at present mostly in the state that runs its course.The industrial main raw material of China's sodium alginate is the sargassun of the sea-tangle propagated artificially and Guangdong Coastal growth, and industrial abstract sodium alginate viscosity is generally lower at present.
Summary of the invention
For the problems referred to above, the invention provides a kind of sargassun is raw material, adopts ion exchange method to produce the method for sodium alginate.
A kind of method of extracting Lalgine from sargassun of the present invention, according to following steps, carry out:
(1) soak, with 0. 1 mol/ L HCl, by cleaning the sargassun of drying, invade bubble 2 ~ 4h;
(2) digestion, under 70 ~ 80 ℃ of conditions by above-mentioned soaked sargassun the Na at 1. 5 %
2cO
3digestion 4 ~ 5 h;
(3) calcium is analysed, and HCl is added to CaCl
2in solution, HCl adds total amount to account for 11 % of raw material, and the glue pH value while guaranteeing that calcium is analysed of take is 6. 0～7. 0, and every liter of glue adds 25 ml 10 % CaCl
2solution;
(4) ion-exchange drops into calcium alginate gel in the NaCl solution of 6 times of volumes, and stirring at normal temperature 60 min, leach NaCl solution, completes exchange for the first time; Repeat said process 5～6 times; Giving up, NaCl solution is renewable to be reused; Gained sodium alginate is through H
2o
2after bleaching, being dried, be finished product.
The sodium alginate extracting from sargassun, the content of its L-guluronic acid is higher, has special space structure.Stronger to heavy metal and radioelement bonding force, there is better nourishing function.Through experimentation on animals, show, malignant tumour tumour inhibiting rate is greater than to 30 %.Full-bodied sodium alginate except thickening property well, the feature such as also have that gel-strength is high, film-forming properties, ropiness are good, is expected the make new advances product of purposes of exploitation, as hemostatic gauze, eat film etc.
The present invention uses ion exchange method, with sargassun, makes the full-bodied sodium alginate of raw material production, and productive rate is 23. 7%, and product viscosity is greater than 1 300 mPas.Be applied to industrial production, expectation can produce very large economic benefit and social benefit.
Embodiment
embodiment 1
From sargassun, extract a method for Lalgine, according to following steps, carry out:
(1) soak, with 0. 1 mol/ L HCl, by cleaning the sargassun of drying, invade bubble 4h;
(2) digestion, under 80 ℃ of conditions by above-mentioned soaked sargassun the Na at 1. 5 %
2cO
3digest 5 h,
(3) calcium is analysed, and HCl is added to CaCl
2in solution, HCl adds total amount to account for 11 % of raw material, and the glue pH value while guaranteeing that calcium is analysed of take is 7. 0, and every liter of glue adds 25 ml 10 % CaCl
2solution,
(4) ion-exchange drops into calcium alginate gel in the NaCl solution of 6 times of volumes, and stirring at normal temperature 60 min, leach NaCl solution, completes exchange for the first time; Repeat said process 6 times.Giving up, NaCl solution is renewable to be reused; Gained sodium alginate is through H
2o
2after bleaching, being dried, be finished product.
Sodium alginate productive rate of the present invention is 23. 7%, and product viscosity is greater than 1 300 mPas.
embodiment 2
From sargassun, extract a method for Lalgine, according to following steps, carry out:
(1) soak, with 0. 1 mol/ L HCl, by cleaning the sargassun of drying, invade bubble 2h;
(2) digestion, under 70 ℃ of conditions by above-mentioned soaked sargassun the Na at 1. 5 %
2cO
3digest 5 h,
(3) calcium is analysed, and HCl is added to CaCl
2in solution, HCl adds total amount to account for 11 % of raw material, and the glue pH value while guaranteeing that calcium is analysed of take is 7. 0, and every liter of glue adds 25 ml 10 % CaCl
2solution,
(4) ion-exchange drops into calcium alginate gel in the NaCl solution of 6 times of volumes, and stirring at normal temperature 60 min, leach NaCl solution, completes exchange for the first time; Repeat said process 5～6 times.Giving up, NaCl solution is renewable to be reused; Gained sodium alginate is through H
2o
2after bleaching, being dried, be finished product.
The present invention makes the full-bodied sodium alginate of raw material production with sargassun, and productive rate is 23. 8%, and product viscosity is greater than 1 300 mPas.
Claims (1)
1. a method for sodium alginate extraction from sargassun, is characterized in that carrying out according to following steps:
(1) soak, with 0. 1 mol/ L HCl, by cleaning the sargassun of drying, invade bubble 2 ~ 4h;
(2) digestion, under 70 ~ 80 ℃ of conditions by above-mentioned soaked sargassun the Na at 1. 5 %
2cO
3digestion 4 ~ 5 h;
(3) calcium is analysed, and HCl is added to CaCl
2in solution, HCl adds total amount to account for 11 % of raw material, and the glue pH value while guaranteeing that calcium is analysed of take is 6. 0～7. 0, and every liter of glue adds 25 ml 10 % CaCl
2solution;
(4) ion-exchange drops into calcium alginate gel in the NaCl solution of 6 times of volumes, and stirring at normal temperature 60 min, leach NaCl solution, completes exchange for the first time; Repeat said process 5～6 times; Giving up, NaCl solution is renewable to be reused; Gained sodium alginate is through H
2o
2after bleaching, being dried, be finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310621839.2A CN103613683A (en) | 2013-11-30 | 2013-11-30 | Method for extracting sodium alginate from gulfweed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310621839.2A CN103613683A (en) | 2013-11-30 | 2013-11-30 | Method for extracting sodium alginate from gulfweed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103613683A true CN103613683A (en) | 2014-03-05 |
Family
ID=50164410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310621839.2A Pending CN103613683A (en) | 2013-11-30 | 2013-11-30 | Method for extracting sodium alginate from gulfweed |
Country Status (1)
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| CN (1) | CN103613683A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105504086A (en) * | 2015-12-09 | 2016-04-20 | 江苏明月海洋科技有限公司 | Preparation method of food-grade calcium alginate |
| CN113061196A (en) * | 2021-04-20 | 2021-07-02 | 广西科学院 | Method for extracting sodium alginate by high-pressure homogenization |
-
2013
- 2013-11-30 CN CN201310621839.2A patent/CN103613683A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105504086A (en) * | 2015-12-09 | 2016-04-20 | 江苏明月海洋科技有限公司 | Preparation method of food-grade calcium alginate |
| CN113061196A (en) * | 2021-04-20 | 2021-07-02 | 广西科学院 | Method for extracting sodium alginate by high-pressure homogenization |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140305 |