CN103599172A - Method of preparing liquorice extract - Google Patents
Method of preparing liquorice extract Download PDFInfo
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- CN103599172A CN103599172A CN201310466759.4A CN201310466759A CN103599172A CN 103599172 A CN103599172 A CN 103599172A CN 201310466759 A CN201310466759 A CN 201310466759A CN 103599172 A CN103599172 A CN 103599172A
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Abstract
The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a method of preparing a liquorice extract. The method comprises: 1) a step of extraction, namely, a step of adding an organic solvent into liquorice according to a ratio of (4-12):1, extracting and filtering to obtain an extract; 2) a step of concentration, namely, a step of concentrating the extract to a concentration ratio of 30-70 brix; 3) a step of washing with a washing agent, namely, a step of adding distilled water into the concentrated extract according to a ratio of 1-3:1 and washing the extract after concentration; 4) a step of concentration, namely, a step of subjecting the washed extract to vacuum concentration again; and 5) a step of drying, namely, a step of drying the extract after concentration to obtain the liquorice extract. Compared with traditional extraction technology, the method of preparing the liquorice extract is capable of adjusting the content of the active component liquorice chalcone A, improving the relative content of the liquorice chalcone, reducing the content of glycyrrhizic acid which can induce side effects, and improving the utilization rate of effective anti-ulcer components in the liquorice extract.
Description
Technical field
The invention belongs to Technology of Processing Chinese Herbal Medicines field, be specifically related to a kind of method of preparing Radix Glycyrrhizae extract.
Background technology
Variation along with modern's dietary habit, to suppressing and preventing the concern of digestive system disease and demand to increase gradually, as representational digestive system disease, there are gastritis, gastric ulcer, reflux esophagitis, esophageal carcinoma and gastric cancer etc., for aforesaid gastritis, generally at overfeeding or when too urgent, or while having eaten special diet, can be in the dirty inflammation of bringing out of stomach, the medicines such as Helicobacter pylori infection or analgesics, antiinflammatory and aspirin also can bring out.In addition, serious stress, smoking and drink etc. and also can cause gastritis.Aforesaid gastric ulcer, refer to that the dirty mucosa of stomach damages because of smoking, pressure, medicament, helicobacter infection and malignant tumor etc., the degree of depth surpasses most surface mucous layer, and damage enters to state more than muscularis mucosae, in the situation of failing in early days to treat, can develop into gastritis and gastric cancer.
Radix Glycyrrhizae extract is the composition that has medical value extracting from Radix Glycyrrhizae.Radix Glycyrrhizae extract generally comprises: glycyrrhizin, glycyrrhizic acid, liquiritin, flavonoids of Glycyrrhiza, rear curtain are than wingceltis element, formoononetin, Quercetin etc.For yellow is to brown color powder.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Be used for the treatment of weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the diseases such as gastral cavity abdomen, the anxious pain of extremity contraction.Modern study shows, the flavonoid material licochalcone A in Radix Glycyrrhizae extract has obvious antiulcer, antibacterial and anti-inflammation functions.Traditional extraction process is simple consisting of extract-filtration-concentrated-drying and other steps, in the Radix Glycyrrhizae extract of preparation, often contain a large amount of glycyrrhizic acids, and the content of licochalcone A is relatively low, in treatment gastritis, gastric ulcer application, in Radix Glycyrrhizae extract, antiulcer utilization rate of active components is low, and excessive absorption glycyrrhizic acid can have side effects to cardiovascular system.
Summary of the invention
The object of the invention is the deficiency existing in order to solve traditional extraction technique, a kind of method that can reduce glycyrrhizic acid in Radix Glycyrrhizae extract is provided, thereby relatively improves the content of licochalcone A, improve the utilization rate of antiulcer effective ingredient in Radix Glycyrrhizae extract.
To achieve these goals, the technical solution used in the present invention is: a kind of method of preparing Radix Glycyrrhizae extract, comprises the following steps: 1, extraction step, according to 1:(4～12) weight ratio, in Radix Glycyrrhizae, drop into organic solvent and extract, filter, obtain extracting solution; 2, concentration step, concentrates extracting solution, and concentrated ratio is 30～70 Brix degrees; 3, detergent washing: add distilled water according to the ratio of 1:1～3 in the extracting solution after above-mentioned concentrating, the extracting solution after concentrated is washed; 4, concentrated: the extracting solution after washing carries out concentrating under reduced pressure again; 5, dry: the extracting solution after concentrated to be dried, to obtain Radix Glycyrrhizae extract.
Organic solvent described in step 1 is alcohol organic solvent, the organic compound that the hydrogen atom that described alcohols is Hydrocarbon is replaced by hydroxypropyl, particular methanol, ethanol and ethylene glycol.
Aforementioned concentration step preferably utilizes decompression concentrator, the concentrated ratio of extracting solution simmer down to 30 to 70 Brix degrees of extracting by aforementioned extraction step, this is for reducing the amount of glycyrrhizic acid, extracting the required concentrated ratio of Licochalcone A to greatest extent, in the situation that the concentrated ratio of simmer down to less than 30 Brix degrees, because the concentration of concentrated solution is too low, extract Licochalcone A efficient not
Aforementioned detergent washing step is preferably with respect to passing through concentrated extracting solution 100 weight portions of aforementioned concentration step, add distilled water 100 to 300 weight portions, this is for reducing the amount of glycyrrhizic acid, extracts to greatest extent the adding proportion of the required distilled water of Licochalcone A, in the situation that add the distilled water of less than 100 weight portions, the useful composition of Xinjiang Radix Glycyrrhizae cannot high efficiency extraction, in the situation that add the amount of the distilled water that surpasses 300 weight portions, the useful composition of Xinjiang Radix Glycyrrhizae is diluted, and occurs the shortcoming that Licochalcone A cannot high efficiency extraction.
The method of preparing Radix Glycyrrhizae extract provided by the invention, before comparing, traditional extraction process can be adjusted the content of required effective ingredient (Licochalcone A), improve the relative amount of licochalcone, and reduced the content of the material (glycyrrhizic acid) that can bring out side effect, improve the utilization rate of antiulcer effective ingredient in Radix Glycyrrhizae extract.
Accompanying drawing explanation
Fig. 1 is the process chart of preparing the method for Radix Glycyrrhizae extract of the present invention.
The specific embodiment
The method technological process of preparing Radix Glycyrrhizae extract of embodiment 1 the present embodiment as shown in Figure 1, specifically comprises the following steps:
1, extraction step: according to 1:4 weight ratio, drop into organic solvent ethanol and extract, filter in Radix Glycyrrhizae, obtain extracting solution;
2, concentration step: extracting solution is concentrated, make the concentrated ratio of extracting solution simmer down to 30 Brix degrees;
3, detergent washing: add distilled water according to the ratio of 1:1 in the extracting solution after above-mentioned concentrating, the extracting solution after concentrated is washed;
5, concentrated: the extracting solution after washing carries out concentrating under reduced pressure again;
6, dry: the extracting solution after concentrated to be dried, to obtain Radix Glycyrrhizae extract.
The method technological process of preparing Radix Glycyrrhizae extract of embodiment 2 the present embodiment as shown in Figure 1, specifically comprises the following steps:
1, extraction step: according to 1:12 weight ratio, drop into organic solvent ethylene glycol and extract, filter in Radix Glycyrrhizae, obtain extracting solution;
2, concentration step: extracting solution is concentrated, make the concentrated ratio of extracting solution simmer down to 60 Brix degrees;
3, detergent washing: add distilled water according to the ratio of 1:3 in the extracting solution after above-mentioned concentrating, the extracting solution after concentrated is washed;
5, concentrated: the extracting solution after washing carries out concentrating under reduced pressure again;
6, dry: the extracting solution after concentrated to be dried, to obtain Radix Glycyrrhizae extract.
Claims (3)
1. a method of preparing Radix Glycyrrhizae extract, comprises the following steps: 1, extraction step: according to 1:(4～12) weight ratio, and in Radix Glycyrrhizae, drop into organic solvent and extract, filter, obtain extracting solution; 2, concentration step: extracting solution is concentrated, and concentrated ratio is 30～70 Brix degrees; 3, detergent filters: in the extracting solution after above-mentioned concentrating, according to the ratio of 1:1～3, add distilled water, the extracting solution after concentrated is washed; 4, concentrated: the extracting solution after washing carries out concentrating under reduced pressure again; 5, dry: the extracting solution after concentrated to be dried, to obtain Radix Glycyrrhizae extract.
2. the method for preparing Radix Glycyrrhizae extract according to claim 1, is characterized in that: the organic solvent described in step 1 is alcohol organic solvent, the organic compound that the hydrogen atom that described alcohols is Hydrocarbon is replaced by hydroxypropyl.
3. the method for preparing Radix Glycyrrhizae extract according to claim 2, is characterized in that: described alcohol organic solvent is selected from a kind of in methanol, ethanol and ethylene glycol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310466759.4A CN103599172A (en) | 2013-10-09 | 2013-10-09 | Method of preparing liquorice extract |
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| CN201310466759.4A CN103599172A (en) | 2013-10-09 | 2013-10-09 | Method of preparing liquorice extract |
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| CN103599172A true CN103599172A (en) | 2014-02-26 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106010451A (en) * | 2016-06-25 | 2016-10-12 | 丁玉琴 | Preparation method of soft-film type degradable dust suppressant |
| CN106619799A (en) * | 2017-03-03 | 2017-05-10 | 四川德成动物保健品有限公司 | Method for extracting effective components of licorice in Yimu Shenghua mixture |
| CN111944743A (en) * | 2020-08-17 | 2020-11-17 | 广州同康生物科技有限公司 | Human embryonic stem cell culture medium and preparation method thereof |
| CN114939090A (en) * | 2022-06-06 | 2022-08-26 | 广州一璇生物科技有限公司 | Anti-allergy, soothing and repairing formula composition |
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| CN1359905A (en) * | 2001-12-15 | 2002-07-24 | 宁夏大学 | Process for extracting licoflavone, lycyrrhizic acid and licopolyose from liquorice root |
| CN1803789A (en) * | 2006-01-20 | 2006-07-19 | 华中科技大学 | Method for extracting glycyrrhizicacid, licorice flavone and licorice polysaccharide |
| CN102010313A (en) * | 2010-11-09 | 2011-04-13 | 苏州派腾生物医药科技有限公司 | Preparation method of licochalcone A |
| CN102204950A (en) * | 2011-05-18 | 2011-10-05 | 新疆维吾尔自治区中药民族药研究所 | Method for extracting flavonoid from liquorice waste residue |
| CN102633895A (en) * | 2012-04-19 | 2012-08-15 | 南京中医药大学 | Extraction and preparation method by comprehensively utilizing liquorice |
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2013
- 2013-10-09 CN CN201310466759.4A patent/CN103599172A/en not_active Withdrawn
Patent Citations (5)
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| CN1359905A (en) * | 2001-12-15 | 2002-07-24 | 宁夏大学 | Process for extracting licoflavone, lycyrrhizic acid and licopolyose from liquorice root |
| CN1803789A (en) * | 2006-01-20 | 2006-07-19 | 华中科技大学 | Method for extracting glycyrrhizicacid, licorice flavone and licorice polysaccharide |
| CN102010313A (en) * | 2010-11-09 | 2011-04-13 | 苏州派腾生物医药科技有限公司 | Preparation method of licochalcone A |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106010451A (en) * | 2016-06-25 | 2016-10-12 | 丁玉琴 | Preparation method of soft-film type degradable dust suppressant |
| CN106619799A (en) * | 2017-03-03 | 2017-05-10 | 四川德成动物保健品有限公司 | Method for extracting effective components of licorice in Yimu Shenghua mixture |
| CN111944743A (en) * | 2020-08-17 | 2020-11-17 | 广州同康生物科技有限公司 | Human embryonic stem cell culture medium and preparation method thereof |
| CN114939090A (en) * | 2022-06-06 | 2022-08-26 | 广州一璇生物科技有限公司 | Anti-allergy, soothing and repairing formula composition |
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Application publication date: 20140226 |