CN103585572B - Oral medicine for treating endometriosis - Google Patents
Oral medicine for treating endometriosis Download PDFInfo
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Abstract
The invention relates to an oral medicine for treating endometriosis, belonging to the technical field of Chinese medicinal herbs. The composition is composed of the following active pharmaceutical ingredients: 14-16g of dangshen, 29-31g of radix astragali, 8-10g of rhizoma sparganii, 8-10g of Rhizoma Zedoariae, 11-13g of spina gleditsiae, 9-11g of brazilwood, 11-13g of self-heal, 9-11g of pollen typhae, 5-7g of trogopterus dung, 5-7g of eupolyphage sinensis, 5-7g of hirudo, 19-21g of Concha Arcae, 9-11g of seaweed, 9-11g of himalayan teasel root, 9-11g of herba epimedii, 4-6g of cassia twig, 4-6g of peach kernel, 9-11g of dodder, 9-11g of rhizoma corydalis and 5-7g of licorice. The oral medicine has the characteristics of accessible materials, simple manufacturing process, low cost, high practicality, small dosage, low content of harmful ingredients, no toxic or side effect, obvious curative effect and the like.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to one and be used for the treatment of endometriotic endo-medicine.
Background technology
Endometriosis (gynecopathy, Endonmetriosis, En) refers to that the endometrium of movable function comes across the position beyond the inwall of uterus, grows at other positions of health.Site of pathological change is common with ovary, jarjavay's ligaments, uterus rectal sinuses, and other is as vagina, cervix uteri, Rectovaginal septum, fallopian tube, pudendum, groin, umbilical part, Cesarean esction abdominal incision, Episiomy Wounds, even occur ectopic focus at the place such as lung, meninges.Endometriosis is commonly encountered diseases, the frequently-occurring disease of gynecological, and one of Ye Shi gynecological refractory disease, its sickness rate is in rising trend.Primary disease clinical manifestation is dysmenorrhea, infertile, pelvic cavity tuberosity or enclosed mass etc.Doctor trained in Western medicine mainly adopts gonadal hormone and operative treatment both at home and abroad at present, but any gonadotherapy gynecopathy, all can only alleviate, control symptom, and can not effect a radical cure, and side effect is large, patient is difficult to accept.
Chinese medicine is thought, it is periodically hemorrhage that endometriosis is that the inner membrance of dystopy has, and accumulate in local, and cause its surrounding tissue fibrosis, this be " blood circulating out of vessels ", title blood-retention or blood stasis.Endometriosis belongs to the traditional Chinese medical science " dysmenorrhea " " addiction abdominal mass " " infertile " category, think that qi depression to blood stasis is Etiological, the pathogenesis of this disease, the main rule for the treatment of is based on blood circulation promoting and blood stasis dispelling, be aided with the method for the treatment of such as invigorating kidney for regulating menstruation, mainly according to clinical practice determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, there is good effect to the symptom and symptom management development alleviating endometriosis patients.
Summary of the invention
It is high that technical problem to be solved by this invention is to provide a kind of cure rate, and safe and reliable is used for the treatment of endometriotic endo-medicine.
Technical problem to be solved by this invention realizes by the following technical solutions:
One is used for the treatment of endometriotic endo-medicine, the medicament be made up of the crude drug of following weight,
Radix Codonopsis 14-16 gram, Radix Astragali 29-31 gram, Rhizoma Sparganii 8-10 gram, Rhizoma Curcumae 8-10 gram, Spina Gleditsiae 11-13 gram, Lignum Sappan 9-11 gram, Spica Prunellae 11-13 gram, Pollen Typhae 9-11 gram, Oletum Trogopterori 5-7 gram, Eupolyphaga Seu Steleophaga 5-7 gram, Hirudo 5-7 gram, Concha Arcae 19-21 gram, Sargassum 9-11 gram, Radix Dipsaci 9-11 gram, Herba Epimedii 9-11 gram, Ramulus Cinnamomi 4-6 gram, Semen Persicae 4-6 gram, Semen Cuscutae 9-11 gram, Rhizoma Corydalis 9-11 gram, Radix Glycyrrhizae 5-7 gram.
Preferred weight part of each crude drug is: Radix Codonopsis 15 grams, the Radix Astragali 30 grams, Rhizoma Sparganii 9 grams, Rhizoma Curcumae 9 grams, Spina Gleditsiae 12 grams, Lignum Sappan 10 grams, Spica Prunellae 12 grams, Pollen Typhae 10 grams, Oletum Trogopterori 6 grams, Eupolyphaga Seu Steleophaga 6 grams, Hirudo 6 grams, Concha Arcae 20 grams, Sargassum 10 grams, Radix Dipsaci 10 grams, Herba Epimedii 10 grams, Ramulus Cinnamomi 5 grams, 5 grams, Semen Persicae, Semen Cuscutae 10 grams, Rhizoma Corydalis 10 grams, 6 grams, Radix Glycyrrhizae.
Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., the conventional oral formulations of any one is prepared into the method for Chinese medicinal of routine, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method preparing oral medicine of the present invention, comprises the steps,
1) following each taste crude drug is taken by prescription weight number: Radix Codonopsis 15 grams, the Radix Astragali 30 grams, Rhizoma Sparganii 9 grams, Rhizoma Curcumae 9 grams, Spina Gleditsiae 12 grams, Lignum Sappan 10 grams, Spica Prunellae 12 grams, Pollen Typhae 10 grams, Oletum Trogopterori 6 grams, Eupolyphaga Seu Steleophaga 6 grams, Hirudo 6 grams, Concha Arcae 20 grams, Sargassum 10 grams, Radix Dipsaci 10 grams, Herba Epimedii 10 grams, Ramulus Cinnamomi 5 grams, 5 grams, Semen Persicae, Semen Cuscutae 10 grams, Rhizoma Corydalis 10 grams, 6 grams, Radix Glycyrrhizae;
2) above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, can add after preparation commonly uses adjuvant or carrier in decoction, preparations shaping, obtains pill, capsule or tablet.
Radix Codonopsis: control asthenia internal injury, intestinal cold in the stomach, slides and rushes down chronic dysentery, asthma excessive thirst, and heating spontaneous perspiration, metrorrhagia, tire produce all diseases.There is enhancing immunity, blood vessel dilating, blood pressure lowering, improve microcirculation, strengthen the effects such as hemopoietic function.
The Radix Astragali: sweet in the mouth, slightly warm in nature, returns liver, spleen, lung, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.
Rhizoma Sparganii: swollen pain, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer swell hard down to control lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the side of body.
Rhizoma Curcumae: cure mainly coagulation of QI-blood, trusted subordinate's distending pain, lump in the abdomen, gathers, and dyspepsia does not disappear, and women's blood stasis amenorrhea, traumatic injury is had a pain.
Spina Gleditsiae: swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, leprosy.
Lignum Sappan: promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.For amenorrhea dysmenorrhea, postpartum stagnation, breast ventral spine pain, wound swells and ache.
Spica Prunellae: liver heat removing, eliminating stagnation, diuresis; Control the diseases such as pestilence, acute mastitis, ophthalmalgia, jaundice, gonorrhea, metrorrhagia, leukorrhagia, hypertension.
Pollen Typhae: hemostasis, blood stasis dispelling, treating stranguria.For haematemesis, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea, dysmenorrhea, gastral cavity ventral spine pain, treating swelling and pain by traumatic injury, the wet pain of stranguria with blood.
Oletum Trogopterori: for blood-stasis internal-depression, escape of blood from meridian hemorrhage, if woman uterine bleeding is through many, the purple polylith of color, stabbing pain of the lower abdomen.
Eupolyphaga Seu Steleophaga: have blood stasis staying below the umbilicus also main menstrual disorders in treatment puerpera stomachache, abdomen.
Hirudo: to invigorate blood circulation, dissipating blood stasis, the effect of stimulating the menstrual flow.
Concha Arcae: abdominal pain due to blood stasis, accumulation of blood disease block, hyperchlorhydria, stomachache.
Sargassum: bitter in the mouth, salty, cold in nature, nontoxic.Cure mainly: scrofula; Goiter; Gather; Edema; Foot gas; Painful and swollen testis; (Epileptic is ruined) hernia.
Radix Dipsaci: invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.For aching pain in waist and back; Podomere flaccidity syndrome and arthralgia syndrome; Fall flutter wound, damage muscle folding bone, red, metrorrhagia is leaked in fetal movement, seminal emission, leukorrhagia, carbuncle skin ulcer swell.
Herba Epimedii: acrid, sweet, warm.Return Liver and kidney through curing mainly function: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.
Ramulus Cinnamomi: expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea is suffered from abdominal pain; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention water-retention, edema, cardiopalmus, renal mass.
Semen Persicae: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Semen Cuscutae: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.
Rhizoma Corydalis: invigorate blood circulation, promoting the circulation of QI, pain relieving.Pain for stagnation of QI-blood is demonstrate,proved.The breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Radix Glycyrrhizae: QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.
Usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.
Instruction: decoction, adult 100-300ml every day, a point morning and evening takes after mixing it with water for 2 times; Within one month, be a course for the treatment of, must adhere to taking lastingly for stubborn disease, can control.
Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:
1. the decoction that prepared by couple the present invention carries out animal acute toxicity test:
Medicine: the decoction prepared by prescription of the present invention.
Experimental animal: white mice, body weight is at 30-50g, and male and female Stochastic choice, is provided by Medical University Of Anhui.
Method and result: get white mice 50, be divided into 5 groups, often organize 10, hungry 15 hours, fill with medicine feed thing by every only each 20ml, in 24 hours, fill with medicine feed thing respectively 1,2,3,4,5 times for the 1st, 2,3,4,5 group, observe 5 days, white mice is movable normal, non-toxic reaction, without dead.Wherein white mice dosage is by kg body weight medicine calculation, shows that oral liquid is without acute toxicity, clinical medicine dose safety.
2. the decoction that prepared by couple the present invention carries out long-term toxicity test for animals:
Experimental animal: rat, body weight, at 120-130g, all selects male white rat, is provided by Medical University Of Anhui.
Method and result: get rat 50, be divided into 5 groups, often organize 10, wherein the 1st, 2, 3, 4 groups as administration group, often organize and fill with medicine feed thing 15ml respectively, 20ml, 30ml, 40ml, 5th group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, a kind of safe drugs.
3. diagnostic criteria
1) within the 15th day, all check Ca125>37.2ku/L through serum in menstrual cycle before patient treatment, anti-endometrial antibodies is positive, ultrasound diagnosis prompting endometriosis.
2) in order to verify clinical efficacy, this prescription is tried out in First Attached Hospital, Anhui Medical Univ. and The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine respectively, and by random selecting wherein 50 routine adult patients, the course for the treatment of the shortest is 2 months, and what the course for the treatment of was the longest is 1 year.
3) Therapeutic Method
According to drug ratios of the present invention, take raw material (dose), the method according to usual preparation obtains decoction, every day 300ml, sooner or later service once, taking 30 days is a course for the treatment of.
4) efficacy determination:
Recovery from illness: symptom all disappears, the local such as pelvic lump sign disappears substantially, and Sterility patient is gestation or fertility in 3 years, and anti-endometrial antibodies is negative;
Effective: symptom disappears substantially, pelvic lump reduces, though local sign exists, infertile patient is become pregnant:
Effective: symptom alleviates, pelvic lump is without increase or slightly reduce, and in drug withdrawal 3 months, symptom is without increasing the weight of;
Invalid: cardinal symptom is unchanged or worsen, local disease becomes to have increases the weight of trend.
Concrete therapeutic outcome is see table 1.
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 50 | 15 | 23 | 10 | 2 | 96 |
The invention has the beneficial effects as follows: the present invention draws materials easily, make the features such as simple, with low cost, practicality is good, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Each crude drug is taken: Radix Codonopsis 14 grams, the Radix Astragali 29 grams, Rhizoma Sparganii 8 grams, Rhizoma Curcumae 8 grams, Spina Gleditsiae 11 grams, Lignum Sappan 9 grams, Spica Prunellae 11 grams, Pollen Typhae 9 grams, Oletum Trogopterori 5 grams, Eupolyphaga Seu Steleophaga 5 grams, Hirudo 5 grams, Concha Arcae (calcined) 19 grams, Sargassum 9 grams, Radix Dipsaci 9 grams, Herba Epimedii 9 grams, Ramulus Cinnamomi 4 grams, 4 grams, Semen Persicae, Semen Cuscutae 9 grams, Rhizoma Corydalis 9 grams, 5 grams, Radix Glycyrrhizae by following weight.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.
Embodiment 2
Each crude drug is taken: Radix Codonopsis 15 grams, the Radix Astragali 30 grams, Rhizoma Sparganii 9 grams, Rhizoma Curcumae 9 grams, Spina Gleditsiae 12 grams, Lignum Sappan 10 grams, Spica Prunellae 12 grams, Pollen Typhae 10 grams, Oletum Trogopterori 6 grams, Eupolyphaga Seu Steleophaga 6 grams, Hirudo 6 grams, Concha Arcae 20 grams, Sargassum 10 grams, Radix Dipsaci 10 grams, Herba Epimedii 10 grams, Ramulus Cinnamomi 5 grams, 5 grams, Semen Persicae, Semen Cuscutae 10 grams, Rhizoma Corydalis 10 grams, 6 grams, Radix Glycyrrhizae by following weight.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, in decoction, add adjuvant, make capsule.
Embodiment 3
Each crude drug is taken: Radix Codonopsis 16 grams, the Radix Astragali 31 grams, Rhizoma Sparganii 10 grams, Rhizoma Curcumae 10 grams, Spina Gleditsiae 13 grams, Lignum Sappan 11 grams, Spica Prunellae 13 grams, Pollen Typhae 11 grams, Oletum Trogopterori 7 grams, Eupolyphaga Seu Steleophaga 7 grams, Hirudo 7 grams, Concha Arcae 21 grams, Sargassum 11 grams, Radix Dipsaci 11 grams, Herba Epimedii 11 grams, Ramulus Cinnamomi 6 grams, 6 grams, Semen Persicae, Semen Cuscutae 11 grams, Rhizoma Corydalis 11 grams, 7 grams, Radix Glycyrrhizae by following weight.
Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 20 ~ 40 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction, in decoction, add adjuvant, make tablet.
Model case
Case 1
Thank so-and-so, female, 31 years old, people from Mingguang City, Anhui Province.Patient's dysmenorrhea for many years, has serious endometriosis, infertile for many years after marriage, has eaten a lot of medicine, has had no obvious curative effects, and after taking three courses for the treatment of of Drug therapy of the present invention, above-mentioned symptom disappears.Follow up a case by regular visits to after 1 year, health is fine.
Case 2
Take so-and-so, female, 29 years old, Anhui Province Fuyang City people.Suffer from endometriosis, menoxenia, has clot, not to the utmost dripping, and menstrual period, hurt like hell, had the symptoms such as dizziness, insomnia, dreaminess.Take medicine two of the present invention course for the treatment of, symptom obviously alleviates, and continues two courses for the treatment of of taking medicine, and all symptoms are eliminated, and follow up a case by regular visits to and do not recur so far again.
Case 3
Zheng, female, 36 years old, people from Hefei City, Anhui Province.For many years, menstruation is rule comparatively for patient's dysmenorrhea, many through measuring, color is dark red clot, and menstrual period, lower abdominal pain, accompanied dizziness, Nausea and vomiting, unable symptom to increase the weight of year by year, several days menstrual period, cisco unity malfunction, lived, often oral or injection analgesic, hospital diagnosis is endometriosis, after taking two courses for the treatment of of Drug therapy of the present invention, menstrual period, lower abdominal pain obviously alleviated, dizzy, Nausea and vomiting transference cure, menstrual blood volume, color are normal, without clot.The continual cure two recovery from illness course for the treatment of.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (5)
1. one kind is used for the treatment of endometriotic endo-medicine, it is characterized in that, the medicament be made up of the crude drug of following weight: Radix Codonopsis 14-16 gram, Radix Astragali 29-31 gram, Rhizoma Sparganii 8-10 gram, Rhizoma Curcumae 8-10 gram, Spina Gleditsiae 11-13 gram, Lignum Sappan 9-11 gram, Spica Prunellae 11-13 gram, Pollen Typhae 9-11 gram, Oletum Trogopterori 5-7 gram, Eupolyphaga Seu Steleophaga 5-7 gram, Hirudo 5-7 gram, Concha Arcae 19-21 gram, Sargassum 9-11 gram, Radix Dipsaci 9-11 gram, Herba Epimedii 9-11 gram, Ramulus Cinnamomi 4-6 gram, Semen Persicae 4-6 gram, Semen Cuscutae 9-11 gram, Rhizoma Corydalis 9-11 gram, Radix Glycyrrhizae 5-7 gram.
2. one according to claim 1 is used for the treatment of endometriotic endo-medicine, it is characterized in that, the medicament be made up of the crude drug of following weight: Radix Codonopsis 15 grams, the Radix Astragali 30 grams, Rhizoma Sparganii 9 grams, Rhizoma Curcumae 9 grams, Spina Gleditsiae 12 grams, Lignum Sappan 10 grams, Spica Prunellae 12 grams, Pollen Typhae 10 grams, Oletum Trogopterori 6 grams, Eupolyphaga Seu Steleophaga 6 grams, Hirudo 6 grams, Concha Arcae 20 grams, Sargassum 10 grams, Radix Dipsaci 10 grams, Herba Epimedii 10 grams, Ramulus Cinnamomi 5 grams, 5 grams, Semen Persicae, Semen Cuscutae 10 grams, Rhizoma Corydalis 10 grams, 6 grams, Radix Glycyrrhizae.
3. one according to claim 1 and 2 is used for the treatment of endometriotic endo-medicine, it is characterized in that: described medicament is the preparation that any one is suitable for clinically.
4. one according to claim 3 is used for the treatment of endometriotic endo-medicine, it is characterized in that: described preparation is oral formulations.
5. one according to claim 4 is used for the treatment of endometriotic endo-medicine, it is characterized in that: described oral formulations is decoction, pill, capsule or tablet.
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| CN101259241A (en) * | 2008-04-25 | 2008-09-10 | 北京中泰天和科技有限公司 | Chinese medicinal composition for treating endometriosis symptoms and preparation thereof |
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| CN101259241A (en) * | 2008-04-25 | 2008-09-10 | 北京中泰天和科技有限公司 | Chinese medicinal composition for treating endometriosis symptoms and preparation thereof |
Non-Patent Citations (2)
| Title |
|---|
| 从瘀探析子宫内膜异位症的中医病因病机;常青芸等;《中医药信息》;20111231;第28卷(第1期);第3-5页 * |
| 子宫内膜异位症的中医诊治思路;郑泳霞;《光明中医》;20110228;第26卷(第2期);第194-195页 * |
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