CN103565493B - Nanoscale ultrasonic vibrator - Google Patents
Nanoscale ultrasonic vibrator Download PDFInfo
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- CN103565493B CN103565493B CN201210262012.2A CN201210262012A CN103565493B CN 103565493 B CN103565493 B CN 103565493B CN 201210262012 A CN201210262012 A CN 201210262012A CN 103565493 B CN103565493 B CN 103565493B
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- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 101
- 229920000049 Carbon (fiber) Polymers 0.000 claims abstract description 83
- 239000004917 carbon fiber Substances 0.000 claims abstract description 83
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims abstract description 83
- 230000008450 motivation Effects 0.000 claims abstract description 24
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 12
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 9
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims description 6
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 6
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- 229910052697 platinum Inorganic materials 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 239000007772 electrode material Substances 0.000 claims description 2
- 208000007536 Thrombosis Diseases 0.000 abstract description 32
- 210000004204 blood vessel Anatomy 0.000 abstract description 26
- 230000005684 electric field Effects 0.000 abstract description 17
- 238000002604 ultrasonography Methods 0.000 abstract description 14
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- 238000000034 method Methods 0.000 description 14
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- 229960001296 zinc oxide Drugs 0.000 description 14
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 208000005189 Embolism Diseases 0.000 description 6
- 208000001435 Thromboembolism Diseases 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 229910052786 argon Inorganic materials 0.000 description 5
- 239000002070 nanowire Substances 0.000 description 5
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- 239000011701 zinc Substances 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
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- 239000000843 powder Substances 0.000 description 2
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- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
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- 239000004020 conductor Substances 0.000 description 1
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- 238000002716 delivery method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Chemical compound CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
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- 239000012634 fragment Substances 0.000 description 1
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- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
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- 230000001052 transient effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000000264 venule Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00345—Micromachines, nanomachines, microsystems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
- A61B2017/22014—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire
- A61B2017/22015—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire with details of the transmission member
- A61B2017/22017—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire with details of the transmission member the ultrasonic transmitting members being fibres
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mechanical Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
Abstract
The invention provides a kind of nanoscale ultrasonic vibrator.This Under Ultrasonic Vibration motivation comprises: carbon fiber, zinc oxide nano-wire array and polymeric dielectric layer; The surface of carbon fiber comprises zinc oxide nanowire vitellarium and exposed area; In zinc oxide nanowire vitellarium, described zinc oxide nano-wire array vertical-growth is on carbon fiber surface, and being formed with carbon fiber is core, and zinc oxide nano-wire array is as the nucleocapsid structure of cylindrical shell; Described zinc oxide nano-wire array is coated with described polymeric dielectric layer.Under electric field action, zinc oxide nanowire can produce ultrasound wave (supersonic vibration), for driving foreign body or thrombosis in body cavity and blood vessel.
Description
Technical field
The present invention relates to a kind of nanoscale ultrasonic vibrator, concrete, relate to a kind of Under Ultrasonic Vibration motivation utilizing zinc oxide nanowire.
Background technology
Thrombosis be heart or an Ink vessel transfusing part because of blood constituent separate out, coagulation and solidify formed solid material.Thromboembolism can cause oxygen or nutrient substance to the supply discontinuity of linked groups, thus causes structure dysbolismus, linked groups's infarction etc.The technology of existing dissolving or removal thrombosis is divided into two classes.One adopts thrombolytic agent or anticoagulant, and for realizing thromboembolism or suppressing thrombus growth, but to be dosage period long for the defect of the method, can not be applied to especially in Endovascular formation art.Another adopts conduit guiding interventional therapy method, and Thrombectomy device will be gone to import in blood vessel, utilizes mechanical energy to remove thrombosis from the health of patient.
The Chinese patent application of number of patent application 200680050755.6 discloses a kind of device for removing thrombosis, this device utilizes little inner chamber microtubular to be sent to lesions position, then puncture thrombosis, flexible fibre hook is stumbled thrombosis, thus reach the thrombosis object scraping off and be attached to blood vessel wall, but this device is comparatively complicated, and cost is high.The Chinese patent application of number of patent application 01127619.3 discloses a kind of novel implantation type thrombus filter, and this device adheres to thrombosis by drainage screen, thus reaches the object removing thrombosis, but this device can not remove the thrombosis being attached to blood vessel wall.
Nano zinc oxide wires is a kind of known piezoelectric, is usually applied to nano generator, and when nano zinc oxide wires during dynamic tensile, generates piezoelectricity electromotive force under external force in nano wire, corresponding transient current flows at two ends.At present, under applied voltage, nano zinc oxide wires does not produce the design of supersonic vibration.
Summary of the invention
The object of this invention is to provide a kind of nanoscale ultrasonic vibrator, zinc oxide nanowire can produce ultrasound wave (supersonic vibration) under applied voltage effect, for driving foreign body or thrombosis at body cavity and blood vessel, especially this nanoscale ultrasonic vibrator in implantable intravascular, and can impel thromboembolism in blood vessel wall.
According to the difference of application, supersonic vibration machine of the present invention can produce the ultrasound wave of different frequency, and such as frequency is the ultrasound wave of 1KHz to 10MHz, can be used in impelling thromboembolism in blood vessel wall.
In order to solve the problems of the technologies described above, the first technical scheme provided by the invention is, a kind of nanoscale ultrasonic vibrator, and this Under Ultrasonic Vibration motivation (electric energy-mechanic energy deformation conversion is single) comprises carbon fiber, zinc oxide nano-wire array and polymeric dielectric layer; The surface of carbon fiber comprises zinc oxide nanowire vitellarium and exposed area; In zinc oxide nanowire vitellarium, described zinc oxide nano-wire array vertical-growth is on carbon fiber surface, and being formed with carbon fiber is core, and zinc oxide nano-wire array is as the nucleocapsid structure of cylindrical shell; Described zinc oxide nano-wire array is coated with described polymeric dielectric layer.
Aforesaid nanoscale ultrasonic vibrator, described polymeric dielectric layer material used is polymethyl methacrylate or polydimethylsiloxane.
Aforesaid nanoscale ultrasonic vibrator, this Under Ultrasonic Vibration motivation comprises power supply further, and described power supply comprises two current output terminals, and one of them current output terminal connects the exposed area of carbon fiber, and another current output terminal connects receptor.
Aforesaid nanoscale ultrasonic vibrator, this Under Ultrasonic Vibration motivation comprises distributed electrode further, and this distributed electrode is arranged on polymeric dielectric layer; A current output terminal of described power supply connects the exposed area of carbon fiber, and another current output terminal connects distributed electrode.
Aforesaid nanoscale ultrasonic vibrator, described distributed electrode material is any one in gold, platinum, titanium or Nitinol.
Aforesaid nanoscale ultrasonic vibrator, described zinc oxide nanowire growth district accounts for 4/1 to five/4ths of carbon fiber length.
Aforesaid nanoscale ultrasonic vibrator, described power supply is alternating current, and power is between 5 ~ 100W, and frequency is between 1KHz-10MHz.
Under Ultrasonic Vibration motivation of the present invention, under electric field action, zinc oxide nanowire can produce ultrasound wave (supersonic vibration), for driving foreign body or thrombosis at body cavity and blood vessel.According to the difference of application, supersonic vibration machine of the present invention can produce the ultrasound wave of different frequency.
Accompanying drawing explanation
Fig. 1 is nanoscale ultrasonic vibrator axonometric chart of the present invention.
Fig. 2 is the exemplary plot that nanometer supersonic vibration of the present invention is applied in the blood vessel.
Fig. 3 is embodiment of the present invention nanoscale ultrasonic vibrator generalized section.
Fig. 4 is another embodiment of the present invention nanoscale ultrasonic vibrator generalized section.
Detailed description of the invention
For fully understanding the object of the present invention, feature and effect, by following concrete embodiment, the present invention is elaborated.
Nanoscale ultrasonic vibrator of the present invention is under electric field action, and zinc oxide nanowire can produce ultrasound wave (supersonic vibration), for driving foreign body or thrombosis at body cavity and blood vessel.According to the difference of application, nanoscale ultrasonic vibrator of the present invention can produce the ultrasound wave of different frequency.Nanoscale ultrasonic vibrator diameter of the present invention is 10 ~ 15 microns, can pass through, for driving the thrombosis and thrombus that are attached to blood vessel wall except capillary other blood vessels EV.
Nanoscale ultrasonic vibrator of the present invention is that the reciprocal piezoelectric effect of application zinc oxide nanowire is succeeded in developing.Concrete, from structural point, zinc oxide is hexagonal structure (the space group C with lattice paprmeter a=0.3296 and c=0.52065nm
6V).The structure of zinc oxide simply can be described as some O by tetrahedral coordination
2-and Zn
2+the alternate planes of ion composition, along c-axis interactive stacking.Tetrahedral coordination in zinc oxide causes non-centrosymmetric structure, and thus causes piezoelectricity and pyroelectric phenomena.Because tetrahedral coordination is along the unsymmetric structure of+c and-c, for the micro belt grown along c-axis, when an electric field E along zinc oxide a axle is employed, can the shear stress in induced oxidation zinc a-c face.
As shown in Figure 1, a kind of nanoscale ultrasonic vibrator, this Under Ultrasonic Vibration motivation (electric energy-mechanic energy deformation converting unit) comprising: carbon fiber, zinc oxide nano-wire array and polymeric dielectric layer; The surface of carbon fiber comprises zinc oxide nanowire vitellarium and exposed area; In zinc oxide nanowire vitellarium, described zinc oxide nano-wire array vertical-growth is on carbon fiber surface, and being formed with carbon fiber is core, and zinc oxide nano-wire array is as the nucleocapsid structure of cylindrical shell; Described zinc oxide nano-wire array is coated with described polymeric dielectric layer.
This Under Ultrasonic Vibration motivation comprises power supply further, and described power supply comprises two current output terminals, and one of them current output terminal connects the exposed area of carbon fiber; Another current output terminal is connected with human body surface, thus conducts electricity with human body fluid and be connected.The preferred high frequency voltage of the present invention's power supply used is powered, and the voltage magnitude of this high frequency voltage, within 10V, does not damage human body.
Preferably, this Under Ultrasonic Vibration motivation comprises distributed electrode further, and this distributed electrode is arranged on polymeric dielectric layer; A current output terminal of described power supply connects the exposed area of carbon fiber, and another current output terminal connects distributed electrode.
Due to the insulating effect of polymeric dielectric layer, at carbon fiber and human body or form electric field between carbon fiber and distributed electrode, zinc oxide nanowire produces supersonic vibration under this electric field action.Those skilled in the art, according to the difference of application, can adjust the current intensity of external power and the gross area of zinc oxide nano-wire array, and the ultrasound wave that the application's Under Ultrasonic Vibration motivation is produced has suitable frequency, cycle and amplitude.
Resistance is less than 30 Ω/m, the Medical carbon fiber with electric conductivity that intensity is greater than T300 all can be applicable to the present invention, such as polypropylene for medical article nitrile carbon fiber and medical asphalt-based carbon fiber, preferred domestic Medical C CF300, CCF500 carbon fiber can be applied to the present invention.
The specification of the present invention to carbon fiber does not have particular/special requirement, in order to can blood vessel be applied to, and the carbon fiber of the preferred diameter of the present invention 8 ~ 12 μm (more preferably 10 μm).The length of the present invention to carbon fiber does not have particular/special requirement, can meet zinc oxide nano-wire array growth and remaining exposed area.The hyperacoustic frequency, the amplitude that produce is needed according to application, those skilled in the art can adjust the zinc oxide nanowire vitellarium of carbon fiber surface and the ratio of exposed area, and the length of usual zinc oxide nanowire is the preferred 500-800nm of 300nm-1um().
The medical macromolecular materials that can play insulating effect all can be applicable to the present invention, preferred medical polymethyl methacrylate (PMMA) or medical polydimethylsiloxane.The thickness of the present invention to polymeric dielectric layer does not have particular/special requirement, can play insulation to make to be formed between carbon fiber and distributed electrode the polymer insulation layer thickness of electric field all within scope, preferred 150-250nm(more preferably 200nm).
Owing to have employed polymeric dielectric layer, the existence of insulating barrier provides the potential barrier of an infinite height, stops the electronics of extra electric field by zinc oxide, and forms electric field.Polymeric dielectric layer forms cover layer on nano wire, and cover layer is also coated on nano-wire array top and surrounding simultaneously, when nano wire bears electric field action, improves the stability of nanoscale ultrasonic vibrator.
The present invention's distributed electrode used material is medical conductor material, such as, in gold, platinum, titanium or Nitinol any one.The thickness of the present invention to distributed electrode does not have particular/special requirement, preferred 100-250nm.
The following detailed description of the preparation method of nanoscale ultrasonic vibrator of the present invention.
A, prepares zinc oxide nanowire growth source
Zinc oxide powder is mixed with the ratio of activated carbon powder according to 1-1:1-5, obtains mixture.This mixture is zinc oxide growth source.Preferably, by this mixture through corase grind and fine grinding 15-60min, then (50-100 DEG C) is dried.
B, zinc oxide nanowire grows
Be placed in by 0.5-5g step a gained mixture below the vertical carbon fiber placed, first vacuum, to being less than 0.05 holder, then passes into oxygen and argon, and wherein the total flow of oxygen and argon is for being less than 100ml/min, and the flow proportional of oxygen and argon is 1:1-1:5; Be less than or equal to 30 DEG C/min according to heating rate, by described mixture and carbon fiber heating to 850 DEG C, be incubated 10 minutes, be then heated to 960 DEG C with the speed of 1-10 DEG C/min, be incubated cool to room temperature after 30 minutes and take out.
Concrete, carbon fiber is before carrying out step b, and the method first specify according to GJB1982-94 appendix A removes the sizing agent of carbon fiber surface, then oven dry at 50-100 DEG C.
Preferably, in vacuum tube furnace, step b is carried out.Concrete, be placed in bottom the quartz ampoule of one end open by step a gained mixture, carbon fiber is placed on quartz ampoule inwall.Quartz ampoule is outwards placed in the middle part of tube furnace, and sealing tube furnace, with vacuum pump evacuation to being less than 0.05 holder.
Described step b preferably also comprises:
B1. photoetching carbon fiber surface, carbon fiber arranges photoresist layer, then forms multiple zinc oxide nanowire growth district at carbon fiber surface;
In multiple growth districts of the carbon fiber surface that b2 is formed at photoresist, adopt the method growth of zinc oxide nano linear array as above-mentioned steps b, make zinc oxide nanowire only grow carbon fiber surface in exposure;
B3. all residue photoresists are peeled off.
Concrete, carbon fiber covers photoresist, on photoresist, the square window array of rule is one by one opened with micro Process lithographic methods, square window inner region, exposed have carbon fiber surface, as zinc oxide nano-wire array growth district, there is photoresist and zinc oxide nanowire cannot be grown in square window gap.Photoresist is equivalent to a subregion mould in zinc oxide nanowire growth course subsequently, makes zinc oxide nanowire only grow the region exposed, thus realizes the subregion growth of zinc oxide nano-wire array.
The present invention does not have particular/special requirement to photoresist used, the conventional photoresist being used for substrate photoengraving all can be applicable to the present invention, such as comprise 5-60 mass percent photosensitive resin (such as epoxy resin modification thing), the reactive diluent (such as polyethylene glycol dimethacrylate) of 5-50 mass percent, the light trigger of 0.1-15 mass percent.
C, corrosion carbon fiber exposed area
With the surface of diluted alkaline (preferred < 0.01mol/L sodium hydroxide or potassium hydroxide solution) corrosion carbon fiber one end, obtain carbon fiber exposed area.
Optionally, the present invention, when step b zinc oxide nanowire grows, can only grow zinc oxide nanowire vitellarium at carbon fiber surface by controlled oxidization zinc nano wire, thus omit step c.
D, to be covered in macromolecular material (preferred polymethyl methacrylate) on zinc oxide nano-wire array layer by spin-coating method and to form polymeric dielectric layer, obtain electric energy-mechanic energy deformation converting unit.
Selectable, e, is arranged on distributed electrode on polymeric dielectric layer.
The distributed electrode method be arranged on polymeric dielectric layer is this area convenient technical process, such as, utilize radio frequency sputter, is set on polymeric dielectric layer by any one in gold, platinum, titanium or Nitinol.
F, one of them current output terminal of power supply is connected to the exposed area of carbon fiber, another current output terminal is connected to human body surface or distributed electrode.
Described power supply is alternating voltage, and supply frequency can be that unifrequency is powered, and also can be that multi-frequency is powered.Need the hyperacoustic frequency, the amplitude that produce according to application, those skilled in the art are easy to type and the frequency of selecting power supply.Preferably, power supply of the present invention is high frequency electric source, and power is adjustable between 5 ~ 100W, and frequency is between 1KHz-10MHz.
Below in conjunction with Fig. 2, describe nanoscale ultrasonic vibrator of the present invention in detail at intravascular in the application principle removing thrombosis.
The normal average lumen diameter of usual blood vessel is as follows: elastic artery: 1.5 centimetres; Muscle arteries: about 6 millimeters; Small artery: about 37 microns; Blood capillary: about 9 microns; Venule: 20 microns; Vein: 5 millimeters.Under Ultrasonic Vibration motivation diameter of the present invention is 10 ~ 15 microns, therefore can pass through except capillary other blood vessels EV.
Adopt existing conventional delivery methods, such as, adopt little inner chamber microtubular that Under Ultrasonic Vibration motivation of the present invention is transported to application site in target blood (as shown in Figure 2).After arriving application site, Under Ultrasonic Vibration motivation discharges from little inner chamber microtubular, then the power delivery electric current of Under Ultrasonic Vibration motivation is controlled, two current output terminals of power supply, one of them current output terminal connects the exposed area of the carbon fiber of Under Ultrasonic Vibration motivation, another current output terminal connects the distributed electrode of human body or Under Ultrasonic Vibration motivation, therefore Under Ultrasonic Vibration motivation carbon fiber and human body fluid or form electric field between carbon fiber and distributed electrode, the zinc oxide nanowire of Under Ultrasonic Vibration motivation produces supersonic vibration under this electric field action, this supersonic vibration is to the thrombosis generation effect being attached to blood vessel wall, therefore the thrombosis being attached to blood vessel wall is eliminated, in addition, this supersonic vibration has an impact to thrombosis, and thrombosis can produce dissolving.Under Ultrasonic Vibration motivation of the present invention can use together in conjunction with thrombosis acquisition equipment, is removed by large thrombosis fragment from blood vessel.According to thrombosis position and size, by regulating the growth gross area of zinc oxide nanowire and the type of power supply and frequency, hyperacoustic amplitude and cycle can be selected, thus be applied to the thrombosis removing and be attached to blood vessel wall or impel thromboembolism in blood vessel wall.Select suitable ultrasound wave, ultrasound wave is cavitation explosion and vibration in blood, thus can destroy thrombosis.
Set forth the enforcement of method of the present invention below by specific embodiment, one skilled in the art will appreciate that this should not be understood to the restriction to the claims in the present invention scope.
Embodiment 1
Nanoscale ultrasonic vibrator as shown in Figure 3.Carbon fiber 11 adopts domestic CCF300, its diameter 10 μm, length 1.5m; The zinc oxide nanowire vitellarium 111 of carbon fiber surface accounts for 4/5ths of carbon fiber 11 length.In zinc oxide nanowire vitellarium 111, zinc oxide nano-wire array 12 vertical-growth at carbon fiber 11 on the surface, zinc-oxide nano line length 500nm.Adopt polymethyl methacrylate as polymeric dielectric layer 13 material, polymethyl methacrylate layers is spin-coated on zinc oxide nano-wire array 12, and thickness is 200nm.Adopt high frequency electric source 3, it is that alternating voltage is powered, and frequency is 80kHz, and power is adjustable between 5 ~ 100W.A current output terminal of this power supply connects carbon fiber 11, and another current output terminal connects human body surface.
It is as follows that this nanoscale ultrasonic vibrator obtains preparation method.
Mixed with 2g activated carbon powder by 1g Zinc oxide powder (purity 99.9%), corase grind 15min, then Achates fine gtinding 30min, then dry at 50 DEG C.
Carbon fiber 11 adopts domestic CCF300, its diameter 10 μm, length 1.5m.The method that specifies according to GJB1982-94 appendix A removes the sizing agent of carbon fiber surface, then dries at 50 DEG C.
Zinc oxide powder and activated carbon mixture of powders are placed in bottom the closed quartz ampoule in one end, carbon fiber are placed on quartz ampoule inwall.Quartz ampoule after installing is placed on the medium position of vacuum tube furnace, and vacuum pump adjusting air valve is slowly evacuated to and is less than 0.05 holder.Slowly pass into 10ml oxygen and 30ml argon, regulate vacuum to be 2 holders.Vacuum tube furnace heats up heating, and heating rate is 30 DEG C/min, by described mixture and carbon fiber heating to 850 DEG C, be incubated 10 minutes, is then heated to 960 DEG C with the speed of 10 DEG C/min, is incubated cool to room temperature taking-up after 30 minutes.The zinc oxide nano-wire array 12 formed, its zinc-oxide nano line length is 500nm.
With the surface of diluted alkaline (0.01mol/L sodium hydroxide solution) corrosion carbon fiber one end, obtain carbon fiber exposed area 112.The zinc oxide nanowire vitellarium 111 of carbon fiber surface accounts for 4/5ths of carbon fiber 11 length.
By conventional spin-coating method polymethyl methacrylate is covered on zinc oxide nano-wire array layer and forms the polymeric dielectric layer 13 that thickness is 200nm.
Under high frequency electric source effect, between carbon fiber 11 and human body fluid, form electric field, zinc oxide nano-wire array 12 produces supersonic vibration under this electric field action, ultrasound probe equipment is adopted to record, this ultrasonic frequency is 80kHz, and amplitude is 5V, can be applied to thrombus in blood vessel.
Embodiment 2
Nanoscale ultrasonic vibrator as shown in Figure 4.The nanoscale ultrasonic vibrator of the present embodiment, its structure is substantially the same manner as Example 1, and difference is that this nanoscale ultrasonic vibrator has distributed electrode 2, and the type of nanoscale ultrasonic vibrator each layer material therefor and thickness and preparation technology slightly different.Carbon fiber 11 adopts CCF500, its diameter 8 μm, length 1m; The zinc oxide nanowire vitellarium 111 of carbon fiber surface accounts for 3/5ths of carbon fiber 11 length.In zinc oxide nanowire vitellarium 111, zinc oxide nano-wire array 12 vertical-growth at carbon fiber 11 on the surface, zinc-oxide nano line length 300nm.Adopt polymethyl methacrylate as polymeric dielectric layer 13 material, polymethyl methacrylate layers is spin-coated on zinc oxide nano-wire array 12, and thickness is 200nm.Adopt the Nitinol of thickness 100nm as distributed electrode 2, distributed electrode 2 is arranged in polymethyl methacrylate layers.Adopt high frequency electric source 3, it is that alternating voltage is powered, and power is adjustable between 5 ~ 100W, and frequency is 2MHz.A current output terminal of this power supply connects carbon fiber 11, and another current output terminal connects distributed electrode 2.
It is as follows that this nanoscale ultrasonic vibrator obtains preparation method.
Mixed with 2g activated carbon powder by 2g Zinc oxide powder (purity 99.9%), corase grind 15min, then Achates fine gtinding 30min, then dry at 50 DEG C.
Carbon fiber 11 adopts CCF500, its diameter 8 μm, length 1m.The method that specifies according to GJB1982-94 appendix A removes the sizing agent of carbon fiber surface, then dries at 50 DEG C.
Zinc oxide powder and activated carbon mixture of powders are placed in bottom the closed quartz ampoule in one end, carbon fiber are placed on quartz ampoule inwall.Quartz ampoule after installing is placed on the medium position of vacuum tube furnace, and vacuum pump adjusting air valve is slowly evacuated to and is less than 0.05 holder.Slowly pass into 8ml oxygen and 32ml argon, regulate vacuum to be 2.4 holders.Vacuum tube furnace heats up heating, and heating rate is 30 DEG C/min, by described mixture and carbon fiber heating to 850 DEG C, be incubated 10 minutes, is then heated to 960 DEG C with the speed of 10 DEG C/min, is incubated cool to room temperature taking-up after 30 minutes.The zinc oxide nano-wire array 12 formed, its zinc-oxide nano line length is 300nm.
With the surface of diluted alkaline (0.01mol/L sodium hydroxide solution) corrosion carbon fiber one end, obtain carbon fiber exposed area 112.The zinc oxide nanowire vitellarium 111 of carbon fiber surface accounts for 3/5ths of carbon fiber 11 length.
By conventional spin-coating method polymethyl methacrylate is covered on zinc oxide nano-wire array layer and forms the polymeric dielectric layer 13 that thickness is 200nm.
Utilize radio frequency sputter, the Nitinol of thickness 100nm is set on polymeric dielectric layer 13, form distributed electrode 2.
Under high frequency electric source effect, between carbon fiber 11 and distributed electrode 2, form electric field, zinc oxide nano-wire array 12 produces supersonic vibration under this electric field action, ultrasonic oscilloscope apparatus is adopted to record, this ultrasonic frequency is 2MHz, and voltage amplitude is 2V, can be applied to thrombus in blood vessel.
Under Ultrasonic Vibration motivation of the present invention, under electric field action, zinc oxide nanowire can produce ultrasound wave (supersonic vibration), for driving foreign body or thrombosis at body cavity and blood vessel.According to the difference of application, supersonic vibration machine of the present invention can produce the ultrasound wave of different frequency.Under Ultrasonic Vibration motivation diameter of the present invention is 10 ~ 15 microns, can except pass through in capillary other blood vessels EV, for driving the thrombosis that is attached to blood vessel wall or impelling thromboembolism in blood vessel wall.
Claims (7)
1. a nanoscale ultrasonic vibrator, is characterized in that: this Under Ultrasonic Vibration motivation comprises carbon fiber, zinc oxide nano-wire array and polymeric dielectric layer;
Wherein, the surface of carbon fiber comprises zinc oxide nanowire vitellarium and exposed area;
In zinc oxide nanowire vitellarium, described zinc oxide nano-wire array vertical-growth is on carbon fiber surface, and being formed with carbon fiber is core, and zinc oxide nano-wire array is as the nucleocapsid structure of cylindrical shell;
Described zinc oxide nano-wire array is coated with described polymeric dielectric layer.
2. nanoscale ultrasonic vibrator according to claim 1, is characterized in that, described polymeric dielectric layer material used is polymethyl methacrylate or polydimethylsiloxane.
3. nanoscale ultrasonic vibrator according to claim 1 and 2, it is characterized in that, this Under Ultrasonic Vibration motivation comprises power supply further, and described power supply comprises two current output terminals, one of them current output terminal connects the exposed area of carbon fiber, and another current output terminal connects receptor.
4. nanoscale ultrasonic vibrator according to claim 3, is characterized in that, this Under Ultrasonic Vibration motivation comprises distributed electrode further, and this distributed electrode is arranged on polymeric dielectric layer; A current output terminal of described power supply connects the exposed area of carbon fiber, and another current output terminal connects distributed electrode.
5. nanoscale ultrasonic vibrator according to claim 4, is characterized in that, described distributed electrode material is any one in gold, platinum, titanium or Nitinol.
6. nanoscale ultrasonic vibrator according to claim 1 or 5, it is characterized in that, described zinc oxide nanowire vitellarium accounts for 4/1 to five/4ths of carbon fiber length.
7. nanoscale ultrasonic vibrator according to claim 5, is characterized in that, described power supply is alternating current, and power is between 5 ~ 100W, and frequency is between 1KHz-10MHz.
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| CN1951000A (en) * | 2004-05-21 | 2007-04-18 | 守屋正 | Ultrasonic motor |
| CN102283677A (en) * | 2011-07-12 | 2011-12-21 | 中国科学院深圳先进技术研究院 | Ultrasound array sound head and production method thereof |
| CN102315381A (en) * | 2011-01-13 | 2012-01-11 | 李泽唐 | Method for preparing zinc oxide nanometer film carbon fiber piezoelectric material with core-shell structure and application thereof |
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| US6022309A (en) * | 1996-04-24 | 2000-02-08 | The Regents Of The University Of California | Opto-acoustic thrombolysis |
| US7220310B2 (en) * | 2002-01-08 | 2007-05-22 | Georgia Tech Research Corporation | Nanoscale junction arrays and methods for making same |
| JP5031450B2 (en) * | 2007-06-12 | 2012-09-19 | 富士フイルム株式会社 | Composite piezoelectric material, ultrasonic probe, ultrasonic endoscope, and ultrasonic diagnostic apparatus |
| KR101588318B1 (en) * | 2009-11-23 | 2016-01-25 | 삼성전자주식회사 | Tube type piezoelectric energy generating device and method for manufacturing the same |
| KR101594134B1 (en) * | 2010-03-05 | 2016-02-16 | 삼성전자주식회사 | Apparatus for generating electrical energy |
| PT2649653T (en) * | 2010-12-09 | 2021-09-02 | Faculdade De Ciencias E Tecnologia Univ Nova De Lisboa | Mesoscopic optoelectronic devices comprising arrays of semiconductor pillars deposited from a suspension and production method thereof |
| CN202917587U (en) * | 2012-08-17 | 2013-05-01 | 纳米新能源（唐山）有限责任公司 | Hybrid nano-generator |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1951000A (en) * | 2004-05-21 | 2007-04-18 | 守屋正 | Ultrasonic motor |
| CN102315381A (en) * | 2011-01-13 | 2012-01-11 | 李泽唐 | Method for preparing zinc oxide nanometer film carbon fiber piezoelectric material with core-shell structure and application thereof |
| CN102283677A (en) * | 2011-07-12 | 2011-12-21 | 中国科学院深圳先进技术研究院 | Ultrasound array sound head and production method thereof |
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