CN1035550C - Medical 32P series glass microballoon and its preparing process - Google Patents

Medical 32P series glass microballoon and its preparing process Download PDF

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CN1035550C
CN1035550C CN93103780A CN93103780A CN1035550C CN 1035550 C CN1035550 C CN 1035550C CN 93103780 A CN93103780 A CN 93103780A CN 93103780 A CN93103780 A CN 93103780A CN 1035550 C CN1035550 C CN 1035550C
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phosphorus
glass
series
series glass
microballoon
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CN1080266A (en
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孙文豪
李茂良
张丽珠
翟盛庭
王剑云
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Nuclear Power Institute of China
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Nuclear Power Institute of China
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Abstract

The present invention discloses radioactive medical cancer-treating medicine P32 series of glass microspheres and a preparation technology thereof. The P32 series of glass microspheres are manufactured by the following steps: glass materials, such as phosphates which have nontoxicity to human bodies, and are compatible with human bodies, etc., are adopted, the glass materials are smelted under high temperature into phosphorus glass, phosphorus and yttrium glass, phosphorus and samarium glass, phosphorus and molybdenum glass, etc., and after the glass are pulverized, made into spheres and irradiated by pile neutrons, the P32 series of glass microspheres are formed. The P32 series of glass microspheres are suitable for the treatment of malignant tumor cancers, and animal experiments and clinical trials prove that the present invention is safe and reliable, has very good curative effect, and is a new ideal radioactive internal irradiation cancer treating medicine.

Description

Medical phosphorus 32 P series glass microballoons and preparation technology thereof
The present invention relates to medical curing cancer drug of a kind of radioactivity and preparation technology thereof, specifically medical phosphorus 32 P series glass microballoons and preparation technology thereof.
To have the existing vicennial history of research that radioactive solids are used for some cancer knurl of vascular peg stay plug radiation therapy.The once used solids of bibliographical information are for carrying 198The carbon granules of Au contains 90The Y of Y 2O 3Powder is marked with 32P or 90The amberlite lipoid microsphere of Y, the surface scribbles 32P or 90The ceramic microsphere of Y.These particles have good effect to cancer therapy, but also have many shortcomings.As Y 2O 3Powder surface is rough, easily causes the surrounding tissue inflammation, and resin microsphere and ceramic microsphere surface scribble 32P with 90Y easily is discharged in the body from microsphere surface, enters the whole body systemic circulation, and the HUMAN HEALTH tissue is caused unnecessary harm.U.S. Pat P4789501 disclosed a kind of phosphorus 32 P series glass microballoons and yttrium 90 glass microspheres and preparation technology thereof in 1988, and this invention has avoided above-mentioned microballoon to discharge the disadvantage of diffusion, but still has its weak point.At first, contain chemical elements such as lead, fluorine in the prescription, can cause savings to poison human body.Secondly, also contain elements such as sodium, potassium, zirconium, manganese in the prescription, can produce stronger gamma active element after the activation, kill and wound cancer knurl normal cell on every side easily, unfavorable to HUMAN HEALTH.The 3rd, in the prescription 32The release rate of P does not meet the requirement and the medicine standard of nuclear medicine greater than 0.1%.The 4th, the oxide compound fusing point height of elements such as silicon, aluminium, magnesium brings difficulty to melting in the prescription.The 5th, P 2O 5Easily suction at normal temperatures, and be difficult for and the other materials mixing, it is inhomogeneous to melt the phosphorus glass content that, and the specific activity of phosphorus 32 microballoons of making goes out just inhomogeneous, and P under the high temperature 2O 5Easily distillation loss, melting are also inconvenient.
The object of the present invention is to provide a kind of any poisonous element, easily melting, phosphorus 32 release rates of not containing less than 0.1%, proportion is less than 2.5g/cm 3, be applicable to phosphorus 32 P series glass microballoons and the preparation technology thereof of treatment cancer knurl.
Adopt pure aluminium silicate, Magnesium Silicate q-agent, aluminum phosphate, trimagnesium phosphate as the glass microsphere basic raw material in the present invention's prescription, they are salt, and fusing point is lower than oxide compound, therefore are easy to melting.Therefore elements such as not leaded in the prescription, fluorine put aside toxication to this nothings of people.Do not contain elements such as sodium, potassium, zirconium, manganese in the prescription, therefore the unlimited strong gamma activity in activation back does not have hazardness to the human normal cell, and is safe in utilization.Do not use P in the prescription 2O 5, so the raw material fusing time also is easy to mixing, release rate meets medicinal standard.
Phosphorus 32 glass microsphere basic recipes are (weight percent):
Al 2(SiO 3) 3 55～65％
MgSiO 3 25～35％
AlPO 4 10～20％
Y 2O 3 0～20％
Sm 2O 3 0～1％
(NH 4) 2MoO 40～1% for improving the specific activity of phosphorus 32 glass microspheres, except the neutron flux and prolongation irradiation time that improve reactor, can prepare phosphorus, yttrium glass microsphere toward adding yttrium 90 oxide compounds in phosphorus 32 glass microspheres, promptly adds 10～20%Y in basic recipe 2O 3, the content of corresponding minimizing pure aluminium silicate and Magnesium Silicate q-agent.For carrying out experimentation on animals, animal carried out external γ takes pictures or tomography is determined microballoon conduct in animal body or the distribution situation in histoorgan, can be in melting phosphorous or add 0.5～1.0% Sm when containing the glass of yttrium 2O 3Or (NH 4) 2MoO 4Make phosphorus samarium, phosphorus molybdenum microballoon or phosphorus yttrium samarium microballoon, as the γ tracer agent, these microballoons produce gamma-rays behind neutron irradiation in reactor, during experimentation on animals, detect with regard to available gamma camera or ECT, thereby can observe microballoon dynamic change in animal body, distributed areas and anticarcinogenic effect easily.Also can add a spot of Fe respectively 2O 3, CuO, CoO, MnO 2, content is 0.1～1.0%, produces to be used for (as black, green, blue, purple) of all kinds phosphorus 32 P series glass microballoons that cold experiment spike is used.Preparation technology of the present invention is as follows:
To prepare the required component of phosphorus 32 P series glass microballoons mixing by a certain percentage, put into platinum crucible, on high temperature resistance furnace, be heated to 1400～1500 ℃ of fusions, constant temperature 3～5 hours, again crucible is put into the normal temperature redistilled water simultaneously together with Sheng glass, glass is scraped, pour out 110 ℃ of oven dry and--pulverize----chloroazotic acid boiled 10～30 minutes--normal temperature second distillation water rinse is to neutral--oven dry--apparatus for making pearl ball system ball--acetone cleanings--redistilled water cleanings--oven dry--screening--salt acid soak 20 minutes--second distillation is washed to neutrality--oven dry--400～500 ℃ of constant temperature is 4 hours in muffle furnace--target spare is made in sealing in the silica tube of packing into------second distillation is washed to neutrality----high pressure 0.14MPa sterilized 30 minutes--finished product of drying packing that takes out the hydrochloric acid cleaning of putting irradiation in the reactor that filters out the suitable particle size microballoon.
Utilizing above-mentioned prescription and technology can prepare particle diameter is 10～20 μ m, 20～30 μ m, 45～76 μ m, 100～150 μ m, proportion are various phosphorus 32 P series glass microballoons (phosphorus 32 glass microspheres, phosphorus 32 yttriums 90 glass microspheres, phosphorus 32 samariums 153 glass microspheres, phosphorus 32 molybdenums 99 glass microspheres, phosphorus 32 yttriums 90 samariums 153 glass microspheres) of 2.5g/cm.Particle diameter is but that 10～20 μ m microballoon direct injection are in the cancer tumor tissue, particle diameter is 20～30 μ m, 45～76 μ m microballoons are used for the tumour of arterial perfusion embolism radiation therapy capillary vessel than thin and thicker part position, and particle diameter is that the microballoon of 100～150 μ m is mainly used in experimentation on animals.
Adopt phosphorus 32 P series glass microballoons of prescription of the present invention and prepared not contain any poisonous element, easily melting.Microsphere particle is even, and density is less than 2.5g/cm 3, be easy to perfusion, no bonding under high temperature, high pressure, physiological saline and soda acid soak, there is not distortion, nothing is damaged, serviceability rate 100%.After testing, the phosphorus 32 radioactivity release rates of microballoon meet medical standard less than 0.1%.
Embodiment one
The preparation of phosphorus 32 glass microspheres
1. with 57.9% Al 2(SiO 3) 3, 29% MgSiO 3, 13.1% AlPO 4Abundant mixing, put into platinum crucible, then crucible is placed on and is heated to 1400 ℃ on the high temperature resistance furnace, make the mixture fusion, and fully stir constant temperature 3 hours, mixture in the crucible has become phosphorus glass, then crucible is put into the redistilled water of normal temperature simultaneously together with Sheng glass, make it burst into glass cullet, pour out the back 110 ℃ of oven dry down;
2. with pulverizer phosphorus glass being pulverized is the glass powder of particle diameter 30～76 μ m, filters out the glass powder of desired particle size again with sieve shaker, boils 20 minutes with chloroazotic acid, uses the second distillation water rinse to neutral, 110 ℃ of oven dry then;
3. will dry back glass powder and spray in apparatus for making pearl ball methane-oxygen thermal-flame, fall after the glass powder fusing, just make microballoon, receive with aluminium matter drum then through spraying gun;
4. the microballoon of collecting is washed 3 times with acetone earlier, again with second distillation washing 3 times, 110 ℃ of oven dry down.Filter out the microballoon of required particle diameter (45～76 μ m) with the standard sub-sieve,, be washed to neutrality with second distillation again, 110 ℃ of oven dry down with 0.5mol1 salt acid soak 20 minutes;
5. glass microsphere is put into muffle furnace 400 ℃ of following constant temperature 4 hours;
6. glass microsphere being packed into seals in the silica tube, reinstalls aluminium target tube, makes target spare, is placed on irradiation in the reactor, and specific radioactivity is 54mci/g;
7. the glass microsphere behind the irradiation is taken out from the antimicrobial gloves case, the hydrochloric acid cleaning with 0.5mol/l is washed to neutrality with second distillation again, 110 ℃ of oven dry down;
8. with weighing method microballoon is divided in the vial of 10ml, seals, sterilization took out after 30 minutes under the pressure of 0.14MPa in the autoclave sterilization Sterilizers.
Phosphorus 32 glass microspheres that present embodiment is prepared (particle diameter 45～76 μ m, color beige, proportion 2.3g cm 3) can be used for local intra-arterial and be poured in radiation therapy cancer knurl in the cancer tumor tissue.
Embodiment two
The preparation of phosphorus 32 yttriums 90 glass microspheres
1. with 60% Al 2(SiO 3) 3, 10% MgSiO 3, 10% AlPO 4With 20% Y 2O 3Mix, put into platinum crucible, then crucible is placed on and is heated to 1450 ℃ on the high temperature resistance furnace, make the mixture fusion, and fully stir, constant temperature 4 hours, mixture in the crucible has become phosphorus yttrium glass, then crucible is put into the redistilled water of normal temperature together with glass, makes it burst into glass cullet, pour out the back 110 ℃ of oven dry down
2. identical with embodiment one;
3. identical with embodiment one;
4. identical with embodiment one;
5. glass microsphere is packed in the muffle furnace 450 ℃ of following constant temperature 4 hours;
6. glass microsphere being packed into seals in the silica tube, reinstalls aluminium target tube and makes target spare, is placed on irradiation in the reactor, and yttrium 90 specific radioactivities are about 3.6Ci/g; Phosphorus 32 specific radioactivities are 24mci/g;
7. identical with embodiment one;
8. identical with embodiment one.
Phosphorus 32 yttriums 90 glass microspheres (particle diameter 21～30 μ m, 45～75 μ m, colours white, proportion 2.5g/cm that present embodiment is prepared 3), be used for by arterial perfusion embolism radiation therapy capillary vessel than cancer knurl thick and thin position.
Embodiment three
The preparation of phosphorus 32 molybdenums 99 glass microspheres
1. with 60.8% Al 2(SiO 3) 3, 26.5% MgSiO 3, 11.9% AlPO 4, 0.8% (NH 4) 2MoO 4Mix. put into platinum crucible, then crucible is placed on and is heated to 1500 ℃ on the high temperature resistance furnace, make the mixture fusion, and fully stir, constant temperature 5 hours. the mixture in the crucible has become the phosphorus molybdenum glass, then crucible is put into the redistilled water of normal temperature together with glass, makes it burst into glass cullet, pour out the back 110 ℃ of oven dry down:
2. identical with embodiment one;
3. identical with embodiment one;
4. identical with embodiment one;
5. glass microsphere is put into muffle furnace 500 ℃ of following constant temperature 4 hours;
6. with the glass microsphere sealing, make target spare, be placed on irradiation in the reactor, phosphorus 32 specific radioactivities are 54mci/g; The specific radioactivity of molybdenum 99 is 17mci/g
7. identical with embodiment one;
8. identical with embodiment one.
(particle diameter 10O～150 μ m colors are sky-blue to phosphorus 32 molybdenums 99 glass microspheres that present embodiment is prepared, proportion 2.2g/cm 3), can be used for
Figure C9310378000071
The spike experimentation on animals.
Phosphorus 32 glass microspheres according to method for preparing; Phosphorus 32 yttriums 90 glass microspheres; Phosphorus 32 molybdenums 99 glass microspheres are respectively applied for the clinical treatment oral carcinoma: cervical cancer, mammary cancer; And experimentation on animals, curative effect is excellent, does not have any complication and sequela, and is safe and reliable, is a kind of ideal radioactivity internal radiation PTS.

Claims (3)

1. a smooth surface, solid, diameter are 10～20 μ m, 21～30 μ m, and 45～75 μ m, medical phosphorus 32 P series glass microballoons of 76～10 μ m is characterized in that: making phosphorus 32 P series glass microballoon formulation weight per-cents is:
Al 2(SiO 3) 3 55～65％
MgSiO 3 25～35％
AlPO 4 10～20％
Y 2O 3 0～20％
Sm 2O 3 0～1％
(NH 4) 2MoO 40～1% particles specific weight is less than 2.5g/cm 3, the release rate of phosphorus 32 is less than 0.1%, and specific radioactivity is 20～60mc/g.
2. medical phosphorus 32 P series glass microballoons according to claim 1 is characterized in that also can adding 0.1～1.0% Fe in above-mentioned prescription 2O 3Or CuO, CoO, MnO 2Produce and be used for black, green, blue, purple phosphorus 32 P series glass microballoons that cold experiment spike is used.
3. the preparation technology of medical phosphorus 32 P series glass microballoons, comprise raw material in proportion uniform mixing, burst, dry, pulverize, screen, granulation, packing operation, it is characterized in that: melt temperature is 1400-1500 ℃, constant temperature 3-5 hour; The screening back is cleaned and is used chloroazotic acid to boil 3-5 minute, is washed to neutrality with second distillation again; The back microballoon of granulating uses acetone to clean 3-5 time, is washed to neutrality with second distillation again; Microballoon behind the irradiation uses 0.2-0.6mol/1 hydrochloric acid to clean, and is washed to neutrality with second distillation again; Sterilization pressure is 0.1-0.2MPa, and sterilization time is 20-40 minute.
CN93103780A 1993-04-23 1993-04-23 Medical 32P series glass microballoon and its preparing process Expired - Lifetime CN1035550C (en)

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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040197264A1 (en) * 2003-04-04 2004-10-07 Alexander Schwarz Microspheres comprising therapeutic and diagnostic radioactive isotopes
CN106653134B (en) * 2017-01-22 2018-04-27 中国核动力研究设计院 The preparation method of carrier-free P 32
CN106683735B (en) * 2017-01-22 2018-03-06 中国核动力研究设计院 A kind of preparation method for having carrier P 32
CN114699542B (en) * 2019-09-15 2023-09-15 合肥启灏医疗科技有限公司 Radioactive glass microsphere
CN112457143A (en) * 2020-11-27 2021-03-09 山西江阳兴安民爆器材有限公司 Emulsion explosive containing tracer marker and preparation method thereof
CN114652865A (en) * 2020-12-23 2022-06-24 成都纽瑞特医疗科技股份有限公司 Radioactive glass microsphere injection and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314909A (en) * 1980-06-30 1982-02-09 Corning Glass Works Highly refractory glass-ceramics suitable for incorporating radioactive wastes
US4464294A (en) * 1981-08-07 1984-08-07 Kernforschungsanlage Julich Gesellschaft Mit Beschrankter Haftung Process for the stabilization of radioactive wastes
US4789501A (en) * 1984-11-19 1988-12-06 The Curators Of The University Of Missouri Glass microspheres
JPH03235098A (en) * 1990-02-10 1991-10-21 Nippon Electric Glass Co Ltd Vitrification material for vitrification treatment of low level radioactive waste
JPH06127973A (en) * 1992-10-14 1994-05-10 Nippon Electric Glass Co Ltd Radiation shielding glass

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314909A (en) * 1980-06-30 1982-02-09 Corning Glass Works Highly refractory glass-ceramics suitable for incorporating radioactive wastes
US4464294A (en) * 1981-08-07 1984-08-07 Kernforschungsanlage Julich Gesellschaft Mit Beschrankter Haftung Process for the stabilization of radioactive wastes
US4789501A (en) * 1984-11-19 1988-12-06 The Curators Of The University Of Missouri Glass microspheres
JPH03235098A (en) * 1990-02-10 1991-10-21 Nippon Electric Glass Co Ltd Vitrification material for vitrification treatment of low level radioactive waste
JPH06127973A (en) * 1992-10-14 1994-05-10 Nippon Electric Glass Co Ltd Radiation shielding glass

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