CN103550605A - Traditional Chinese medicine (TCM) composition for treating nephrosis - Google Patents
Traditional Chinese medicine (TCM) composition for treating nephrosis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine (TCM) composition for treating nephrosis. The composition is prepared from radix astragali, Indian bread, radix polygonum multiflorum preparata, radix bupleuri, cordyceps sinensis, agilawood, cortex eucommiae, tortoise plastron, semen coicis, twotoothed achyranthes root, China dodder, glossy privet fruit, lophatherum herb, gentiana scabra bunge, Japanese climbing fern spore, christina loosestrife, white mulberry root-bark, spreading hedyotis herb, malaytea scurfpea fruit and cornu cervi degelatinatum. Conventional auxiliary materials are added to the TCM composition to prepare clinically acceptable pills, capsules, tablets, granules, powder, decoction or oral liquid according to the conventional processes. The TCM composition has the functions of tonifying qi and yin, warming and tonifying the spleen and kidneys and activating yang and promoting diuresis, has obvious curative effects on chronic nephritis, chronic renal failure-uraemia and renal hypertension, and does not have toxic or side effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of Chinese medicine composition for the treatment of nephropathy.
Background technology
The nephrotic syndrome is called for short nephropathy, is to take glomerular basement membrane permeability as main symptom grouping, can be caused by Different types of etiopathogenises, and its Clinical symptoms is High-grade Proteinuria, hypoproteinemia, hypercholesterolemia and hydrosarca.Primary disease is comparatively common in children's's kidney disease, minute nephrotic syndrome and the large class of the Secondary cases nephrotic syndrome two.Primary nephrotic syndrome can be divided into again Steroid Responsive Nephrotic Syndrome and nephritis nephropathy, congenital nephropathy three types.Children's is the most common with Steroid Responsive Nephrotic Syndrome, account in primary nephrotic syndrome of children more than 80%, this kind of age of onset is many in 2-7 year, prognosis bona.Nephritic nephrosis is more common in 7 years old above children's, and prognosis is poor, often easily causes renal failure.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine composition for the treatment of nephropathy.
The present invention is achieved through the following technical solutions:
The crude drug of Chinese medicine composition of the present invention consists of:
Radix Astragali 5-15 weight portion Poria 5-15 weight portion Radix Polygoni Multiflori Preparata 3-9 weight portion
Radix Bupleuri 3-9 weight portion Cordyceps 1.5-4.5 weight portion Lignum Aquilariae Resinatum 2-8 weight portion
Cortex Eucommiae 2-8 weight portion Carapax et Plastrum Testudinis 1.5-4.5 weight portion italian-jobi jen 5-15 weight portion
Radix Achyranthis Bidentatae 2-8 weight portion Semen Cuscutae 2-8 weight portion Fructus Ligustri Lucidi 5-15 weight portion
Herba Lophatheri 1.5-4.5 weight portion Radix Gentianae 1.5-4.5 weight portion Spora Lygodii 3-9 weight portion
Herba Lysimachiae 2-8 weight portion Cortex Mori 2-8 weight portion Herba Hedyotidis Diffusae 5-15 weight portion
Fructus Psoraleae 3-9 weight portion Cornu Cervi Degelatinatum 4-14 weight portion.
The crude drug composition of Chinese medicine composition of the present invention is preferably:
The crude drug composition of Chinese medicine composition of the present invention is preferably:
The crude drug composition of Chinese medicine composition of the present invention is preferably:
Chinese medicine composition of the present invention adds conventional adjuvant to make the pill of clinical acceptance, capsule, tablet, granule, powder, decoction or oral liquid according to common process.
Chinese medicine composition of the present invention has supplementing QI and nourishing YIN, warming and recuperating the spleen and kidney, the effect of activating YANG for promoting diuresis.To treatment chronic nephritis, chronic renal insufficiency-Uremic, renal hypertension effect is remarkable, has no side effect.
Experimental example is used for further illustrating the present invention below, but is not limited to the present invention.
One, experimental example
1, clinical observation
Treatment group anthology invention pill (according to embodiment 1 method preparation) treatment chronic nephritis, chronic renal insufficiency, the nephropathy such as renal hypertension 100 examples, male's 50 examples wherein, women's 50 examples.
2, medicament selection
Treatment group: pill of the present invention (according to embodiment 1 method preparation), treat three courses for the treatment of (15 days courses for the treatment of), oral, every 2mg.Three times on the one, one time 8.
3, diagnostic criteria
1.. anasarca: start to see eyelid and face, spread all over gradually whole body, severe patient can have thoracic cavity, seroperitoneum and scrotum, penis, labia edema, and mostly being can concavity.
2.. High-grade Proteinuria (+++-++++) or twenty-four-hour urine albumen surpass 0.1g/kg, continue more than 2 weeks.
3.. hypoproteinemia: blood plasma total protein is lower than normally, more obvious with albumin reduction, often < 30g/L.A2 and relative rising of beta Globulin.
4. hypercholesterolemia: the normal > 5.7mmol/L of plasma cholesterol (220mg/d1).
4, criterion of therapeutical effect
The Standardization of diagnosis and curative effect > > that cures the desease in the < < implementing for 1994 with reference to State Administration of Traditional Chinese Medicine drafts as follows:
Recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear;
Effective: tcm clinical practice symptom, sign obviously change;
Effective: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign are all not improved;
5, therapeutic outcome
The efficacy result of table 1 treatment nephropathy
6, conclusion
Pill of the present invention (according to embodiment 1 method preparation) treatment chronic nephritis, chronic renal insufficiency, three courses for the treatment of of the nephropathy such as renal hypertension (15 days each courses for the treatment of), therapeutic outcome demonstration, total effective rate is 99%.
7, discuss
The Radix Astragali in Chinese medicine composition of the present invention: nature and flavor: sweet, tepor.Gui Jing: return lung, spleen, liver, kidney channel.The effect that benefiting QI for strengthening the superficies, arresting sweating admittedly take off, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Poria: nature and flavor: sweet, light, flat.Gui Jing: GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness.Radix Polygoni Multiflori Preparata: bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Function invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening.Radix Bupleuri: meridian distribution of property and flavor: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, elevate a turnable ladder yang-energy.Cordyceps: nature and flavor are sweet, temperature.Function invigorating the lung and the kidney, preventing phlegm from forming and stopping coughing.Can be used for chronic cough dyspnea due to deficiency, the disease that puerperal asthenia, sexual impotence are sombre etc. " void ".Lignum Aquilariae Resinatum: pungent, bitter, temperature.Return spleen, stomach, kidney, lung meridian.Sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI.> > is wanted in the bun of < < medical center: " hard kidney, mends the gate of vitality, and warming middle-JIAO, dry spleen wet, removing pathogen in the heart, lowering the adverse flow of QI, and all uncomfortable gas all can be adjusted it.And control keep silent mouthful fulminant dysentery and evil cold wind arthralgia due to cold." Cortex Eucommiae: Gan Weixin, temperature.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, foot and knee flaccidity.< < herbal classic > >: " main pain along the spinal column, invigorating middle warmer benefit vital essence, hard muscles and bones." Carapax et Plastrum Testudinis: salty sweet, flat.Enter the heart, spleen, liver three warps.YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone.Semen Coicis: property slightly sweet flavor is slightly cold, and returns spleen, stomach, lung meridian.There is inducing diuresis to remove edema, invigorating the spleen to clear away damp pathogen, arthralgia relieving by relaxing muscles and tendons, the effects such as clearing away heat and discharging pus, are conventional damp-clearing drug.Radix Achyranthis Bidentatae: hardship; Acid; Property is put down.Medicine dispels the wind; Blood circulation and stasis-eliminating medicine.Invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow.Semen Cuscutae: nature and flavor: warm in nature, sweet in the mouth.Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight, antidiarrheal.Fructus Ligustri Lucidi: nature and flavor: sweet, hardship, cool.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees.Herba Lophatheri: sweet light, cold, nontoxic.Enter heart channel, kidney channel.The sweet light profit of oozing, cold in naturely falls clearly, the descending and inducing diuresis for treating stranguria syndrome of kind fire of leading the heart and small intestinal.Radix Gentianae: bitter in the mouth, cold in nature.Return liver, gallbladder meridian.Heat clearing and damp drying; Eliminating pathogen in the liver arresting convulsion.Jaundice due to damp-heat; Urine leaching pain; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear is swollen; Hypochondriac pain bitter taste; Calentura convulsion with spasms.Spora Lygodii: cold in nature, sweet in the mouth.Return bladder, small intestine meridian.Eliminating damp-heat, treating stranguria pain relieving.For pyretic stranguria, sand Stranguria, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain.< < Guangxi Chinese medicinal herbal > >: spit blood for edema and calentura.Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel.Relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Cortex Mori: sweet cold, enter lung meridian.Eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.Herba Hedyotidis Diffusae: micro-hardship, micro-sweet, is slightly cold.GUIXIN, liver, spleen channel.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema.Fructus Psoraleae: nature and flavor are pungent, bitter, temperature; Return kidney, spleen channel.There is warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, the effect of antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily.Cornu Cervi Degelatinatum is that the angle of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus boils remaining bone slag after Colla cornus cervi, salty, temperature.Return liver, kidney channel.Warming the kidney to activate YANG, astringing to arrest bleeding.For spleen kidney yang flaccidity.Pharmaceutical composition of the present invention has supplementing QI and nourishing YIN, warming and recuperating the spleen and kidney, the effect of activating YANG for promoting diuresis.To treatment chronic nephritis, chronic renal insufficiency-Uremic, renal hypertension effect is remarkable, has no side effect.
Experimental example two, model case
Case 1: Zhang, female, 37 years old.In in December, 02, without obvious inducement, occur dizzy, weak symptom, time without frequent micturition, urgent micturition, dysurea symptom, without face red spot and limbs edema, purpura, in local hospital measuring blood pressure 160/90mmHg, routine has urine examined: PRO4+ BLD2+, renal function: Cr142umol/L, the atrophy of Kidney Volume moderate, afterwards toward hospital treatment, press chronic glomerulonephritis diagnosis and treatment, and in while in hospital row kidney puncture, do pathology and show (the Lee classification of hypertrophy hardening IgA nephropathy, visible 10 glomerule under light microscopic, wherein 7 whole world sclerosis, 1 sections sclerosis, in all the other mesangial cells and substrate diffusivity to severe hypertrophy, endotheliocyte segmental hypertrophy), concrete treatment situation is not quite clear, be in hospital and take a turn for the better and leave hospital after 2 months.After leaving hospital, interruption is taken hundred and is made capsule, shenyankangfu tablet and Chinese medicine decoction treatment, and repeatedly PRO2+ BLD2+ is shown in urine examination therebetween, and kidney power control system is undesirable.Diagnosis: chronic renal insufficiency.By taking pill of the present invention (according to embodiment 1 method preparation), three times on the one, one time 8, take two courses for the treatment of after the state of an illness basicly stable, after continue to take and look into blood creatinine after 1 course for the treatment of and be down to 193umol/L, routine urinalysis: PRO+-, BLD-, anemia is corrected at present, controlling of blood pressure is stable, receive sleep can, two just adjust, conscious health is good.
Case 2: Pan, man, 34 years old.Patient occurred dizzy without obvious inducement before 1 year, headache, vexed without edema and breast at that time, do not give and paying attention to and diagnosis and treatment, flu before 1 week, after heating, occur that the whole body is weak, edema of pair of lower extremities, breast is vexed, breathe hard, time have nauseating, vomiting, at that time without urgent micturition, frequent micturition, without erythra and arthralgia, then medical to local hospital, inspection PRO+3 has urine examined, BLD-, be thought of as " nephritis ", do not give systematic treating, measuring blood pressure 200/140mmhg, creatinine 815umol/L has a blood test, B ultrasonic: two kidney diffuse lesions, be diagnosed as " chronic renal insufficiency ", give betaloc tablet, the treatment such as Plendil sheet blood pressure lowering 4 days, symptom has no alleviation, then to our hospital upon somebody's introduction, spirit while being admitted to hospital, the dormancy of receiving is not good enough, general edema, weak, breast is vexed, breathe hard, two just adjust.Diagnosis: chronic nephritis, chronic renal insufficiency-Uremic, renal hypertension.By taking capsule of the present invention (according to embodiment 2 methods preparations), three times on the one, one time 3, take after two courses for the treatment of, the state of an illness is clearly better, blood pressure drops, check routine blood test WBC 3.9x109/L, RBC 3.42x1012/L, Hgb 97g/L, kidney merit: Bun 29mmol/L, Cr738umol/L, four normals of blood coagulation, are before clearly better.Take continuously again 1 course for the treatment of of capsule of the present invention, the state of an illness heals entirely, and blood pressure is steady, rear check routine blood test Hgb 103g/L, urine examination PRO+2, BLD-, kidney merit: Bun 19mmol/L, Cr463umol/L.
Case 3: Lee so-and-so, female, 52 years old.In February, 08, there is dizzy, weak symptom, time without frequent micturition, urgent micturition, dysurea symptom, without face red spot and limbs edema, purpura, in local hospital measuring blood pressure 165/91mmHg, routine has urine examined: PRO5+ BLD3+, renal function: Cr145umol/L, the treatment of Kidney Volume moderate atrophy ，Lai Wo institute.Diagnosis: chronic renal insufficiency.By taking tablet of the present invention (according to embodiment 3 method preparations), three times on the one, one time 3, take two courses for the treatment of after the state of an illness basicly stable, rear continue to take look into blood creatinine after 1 course for the treatment of and be down to 190umol/L, routine urinalysis: PRO+-, BLD-, anemia is corrected at present, and controlling of blood pressure is stable, receive sleep can, health is good.
The specific embodiment
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1 pill
According to common process, add conventional adjuvant to make pill said medicine, every 2mg.Three times on the one, one time 8.
Embodiment 2 capsules
According to common process, add conventional adjuvant to make capsule said medicine, three times on the one, one time 3.
Embodiment 3 tablets
According to common process, add conventional adjuvant to make tablet said medicine, three times on the one, one time 3.
Embodiment 4 granules
Said medicine is added to the agent of conventional adjuvant granulation according to common process.
Embodiment 5 oral liquids
According to common process, add conventional adjuvant to make oral liquid said medicine.
Claims (7)
1. a Chinese medicine composition for the treatment of nephropathy, is characterized in that, the crude drug of said composition consists of:
Radix Astragali 5-15 weight portion Poria 5-15 weight portion Radix Polygoni Multiflori Preparata 3-9 weight portion
Radix Bupleuri 3-9 weight portion Cordyceps 1.5-4.5 weight portion Lignum Aquilariae Resinatum 2-8 weight portion
Cortex Eucommiae 2-8 weight portion Carapax et Plastrum Testudinis 1.5-4.5 weight portion italian-jobi jen 5-15 weight portion
Radix Achyranthis Bidentatae 2-8 weight portion Semen Cuscutae 2-8 weight portion Fructus Ligustri Lucidi 5-15 weight portion
Herba Lophatheri 1.5-4.5 weight portion Radix Gentianae 1.5-4.5 weight portion Spora Lygodii 3-9 weight portion
Herba Lysimachiae 2-8 weight portion Cortex Mori 2-8 weight portion Herba Hedyotidis Diffusae 5-15 weight portion
Fructus Psoraleae 3-9 weight portion Cornu Cervi Degelatinatum 4-14 weight portion.
2. Chinese medicine composition as claimed in claim 1, is characterized in that, the crude drug of said composition consists of:
3. Chinese medicine composition as claimed in claim 1, is characterized in that, the crude drug of said composition consists of:
4. Chinese medicine composition as claimed in claim 1, is characterized in that, the crude drug of said composition consists of:
5. the Chinese medicine composition as described in one of claim 1-4, is characterized in that said composition adds conventional adjuvant to make the pill of clinical acceptance, capsule, tablet, granule, powder, decoction or oral liquid according to common process.
6. the application of the Chinese medicine composition as described in one of claim 1-4 in the medicine of preparation treatment nephropathy.
7. the application of Chinese medicine composition as claimed in claim 6 in the medicine of preparation treatment nephropathy, is characterized in that described nephropathy refers to chronic nephritis, chronic renal insufficiency or renal hypertension.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933416A (en) * | 2014-04-15 | 2014-07-23 | 张文艳 | Combined Chinese medicament for treating chronic nephritis |
| CN104096211A (en) * | 2014-08-06 | 2014-10-15 | 张文明 | Traditional Chinese medicine composition for treating stomach disease and kidney disease |
| CN104706911A (en) * | 2015-03-31 | 2015-06-17 | 赵如风 | Medicine for treating chronic renal insufficiency by targeted positioning method and preparation method of medicine |
| CN105902647A (en) * | 2016-05-04 | 2016-08-31 | 刘法政 | Traditional Chinese medicine enema for treating chronic renal failure |
| CN105998936A (en) * | 2016-05-18 | 2016-10-12 | 孙福强 | Traditional Chinese medicine composition for treating chronic nephritis and renal insufficiency |
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| CN1150911A (en) * | 1995-11-15 | 1997-06-04 | 王振 | Medicinal liquor for tonifying kidney and prolonging life |
| CN1682982A (en) * | 2005-02-22 | 2005-10-19 | 黄资源 | A Chinese medicinal pill for treating chronic nephropathy and renal insufficiency |
| CN102319376A (en) * | 2011-09-28 | 2012-01-18 | 易国松 | Chinese herbal medicament for treating nephropathy |
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| CN1150911A (en) * | 1995-11-15 | 1997-06-04 | 王振 | Medicinal liquor for tonifying kidney and prolonging life |
| CN1682982A (en) * | 2005-02-22 | 2005-10-19 | 黄资源 | A Chinese medicinal pill for treating chronic nephropathy and renal insufficiency |
| CN102319376A (en) * | 2011-09-28 | 2012-01-18 | 易国松 | Chinese herbal medicament for treating nephropathy |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933416A (en) * | 2014-04-15 | 2014-07-23 | 张文艳 | Combined Chinese medicament for treating chronic nephritis |
| CN104096211A (en) * | 2014-08-06 | 2014-10-15 | 张文明 | Traditional Chinese medicine composition for treating stomach disease and kidney disease |
| CN104706911A (en) * | 2015-03-31 | 2015-06-17 | 赵如风 | Medicine for treating chronic renal insufficiency by targeted positioning method and preparation method of medicine |
| CN105902647A (en) * | 2016-05-04 | 2016-08-31 | 刘法政 | Traditional Chinese medicine enema for treating chronic renal failure |
| CN105998936A (en) * | 2016-05-18 | 2016-10-12 | 孙福强 | Traditional Chinese medicine composition for treating chronic nephritis and renal insufficiency |
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| CN103550605B (en) | 2016-04-06 |
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