CN103520842A - Terahertz-wave diagnosis and treating instrument - Google Patents
Terahertz-wave diagnosis and treating instrument Download PDFInfo
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- CN103520842A CN103520842A CN201310526355.XA CN201310526355A CN103520842A CN 103520842 A CN103520842 A CN 103520842A CN 201310526355 A CN201310526355 A CN 201310526355A CN 103520842 A CN103520842 A CN 103520842A
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Abstract
The invention provides a terahertz-wave diagnosis and treating instrument. The terahertz-wave diagnosis and treating instrument comprises a probe and a controller, wherein the controller is used for driving the probe and processing acquired information input by the probe, and the probe comprises a terahertz wave generator for generating terahertz waves and an acquiring electrode for performing electrocardio acquisition. The terahertz-wave diagnosis and treating instrument can be used for treating cardiovascular diseases of users as well as performing electrocardio acquisition and analyzing the acquired electrocardio information, so that the purpose of diagnosis is achieved. Meanwhile, the probe of the terahertz-wave diagnosis and treating instrument can be sucked at a preset treatment or diagnosis part of a human body through a sucker without being held by hand, and the operation of a user is facilitated. In addition, the terahertz-wave diagnosis and treating instrument further has the advantages of being simple to use and convenient to carry.
Description
Technical field
The present invention relates to armarium, particularly relate to a kind of Terahertz therapeutic instrument.
Background technology
Along with the quick variation of China's age composition in the population, China has entered aging society in advance, cardiovascular disease incidence and mortality rate sustainable growth simultaneously, and cardiovascular burden, becomes important public hygiene problem.Strengthen preventing and treating cardiovascular disease very urgent, a lot of hypertensive patients are in order to prevent and treat great unexpected generation, have to adopt the therapeutic modality of taking medicine all the life, yet the therapeutic modality of taking medicine all the life also can be followed the generation of a lot of side effect, and human body itself is brought to very major injury.
1998, three American scientist Furchgott, Ignarro and Ferid Murad have been awarded in Nobel physiology's prize, to commend them, find that nitric oxide (NO) molecule is that body weight for humans is wanted courier's material, it is the interior a kind of extensive and unique signaling molecule that acts on of body, communication for information between neurocyte and transmission, the aspects such as blood pressure maintains consistently, immune host defense, all play a very important role and participate in generation and the evolution of body various diseases.NO or a kind of important vascular relaxing factor, after vascular endothelial cell produces, be applied to vascular smooth muscle, through a series of biochemical reactions, produces c-GMP, makes smooth muscle relaxation.For alleviating the cardiovascular disease symptoms such as hypertension, angina pectoris, there is good effect.A characteristic resonance frequency of NO molecule, exactly just at THz wave (THz ripple) wave band.By the THz ripple to organism radiation NO characteristic frequency, can increase the growing amount of NO in body, play the effect of blood vessel dilating, adjusting vascular flow amount.
THz wave (THz ripple) or to be called Terahertz ray (THz ray) be from the eighties of last century middle and late stage eighties, just by definite designation, scientists will be referred to as far ir ray before this.THz wave refer to frequency at 0.1THz to the electromagnetic wave of 10THz scope, wavelength probably 0.03 to 3mm scope, between microwave and infrared between.Up to the present, the application of THz technology mainly concentrates in above-described Molecular Detection and organism imaging.The electromagnetic wave that experiment showed, this wave band has beyond thought biological effect, such as affecting Growth of Cells, gene expression etc.More make us being surprised, millimeter wave and submillimeter can only be penetrated into organism less than the degree of depth of 1mm conventionally, but usually the disease of human body depths internal organs are brought to curative effect.
In traditional Terahertz armarium, instrument and equipment only have treatment function, the effect before and after treatment contrast to diagnosis, can only, by the intuitive judgment of sufferer, must bring certain drawback to the effect for the treatment of and the improvement of method like this.Although can have certain detection to the variation of physiological parameter before and after treatment by external instrument (physical parameter detector etc.), but testing result does not have uniqueness and specific aim, and need to purchase corresponding instrument and take up room, portable and the comfortableness that is unfavorable for whole instrument, is more unfavorable for that instrument moves towards community and family from hospital and realizes the low-cost healthy theory of the whole people.
Summary of the invention
For solving the existing problem of above-mentioned prior art, the object of the present invention is to provide the Terahertz medical instrument of a kind of diagnosis, treatment one, its use is simple, easy to carry.
To achieve these goals, the invention provides a kind of THz wave medical instrument, comprise a plurality of probes and the controller for driving probe and processing the Information Monitoring of probe input, described probe comprises for there is the THz wave generator of THz wave and for carrying out the acquisition electrode of electrocardiogram acquisition.
Preferably, described probe comprises and is provided with the first probe of LA acquisition electrode, the second probe and the 3rd probe of RL acquisition electrode of RA acquisition electrode.
Preferably, described probe is provided with for being adsorbed in the sucker of intended treatment site, and described acquisition electrode is located in described sucker.
Preferably, the THz wave frequency of described Terahertz generator transmitting is 0.1THZ-10THZ.
Preferably, the THz wave mid frequency of described Terahertz generator transmitting is 0.15THZ.
Preferably, described controller comprises:
Described controller comprises:
Control processing module: receive the instruction of human-computer interaction module generation and produce a driving signal, for selecting to drive THz wave driver module or electrocardiogram acquisition module; Transfer and analyzing stored module in the Information Monitoring of storing, analysis result is transferred in memory module;
THz wave driver module: thus the duty that the driving signal of processing module input is controlled THz wave generator is controlled in reception;
Electrocardiogram acquisition module: thus the duty of controlling the driving signal control acquisition electrode of processing mould input received, the electrocardiosignal of acquisition electrode feedback is gathered, and the ecg information collecting is transferred to memory module;
Memory module: receive and store the ecg information of electrocardiogram acquisition module input and control the analysis result that processing module is inputted;
Human-computer interaction module: for to controlling processing module transfer instruction, and show the input/output information of controlling processing module.
Preferably, described electrocardiogram acquisition module comprises:
Electrocardiogram acquisition chip: receive to control the driving signal of processing module, carry out electrocardiogram acquisition thereby export an acquired signal to controlling acquisition electrode in probe;
Current limliting unit: acquired signal is carried out to current limliting;
Pull-up unit: for the electrocardiosignal of acquisition electrode feedback is tentatively amplified, and the signal after amplifying is input in electrocardiogram acquisition chip;
Reference voltage module: for electrocardiogram acquisition module provides reference voltage level;
The first impedance matching module: for the amplifier of electrocardiogram acquisition chip internal and high-pass filtering module are carried out to impedance matching;
The second impedance matching module: for the low-pass filtering module of electrocardiogram acquisition chip internal is carried out to impedance matching.
Preferably, described current limliting unit comprises: the first resistance, the second resistance, the 3rd resistance and the 7th electric capacity, and wherein, described first resistance one end is connected with the RL acquisition electrode of described the 3rd probe, the other end and described electrocardiogram acquisition chip+IN pin is connected; Described second resistance one end is connected with the RA acquisition electrode of described the second probe, the other end and described electrocardiogram acquisition chip-IN pin is connected; Described the 3rd resistance one end is connected with the LA acquisition electrode of described the first probe, and the other end is connected with the RLD pin of described electrocardiogram acquisition chip; Described the 7th electric capacity one end is connected with the RLDFB pin of described electrocardiogram acquisition chip, and the other end is connected with the RLD pin of described electrocardiogram acquisition chip;
Described pull-up unit comprises: the 4th resistance and the 5th resistance, and wherein, described the 4th resistance one end is connected with described the first reference voltage, the other end and described electrocardiogram acquisition chip-IN pin is connected; Described the 5th resistance one end is connected with described the first reference voltage, the other end and described electrocardiogram acquisition chip+IN pin is connected;
Described reference voltage module comprises: the 6th resistance, the 7th resistance, the first electric capacity and the second electric capacity, wherein, wherein said the first electric capacity is connected with the REFIN pin of described electrocardiogram acquisition chip with the one end after described the 6th resistance parallel connection, and the other end is electrically connected with ground; Described the 7th resistance one end is connected with described the second reference voltage, and the other end is connected with the REFIN pin of described electrocardiogram acquisition chip; Described second electric capacity one end is connected with described the second reference voltage, and the other end is connected in GND pin, ACDC pin and the ground of described electrocardiogram acquisition chip;
Described the first impedance matching module comprises: the 8th resistance, the 9th resistance, the tenth resistance, the 3rd electric capacity and the 4th electric capacity, wherein, shown in the 8th resistance one end with shown in electrocardiogram acquisition chip IAOUT pin and shown in the second impedance matching module be connected, the other end with shown in the 9th resistance be connected with the tenth resistance; Shown in the 9th resistance the other end with shown in the SW pin of electrocardiogram acquisition chip be connected and pass through shown in the 4th electric capacity with shown in the REFOUT pin of electrocardiogram acquisition chip be connected; Shown in the tenth resistance the other end with shown in the HPSENSE pin of electrocardiogram acquisition chip be connected and cross shown in the 3rd electric capacity with shown in the HPDRIVE pin of electrocardiogram acquisition chip be connected.
Described the second impedance matching module comprises: the 11 resistance, the 12 resistance, the 13 resistance, the 14 resistance, the 5th electric capacity and the 6th electric capacity, wherein, described the 12 resistance one end is connected with the REFOUT pin of described electrocardiogram acquisition chip by described four or five electric capacity after being connected with the OPAMP+ pin of described electrocardiogram acquisition chip; The other end is connected with described the first impedance matching module by the 11 resistance, is connected by described the 6th electric capacity with the OUT pin of described electrocardiogram acquisition chip simultaneously; Described the 13 resistance one end is connected with the REFOUT pin of described electrocardiogram acquisition chip, and the other end is connected with the OPAMP-pin of described electrocardiogram acquisition chip; Described the 14 resistance one end is connected with the OPAMP-pin of described electrocardiogram acquisition chip, and the other end is connected with the OUT pin of described electrocardiogram acquisition chip;
Preferably, described controller also comprises for alternating current being converted to the needed galvanic power transfer module of THz wave medical instrument.
Preferably, described controller also comprises transport module, for the transmission of data.
Beneficial effect:
THz wave medical instrument provided by the invention, not only can carry out to user the treatment of cardiovascular disease, can also carry out electrocardiogram acquisition and analyze the ecg information collecting user, thereby reach the object of diagnosis.Meanwhile, the probe of THz wave medical instrument can be adsorbed in predetermined treatment or the diagnosis position of human body by its sucker, carry out hand-heldly without people, is convenient to user and operates.And THz wave medical instrument also has advantages of that use is simple, easy to carry.
Accompanying drawing explanation
The structural representation of the THz wave medical instrument that Fig. 1 provides for one embodiment of the invention.
Fig. 2 is the profile of popping one's head in Fig. 1.
The principle framework figure of the controller that Fig. 3 provides for one embodiment of the invention.
The electrocardiogram acquisition module principle figure that Fig. 4 provides for one embodiment of the invention.
The THz wave driver module schematic diagram that Fig. 5 provides for one embodiment of the invention.
The THz wave medical instrument software flow pattern that Fig. 6 provides for one embodiment of the invention.
The specific embodiment
In order to set forth better technical characterstic of the present invention and structure, below in conjunction with the preferred embodiments of the present invention and accompanying drawing thereof, be described in detail.
Consult Fig. 1, a kind of THz wave medical instrument that the present embodiment provides comprises probe and for driving probe and processing the controller of the Information Monitoring of probe input.
Consult Fig. 2, profile for probe, probe comprises THz wave generator 202, poly-ripple lens 203, sucker 204, acquisition electrode 201 and housing 205, wherein THz wave generator 202 comprises generator main body 2021 and waveguide window 2022, the core component of generator main body 2021 is indium phosphide Gunn diode, for launching the THz wave of 0.1T～10T, in a kind of preferred embodiment, the THz wave mid frequency of generator main body 2021 transmittings is 0.15THZ; Waveguide window 2022 is roughly disc, is arranged in generator main body 2021, and the THz wave that generator main body 2021 produces sees through waveguide window 2022 and launches.Poly-ripple lens 203 are arranged on waveguide window 2022, and waveguide window 2022 is covered, and for the THz wave that probe is sent, assemble.THz wave generator 202 is contained in housing 205, and housing 205 lower ends have the first through hole 2051, and the side of housing 205 offers the first guidewire port 2052, and waveguide window 2022, through the first through hole 2051, together enters in sucker 204 with the poly-ripple lens 203 of part.Sucker 204 is roughly bowl structure, comprise sucker sidewall 2041 and sucker chassis 2042, wherein, sucker sidewall 2041 inside are provided with the second through hole 2043 that sucker sidewall 2041 parallels, sucker sidewall 2041 is fixedly connected with housing 205, and the housing 205 of fixed connection place is provided with the second guidewire port 2053 with respect to the second through hole 2043.Probe also comprises coaxial cable 206, and one end of coaxial cable 206 is connected in generator main body 2021, and the other end is through the first guidewire port 2052 extending to outside housing 205, and coaxial cable 206 ends are provided with a plug 207 for being connected with controller 1.Acquisition electrode 201 one end are connected with the first plug 207, and the other end enters housing 205 inside through the first guidewire port 2052 and then passes successively the second guidewire port 2053 of housing 205 and the second through hole 2043 of sucker sidewall 2041 to sucker chassis 2042.When probe is used for the treatment of or diagnoses, only sucker 204 need to be adsorbed in to human body predetermined treatment or diagnosis position by sucker chassis 2042, without people, carry out hand-heldly, convenient operation personnel operate.
In the present embodiment, probe comprises the first probe 21, the second probe the 22 and the 3rd probe 23, wherein, acquisition electrode, THz wave generator and the plug of first probe the 21, second probe the 22 and the 3rd probe 23 are respectively: LA acquisition electrode, RA acquisition electrode and RL acquisition electrode; The first THz wave generator, the second THz wave generator and the 3rd THz wave generator; The first plug, the second plug and the 3rd plug.For with control probe, controller 1 is provided with respectively the first probe interface 181, the second probe interface 182 and the 3rd probe interface 183 matching with the first plug, the second plug, the 3rd plug; Meanwhile, on controller 1, be also provided with the power interface 190 being connected with power supply.
Consult Fig. 3 simultaneously, the principle framework figure of the controller providing for one embodiment of the invention, controller comprises: control processing module 110: receive the instruction of human-computer interaction module 140 generations and produce a driving signal, be used for selecting to drive THz wave driver module 120 or electrocardiogram acquisition module 130, transfer and analyzing stored module 150 in storage Information Monitoring, analysis result is transferred in memory module 150; THz wave driver module 120: thus the duty that the driving signal of processing module 110 is controlled the first THz wave generator, the second THz wave generator and the 3rd THz wave generator is controlled in reception; Electrocardiogram acquisition module 130: thus the duty that the driving signal of processing module 110 is controlled acquisition electrode 201 is controlled in reception, the electrocardiosignal of acquisition electrode 201 feedbacks is gathered, and the ecg information collecting is transferred to memory module 150; Memory module 150: receive and store the ecg information of electrocardiogram acquisition module 130 transmission and control the analysis result that processing module 110 is transmitted; Human-computer interaction module 140: for to controlling processing module 110 transfer instructions, and show the input/output information of controlling processing module 110; Transport module 160: for the transmission of data; Power transfer module 170: alternating current is converted to the needed unidirectional current of THz wave medical instrument.
Referring to Fig. 4, THz wave driver module 120 comprises voltage transformation module 121 and driver module 122 simultaneously, and wherein voltage transformation module 121 is that input voltage is converted to the needed running voltage of THz wave generator 202.Voltage transformation module 121 comprises voltage transitions chip 1211, the 17 resistance R 17, the 18 resistance R 18, the 19 resistance R 19, the 20 resistance R 20, the 8th capacitor C 8, the 9th capacitor C 9, the tenth capacitor C 10, diode D1, inductance L 1 and the second audion Q2, wherein, the 17 resistance R 17 one end are connected in the 4th reference voltage V cc4, 6 pins of voltage transitions chip 1211 and the positive pole of the 8th capacitor C 8, the other end is connected in 1 pin of voltage transitions chip 1211, 7 pins, the source electrode of 8 pins and the second audion Q2, the minus earth of the 8th capacitor C 8, the grid of the second audion Q2 is connected with 2 pins of voltage transitions chip 1211, simultaneously by the 18 resistance R 18 ground connection, the drain electrode of the second audion Q2 is connected with the negative pole of diode D1, the plus earth of diode D1, the drain electrode of the second audion Q2 is connected with the positive pole of the tenth capacitor C 10 with driver module 122 by inductance L 1, the minus earth of the tenth capacitor C 10.One end of the 20 resistance R 20 is connected with the positive pole of the tenth capacitor C 10, and the other end is connected with 5 pins of voltage transitions chip 1211 and passes through the 19 resistance R 19 ground connection; Voltage transitions chip 1211 also comprises 4 pins of ground connection and passes through 3 pins of the 9th capacitor C 9 ground connection; Wherein, the 8th capacitor C 8 and the tenth capacitor C 10 are electrochemical capacitor.The 4th reference voltage V cc4 is 9V in the present embodiment, the main KA34063 chip that adopts of voltage transitions chip 1211, and after voltage transformation module 121 conversions, its output voltage is 3.5V.
Described electrocardiogram acquisition module 130 comprises: electrocardiogram acquisition chip 136: receive to control the driving signal of processing module, thereby export an acquired signal, to controlling acquisition electrode in probe, carry out electrocardiogram acquisition; Current limliting unit 131: acquired signal is carried out to current limliting; Pull-up unit 132: for the electrocardiosignal of acquisition electrode feedback is tentatively amplified, and the signal after amplifying is input in electrocardiogram acquisition chip 136; Reference voltage module 133: for 136 of electrocardiogram acquisition moulds provide reference voltage level; The first impedance matching module 134: for the amplifier of electrocardiogram acquisition chip 136 inside and high-pass filtering module are carried out to impedance matching; The second impedance matching module 135: for the low-pass filtering module of electrocardiogram acquisition chip 136 inside is carried out to impedance matching.
Wherein, electrocardiogram acquisition chip 136 adopts AD8232, and certainly in other embodiments, electrocardiogram acquisition chip adopts also can adopt ADS1298.Current limliting unit 131 comprises: the first resistance R 1, the second resistance R 2, the 3rd resistance R 3 and the 7th capacitor C 7, and wherein, first resistance R 1 one end and the RL acquisition electrode of the 3rd probe in 23 are connected, the other end and electrocardiogram acquisition chip+IN pin is connected; Second resistance R 2 one end are connected with the RA acquisition electrode in the second probe 22, the other end and electrocardiogram acquisition chip-IN pin is connected; The 3rd resistance R 3 one end are connected with the LA acquisition electrode in the first probe 21, and the other end is connected with the RLD pin of electrocardiogram acquisition chip; The 7th capacitor C 7 one end are connected with the RLDFB pin of electrocardiogram acquisition chip, and the other end is connected with the RLD pin of electrocardiogram acquisition chip; In order to prevent that LA acquisition electrode drive current is excessive, human body is damaged, in the present embodiment, the value of R3 is 360K Ω, and simultaneously in order to make the balance of RA acquisition electrode and RL acquisition electrode, R1 resistance value is identical with the resistance value of R2.
Pull-up unit 132 comprises: the 4th resistance R 4 and the 5th resistance R 5, and wherein, the 4th resistance R 4 one end are connected with the first reference voltage V cc1, the other end and electrocardiogram acquisition chip-IN pin is connected; The 5th electric R5 resistance one end is connected with the first reference voltage, the other end and electrocardiogram acquisition chip+IN pin is connected.
The first impedance matching module 134 comprises: the 8th resistance R 8, the 9th resistance R 9, the tenth resistance R 10, the 3rd capacitor C 3 and the 4th capacitor C 4, wherein, the 8th resistance one end is connected with the second impedance matching module 135 with the IAOUT pin of electrocardiogram acquisition chip, and the other end is connected with the tenth resistance R 10 with the 9th resistance R 9; The other end of the 9th resistance R 9 is connected with the SW pin of electrocardiogram acquisition chip and passes through the 4th capacitor C 4 and is connected with the REFOUT pin of electrocardiogram acquisition chip 136; The other end of the tenth resistance R 10 is connected with the HPSENSE pin of electrocardiogram acquisition chip and crosses the 3rd capacitor C 3 and is connected with the HPDRIVE pin of electrocardiogram acquisition chip.
The second impedance matching module 135 comprises: the 11 resistance R the 11, the 12 resistance R the 12, the 13 resistance R the 13, the 14 resistance R 14, the 5th capacitor C 5 and the 6th capacitor C 6, wherein, the 12 resistance R 12 one end are connected with the OPAMP+ pin of electrocardiogram acquisition chip, by the 5th capacitor C 5 devices, be connected with the REFOUT pin of electrocardiogram acquisition chip simultaneously, the other end is connected with the first impedance matching module 134 by the 11 resistance R 11, is connected by the 6th capacitor C 6 with the OUT pin of electrocardiogram acquisition chip simultaneously; The 13 resistance R 13 one end are connected with the REFOUT pin of electrocardiogram acquisition chip, and the other end is connected with the OPAMP-pin of electrocardiogram acquisition chip; The 14 resistance R 14 one end are connected with the OPAMP-pin of electrocardiogram acquisition chip, and the other end is connected with the OUT pin of electrocardiogram acquisition chip.
Compare with the electrocardiogram acquisition module of discrete element in prior art, the electrocardiogram acquisition module that the present embodiment provides has advantages of that integrated level is high, saves space and the steady point of cost signal.
Referring to Fig. 1, Fig. 3, human-computer interaction module 140 comprises for the Keysheet module 141 to control processing module 110 transfer instructions with for showing the display module 142 of the input/output information of controlling processing module 110 again.In the present embodiment, display module 142 is LCD LCDs, and the content that display module 142 shows comprises: the work of electrocardiogram acquisition module 130 or quit work and working time and working time state diagram; The work of the first THz wave generator, the second THz wave generator and the 3rd THz wave generator or quit work and working time and the time state figure of THz wave driver module 120; Control the Information Monitoring analysis result of processing module 110 outputs.Keysheet module 141 is thin film type keyboard, comprise three groups of keyboards: probe is selected keyboard 1411, comprise THz1 key, THz2 key, THz3 key, ECG key, be respectively used to select the duty of the first THz wave generator, the second THz wave generator and the 3rd THz wave generator or electrocardiogram acquisition module 130; Selection of time module 1412, comprise+key and-key, be respectively used to increase or reduce working time of electrocardiogram acquisition module 130 or THz wave driver module 120; System is controlled options button 1413, comprises initiating key, Pause key and ON/OFF key, for controlling the duty of THz wave medical instrument.
Memory module 150, for receiving and store the ecg information of electrocardiogram acquisition module 130 transmission and controlling the analysis result that processing module 110 is transmitted, meanwhile, also for pre-stored, control the data such as the needed complexity algorithmic formula of processing module 110, complexity scale factor.
Transport module 160 is Bluetooth transmission module, certainly, and in other embodiments also can be for infrared transmission module or other be for carrying out the data transmission module of transfer of data with computer or mobile terminal.
Power transfer module 170 comprises DC conversion modules and voltage reduction module, and wherein, DC conversion modules, for alternating current is converted to unidirectional current, is given THz wave diagnosis and treatment power supply, and in the present embodiment, the galvanic voltage after changing is 9V; Voltage reduction module is used for the further blood pressure lowering of unidirectional current after conversion, and for giving the chip power supply of THz wave diagnosis and treatment, in the present embodiment, the voltage after voltage reduction module blood pressure lowering is 3.3V.
Control processing module 110 and mainly MSP430FG4618 type single-chip microcomputer, consist of, it is the core of THz wave medical instrument.When user operates Keysheet module 141, control processing module 110 for receiving the instruction of Keysheet module 141, and control corresponding module and make corresponding action, control display module 142 simultaneously and show corresponding information.After electrocardio acquisition module 130 control acquisition electrodes 201 carry out the collection of information, controlling processing module 110 transfers the Information Monitoring of storing storage in memory module 150 into and analyzes, analysis result is input in memory module 150 simultaneously, controls display module 142 simultaneously and show corresponding information.The analysis of controlling 110 pairs of Information Monitorings of processing module comprises to be carried out digital filtering, the filtered information of numeral is carried out to peak extraction and analysis of complexity Information Monitoring.
At medical domain, the complexity of physiological system has quantized the adaptive capacity of body in changing environment continuously, and generally 1. the complexity of health system is greater than the complexity of pathology system; 2. pathology system, as aging, can reduce the adaptive capacity of system, and the entrained quantity of information of physiological parameter diminishes so, corresponding airframe systems reduced complexity, and the reduction of complexity is the universals of pathology dynamical system.Complexity algorithm comes physiological system state of complete as far as possible description and assessment THz wave medical instrument to use the effect of front and back by extracting useful information as much as possible in Information Monitoring.
For convenient, understand, complexity algorithm is summarized as follows:
Its computational methods are by a string ordered series of numbers y (1), y (2) ... y (n) consecutive order forms one group of m dimensional vector, when m=2, vectorial
definition threshold value is r, calculate all two dimensional component with
apart from the number lower than threshold value
with the ratio of important sum, be defined as
its value representative is as component of a vector y
jat y
iwhile around (defining according to threshold value), another component y
j+1also at y
i+1probability around.So be worth highlyer, the rule degree of representation signal is also higher.Each component is all tried to achieve in the above described manner
after get natural logrithm and be added, be defined as φ
r m=2.When dimension is expanded to three-dimensional, during m=3, according to identical algorithms, we can try to achieve φ
r m (=2)+1, by preceding paragraph φ
r m=2deduct φ
r m (=2)+1, can be used to quantize this sequence signal by 2 D extension the unpredictability when three-dimensional, finally to trying to achieve the relation analysis separately again between its unpredictability and corresponding yardstick under different scale.This method has been proved can be distinguished the whether unpredictability of signal all have meaning under each yardstick structure, and we can carry out the judgement in macroscopic view to the health status of goal systems by calculating the complexity of signal under each yardstick.
The THz wave medical instrument that the present embodiment provides also comprises Hardware drive module, Hardware drive module in the framework of system design between hardware and application software.The object of system hardware driver module exploitation is on designed hardware foundation, and perfect in shape and function is provided, the software programming interface that facilitates application program to use.Wherein hardware circuit mainly provides the realization of basic function, and the programming resources such as the various depositors that Hardware drive module provides hardware, memorizer are integrated, and functional routine call is provided, for the application software use on upper strata.In the present embodiment, for the ease of transplanting, upgrading, modification and the system call of program, Hardware drive module adopts modularization programming, comprising: electrocardiogram acquisition program, display routine, port program, timer program and THz control sequence.
In use, first the power interface of controller 190 is connected with power supply, the first probe 21, the second probe the 22 and the 3rd probe 23 are inserted respectively in the first probe interface 181, the second probe interface 182 and the 3rd probe interface 183.When selecting keyboard 1411 to operate to probe, user can select the mode of operation of THz wave medical instrument.When user is selected THz1 key, THz2 key or THz3 key, for treatment pattern, now user is adsorbed on first probe 21, second probe the 22 or the 3rd probe 23 of answering in contrast on the acupuncture point that will treat by sucker, control processing module 110 and drive THz wave driver modules 120 to control corresponding the first THz wave generator, the second THz wave generator or the 3rd THz wave generator to send out and establish THz wave, terahertz radiation is to the object that can reach treatment on the acupuncture point that will treat.When user is selected ECG key, be diagnostic mode, now user need to be adsorbed in left forearm by the first probe 21, the second probe 22 is adsorbed in right forearm, the 3rd probe 23 is adsorbed in right lower limb, control processing module 110 and drive electrocardiogram acquisition module 130 control LA acquisition electrodes, RA acquisition electrode and RL acquisition electrode to carry out electrocardiogram acquisition, in the process gathering, the ecg information collecting is stored in memory module 150.We take the acquisition time of information and described as example as 10 minutes, ecg information=sample rate * acquisition time of Information Monitoring, wherein gathering sample is the fixed value being pre-stored in electrocardiogram acquisition module 130, in the present embodiment, sample rate is 125Hz, and the data of Information Monitoring are 75000.When information gathering finishes, the ecg information that control processing module 110 is transferred in memory module 150 is analyzed and result is outputed in memory module 150 and display module 142, has so just reached the object of diagnosis.
Consulting Fig. 6, is the THz wave medical instrument software flow pattern that the present embodiment provides, and according to flow chart, its concrete operations flow process is as follows:
1, instrument is connected after external power source, presses the ON/OFF key in Keysheet module 141, and system enters beginning flow process; And then system enters initialization flow process, and system initializes setting, checks whether every indication and operation be normal, if normally enter step 2.
2,, to Keysheet module 141 scan rounds, check and whether have key-press input.
If 3 return to step 2 without key-press input, if there is key-press input to enter step 4.
4, check whether input has time delay and input signal whether to stablize, as unstable in input signal, there is jitter phenomenon, by de-twitter circuit debounce.After input signal is stable, again check it is to truly have key-press input, if return to step 2 without key-press input, if there is key-press input to enter step 5.
5, read key value, judge whether button is THz1, THz2 or THz3 button, if transfer corresponding THz driver, if not enter step 6.
6, judge whether button is ECG key, if transfer electrocardiogram acquisition program and return to step 2, if not enter step 7.
7, determine whether+key of this step or-key, if not enter step 8; If transfer timer program and return to step 2.If enter this step, illustrate that user selected the mode of operation of THz wave medical instrument, be treatment pattern or diagnostic mode, the object of this step is to select the working time for the treatment of pattern or diagnostic mode.
8, judge whether it is initiating key, if not enter step 9; If start corresponding program, when being chosen as treatment pattern, open the THz wave generator in corresponding probe, and according to the working time of the time control THz wave generator of selecting in step 7, call display routine simultaneously information is shown in display module 142, then return to step 2; When being chosen as diagnostic mode, open probe and carry out electrocardiogram acquisition, and according to the time of the time control electrocardiogram acquisition of selecting in step 7, call storage program stores ecg information in memory module 150 into simultaneously, call display routine information is shown in display module 142, then return to step 2.In the present embodiment, timer is countdown, and therefore, along with treatment or diagnosis make progress forward, timing falls back, until be zero.In treatment pattern, when timing is zero, treatment finishes.In diagnostic mode, when timing is zero, information gathering finishes, and now controls the ecg information that processing module 110 transfers in memory module 150 and analyzes and result is outputed in memory module 150 and display module 142, and diagnosis finishes.
9, judge whether it is Pause key, if not return to step 2, if suspend the program of moving, and return to step 2.
10, in treatment pattern and diagnostic mode, be unlatching, and do not have for a long time in the situation of button, system is closed automatically.
In sum, THz wave medical instrument provided by the invention, not only can carry out to user the treatment of cardiovascular disease, can also carry out electrocardiogram acquisition and analyze the ecg information collecting user, thereby reach the object of diagnosis.Meanwhile, the probe of THz wave medical instrument can be adsorbed in predetermined treatment or the diagnosis position of human body by its sucker, carry out hand-heldly without people, is convenient to user and operates.And THz wave medical instrument also has advantages of that use is simple, easy to carry.
It should be noted that, in this article, relational terms such as the first and second grades is only used for an entity or operation to separate with another entity or operating space, and not necessarily requires or imply and between these entities or operation, have the relation of any this reality or sequentially.And, term " comprises ", " comprising " or its any other variant are intended to contain comprising of nonexcludability, thereby the process, method, article or the equipment that make to comprise a series of key elements not only comprise those key elements, but also comprise other key elements of clearly not listing, or be also included as the intrinsic key element of this process, method, article or equipment.The in the situation that of more restrictions not, the key element being limited by statement " comprising ... ", and be not precluded within process, method, article or the equipment that comprises described key element and also have other identical element.
Although the present invention is described in detail and shows with reference to its exemplary embodiment, but will be understood by those skilled in the art that, in the situation that do not depart from the spirit and scope of the present invention that are defined by the claims, can carry out to it various changes of form and details.
Claims (10)
1. a THz wave medical instrument, it is characterized in that, comprise probe and the controller for driving probe and processing the Information Monitoring of probe input, described probe comprises for launching the THz wave generator of THz wave and for carrying out the acquisition electrode of electrocardiogram acquisition.
2. THz wave medical instrument according to claim 1, is characterized in that, described probe comprises and is provided with the first probe of LA acquisition electrode, the second probe and the 3rd probe of RL acquisition electrode of RA acquisition electrode.
3. THz wave medical instrument according to claim 1 and 2, is characterized in that, described probe is provided with sucker, and described acquisition electrode is located in described sucker.
4. THz wave medical instrument according to claim 1 and 2, is characterized in that, the THz wave frequency of described Terahertz generator transmitting is 0.1THZ-10THZ.
5. THz wave medical instrument according to claim 4, is characterized in that, the THz wave mid frequency of described Terahertz generator transmitting is 0.15THZ.
6. THz wave medical instrument according to claim 1, is characterized in that, described controller comprises:
Control processing module: receive the instruction of human-computer interaction module generation and produce a driving signal, for selecting to drive THz wave driver module or electrocardiogram acquisition module; Transfer and analyzing stored module in the Information Monitoring of storing, analysis result is transferred in memory module;
THz wave driver module: thus the duty that the driving signal of processing module input is controlled THz wave generator is controlled in reception;
Electrocardiogram acquisition module: thus the duty of controlling the driving signal control acquisition electrode of processing mould input received, the electrocardiosignal of acquisition electrode feedback is gathered, and the ecg information collecting is transferred to memory module;
Memory module: receive and store the ecg information of electrocardiogram acquisition module input and control the analysis result that processing module is inputted;
Human-computer interaction module: for to controlling processing module transfer instruction, and show the input/output information of controlling processing module.
7. THz wave medical instrument according to claim 6, is characterized in that, described electrocardiogram acquisition module comprises:
Electrocardiogram acquisition chip: receive to control the driving signal of processing module, carry out electrocardiogram acquisition thereby export an acquired signal to controlling acquisition electrode in probe;
Current limliting unit: acquired signal is carried out to current limliting;
Pull-up unit: for the electrocardiosignal of acquisition electrode feedback is tentatively amplified, and the signal after amplifying is input in electrocardiogram acquisition chip;
Reference voltage module: for electrocardiogram acquisition module provides reference voltage level;
The first impedance matching module: for the amplifier of electrocardiogram acquisition chip internal and high-pass filtering module are carried out to impedance matching;
The second impedance matching module: for the low-pass filtering module of electrocardiogram acquisition chip internal is carried out to impedance matching.
8. THz wave medical instrument according to claim 7, is characterized in that:
Described current limliting unit comprises: the first resistance, the second resistance, the 3rd resistance and the 7th electric capacity, and wherein, described first resistance one end is connected with the RL acquisition electrode of described the 3rd probe, the other end and described electrocardiogram acquisition chip+IN pin is connected; Described second resistance one end is connected with the RA acquisition electrode of described the second probe, the other end and described electrocardiogram acquisition chip-IN pin is connected; Described the 3rd resistance one end is connected with the LA acquisition electrode of described the first probe, and the other end is connected with the RLD pin of described electrocardiogram acquisition chip; Described the 7th electric capacity one end is connected with the RLDFB pin of described electrocardiogram acquisition chip, and the other end is connected with the RLD pin of described electrocardiogram acquisition chip;
Described pull-up unit comprises: the 4th resistance and the 5th resistance, and wherein, described the 4th resistance one end is connected with described the first reference voltage, the other end and described electrocardiogram acquisition chip-IN pin is connected; Described the 5th resistance one end is connected with described the first reference voltage, the other end and described electrocardiogram acquisition chip+IN pin is connected;
Described reference voltage module comprises: the 6th resistance, the 7th resistance, the first electric capacity and the second electric capacity, wherein, wherein said the first electric capacity is connected with the REFIN pin of described electrocardiogram acquisition chip with the one end after described the 6th resistance parallel connection, and the other end is electrically connected with ground; Described the 7th resistance one end is connected with described the second reference voltage, and the other end is connected with the REFIN pin of described electrocardiogram acquisition chip; Described second electric capacity one end is connected with described the second reference voltage, and the other end is connected in GND pin, ACDC pin and the ground of described electrocardiogram acquisition chip;
Described the first impedance matching module comprises: the 8th resistance, the 9th resistance, the tenth resistance, the 3rd electric capacity and the 4th electric capacity, wherein, shown in the 8th resistance one end with shown in electrocardiogram acquisition chip IAOUT pin and shown in the second impedance matching module be connected, the other end with shown in the 9th resistance be connected with the tenth resistance; Shown in the 9th resistance the other end with shown in the SW pin of electrocardiogram acquisition chip be connected and pass through shown in the 4th electric capacity with shown in the REFOUT pin of electrocardiogram acquisition chip be connected; Shown in the tenth resistance the other end with shown in the HPSENSE pin of electrocardiogram acquisition chip be connected and cross shown in the 3rd electric capacity with shown in the HPDRIVE pin of electrocardiogram acquisition chip be connected.
Described the second impedance matching module comprises: the 11 resistance, the 12 resistance, the 13 resistance, the 14 resistance, the 5th electric capacity and the 6th electric capacity, wherein, described the 12 resistance one end is connected with the REFOUT pin of described electrocardiogram acquisition chip by described four or five electric capacity after being connected with the OPAMP+ pin of described electrocardiogram acquisition chip; The other end is connected with described the first impedance matching module by the 11 resistance, is connected by described the 6th electric capacity with the OUT pin of described electrocardiogram acquisition chip simultaneously; Described the 13 resistance one end is connected with the REFOUT pin of described electrocardiogram acquisition chip, and the other end is connected with the OPAMP-pin of described electrocardiogram acquisition chip; Described the 14 resistance one end is connected with the OPAMP-pin of described electrocardiogram acquisition chip, and the other end is connected with the OUT pin of described electrocardiogram acquisition chip.
9. THz wave medical instrument according to claim 6, is characterized in that, described controller also comprises for alternating current being converted to the needed galvanic power transfer module of THz wave medical instrument.
10. THz wave medical instrument according to claim 6, is characterized in that, described controller also comprises transport module, for the transmission of data.
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