CN103519915A

CN103519915A - Fixing device for mouse tail injection

Info

Publication number: CN103519915A
Application number: CN201210224830.3A
Authority: CN
Inventors: 赵菁
Original assignee: 赵菁
Current assignee: First Affiliated Hospital of Zhengzhou University
Priority date: 2012-07-03
Filing date: 2012-07-03
Publication date: 2014-01-22
Anticipated expiration: 2032-07-03
Also published as: CN103519915B

Abstract

The invention provides a fixing device for mouse tail injection. The fixing device for mouse tail injection comprises a base, a stand column and a mouse bin. The base is a disc made of steel. The lower end of the stand column is welded to the center of the base. The mouse bin is made of a steel tube. The mouse bin is horizontally welded to the upper end of the stand column. A round end cap is welded to the right end of the mouse bin. The upper portion and the lower portion of the left end of the mouse bin are respectively provided with a protruding block in a welded mode. A screw hole is formed in each protruding block. A screw is screwed in the screw hole of the protruding block arranged at the lower end. A valve is made of a steel plate. The upper end of the valve is provided with a semicircle protruding upwards. A small hole is formed in the semicircle. The left upper portion of the valve is provided with a mouse tail groove. The lower end of the valve is provided with a lug. The upper right portion of the valve is provided with a locating sheet. A screw penetrates through the small hole formed in the valve to be screwed in the screw hole formed in the protruding block of the upper portion of the mouse bin, so that the valve is connected with the mouse bin. Compared with the prior art, the fixing device for mouse tail injection has the advantages of being simple in structure, convenient to use, safe, reliable and free of damage to the hind limbs of a mouse in the process of operation.

Description

Mouse tail injection holder

Technical field

The present invention relates to a kind of medical experiment utensil, particularly a kind of mouse tail injection holder, it fixes mice while being mainly used in to mouse tail injecting fluid.

Background technology

Smoking is harmful is generally generally acknowledged, and it is the important risk factor of cardiovascular disease, pulmonary disease and other diseases.Smoking at present mainly concentrates on coronary heart disease aspect for the research of cardiovascular disease impact, numerous clinical researches show that smoking is one of most important risk factor of myocardial infarction, and smoking causes the risk of myocardial infarction and the risk of sudden cardiac death far above angina pectoris risk.Reconstructing blood vessel be cells of vascular wall (endotheliocyte, smooth muscle cell, fibroblast) propagation, dead, migration and extracellular matrix (extracellular matrix, ECM) is synthetic and the factor of four aspects of degrading due to blood vessel wall structure dynamic changing process.In the smog of medicated cigarette and microgranule, contain more than 4700 kind of harmful components, main have nicotine, acrylic aldehyde, acetaldehyde and a large amount of oxygen-derived free radicals, and these compositions can directly act on lung blood vessel, thereby cause lung reconstructing blood vessel by affecting above four aspects.

In order to study the impact of smoking on human lung, be by setting up smoking mice pulmonary hypertension model conventionally mostly, variation and the vascular endothelial function of inquiring into blood coagulation in the blood of smoking mice smoking front and back, fibrinolytic factor changes, blood vessel changes.The pathological change of inquiring into after mice smoking is exactly mainly to inquire into the harmful substances such as nicotine mice to be intervened to the pathological reaction of rear mice.Due to the needs of research work, people often will locate liquid medicine injection at the afterbody of mice, subcutaneous, muscle etc., observe the reflection of smoking mice to medicine.Because the struggle that mice can be risked one's life when giving injected in mice medicinal liquid is touched, this will cause injection work normally to carry out.People have also taked some measures for this reason, at present for the method for mouse tail liquid medicine injection is that mice is put in the pipe of one end sealing, make its head inwardly, afterbody outwardly, then with a tampion with gap, clog the mouth of pipe, and the opening position of the afterbody that makes mice from tampion expose, then again its afterbody is carried out to drug injection.But when using the tampion sealing mouth of pipe, because mice back leg is disorderly pedaled, and people's eyes be can't see the situation of the inside, so often can crush mice, impact experiment is normally carried out, and even affects result.

Summary of the invention

The object of the invention is to overcome at present when to mouse tail liquid medicine injection mice touches and affects the situation that experiment is normally carried out, a kind of mouse tail injection holder is provided, it is simple in structure, easy to use, safe and reliable, it is closed to mice health in the pipe of relative one end sealing, and a valve with gap is installed at mouth of pipe place, only mouse tail is exposed, can to its afterbody, carries out drug injection easily for people like this.

For achieving the above object, the technical solution used in the present invention is as follows: a kind of mouse tail injection holder, comprise base, column, Mus storehouse, end socket, valve, pressing plate, wherein base is a steel disc, plays a part to stablize whole in this holder, column is made by steel pipe, plays supporting role, and the lower end of column is welded on the center of base, Mus storehouse is made by steel pipe, its wall thickness is 1～3 millimeter, length is 50～150 millimeters, internal diameter is 30～60 millimeters, the upper end that is welded on column of Mus storehouse level, the right-hand member in Mus storehouse is welded with a circular head, in the plane of end socket, be shaped with air-vent, the top at Mus storehouse middle part is horizontal is shaped with an open slot, in open slot, activity is fitted with one for pressing the pressing plate of mice, the upper and lower of Mus storehouse left end is respectively welded with a projection, is shaped with a screw on projection, and in the screw on the projection of lower end, is connected with a screw, valve is made by steel plate, its main body is circular, there is a semicircle raising up the upper end of valve, on this semicircle, be shaped with an aperture, the upper left side of valve is shaped with Mus stern notch one, this Mus stern notch can be kept apart the health of mice and afterbody, the lower end of valve is shaped with a hangers, the upper right side of valve is shaped with a spacer for bending backward, screw screws in the screw on the projection of top, Mus storehouse valve is connected with Mus storehouse through the aperture on valve, now the hangers of valve lower end is stuck in the screw place on the projection of lower end, Mus storehouse, screwing this screw can be fixed on valve on Mus storehouse.When valve is rotated counterclockwise about 210 while spending centered by the aperture of upper end, the spacer on valve is just in time blocked by Mus storehouse outer wall, can make valve rest against herein.

The using method of this stopper is: be rotated counterclockwise valve valve is opened, the afterbody that hauls mice is put into Mus storehouse by mice, closing clockwise valve and mouse tail put into Mus stern notch slowly, when the hangers of valve lower end snaps in the screw of lower end, Mus storehouse, screw this screw, mice has just been fixed in Mus storehouse, and the mouse tail that at this moment can start being exposed to outside valve carries out injecting liquid drug.If mice is frightened, touch, pressing plate can be inserted and in open slot, push down mice.

The present invention compared with prior art beneficial effect is: simple in structure, easy to use, safe and reliable, in operation, can not cause the damage of mouse hind leg.

Accompanying drawing explanation

Fig. 1 is assembling schematic diagram of the present invention.

Fig. 2 is structural representation of the present invention.

In figure, 1. base, 2. column, 3. Mus storehouse, 4. end socket, 5. valve, 6,36. screws, 7. pressing plate, 31. open slots, 32,34. projections, 33,35. screws, 51. apertures, 52. spacers, 53. hangers, 54. Mus stern notches.

The specific embodiment

In figure, a kind of mouse tail injection holder, comprises base 1, column 2, Mus storehouse 3, end socket 4, valve 5, pressing plate 7, and wherein base 1 is a steel disc, and column 2 is made by steel pipe, and the lower end of column 2 is welded on the center of base 1, Mus storehouse 3 is made by steel pipe, because the volume difference of mice and rat is larger, in order to make this holder, also can inject for the afterbody of rat, therefore set 1～3 millimeter of this thickness of steel pipe, length is 50～150 millimeters, internal diameter is 30～60 millimeters, the upper end that is welded on column 1 of Mus storehouse 3 levels, the right-hand member in Mus storehouse 3 is welded with a circular end socket 4, in the plane of end socket 4, be shaped with air-vent, the top at 3 middle parts, Mus storehouse is horizontal is shaped with an open slot 31, open slot 31 interior activities be fitted with one for pressing the pressing plate 7 of mice, the top of Mus storehouse 3 left ends is welded with a projection 32, the bottom of Mus storehouse 3 left ends is welded with a projection 34, on projection 32, be shaped with a screw 33, on projection 34, be shaped with a screw 35, and in the screw 35 on the projection 34 of lower end, be connected with a screw 36, valve 5 is made by steel plate, its main body is circular, its diameter equals the external diameter in Mus storehouse 3, there is a semicircle raising up the upper end of valve 5, on this semicircle, be shaped with an aperture 51, the upper left side of valve 5 is shaped with Mus stern notch 54 one, the lower end of valve 5 is shaped with a hangers 53, the upper right side of valve 5 is shaped with a spacer 52 for bending backward, screw 6 is connected valve 5 through the screw 33 on the aperture 51 screw-in Mus storehouse 3 top projections 32 on valve 5 is interior with Mus storehouse 3, now the hangers 53 of valve 5 lower ends is just in time stuck in screw 36 places on the 3 lower end projections 34 of Mus storehouse, screwing this screw 36 can be fixed on valve 5 on Mus storehouse 3.

Claims

1. a mouse tail injection holder, it is characterized in that: it comprises base, column, Mus storehouse, end socket, valve, pressing plate, wherein base is a steel disc, the lower end of column is welded on the center of base, Mus storehouse is made by steel pipe, the upper end that is welded on column of Mus storehouse level, the right-hand member in Mus storehouse is welded with a circular head, the top at Mus storehouse middle part is horizontal is shaped with an open slot, the movable block pressur plate that is fitted with in open slot, the upper and lower of Mus storehouse left end is respectively welded with a projection, on projection, be shaped with a screw, and in the screw on the projection of lower end, be connected with a screw, valve is made by steel plate, its main body is circular, there is a semicircle raising up the upper end of valve, on this semicircle, be shaped with an aperture, the lower end of valve is shaped with a hangers, screw screws in the screw on the projection of top, Mus storehouse valve is connected with Mus storehouse through the aperture on valve, and now the hangers of valve lower end is stuck in the screw place on the projection of lower end, Mus storehouse, and screwing this screw can be fixed on valve on Mus storehouse.

2. mouse tail injection holder according to claim 1, is characterized in that: its wall thickness of described Mus storehouse is 1～3 millimeter, and length is 50～150 millimeters, and internal diameter is 30～60 millimeters.

3. mouse tail injection holder according to claim 1, is characterized in that: the upper left side of described valve is shaped with Mus stern notch one.

4. mouse tail injection holder according to claim 1, is characterized in that: the upper right side of described valve is shaped with a spacer for bending backward.