CN103517701A - A method of lightening skin - Google Patents
A method of lightening skin Download PDFInfo
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- CN103517701A CN103517701A CN201280022899.6A CN201280022899A CN103517701A CN 103517701 A CN103517701 A CN 103517701A CN 201280022899 A CN201280022899 A CN 201280022899A CN 103517701 A CN103517701 A CN 103517701A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention relates to a method of lightening skin, more particularly a method which provides enhanced skin lightening from a natural extract. It is known that extract of Salvia officinalis has been used for application on skin for various benefits. The inventors have demonstrated higher efficacy in skin lightening, from this natural material through the use of select class of activity enhancers.
Description
Invention field
The present invention relates to the method for bright skin.The method that the present invention relates more particularly to provide the skin of enhancing to highlight from natural extract.
background of invention
The skin appearance of height pleasant is one of expectation of personal care product being craved for most from most consumers all over the world.In consumer, conventionally have in the tropic countries of dark skin, people's expectation has more shallow skin appearance.In the consumer of living away from tropic countries, for example, conventionally there are the white people of more shallow skin, have freckle and hyperpigmentation problem when they are exposed to bright sun, so they expect the even solarization black tone of their skin.Most consumers after being exposed to the sun, on wound healing or in acne mummification by the speckle problem of going through on their skin.In all above-mentioned situation Xia， consumer, rely on cosmetics to solve their skin appearance problem.
Therefore smooth, the soft and ruddy skin that, has even skin color and a color is the consumer's expectation of using personal care compositions of all skin to them.For this benefit is provided, from manufacturer all over the world, many methods have been attempted.A kind of method of very generally using is to comprise opacifier or sunscreen cream in this class cosmetic product.Control the color of skin and highlight method, the other method of color harmony outward appearance is so-called skin, wherein the chemical compound of natural or synthetic source is added to personal care composition, it changes melanic formation in skin by the biochemical transformation in horny layer, changes thus color and the outward appearance of skin.One of method of the inventor is to obtain maximum effect from the extract of natural source.
JP 418 017 (Noevir, 1992) disclose by select one or more compounds that are selected from citric acid, succinic acid, fumaric acid, malic acid or its ester and containing the Salvia farinacea of ethanol (
salvia officinalissebum secretion promoter prepared by extraction solution L.).
JP 2,001 163755 (Shisheido) discloses by comprising at least one and has been selected from derived from the plant extract of following those for improving skin lightening effect, the outside preparation using of the skin of stability and excellent in safety: mulberry (
morus alba), Radix Scutellariae (Scutellaria baicalensis), Herba Rosmarini Officinalis (Rosamarinus officinalis), Flos Matricariae chamomillae (Matricaria chamomilla), Aloe ferox Miller (Aloe ferox) (or African Aloe (Aloeafricane), queen's brocade Aloe (Aloe spicata), Aloe vulgaris (Aloe barbadensis) or Aloe arborescens var. natalensis (Aloe arborescens)), Radix Hamamelidis Mollis (Hamamelis virginiana), Aesculus hippocastanum L. (Aesculus hippocastanum), Flos rosae multiflorae (Rose multiflora) or the species (Rosaceae) that are closely related with it, Salvia japonica Thunb. (Salvia officinalis), Herba Lamii albi (Lamium album), Rabdosia japonica (Burm. f.) Hara (Isodon japonicus) (or comospore Herba Rabdosiae glaucocalycis (Isodon trichocarpus)), Glycyrrhiza glabra L. (Glycyrrhiza glabra) (or Glycyrrhiza uralensis Fisch. (Glycyrrhiza uralensis)), Herba Saxifragae (Saxifraga stolonfera), the acylated derivatives of Rosa centifolia L (Rosa centigolia) and/or fiery sour jujube (Pyracantha fortuneana) and glycosyl-L-AA.
US 2001/029266 discloses at least one the pentacyclic triterpene acid that comprises at least 0.02%, the preferred compositions of ursolic acid or oleanolic acid and at least one emulsifying agent, wherein said emulsifying agent at 25 ℃ for the fatty-acid monoester of the optional oxygen base alkylidene of liquid and there is the HLB that is more than or equal to 12.
Known for multiple benefit by the extract of Salvia japonica Thunb. for using on skin.The inventor recognizes in order to offer consumer allows the product of their happiness, and they must prove effect higher in skin highlights.The active reinforcing agent kind that they select by use through the research of several years in Gai field has realized this object.
The object of this invention is to provide the bright skin method of comparing enhancing with available known product in market.
Another object of the present invention is to provide by using the skin of the enhancing of the sp act thing extracting from natural source to highlight.
summary of the invention
The invention provides the method for bright skin, it comprises to the skin surface of needs uses the step that skin highlights compositions, and described skin highlights compositions and comprises,
A) extract of the plant material of 0.01 to 5 % by weight, it comprises 0.1% to 100% ursolic acid;
B) 0.05 to 20% active reinforcing agent, the mixture that it comprises organic amine, polyhydric alcohol and non-ionic surface active agent; With
C) the acceptable vehicle of improving looks.
detailed Description Of The Invention
From reading following detailed description and additional claim, these and other aspects, features and advantages is apparent for persons skilled in the art.For fear of doubt, any feature of one aspect of the invention can be used for any other side of the present invention.Intention that word " comprises (comprising) " refer to " (including) " but needn't " by ... form (consisting of) " or " by ... form (composed of) ".In other words, the step of enumerating or selection need not to be exhaustive.It should be noted that the embodiment meant for illustration the present invention who provides in description below and be not intended to limit those embodiment that the present invention is itself.Similarly, all percentage ratio is weight/percentage by weight, unless specified otherwise herein.Except in operation and comparing embodiment, or in the place of clearly stipulating in addition, all in this manual expression amount of substances or reaction condition, the physical property of material and/or the numeral of purposes are understood to be revised by word " approximately ".The digital scope of expressing in form " x to y " is interpreted as comprising x and y.When describing the multiple preferable range that is used for special characteristic in form " x to y ", be to be understood that all scopes that also comprise in conjunction with different end points.The disclosure of the present invention of finding is herein believed to comprise all embodiments of finding in the claims, as multiple dependence each other and no matter can be in the fact that there is no to find under multiple dependency or redundancy claim.
" skin highlights compositions " used herein refers to and comprises for topical application to the mammal compositions of people's skin particularly.This based composition can be classified as leave (leave-on) or washing-off type (rinse off) conventionally, is preferably leave.It comprises any product that is applied to human body, is mainly used in making the color of skin to brighten, but also can provide improvement outward appearance, clean, abnormal smells from the patient is controlled, against sunshine or overall aesthetic.Also they can be combined in and mainly refer in the compositions of antiperspirant, deodorizer, depilatory, lip pomade, foundation cream, mascara, sunlight lotion, shampoo or hair conditioner but the additional benefit that provides skin to highlight." skin " used herein meaning comprises for example, skin on face and health (, cervical region, chest, back, arm, oxter, hands, lower limb, buttocks and scalp).
Main target of the present invention is that skin highlights application.The inventor shockingly finds except providing skin to highlight benefit, defying age is for example also provided and alleviated the advantage of photic damage.
Skin highlights compositions and is preferably cream, lotion, club (stick), ball, gel form or the aerosol form for comprising propellant.They are preferably cream, lotion, gel or club form, most preferably are cream form.
Skin highlights the special extract that compositions comprises plant material, active reinforcing agent, and it is the mixture of organic amine, polyhydric alcohol and non-ionic surface active agent, and the acceptable vehicle of improving looks.
Compositions comprises 0.01 to 5 % by weight, the preferred extract of the plant material of 0.1 to 5 % by weight, and it comprises 0.1 to 100% ursolic acid.The extract of plant material preferably comprises 0.1 to 50% oleanolic acid in addition.
Ursolic acid and oleanolic acid have structure given below:
For being provided for the plant material of extract of the present invention, be preferably Salvia japonica Thunb..
Salvia japonica Thunb. is conventionally by common title Salvia farinacea
(garden sage) or Herba Salviae Plebeiae (Common sage) indication.It is short and small perennial evergreen fruticuli, has woody stems, light grey leaf and blue to purplish flower.It is the member of Labiatae and originates in Mediterranean Region.It is in many European countries and North America plantation.It has been used to pharmaceutical preparation and food.In the present invention, the leaf of Salvia japonica Thunb. and soft stem, for extracting the active matter of expectation, are preferably leaf.The chemical classification that sage comprises following compounds: catechin-type tannin, phenolic acid, flavonoid, quintessence oil and comprise oleanolic acid and the triterpenes of ursolic acid.
The method for optimizing (a) that the method preparation that use comprises the following steps is extracted for the extract of compositions of the present invention from the plant material that comprises 0.1% to 100% ursolic acid makes plant material Salvia japonica Thunb. contact to prepare mixture with the non-polar solven that is selected from hexane, ethyl acetate, toluene, chloroform, ether or dichloromethane or its mixture; (b) from mixture separated solvent to prepare extract.Can carry out by any known method the separation of solvent.Method for optimizing is vaporising under vacuum solvent, preferably subsequent filtration, wash and be dried to powder.
Can be by using the step of solvent wash extract to be further purified extract, described solvent can be hexane, acetone or its mixture.Further purification step can be included in alkaline solution as dissolved extract in alkaline ammonia, by filtration, there is no the solution of insoluble matter and use acid that solution is neutralized to neutral pH with the extract of precipitation expectation subsequently, can use distilled water that it is further washed and be dried to powder, described powder packets is containing ursolic acid.
Plant extract preferably comprises 0.1 to 100% ursolic acid.In aspect highly preferred, exist ursolic acid and oleanolic acid the two.Also more highly preferred aspect provides with 60 to 85% ursolic acids that exist with 15 to 40% oleanolic acid that exist, with the weighing scale of plant extract.Term extraction thing refers to the product of dried forms, and it can be powder, granule or piece form.Unless specified otherwise herein, in whole description in plant material extract the percentage ratio of fatty acid based on dry weight.
Compositions comprises the active reinforcing agent that is selected from organic base.Term organic base refers to and comprises functional group-NH
2,-NHR or-NR
2the compound of (wherein R can be alkyl or aryl) and produce approximately 10 to 12 pH under 1% concentration in water.Preferred organic base is amines.Preferred amines comprises that alkanolamine is if monoethanolamine, diethanolamine, triethanolamine and alkylamine are as methyl amine, ethylamine, dimethyl amine, diethylamide, dimethylethyl amine and triethylamine.Amine is preferably with 0.05 to 5%, and more preferably 0.1 to 2.5% existence, with the weighing scale of compositions.
Compositions comprises the other active reinforcing agent that is selected from polyhydric alcohol.For being included in the polyhydric alcohol of compositions of the present invention, can be selected from aklylene glycol or poly alkylene glycol.The example that is used for the polyhydric alcohol of the present composition is ethylene glycol, diethylene glycol, triethylene glycol, TEG, Polyethylene Glycol, propylene glycol, butanediol, pentanediol, hexanediol, glycerol or phytantriol.When comprising, polyhydric alcohol is with 0.01 to 10%, and preferably 0.1 to 5% existence, with the weighing scale of compositions.
The proper ratio of amine and polyhydric alcohol is 1:1 to 1:5.The total amount of active reinforcing agent is preferably 1 to 10%, with the weighing scale of compositions.Most preferred organic amine is triethanolamine.Most preferred polyhydric alcohol is propylene glycol.Do not expect bound by theory, find to rely on the active reinforcing agent using, they are worked and are comprised the dissolubility that improves the Aromatic acid existing in plant extract by different mechanisms, provide main skin to highlight transdermal delivery that active matter improves or the combination of the two to provide the skin of overall raising to highlight.
Provide the compositions of the present invention that skin highlights to comprise the acceptable vehicle of beauty treatment.The acceptable vehicle of improving looks preferably comprises 1 to 25% fatty acid.The acceptable vehicle of improving looks is preferably cream, lotion, gel or emulsion form.Preferred form is cream, also vanishing cream more preferably.Vanishing cream substrate is to comprise 1 to 25%, and more preferably 5 to 20% fatty acids is that.This matrix optimization comprises 0.1 to 10%, more preferably 0.1Zhi3% soap.C
12to C
20fatty acid is particularly preferred in vanishing cream substrate, also C more preferably
14to C
18fatty acid.In cream, fatty acid is preferably essentially the mixture of stearic acid and Palmic acid.The alkali metal salt that vanishing cream substrate Zhong soap comprises fatty acid, as sodium salt or potassium salt.Soap is preferably the potassium salt of fatty acid mixt.Conventionally use and substantially (be generally approximately 90% to 95%) for the hystric processed with acid of the mixture of stearic acid and Palmic acid is for the fatty acid in vanishing cream substrate.Therefore, comprise hystric acid and soap thereof to prepare vanishing cream substrate within the scope of the invention.Particularly preferably, compositions comprises at least 6%, and preferably at least 10%, more preferably at least 12% fatty acid.The acceptable vehicle of improving looks is generally 10 to 99.9%, and preferably 50 to 99%, with the weighing scale of compositions.The acceptable vehicle of improving looks preferably comprises water.With the weighing scale of compositions, preferably with 35 to 90%, more preferably 50 to 85%, also more preferably 50 to 80% comprise water.
Compositions comprises non-ionic surface active agent.In some cases, non-ionic surface active agent is also considered to skin and highlights active reinforcing agent, except its known character.Except the mechanism of action of above-mentioned other active reinforcing agent, non-ionic surface active agent can strengthen skin and highlight activity, in the present invention by improving preparation in the expansion of using on its skin.Non-ionic surface active agent can 0.01 to 10%, and preferably 0.1 to 5%, more preferably 0.1 to 3% existence, with the weighing scale of compositions.Preferred non-ionic surface active agent is to have those of at least 9.0 HLB value.
The non-ionic surface active agent that is applicable to be included in the present composition is
(i) there is saturated carbon chains and there is the alcohol ethoxylate of the HLB that is greater than 15; Or
(ii) there is unsaturated carbon chains and there is the alcohol ethoxylate of the HLB that is greater than 12; Or
(iii) alkylphenol ethoxylate; Or
(iv) to have carbon chain lengths be 12 to 16 and have a polyoxyethylene sorbitol acid anhydride mono alkyl ester of the HLB value that is greater than 12; Or
(v) unsaturated C
18and the polyoxyethylene sorbitol acid anhydride mono alkyl ester with the HLB value that is greater than 12.
Among above-mentioned, kind (i) and (ii) be commonly called Brij surfactant, kind (iii) is commonly called Triton kind and kind (iv) and (v) is called as tween kind.
(a) there is saturated carbon chains and there is the alcohol ethoxylate of the HLB that is greater than 15.5 or the suitable example that has unsaturated carbon chains and have an alcohol ethoxylate kind of the HLB that is greater than 12 from (b) is Brij 35 (C12EO23 compound), Brij 97 (unsaturated C18EO12), Brij 700 (C18EO100) or Brij 99 (unsaturated C18EO20).The suitable example for (c) of the present composition with the alkylphenol ethoxylate of the HLB that is greater than 15 is Triton X 165, Triton X 305, Triton 405 or Triton X 705.(d) there is saturated C
12to C
16carbochain also has the polyoxyethylene sorbitol acid anhydride Arrcostab of the HLB that is greater than 12 and (e) has unsaturated C
18carbochain the suitable example with the polyoxyethylene sorbitol acid anhydride Arrcostab of the HLB that is greater than 9 are Tween 20, Tween 21, Tween 40, Tween 80, Tween 81 or Tween 85 trioleates.
Preferably, compositions of the present invention has 6 to 8 pH.
Compositions can comprise in addition another skin and highlight agent.Skin highlights agent and is preferably selected from vitamin b 3 compound or its derivant, for example nicotinic acid, niacin, nicotiamide.It is Aloe extract, DL-Lactic acid ammonium salt., Azelaic Acid, kojic acid, butylated hydroxyanisole (BHA), butylated hydroxytoluene, citrate, 2 that other skin of knowing that can comprise highlights agent, 5-resorcylic acid and derivant thereof, ellagic acid, gluconic acid, glycolic, green tea extract, hydroquinone, 4-HBA derivant, Hydroxycaprylic acid, citron extract, linoleic acid, magnesium ascorbyl phosphate, salicylic acid or vitamin are as vitamin B6, vitamin B12, vitamin C, vitamin A, hydroxy carboxylic acid is as lactic acid and salt thereof, sodium lactate for example, and composition thereof.According to the present invention, vitamin b 3 compound or derivatives thereof, if nicotinic acid, nicotinic acid, nicotiamide are that preferred other skin highlights agent, nicotiamide most preferably.In fact, the inventor finds to use this vitamin, and skin of the present invention highlights compositions provides collaborative skin to highlight benefit.When comprising other skin and highlight agent, it is preferably with 0.1 to 10%, and more preferably 0.2 to 5% amount exists, with the weighing scale of compositions.
Personal care composition can preferably comprise one or more UV opacifiers in addition.UV opacifier can be inorganic or organic.
Multiple organic opacifier is applicable to use in conjunction with essential composition of the present invention.Suitable UV-A/UV-B opacifier comprises 2-hydroxyl-4-methoxybenzene ketone, octyldimethyl para-amino benzoic acid, digalloyl trioleate, 2, 2-dihydroxy-4-methoxybenzene ketone, 4-(two (hydroxypropyl)) benzocaine, 2-ethylhexyl-2-cyano group-3, 3-diphenylacrylate ester, Escalol 587, para-amino benzoic acid glyceride, 3, 3, 5-trimethylcyclohexyl salicylate, methyl 2-aminobenzoate, to dimethyl-amino benzoic acid or Aminobenzoate, 2-ethylhexyl is to dimethyl-amino-benzoate, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID, the acid of 2-(to dimethylaminophenyl)-5-sulfo group benzoxazole, 2-Parsol MCX, PAROSOL 1789, 2-hydroxyl-4-methoxybenzene ketone, octyldimethyl para-amino benzoic acid and composition thereof.Most suitable organic opacifier is 2-Parsol MCX and PAROSOL 1789.The highly preferred aspect according to the present invention, compositions comprise 2-Parsol MCX and PAROSOL 1789 the two.Find that 2-Parsol MCX is particularly suitable for being included in compositions, because exist the skin that surpasses the enhancing that the shading character of cinnamate provides to highlight.The inventor finds that oily soluble opacifier, as 2-Parsol MCX provides active matter as the dissolving of the enhancing of ursolic acid and oleanolic acid, strengthens thus skin and highlights effect.
The safety of opacifier and effective dose can be used for compositions of the present invention.Compositions preferably comprises approximately 0.1 to approximately 10%, more preferably from about 0.1 to approximately 5% opacifier.
Useful inorganic sunscreen cream is also preferred for the present invention.These comprise that for example zinc oxide ferrum oxide, silicon dioxide are as fumed silica and titanium dioxide.
Compositions can comprise the body note agent active matter for the preparation of body note agent compositions, the rapid kinetics that it highlights by the invention provides skin in addition.Body note agent compositions is applied in many positions of human body but is especially popular in axillary fossa or underarm region.Body note agent compositions can be distributed for the applicator that hard solid, soft solid, gel, cream, liquid or spray form and use are suitable for compositions physical features conventionally.For the purposes of the present invention, compositions is preferably cream form.Body note agent compositions can comprise in addition or can not comprise retainer base.
Compositions also can comprise other diluent.Diluent serves as dispersant or the carrier of other material existing in compositions, thereby when compositions is applied to skin, promotes their distribution.
Diluent except water can comprise liquid or solid emollient, solvent, wetting agent, thickening agent and powder.
The acceptable vehicle of improving looks is generally 10 to 99.9%, and preferably 50 to 99%, with the weighing scale of compositions, and can in the situation that there is no other cosmetics adjuvant, form the balance of compositions.
Compositions can comprise multiple other optional composition.With its whole content, be incorporated to by reference CTFA Cosmetic Ingredient Handbook herein, second edition, 1992, multiple nonlimiting cosmetic and the ingredient that is generally used for skin nursing industry described, it is applicable to compositions of the present invention.Example comprises: antioxidant, binding agent, bio-additive, buffer agent, coloring agent, thickening agent, polymer, astringent, aromatic, wetting agent, opacifiers, hair conditioner, exfoliator, pH adjusting agent, antiseptic, natural extract, quintessence oil, skin sensing agent (skin sensates), Skin Soothing Agent and skin healing agent.
the source of biomaterial and geographic origin:
The extract of Salvia japonica Thunb. is derived from Sami Labs, Bangalore, and India, it has obtained plant material from Africa.
By following non-limiting examples, further describe the present invention now.
Embodiment
embodiment 1 to 4: the skin of compositions highlights effect and proves that skin of the present invention highlights the synergism of active matter.
Compositions shown in preparation table 1 is also used (MRIV) scheme test skin the following describes to highlight effect.
Scheme: test is carried out 10 days with 15 volunteers.Test is comprised of the step the following describes:
The specific part of volunteer's forearm is marked and with approximately equal interval, preparation is used to (3 mg/cm every day
2) five times.By expertise person, use color scale detection of skin in 1 to 10 grade to highlight score.It is the skin color variation with respect to initial skin color that mean skin highlights score.More negative score represents that the skin of higher degree highlights.More positive score represents that skin is dimmed.
The skin of summarizing compositions while finishing for 10 days in lower list 1 highlights effect.
Data in table 1 show to compare with compositions (embodiment 2) outside the present invention and the routine that highlights active matter without any the skin acceptable substrate (embodiment 1) of improving looks, and the compositions of the present invention (embodiment 3) also except having the natural source extract of ursolic acid of high-load with active reinforcing agent provides the skin greatly improving to highlight effect.In addition, in compositions of the present invention, comprising vitamin b 3 compound is that nicotiamide has further improved skin and highlights activity (embodiment 4).
Claims (12)
1. the method for bright skin, it comprises to the skin surface of needs uses the step that skin highlights compositions, and described skin highlights compositions and comprises,
A) extract of the plant material of 0.01 to 5 % by weight, it comprises 0.1% to 100% ursolic acid;
B) 0.05 to 20% active reinforcing agent, the mixture that it comprises organic amine, polyhydric alcohol and non-ionic surface active agent; With
C) the acceptable vehicle of improving looks.
2. the method for claim 1, the extract of wherein said plant material comprises 0.1 to 50% oleanolic acid.
3. method as claimed in claim 1 or 2, wherein said organic amine is selected from monoethanolamine, diethanolamine, triethanolamine, diethylamide, triethylamine, dimethylethyl amine, methyl amine and ethylamine.
4. as method in any one of the preceding claims wherein, wherein said plant material is Salvia japonica Thunb..
5. as method in any one of the preceding claims wherein, wherein said polyhydric alcohol is selected from aklylene glycol or poly alkylene glycol.
6. as method in any one of the preceding claims wherein, the fatty acid that the acceptable vehicle of wherein said beauty treatment comprises 1 to 25 % by weight.
7. as method in any one of the preceding claims wherein, the soap that the acceptable vehicle of wherein said beauty treatment comprises 0.1 to 10 % by weight.
8. as method in any one of the preceding claims wherein, wherein said non-ionic surface active agent has at least 9.0 HLB value.
9. as method in any one of the preceding claims wherein, it comprises vitamin b 3 compound or derivatives thereof.
10. method as claimed in claim 9, wherein said vitamin b 3 compound is nicotiamide.
11. as method in any one of the preceding claims wherein, wherein use the extract of the plant material that comprises 0.1% to 100% ursolic acid described in the method preparation comprising the following steps:
(a) make plant material contact to prepare mixture with the non-polar solven that is selected from hexane, ethyl acetate, toluene, chloroform, ether and dichloromethane; With
(b) from described mixture separated described solvent to prepare described extract.
12. methods as claimed in claim 11, wherein by being used the step of hexane, acetone or its mixture washing extract to be further purified described extract.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1455/MUM/2011 | 2011-05-12 | ||
| IN1455MU2011 | 2011-05-12 | ||
| EP11177301.6 | 2011-08-11 | ||
| EP11177301 | 2011-08-11 | ||
| PCT/EP2012/057352 WO2012152567A2 (en) | 2011-05-12 | 2012-04-23 | A method of lightening skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103517701A true CN103517701A (en) | 2014-01-15 |
Family
ID=45998370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280022899.6A Pending CN103517701A (en) | 2011-05-12 | 2012-04-23 | A method of lightening skin |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2706973A2 (en) |
| CN (1) | CN103517701A (en) |
| BR (1) | BR112013027775A2 (en) |
| EA (1) | EA201301256A1 (en) |
| WO (1) | WO2012152567A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10869862B2 (en) | 2016-05-26 | 2020-12-22 | Conopco, Inc. | Antimicrobial compositions for topical use |
| US20200404915A1 (en) * | 2018-03-13 | 2020-12-31 | Conopco, Inc., D/B/A Unilever | A sanitizer composition |
| US20240024221A1 (en) * | 2020-12-22 | 2024-01-25 | L'oreal | Composition for brightening and/or whitening keratin materials |
| EP4186488A1 (en) | 2021-11-26 | 2023-05-31 | Unilever IP Holdings B.V. | A topical composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1361666A (en) * | 1999-04-23 | 2002-07-31 | E埃克塞尔国际公司 | Cactus fruit health products |
| JP2002241299A (en) * | 2001-02-13 | 2002-08-28 | Ichimaru Pharcos Co Ltd | Maillard reaction recovering agent |
| JP4528745B2 (en) * | 2006-06-14 | 2010-08-18 | 日光ケミカルズ株式会社 | Tyrosinase production inhibitor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0418017A (en) | 1990-05-09 | 1992-01-22 | Noevir Co Ltd | Sebum secretion promoter |
| JP2001163755A (en) | 1999-12-07 | 2001-06-19 | Shiseido Co Ltd | Preparation for external use for skin |
| FR2802096A1 (en) | 1999-12-10 | 2001-06-15 | Oreal | Topical compositions comprising pentacyclic triterpene acid and a fatty acid monoester emulsifying agent, are used for treatment of acne, erythema, photo-aging or protection of sensitive skin |
| KR20050092313A (en) * | 2004-03-15 | 2005-09-21 | 주식회사 엘지생활건강 | Skin whitening cosmetic containing a herb extract with inhibitory activity of melanin formation |
| JP2010030927A (en) * | 2008-07-28 | 2010-02-12 | Pola Chem Ind Inc | Skin care preparation for external use |
-
2012
- 2012-04-23 EP EP12716012.5A patent/EP2706973A2/en not_active Withdrawn
- 2012-04-23 WO PCT/EP2012/057352 patent/WO2012152567A2/en active Application Filing
- 2012-04-23 BR BR112013027775A patent/BR112013027775A2/en not_active IP Right Cessation
- 2012-04-23 EA EA201301256A patent/EA201301256A1/en unknown
- 2012-04-23 CN CN201280022899.6A patent/CN103517701A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1361666A (en) * | 1999-04-23 | 2002-07-31 | E埃克塞尔国际公司 | Cactus fruit health products |
| JP2002241299A (en) * | 2001-02-13 | 2002-08-28 | Ichimaru Pharcos Co Ltd | Maillard reaction recovering agent |
| JP4528745B2 (en) * | 2006-06-14 | 2010-08-18 | 日光ケミカルズ株式会社 | Tyrosinase production inhibitor |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012152567A2 (en) | 2012-11-15 |
| EA201301256A1 (en) | 2014-03-31 |
| BR112013027775A2 (en) | 2016-08-23 |
| WO2012152567A3 (en) | 2013-09-26 |
| EP2706973A2 (en) | 2014-03-19 |
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Application publication date: 20140115 |