CN103495218B - Activated cell adsorber and control system and control method thereof - Google Patents
Activated cell adsorber and control system and control method thereof Download PDFInfo
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- CN103495218B CN103495218B CN201310493043.3A CN201310493043A CN103495218B CN 103495218 B CN103495218 B CN 103495218B CN 201310493043 A CN201310493043 A CN 201310493043A CN 103495218 B CN103495218 B CN 103495218B
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- 238000000034 method Methods 0.000 title abstract description 12
- 239000008280 blood Substances 0.000 claims abstract description 33
- 210000004369 blood Anatomy 0.000 claims abstract description 31
- 210000004027 cell Anatomy 0.000 claims description 38
- 230000003213 activating effect Effects 0.000 claims description 22
- 210000000265 leukocyte Anatomy 0.000 claims description 18
- 239000012528 membrane Substances 0.000 claims description 16
- 238000003466 welding Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 239000003365 glass fiber Substances 0.000 claims description 3
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- 230000004913 activation Effects 0.000 abstract description 6
- 238000001914 filtration Methods 0.000 abstract description 5
- 230000006378 damage Effects 0.000 abstract description 3
- 238000001179 sorption measurement Methods 0.000 abstract 12
- 230000036772 blood pressure Effects 0.000 description 15
- 230000004087 circulation Effects 0.000 description 9
- 210000004881 tumor cell Anatomy 0.000 description 8
- 230000002612 cardiopulmonary effect Effects 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 210000004969 inflammatory cell Anatomy 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 208000019838 Blood disease Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000011217 control strategy Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 208000014951 hematologic disease Diseases 0.000 description 2
- 229960003444 immunosuppressant agent Drugs 0.000 description 2
- 230000001861 immunosuppressant effect Effects 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 230000001613 neoplastic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000035484 Cellulite Diseases 0.000 description 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 206010033647 Pancreatitis acute Diseases 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 206010069351 acute lung injury Diseases 0.000 description 1
- 201000003229 acute pancreatitis Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
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- 210000003714 granulocyte Anatomy 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
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- 238000000338 in vitro Methods 0.000 description 1
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- 210000004072 lung Anatomy 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses an activated cell adsorber, which comprises an adsorption film support frame, a shell, an adsorption film inner support core and an end cover; the shell wraps the adsorption film, the adsorption film wraps the adsorption film inner support core, two ends of the adsorption film inner support core are respectively connected with the adsorption film support frame, an end cover is arranged on the outer side of the adsorption film support frame, the end cover and two ends of the shell are connected to form a closed cavity, and the adsorption film support frame, the adsorption film and the adsorption film inner support core are all located in the closed cavity; one end cover is provided with a blood inflow port, and the other end cover is provided with a blood outflow port; the adsorption mode is adopted to replace the existing filtration mode, and the excessive removal, damage and activation of the leucocytes can be avoided. The invention also discloses a control system and a control method of the activated cell adsorber, which are safe, reliable and high in intelligent degree.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, particularly relate to a kind of activating cell adsorber and control system thereof
And control method.
Background technology
Systemic inflammatory response syndrome is the most common a kind of syndrome, multiple disease cause, as
The (but not limited to) such as severe trauma, acute pancreatitis, extracorporeal circulation, are to cause these deaths with many
One of the major reason planting complication generation [1-5].The feature of systemic inflammatory response syndrome is multiple in blood
A large amount of activation of inflammatory cell, particularly mononuclear cell, neutrophilic granulocyte, these cells activated are not only
By raising rapidly its surface adhesion molecule, and these adhesion molecules can be made to concentrate by polarization
In cell head end, so that cell presents extremely strong adhesion characteristics.Therewith, these cells and Ink vessel transfusing
Chrotoplast tight adhesion, and swim out of outside blood vessel, on the one hand discharge a large amount of inflammatory cytokine and strengthen cellulites
Property reaction, on the other hand release multiple protein enzyme and destroy tissue.This is probably and causes multiple organ injury
The major reason of (such as acute lung injury, acute injury of kidney, acute liver damage etc.).
Research display[6-8], the leukocyte of activation plays an important role in the generation and development of ALI,
Remove or the leukocyte of suppression activation, can effectively reduce inflammatory cell infiltration in tissue, thus reduce lung
Portion is damaged[9]。
Leukocyte depletion filter can rapidly, effectively remove these inflammatory cells, it is thus possible to scorching at treatment whole body
Property response syndrome have potentially possible.But true really not so, existing leukocyte depletion filter is to use
Screen out the mode of cell: blood, perpendicular through the filter membrane of leukocyte depletion filter, not only has adhesion due to filter membrane
Characteristic, and the filter opening on filter membrane is less, so that major part nucleated cell is removed.This filter
Drawback is: 1. remove nucleated cell ability strong, but selectivity extreme difference, it can preferentially remove volume relatively
Big nucleated cell, but can not selective removal activating cell.And excessive leucocyte removal will cause
A large amount of releases of body leukocyte, are likely to bring immunosuppressant dangerous simultaneously；2. our research
Finding, this filter can result in the leukocyte considerable damage adhered on filter membrane, causes intracellular inflammatory
Material flows out, thus activates unactivated leukocyte, may increase the weight of inflammatory reaction；3. blood is through white thin
During born of the same parents' filter, the interaction of excessive resistance and leukocyte, filter membrane will cause a large amount of leukocyte activation,
Thus cause the aggravation of inflammatory reaction.Therefore, this filter may cause increasing the weight of of conditions of patients, uncomfortable
For clinic.
Most solid tumors, neoplastic hematologic disorder can be shifted by blood, or infiltration distant organs organ.For
Tumor patient, reduce circulation inner tumour cell can make neoplasm metastasis rate decline (and for neoplastic hematologic disorder suffer from
Person, it is possible to alleviate rapidly the state of an illness, alleviate patients symptomatic), do gene or egg as obtained tumor cell specimen
White detection, then the treatment for tumor is particularly important: these information can be selection of clinical sensitivity, spy
Specific agent provides foundation.But the acquisition of active tumour specimen is the most extremely difficult, current research is many
Concentrate on the tumor cell found in blood circulation, but owing to circulating tumor cell content is extremely low, therefore difficult
To find；The methods studying enriched tumor cell more, but the requirement of clinic can not be met.
List of references:
1.Rubenfeld GD,Caldwell E,Peabody E,et al.Incidence and outcomes
of acute lung injury.N Engl J Med2005;353:1685-93.
2.Du B,An Y,Kang Y,et al.Characteristics of Critically Ill
Patients in ICUs in Mainland China.Crit Care
Med.2013;41(1):84-92.
3.Rubenfeld GD,Herridge MS.Epidemiology and outcomes of acute lung
injury.Chest2007;131:554-62.
4.Mikkelsen ME,Christie JD,Lanken PN,et al.The adult respiratory
distress syndrome cognitive outcomes study:long-term
neuropsychological function in survivors of acute lung injury.Am
J Respir Crit Care Med.2012;185(12):1307-15.
5.Johnson ER,Matthay MA.Acute lung injury:epidemiology,
pathogenesis,and treatment.J Aerosol Med Pulm Drug Deliv.
2010;23:243-52.
6.Li T,Luo NF,Du L,et al.Tumor necrosis factor-alpha plays an
initiating role in extracorporeal circulation-induced acute lung
injury.Lung.2013Jan25.[Epub ahead of print].
7.Du L,Zhou J,Zhang J,et al.Actin filament reorganization is a
key step in lung inflammation induced by systemic inflammatory
response syndrome.Am J Respir Cell Mol Biol.2012;47(5):597-603.
8.Tao K,An Q,Lin K,Lui RC,Wu X,Zhou J,Du L.Which is better to
preserve pulmonary function:short-term or prolonged leukocyte
depletion during cardiopulmonary bypass?J Thorac Cardiovasc Surg.
2009;138(6):1385-91.
9.Karaiskos TE,Palatianos GM,Triantafillou CD,et al.Clinical
effectiveness of leukocyte filtration during cardiopulmonary
bypass in patients with chronic obstructive pulmonary disease.Ann
Thorac Surg.2004;78:1339-44.
Summary of the invention
It is desirable to provide a kind of activating cell adsorber, suction type is used to substitute existing filtration side
Formula, provides the surface that an adhesive capacity is stronger, when cell warp for activated leukocyte cell or active tumour cell
When crossing described activating cell adsorber, activating cell therein and adsorber film tight adhesion.
For reaching above-mentioned purpose, the present invention realizes by the following technical solutions:
Activating cell adsorber disclosed by the invention, including adsorbed film bracing frame, shell, adsorbed film, suction
Membrane inner support core, end cap；Described shell parcel adsorbed film, described adsorbed film parcel adsorbed film inner support
Core, the two ends of described adsorbed film inner support core connect adsorbed film bracing frame, described adsorbed film bracing frame respectively
Outside be provided with end cap, described end cap be connected with shell two ends after constitute closed cavity, adsorbed film support
Frame, adsorbed film, adsorbed film inner support core are respectively positioned in described closed cavity；Blood is offered on one end cap
Liquid flow inlet, another end cap offers blood outflow port.
Preferably, the arrangement of described adsorbed film is: use same adsorbed film to be rolled into helical arrangement,
Leaving gap between each layer, the contact site that described adsorbed film bracing frame contacts with adsorbed film is provided with and above-mentioned
The lobe that gap is suitable.
Preferably, described adsorbed film is leukocyte adsorbed film, and its material is non-woven fabrics or glass fibre.
Further, connection, described adsorbed film inner support core and the adsorbed film between described end cap and shell
The connection of bracing frame is welding, and welding manner is ultrasonic bonding.
The invention also discloses a kind of control system being applicable to described activating cell adsorber, including: pressure
Force transducer A, pressure transducer B, temperature sensor, flow transducer are respectively by respective filtered electrical
Being input to processor after road, amplifying circuit, analog-digital converter, Flow-rate adjustment gives module and connects processor
Input port, described processor includes CPU, the delivery outlet of processor connect respectively isolator, on-off circuit,
Display screen, described isolator, on-off circuit are also connected with motor driver, described motor driver connector
Outer circulation pump motor；Described pressure transducer A, temperature sensor, flow transducer are installed in blood
At inflow entrance, described pressure transducer B is arranged at blood outflow port；Described Flow-rate adjustment gives module
Use potentiometer set mode and be provided with the scale of mark uninterrupted.
Further, described processor is also connected with alarm, and described alarm is audible-visual annunciator.
Preferably, described extracorporeal circulation pump motor is servomotor, and described motor driver is servo-drive
Device.
Preferably, described isolator is photoisolator, described on-off circuit include solid-state relay or
Electromagnetic relay, described display screen is LED display or LCD display.
The invention also discloses the control method being applicable to above-mentioned control system, including following control strategy:
Strategy 1, the potentiometer regulation being given module by Flow-rate adjustment arranges predetermined flow value；
Strategy 2, flow transducer detects blood actual flow in real time, and processor is according to the blood detected
Actual flow carries out error compensation computing with the difference of the theoretical delivery of setting, then sends command adapted thereto control
Motor changes rotating speed, forms flow closed loop control.
Further, described control method also includes: detect blood pressure at pressure transducer A less than presetting
Blood pressure lower limit time, processor sends alarm signal by alarm, and cuts out motor driver, body
Outer circulation pump motor stall；When detecting the blood pressure higher limit that blood pressure reaches default at pressure transducer B,
Processor sends alarm signal by alarm, and closes motor driver, cardiopulmonary bypass pump motor stalling；
Described blood pressure lower limit, blood pressure higher limit scalable.
Activating cell adsorber disclosed by the invention, uses suction type to substitute existing filter type, for
Activated leukocyte cell or active tumour cell provide the surface that an adhesive capacity is stronger, when cell is through described
During activating cell adsorber, the stronger activating cell of adhesiveness therein and adsorber film tight adhesion, tool
There is a following beneficial effect:
1, the present invention can remove the cell in blood, but its mechanism removed is no longer " filtering ", and
Being " absorption ", therefore the ability of its selective removal is greatly improved.Owing to filter membrane has stronger adhesion work
Can, therefore there is the cell of adhesion function equally (such as activated leukocyte cell, platelet and adhesion energy in blood
The tumor cell that power is stronger) will combine with the filter membrane in the present invention, thus " absorption " and gone
Remove.Non-activated cell and erythrocyte then can pass through filter.
2, blood and the filter membrane double contact of the present invention, therefore the utilization ratio of filter membrane is higher.
3, activating cell adsorber is little on quantity of leucocyte impact in blood, will not produce immunosuppressant and make
With, it is not result in that bone marrow discharges leukocyte in a large number.
4, blood flows through from filter membrane surface, it is to avoid cell and the normal impact of filter membrane, is significantly reduced
Destruction to hemocyte, thus significantly reduce intracellular Inflammatory substances spill the activation with cell,
Therefore this will improve the therapeutic effect to systemic inflammatory response.
5, tumor cell is not destroyed after the filter membrane adhesion of the present invention, and the cell of this adhesion holds very much
Easily it is cultured and obtains preferable tumor colonies strain.
The control system of activating cell adsorber disclosed by the invention and control method, control accurate, safety
Reliably, intelligence degree is high.
Activating cell adsorber disclosed by the invention can be connected with above-mentioned control system, is used in conjunction with, also
Can be installed in routine in vitro circulation line, not be used in conjunction with the control system in the present invention.
Accompanying drawing explanation
Fig. 1 is the partition schematic diagram of activating cell adsorber；
Fig. 2 is the longitudinal cross-section schematic diagram of activating cell adsorber；
Fig. 3 is the theory diagram of the control system of activating cell adsorber；
In figure: 1-blood inflow entrance, 2-blood outflow port, 3-adsorbed film bracing frame, 4-shell, 5-inhale
Membrane, 6-adsorbed film inner support core, 7-end cap.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with accompanying drawing,
The present invention is further elaborated.
As shown in Figure 1 and Figure 2, activating cell adsorber disclosed by the invention, including adsorbed film bracing frame 3,
Shell 4, adsorbed film 5, adsorbed film inner support core 6, end cap 7；Shell 4 is cylindrical, and wraps up suction
Membrane 5, uses same adsorbed film 5 to be rolled into helical arrangement, forms the layer structure leaving gap,
Adsorbed film 5 wraps up adsorbed film inner support core 6, and the two ends of adsorbed film inner support core 6 connect adsorbed film respectively
Bracing frame 3, the contact site that adsorbed film bracing frame 3 contacts with adsorbed film 5 is provided with and above-mentioned gap is fitted mutually
The lobe joined；The outside of adsorbed film bracing frame 3 is provided with end cap 7, and end cap 7 is with shell 4 two ends even
Constituting closed cavity after connecing, adsorbed film bracing frame 3, adsorbed film 5, adsorbed film inner support core 6 are respectively positioned on institute
State in closed cavity, an end cap 7 offers blood inflow entrance 1, another end cap 7 offers
Blood outflow port 2；During use, blood trickles and mistake from the surface of adsorbed film 5, need not pass adsorbed film 5.
As preferably, adsorbed film 5 use routine for leukocyte adsorbed film, the most existing leukocyte
Adsorbed film used by filter, its material is non-woven fabrics or glass fibre.
As preferably, connection, adsorbed film inner support core 6 between end cap 7 and shell 4 prop up with adsorbed film
The connection of support 3 is welding, and welding manner is ultrasonic bonding；Certainly supporting-core and bracing frame, outer
Shell also can integrated connection.
77 as it is shown on figure 3, the invention also discloses the control system being applicable to this activating cell adsorber,
Including: pressure transducer A, pressure transducer B, temperature sensor, flow transducer are respectively by each
Filter circuit, amplifying circuit, be input to processor after analog-digital converter, filter circuit, amplifying circuit,
Analog-digital converter all uses multichannel integrated, is integrated into multichannel filtering circuit, multichannel amplifying circuit, many respectively
Road analog-digital converter, Flow-rate adjustment gives module and connects processor input port, and processor includes CPU, place
The delivery outlet of reason device connects isolator, on-off circuit, display screen respectively, and isolator, on-off circuit also connect
Connecing motor driver, motor driver connector outer circulation pump motor, motor driver uses servo-drive
Device, extracorporeal circulation pump motor uses servomotor；Pressure transducer A, temperature sensor, flow sensing
Device is installed at blood inflow entrance 1, and pressure transducer B is arranged at blood outflow port 2；Flow is adjusted
The given module of joint uses potentiometer set mode and is provided with the scale of mark uninterrupted.
Further, processor is also connected with alarm, and alarm is audible-visual annunciator.
As preferably, isolator uses photoisolator, and on-off circuit includes solid-state relay or electricity
Magnetic relay, display screen is LED display or LCD display.
The invention also discloses the control method being applicable to above-mentioned control system, including following control strategy:
Strategy 1, the potentiometer regulation being given module by Flow-rate adjustment arranges predetermined flow value；
Strategy 2, flow transducer detects blood actual flow in real time, and processor is according to the blood detected
Actual flow carries out error compensation computing with the difference of the theoretical delivery of setting, then sends command adapted thereto control
Motor changes rotating speed, forms flow closed loop control.
Control method disclosed by the invention also includes: at pressure transducer A detect blood pressure less than preset
During blood pressure lower limit, processor sends alarm signal by alarm, and closes motor driver, external
Circulating pump motor stall；When detecting the blood pressure higher limit that blood pressure reaches default at pressure transducer B, place
Reason device sends alarm signal by alarm, and closes motor driver, cardiopulmonary bypass pump motor stalling；
Described blood pressure lower limit, blood pressure higher limit scalable, such as blood pressure lower limit value are 10mmHg, blood pressure
Higher limit value is 200mmHg, can ensure safety.
During work, blood of human body enters this activating cell adsorber by blood inflow entrance 1, then passes through blood
Fluid outlet 2 returns to human body after flowing out, middle concatenation cardiopulmonary bypass pump, by controlling cardiopulmonary bypass pump
Motor speed regulates the flow of blood；The potentiometer regulation blood stream in module is given by Flow-rate adjustment
The setting value of amount, and the CPU, CPU that this setting value are sent on processor send control according to this setting value
Signal processed, to servo-driver, controls motor speed, the actual flow detected further according to flow transducer
Carry out error compensation computing with the difference setting flow, then send command adapted thereto and control motor change rotating speed,
Form flow closed loop control, so that stability of flow is in setting value.
The detection signal of each sensor above-mentioned processes respectively through corresponding filtering, amplification etc., reconvert
Command adapted thereto is sent by above-mentioned signal is analyzed process, a side for digital signal input CPU, CPU
Face passes information to display screen, on the other hand control volume outer circulation pump motor.
Display screen shows cardiopulmonary bypass pump import and export blood pressure in real time, the blood temperature in cardiopulmonary bypass pump exit
Degree, blood flow.
Certainly, the present invention also can have other various embodiments, spiritual and essence without departing substantially from the present invention
In the case of, those of ordinary skill in the art can make various corresponding change and deformation according to the present invention,
But these change accordingly and deform the protection domain that all should belong to appended claims of the invention.
Claims (2)
1. activating cell adsorber, it is characterised in that include adsorbed film bracing frame (3), shell (4),
Adsorbed film (5), adsorbed film inner support core (6), end cap (7)；Described shell (4) parcel adsorbed film (5),
Described adsorbed film (5) parcel adsorbed film inner support core (6), the two of described adsorbed film inner support core (6)
End connects adsorbed film bracing frame (3) respectively, and the outside of described adsorbed film bracing frame (3) is provided with end cap (7),
Described end cap (7) be connected with shell (4) two ends after constitute closed cavity, adsorbed film bracing frame (3),
Adsorbed film (5), adsorbed film inner support core (6) are respectively positioned in described closed cavity；One end cap (7)
On offer blood inflow entrance (1), another end cap (7) offers blood outflow port (2)；Described
The arrangement of adsorbed film (5) is: use same adsorbed film (5) to be rolled into helical arrangement, each layer
Between leave gap, the contact site that described adsorbed film bracing frame (3) contacts with adsorbed film (5) is provided with
The lobe suitable with above-mentioned gap；Connection between described end cap (7) and shell (4), described
Adsorbed film inner support core (6) is with the connection of adsorbed film bracing frame (3) and welds, and welding manner is super
Sound wave welds.
Activating cell adsorber the most according to claim 1, it is characterised in that described adsorbed film (5)
For leukocyte filter membranes, its material is non-woven fabrics or glass fibre.
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| CN201310493043.3A CN103495218B (en) | 2013-10-21 | 2013-10-21 | Activated cell adsorber and control system and control method thereof |
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| CN201310493043.3A CN103495218B (en) | 2013-10-21 | 2013-10-21 | Activated cell adsorber and control system and control method thereof |
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| CN103495218B true CN103495218B (en) | 2016-10-12 |
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| CN104548235B (en) * | 2014-10-08 | 2018-01-19 | 广西医科大学 | A kind of circulating tumor cell separates digitization system |
| TWI571276B (en) * | 2014-12-26 | 2017-02-21 | 國立高雄大學 | Blood isolation and extraction method and device thereof |
| CN115518219B (en) * | 2022-08-30 | 2023-06-16 | 四川大学华西医院 | Low-capacity activated leukocyte adsorber |
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| US4493693A (en) * | 1982-07-30 | 1985-01-15 | Baxter Travenol Laboratories, Inc. | Trans-membrane pressure monitoring system |
| US4828543A (en) * | 1986-04-03 | 1989-05-09 | Weiss Paul I | Extracorporeal circulation apparatus |
| US5114582A (en) * | 1991-04-12 | 1992-05-19 | W. R. Grace & Co.-Conn. | Filter element and spiral-wound membrane cartridge containing same |
| CN2894710Y (en) * | 2006-03-31 | 2007-05-02 | 天津市海河医院 | Medical blood-qi exchanger |
| CN201139814Y (en) * | 2007-12-25 | 2008-10-29 | 张维青 | Leukocyte filter for intracardiac blood suction |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266195A (en) * | 1992-08-10 | 1993-11-30 | Desalination Systems, Inc. | Spiral wound separation device and method of making same |
| US20110226698A1 (en) * | 2009-11-19 | 2011-09-22 | Abdulsalam Al-Mayahi | Dynamic Filtration |
| TW201247297A (en) * | 2011-03-29 | 2012-12-01 | Toray Industries | Spiral type separation membrane element and method for producing the same |
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2013
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4493693A (en) * | 1982-07-30 | 1985-01-15 | Baxter Travenol Laboratories, Inc. | Trans-membrane pressure monitoring system |
| US4828543A (en) * | 1986-04-03 | 1989-05-09 | Weiss Paul I | Extracorporeal circulation apparatus |
| US5114582A (en) * | 1991-04-12 | 1992-05-19 | W. R. Grace & Co.-Conn. | Filter element and spiral-wound membrane cartridge containing same |
| CN2894710Y (en) * | 2006-03-31 | 2007-05-02 | 天津市海河医院 | Medical blood-qi exchanger |
| CN201139814Y (en) * | 2007-12-25 | 2008-10-29 | 张维青 | Leukocyte filter for intracardiac blood suction |
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|---|---|
| CN103495218A (en) | 2014-01-08 |
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