CN103480035B - Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip - Google Patents

Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip Download PDF

Info

Publication number
CN103480035B
CN103480035B CN201310354547.7A CN201310354547A CN103480035B CN 103480035 B CN103480035 B CN 103480035B CN 201310354547 A CN201310354547 A CN 201310354547A CN 103480035 B CN103480035 B CN 103480035B
Authority
CN
China
Prior art keywords
composite material
base composite
magnesium base
magnesium
hemostatic clip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201310354547.7A
Other languages
Chinese (zh)
Other versions
CN103480035A (en
Inventor
刘德宝
陈民芳
宋融
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tianjin University of Technology
Original Assignee
Tianjin University of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjin University of Technology filed Critical Tianjin University of Technology
Priority to CN201310354547.7A priority Critical patent/CN103480035B/en
Publication of CN103480035A publication Critical patent/CN103480035A/en
Application granted granted Critical
Publication of CN103480035B publication Critical patent/CN103480035B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Materials For Medical Uses (AREA)

Abstract

The invention relates to a hemostatic clip made from an absorbable magnesium-based composite material. The absorbable magnesium-based composite material is adopted to prepare a hemostatic clip body which is in a V shape, the top included angle and an included angle formed by adjacent edges of two folding edges are both obtuse angles less than 180 degrees, the cross section of the hemostatic clip is a rectangular shape with 0.9-1.1mm in length and 0.65-0.75 in width, and cross grains with width of 0.2mm and distance of 1.7mm are formed at the inner side of the hemostatic clip. The preparation method of the hemostatic clip comprises the steps of drawing an absorbable magnesium-based composite material rod used as a preparation material, cutting cross grains, forming, performing annealing treatment and washing. The hemostatic clip has the advantages that the hemostatic clip made from the absorbable magnesium-based composite material has excellent biological degradability and physical and mechanical properties, can be shaped easily and has low preparation cost, the toughness of magnesium alloy can be effectively improved and the fracture phenomenon can be greatly reduced due to the addition of HA (Hydroxyapatite) or beta-TCP (Tertiary Calcium Phosphate), and the hemostatic clip has good effect in minimally invasive surgery of abdominal cavity in department of surgery.

Description

One can absorb magnesium base composite material hemostatic clamp and preparation method thereof
Technical field
The invention belongs to biomedical materials field, relate to one and can absorb magnesium base composite material hemostatic clamp and preparation method thereof.
Background technology
" lockhole " operation that is otherwise known as of so-called laparoscopic surgery is the operation that doctor uses laparoscope system technology set advanced person's the equipment principle such as electronics, optics to complete.Different from traditional laparotomy ventrotomy, laparoscopic surgery is the operation of carrying out at airtight intraperitoneal.Camera system is under good cold light source illumination, by being connected to Intraabdominal peritoneoscope body, Intraabdominal internal organs are photographed and are monitored on screen, under surgical doctor monitors, guides at high-tech display screen, outside abdominal cavity, handle operating theater instruments, to pathological tissues detect, the operation such as coagulation, hemostasis, separate tissue and incision, stitching.
More employing hemostatic clamp hemostasis clinically be now to use operation relatively easy because adopt hemostatic clamp, and haemostatic effect is better.Comparatively conventional hemostatic clamp material can be divided into two large classes: a class is the metal material hemostatic clamp of nonabsorable; An other class is absorbable polymer hemostatic clamp.This two classes hemostatic clamp has use clinically, and cuts both ways.
The metal material feed collet of nonabsorable, the Ti that adopts as main in titanium folder 6al 4v, Ti 6al 2.5the titanium alloys such as Sn, although they have good mechanical property, owing to forever remaining in human body, in alloy, separating out of some element can cause harmful effect.Absorbable polymer material clip, as the ABSOLOK ligation nail clip of Johnson & Johnson of the U.S. adopts PPDO (PPDO).PPDO (PPDO), except having excellent biological degradability, also with excellent physical and mechanical properties, still, the higher and shaping processability of its cost can be poor.
Magnesium is about 25g in the normal contents of growing up in human body, is the important element of needed by human.Density (the 1.74-2.0g/cm of magnesium and magnesium alloy 3) far below medical titanium alloy (4.4-4.59g/cm 3), thering is high specific strength and specific stiffness, Young's modulus is 41-45Gpa.The standard electrode potential (2.37V) of pure magnesium is very low, is containing Cl -human Physiology environment in its corrosion resistance poor, have higher chemistry and electro-chemical activity.Consider above these factors, magnesio biomaterial research worker both domestic and external has concentrated one's gaze on the application direction of magnesio biomaterial in the developmental research of medical degradable magnesio biomaterial.By adding harmless metallic element to carry out alloying, the corrosion resistance of medical magnesio biomaterial has had certain improvement on the basis that keeps its mechanical property and biocompatibility.
Summary of the invention
The object of the invention is to for above-mentioned technical Analysis and existing problems, provide one can absorb magnesium base composite material hemostatic clamp and preparation method thereof, this can absorb magnesium base composite material hemostatic clamp and have excellent biological degradability and physical and mechanical properties, be easy to shaping processing and preparation cost low, respond well for abdominal cavity surgery Minimally Invasive Surgery.
Technical scheme of the present invention:
One can absorb magnesium base composite material hemostatic clamp, employing can absorb magnesium base composite material and prepare hemostatic clamp clamp, hemostatic clamp clamp is shaped as V-type, the top angle of V-type folder and the adjacent edge angle of two flangings are all the obtuse angle that is less than 180 degree, the cross sectional shape of hemostatic clamp is rectangle, length and width is of a size of 0.9-1.1 mm, 0.65-0.75mm, and it is the band that 0.2mm, spacing are 1.7mm that hemostatic clamp inner side is provided with width.
The described preparation method that can absorb magnesium base composite material hemostatic clamp, employing can absorb the preparation of magnesium base composite material rod, comprises the wire drawing of magnesium base composite material rod, cutting band molding, annealing in process, cleaning, and step is as follows:
1) be the magnesium base composite material silk that cross section length and width is of a size of 1.0mm, 0.7mm by Φ 8 mm magnesium base composite material rods by wire-drawing die wire drawing;
2) above-mentioned magnesium base composite material silk is cut to band by cutting equipment, then make magnesium base composite material folder by profile mould;
3) above-mentioned magnesium base composite material folder is carried out to annealing in process, annealing temperature is 350 DEG C, and annealing time is 30 minutes, is cooled to room temperature after taking-up;
4) magnesium base composite material after annealing in process is folded up in dehydrated alcohol and clean until taking-up oven dry after its any surface finish can make and can absorb magnesium base composite material hemostatic clamp.
Described magnesium base composite material rod is by being prepared by the composite that adds HA or β-TCP nano-particle in alloy substrate to Mg-Zn, wherein the content of Mg is 93.5-96wt%, the content of HA or β-TCP is 1wt%, the content of Zn is 2-3.5 wt%, and other alloying element comprises the alloying element of one or more arbitrary proportions in Zr, Ca, Mn and Ag; The preparation method of this magnesium base composite material rod is: the magnesium ingot, the zinc granule that are greater than 99.95% with purity, HA prepared by Mg-Zr alloys, magnesium calcium alloy, magnesium-manganese alloy, magnesium silver alloy and chemical precipitation method or β-TCP nano-particle are raw material, melting in the vacuum drying oven that is connected with argon shield atmosphere, adopt the machinery mode of stirring to stir, be then cast into the magnesium base composite material rod of Φ 60 mm; Magnesium base composite material rod is carried out to homogenizing annealing processing, and annealing temperature is 400-420 DEG C, and then annealing time 12-24 hour takes out composite stick and be cooled to room temperature; This magnesium base composite material rod is squeezed into the magnesium base composite material wire rod of Φ 8 mm by extruder; Finally this magnesium base composite material rod is carried out to artificial aging processing, treatment temperature is 150 DEG C, and the processing time is 24 hours.
Advantage of the present invention is: this can absorb magnesium base composite material hemostatic clamp and have excellent biological degradability and physical and mechanical properties, be easy to shaping processing and preparation cost low, add HA or β-TCP, can effectively improve the obdurability of magnesium alloy, greatly reduce phenomenon of rupture, respond well for abdominal cavity surgery Minimally Invasive Surgery.
Brief description of the drawings
Accompanying drawing is this structural representation that can absorb magnesium base composite material hemostatic clamp.
Detailed description of the invention
Embodiment:
One can absorb magnesium base composite material hemostatic clamp, as shown in drawings, employing can absorb magnesium base composite material and prepare hemostatic clamp clamp, hemostatic clamp clamp is shaped as V-type, top angle 130 degree of V-type folder and the adjacent edge angle of two flangings are 150 degree, the cross sectional shape of hemostatic clamp is rectangle, and length and width is of a size of 1.0 mm, 0.7mm, and it is the band that 0.2mm, spacing are 1.7mm that hemostatic clamp inner side is provided with width.
The described preparation method that absorbs magnesium base composite material hemostatic clamp, employing can absorb the preparation of magnesium base composite material rod, comprises the wire drawing of magnesium base composite material rod, cutting band molding, annealing in process, cleaning, and step is as follows:
1) prepare magnesium base composite material, composition is β-TCP/ Mg-Zn-Zr-Mn, and wherein the content of Zn is 3 wt%, and the content of Zr is 0.8 wt%, and the content of Mn is 1 wt%, and the content of β-TCP is 1 wt%, and surplus is Mg; The preparation method of this magnesium base composite material rod is: the magnesium ingot, the zinc granule that are greater than 99.95% with purity, β-TCP nano-particle prepared by Mg-Zr alloys, magnesium-manganese alloy and chemical precipitation method is raw material, stir-melting in the vacuum drying oven that is connected with argon shield atmosphere, then becomes the magnesium base composite material rod of Φ 60 mm by die casting; Magnesium base composite material rod is carried out to homogenizing annealing processing, and annealing temperature is 420 DEG C, and then annealing time 12 hours takes out composite stick and be cooled to room temperature.The magnesium base composite material rod that this magnesium base composite material rod is squeezed into Φ 8 mm by extruder, extrusion temperature is 350 DEG C; Then magnesium base composite material rod after extruding is carried out to artificial aging processing, treatment temperature is 150 DEG C, and the processing time is 24 hours;
2) be the magnesium base composite material silk that cross section length and width is of a size of 1.0mm, 0.7mm by Φ 8 mm magnesium base composite material rods by wire-drawing die wire drawing, above-mentioned magnesium base composite material silk is cut to band by cutting equipment, then make magnesium base composite material folder by profile mould;
3) above-mentioned magnesium base composite material folder is carried out to annealing in process, annealing temperature is 350 DEG C, and annealing time is 30 minutes, is cooled to room temperature after taking-up;
4) magnesium base composite material after annealing in process is folded up in dehydrated alcohol and clean until taking-up oven dry after its any surface finish can make and can absorb magnesium base composite material hemostatic clamp.
In this embodiment, magnesium base composite material matrix is that Mg-Zn is associated gold, and Zn, as important alloying element, has the dual function of solution strengthening and ageing strengthening, can also improve the corrosion resistance of alloy simultaneously; Zr has very strong Grain Refinement Effect, improves the mechanical property of magnesium alloy; Mn can put forward heavy alloyed yield strength, simultaneously can crystal grain thinning; β-TCP granule can play grain refinement and strengthen toughness reinforcing effect.

Claims (2)

1. one kind can absorb the preparation method of magnesium base composite material hemostatic clamp, described hemostatic clamp clamp is shaped as V-type, the top angle of V-type folder and the adjacent edge angle of two flangings are all the obtuse angle that is less than 180 degree, the cross sectional shape of hemostatic clamp is rectangle, length and width is of a size of 0.9-1.1 mm, 0.65-0.75mm, it is the band that 0.2mm, spacing are 1.7mm that hemostatic clamp inner side is provided with width, it is characterized in that: employing can absorb the preparation of magnesium base composite material rod, comprise the wire drawing of magnesium base composite material rod, cutting band molding, annealing in process, cleaning, step is as follows:
1) be the magnesium base composite material silk that cross section length and width is of a size of 1.0mm, 0.7mm by Φ 8 mm magnesium base composite material rods by wire-drawing die wire drawing;
2) above-mentioned magnesium base composite material silk is cut to band by cutting equipment, then make magnesium base composite material folder by profile mould;
3) above-mentioned magnesium base composite material folder is carried out to annealing in process, annealing temperature is 350 DEG C, and annealing time is 30 minutes, is cooled to room temperature after taking-up;
4) magnesium base composite material after annealing in process is folded up in dehydrated alcohol and clean until taking-up oven dry after its any surface finish can make and can absorb magnesium base composite material hemostatic clamp.
2. can absorb according to claim 1 the preparation method of magnesium base composite material hemostatic clamp, it is characterized in that: described magnesium base composite material rod is by being prepared by the composite that adds HA or β-TCP nano-particle in alloy substrate to Mg-Zn, wherein the content of Mg is 93.5-96wt%, the content of HA or β-TCP is 1wt%, the content of Zn is 2-3.5 wt%, and other alloying element comprises the alloying element of one or more arbitrary proportions in Zr, Ca, Mn and Ag; The preparation method of this magnesium base composite material rod is: the magnesium ingot, the zinc granule that are greater than 99.95% with purity, HA prepared by Mg-Zr alloys, magnesium calcium alloy, magnesium-manganese alloy, magnesium silver alloy and chemical precipitation method or β-TCP nano-particle are raw material, melting in the vacuum drying oven that is connected with argon shield atmosphere, adopt the machinery mode of stirring to stir, be then cast into the magnesium base composite material rod of Φ 60 mm; Magnesium base composite material rod is carried out to homogenizing annealing processing, and annealing temperature is 400-420 DEG C, and then annealing time 12-24 hour takes out composite stick and be cooled to room temperature; This magnesium base composite material rod is squeezed into the magnesium base composite material wire rod of Φ 8 mm by extruder; Finally this magnesium base composite material rod is carried out to artificial aging processing, treatment temperature is 150 DEG C, and the processing time is 24 hours.
CN201310354547.7A 2013-08-15 2013-08-15 Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip Expired - Fee Related CN103480035B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310354547.7A CN103480035B (en) 2013-08-15 2013-08-15 Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310354547.7A CN103480035B (en) 2013-08-15 2013-08-15 Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip

Publications (2)

Publication Number Publication Date
CN103480035A CN103480035A (en) 2014-01-01
CN103480035B true CN103480035B (en) 2014-11-05

Family

ID=49820841

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310354547.7A Expired - Fee Related CN103480035B (en) 2013-08-15 2013-08-15 Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip

Country Status (1)

Country Link
CN (1) CN103480035B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105455869A (en) * 2015-11-20 2016-04-06 天津理工大学 Absorbable magnesium alloy laparoscope hemostatic clip and preparation method thereof
CN113262324B (en) * 2021-05-19 2022-01-18 辽宁工业大学 Multi-phase gradient-distributed porous Zn-Ag-TCP composite material and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101468363B (en) * 2007-12-30 2011-01-26 哈尔滨工业大学 Multi-pass drawing technological process for manufacturing magnesium and magnesium alloy filament
CN101411891B (en) * 2008-12-01 2012-11-21 天津理工大学 Degradable nano calcium phosphorous compound reinforced magnesium-zinc alloy bone fracture internal fixation material
CN202288387U (en) * 2011-10-26 2012-07-04 杭州桐庐尖端内窥镜有限公司 Tissue closing clip capable of absorbing magnesium alloy

Also Published As

Publication number Publication date
CN103480035A (en) 2014-01-01

Similar Documents

Publication Publication Date Title
JP6431957B2 (en) Biodegradable metal alloy
CN101899600B (en) Osteopathic magnesium alloy interstitial implant material and preparation method thereof
ES2485893T3 (en) Magnesium alloys containing heavy rare earths
KR102246887B1 (en) Magnesium-aluminum-zinc alloy, method for the production thereof and use thereof
EP2224032A1 (en) Process for manufacturing magnesium alloy based products
CN101392344A (en) Degradable Mg-Mn-Zn-Ca mulit-element magnesium alloy material in organism
CN101766835A (en) Metal anastomotic nail absorbable in vivo and preparation method thereof
CN101837145A (en) High-toughness corrosion-resistant magnesium alloy implanted material capable of being degraded in organism
CN103480035B (en) Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip
AU2020348320B2 (en) Developable composite biological mesh containing barium sulfate and preparation method therefor
CN107736906A (en) A kind of Absorbale magnesium alloy skin closure nail and preparation method thereof
KR20130082444A (en) Adhesion-preventing material
CN105087980A (en) Method for preparing hemostatic clips through surface-passivated degradable magnesium alloy
CN106086562A (en) Biological degradable in vivo anastomosis staple and production technology thereof
CN109602960A (en) One kind having superplastic medical Zinc alloy bar preparation method
CN108396176A (en) A kind of medical degradable zinc alloy flakes of Guided Bone Regeneration and preparation method thereof
CN102258806A (en) Degradable magnesium-base biomedical material for implantation in orthopaedics, and preparation method thereof
JP2016540128A (en) Implant, production method thereof and use thereof
CN105455869A (en) Absorbable magnesium alloy laparoscope hemostatic clip and preparation method thereof
CN102552993B (en) Magnesium alloy sheet-reinforced absorbable intrabony fixing composite material and preparation method thereof
CN109266909A (en) A kind of medical degradable zinc bismuth system alloy
CN105603282A (en) Method for preparing magnesium alloy laparoscope hemostasis clip
CN108577922A (en) A kind of degradable kirsite laparoscope hemostatic clamp and preparation method thereof
CN105624495A (en) Medical suture material and preparation method
CN108642359B (en) High-strength rapid-degradation biomedical Mg-Zn-Zr-Fe alloy material and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20141105

Termination date: 20160815

CF01 Termination of patent right due to non-payment of annual fee