CN103480035B - Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip - Google Patents
Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip Download PDFInfo
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- CN103480035B CN103480035B CN201310354547.7A CN201310354547A CN103480035B CN 103480035 B CN103480035 B CN 103480035B CN 201310354547 A CN201310354547 A CN 201310354547A CN 103480035 B CN103480035 B CN 103480035B
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- composite material
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- magnesium base
- magnesium
- hemostatic clip
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Abstract
The invention relates to a hemostatic clip made from an absorbable magnesium-based composite material. The absorbable magnesium-based composite material is adopted to prepare a hemostatic clip body which is in a V shape, the top included angle and an included angle formed by adjacent edges of two folding edges are both obtuse angles less than 180 degrees, the cross section of the hemostatic clip is a rectangular shape with 0.9-1.1mm in length and 0.65-0.75 in width, and cross grains with width of 0.2mm and distance of 1.7mm are formed at the inner side of the hemostatic clip. The preparation method of the hemostatic clip comprises the steps of drawing an absorbable magnesium-based composite material rod used as a preparation material, cutting cross grains, forming, performing annealing treatment and washing. The hemostatic clip has the advantages that the hemostatic clip made from the absorbable magnesium-based composite material has excellent biological degradability and physical and mechanical properties, can be shaped easily and has low preparation cost, the toughness of magnesium alloy can be effectively improved and the fracture phenomenon can be greatly reduced due to the addition of HA (Hydroxyapatite) or beta-TCP (Tertiary Calcium Phosphate), and the hemostatic clip has good effect in minimally invasive surgery of abdominal cavity in department of surgery.
Description
Technical field
The invention belongs to biomedical materials field, relate to one and can absorb magnesium base composite material hemostatic clamp and preparation method thereof.
Background technology
" lockhole " operation that is otherwise known as of so-called laparoscopic surgery is the operation that doctor uses laparoscope system technology set advanced person's the equipment principle such as electronics, optics to complete.Different from traditional laparotomy ventrotomy, laparoscopic surgery is the operation of carrying out at airtight intraperitoneal.Camera system is under good cold light source illumination, by being connected to Intraabdominal peritoneoscope body, Intraabdominal internal organs are photographed and are monitored on screen, under surgical doctor monitors, guides at high-tech display screen, outside abdominal cavity, handle operating theater instruments, to pathological tissues detect, the operation such as coagulation, hemostasis, separate tissue and incision, stitching.
More employing hemostatic clamp hemostasis clinically be now to use operation relatively easy because adopt hemostatic clamp, and haemostatic effect is better.Comparatively conventional hemostatic clamp material can be divided into two large classes: a class is the metal material hemostatic clamp of nonabsorable; An other class is absorbable polymer hemostatic clamp.This two classes hemostatic clamp has use clinically, and cuts both ways.
The metal material feed collet of nonabsorable, the Ti that adopts as main in titanium folder
6al
4v, Ti
6al
2.5the titanium alloys such as Sn, although they have good mechanical property, owing to forever remaining in human body, in alloy, separating out of some element can cause harmful effect.Absorbable polymer material clip, as the ABSOLOK ligation nail clip of Johnson & Johnson of the U.S. adopts PPDO (PPDO).PPDO (PPDO), except having excellent biological degradability, also with excellent physical and mechanical properties, still, the higher and shaping processability of its cost can be poor.
Magnesium is about 25g in the normal contents of growing up in human body, is the important element of needed by human.Density (the 1.74-2.0g/cm of magnesium and magnesium alloy
3) far below medical titanium alloy (4.4-4.59g/cm
3), thering is high specific strength and specific stiffness, Young's modulus is 41-45Gpa.The standard electrode potential (2.37V) of pure magnesium is very low, is containing Cl
-human Physiology environment in its corrosion resistance poor, have higher chemistry and electro-chemical activity.Consider above these factors, magnesio biomaterial research worker both domestic and external has concentrated one's gaze on the application direction of magnesio biomaterial in the developmental research of medical degradable magnesio biomaterial.By adding harmless metallic element to carry out alloying, the corrosion resistance of medical magnesio biomaterial has had certain improvement on the basis that keeps its mechanical property and biocompatibility.
Summary of the invention
The object of the invention is to for above-mentioned technical Analysis and existing problems, provide one can absorb magnesium base composite material hemostatic clamp and preparation method thereof, this can absorb magnesium base composite material hemostatic clamp and have excellent biological degradability and physical and mechanical properties, be easy to shaping processing and preparation cost low, respond well for abdominal cavity surgery Minimally Invasive Surgery.
Technical scheme of the present invention:
One can absorb magnesium base composite material hemostatic clamp, employing can absorb magnesium base composite material and prepare hemostatic clamp clamp, hemostatic clamp clamp is shaped as V-type, the top angle of V-type folder and the adjacent edge angle of two flangings are all the obtuse angle that is less than 180 degree, the cross sectional shape of hemostatic clamp is rectangle, length and width is of a size of 0.9-1.1 mm, 0.65-0.75mm, and it is the band that 0.2mm, spacing are 1.7mm that hemostatic clamp inner side is provided with width.
The described preparation method that can absorb magnesium base composite material hemostatic clamp, employing can absorb the preparation of magnesium base composite material rod, comprises the wire drawing of magnesium base composite material rod, cutting band molding, annealing in process, cleaning, and step is as follows:
1) be the magnesium base composite material silk that cross section length and width is of a size of 1.0mm, 0.7mm by Φ 8 mm magnesium base composite material rods by wire-drawing die wire drawing;
2) above-mentioned magnesium base composite material silk is cut to band by cutting equipment, then make magnesium base composite material folder by profile mould;
3) above-mentioned magnesium base composite material folder is carried out to annealing in process, annealing temperature is 350 DEG C, and annealing time is 30 minutes, is cooled to room temperature after taking-up;
4) magnesium base composite material after annealing in process is folded up in dehydrated alcohol and clean until taking-up oven dry after its any surface finish can make and can absorb magnesium base composite material hemostatic clamp.
Described magnesium base composite material rod is by being prepared by the composite that adds HA or β-TCP nano-particle in alloy substrate to Mg-Zn, wherein the content of Mg is 93.5-96wt%, the content of HA or β-TCP is 1wt%, the content of Zn is 2-3.5 wt%, and other alloying element comprises the alloying element of one or more arbitrary proportions in Zr, Ca, Mn and Ag; The preparation method of this magnesium base composite material rod is: the magnesium ingot, the zinc granule that are greater than 99.95% with purity, HA prepared by Mg-Zr alloys, magnesium calcium alloy, magnesium-manganese alloy, magnesium silver alloy and chemical precipitation method or β-TCP nano-particle are raw material, melting in the vacuum drying oven that is connected with argon shield atmosphere, adopt the machinery mode of stirring to stir, be then cast into the magnesium base composite material rod of Φ 60 mm; Magnesium base composite material rod is carried out to homogenizing annealing processing, and annealing temperature is 400-420 DEG C, and then annealing time 12-24 hour takes out composite stick and be cooled to room temperature; This magnesium base composite material rod is squeezed into the magnesium base composite material wire rod of Φ 8 mm by extruder; Finally this magnesium base composite material rod is carried out to artificial aging processing, treatment temperature is 150 DEG C, and the processing time is 24 hours.
Advantage of the present invention is: this can absorb magnesium base composite material hemostatic clamp and have excellent biological degradability and physical and mechanical properties, be easy to shaping processing and preparation cost low, add HA or β-TCP, can effectively improve the obdurability of magnesium alloy, greatly reduce phenomenon of rupture, respond well for abdominal cavity surgery Minimally Invasive Surgery.
Brief description of the drawings
Accompanying drawing is this structural representation that can absorb magnesium base composite material hemostatic clamp.
Detailed description of the invention
Embodiment:
One can absorb magnesium base composite material hemostatic clamp, as shown in drawings, employing can absorb magnesium base composite material and prepare hemostatic clamp clamp, hemostatic clamp clamp is shaped as V-type, top angle 130 degree of V-type folder and the adjacent edge angle of two flangings are 150 degree, the cross sectional shape of hemostatic clamp is rectangle, and length and width is of a size of 1.0 mm, 0.7mm, and it is the band that 0.2mm, spacing are 1.7mm that hemostatic clamp inner side is provided with width.
The described preparation method that absorbs magnesium base composite material hemostatic clamp, employing can absorb the preparation of magnesium base composite material rod, comprises the wire drawing of magnesium base composite material rod, cutting band molding, annealing in process, cleaning, and step is as follows:
1) prepare magnesium base composite material, composition is β-TCP/ Mg-Zn-Zr-Mn, and wherein the content of Zn is 3 wt%, and the content of Zr is 0.8 wt%, and the content of Mn is 1 wt%, and the content of β-TCP is 1 wt%, and surplus is Mg; The preparation method of this magnesium base composite material rod is: the magnesium ingot, the zinc granule that are greater than 99.95% with purity, β-TCP nano-particle prepared by Mg-Zr alloys, magnesium-manganese alloy and chemical precipitation method is raw material, stir-melting in the vacuum drying oven that is connected with argon shield atmosphere, then becomes the magnesium base composite material rod of Φ 60 mm by die casting; Magnesium base composite material rod is carried out to homogenizing annealing processing, and annealing temperature is 420 DEG C, and then annealing time 12 hours takes out composite stick and be cooled to room temperature.The magnesium base composite material rod that this magnesium base composite material rod is squeezed into Φ 8 mm by extruder, extrusion temperature is 350 DEG C; Then magnesium base composite material rod after extruding is carried out to artificial aging processing, treatment temperature is 150 DEG C, and the processing time is 24 hours;
2) be the magnesium base composite material silk that cross section length and width is of a size of 1.0mm, 0.7mm by Φ 8 mm magnesium base composite material rods by wire-drawing die wire drawing, above-mentioned magnesium base composite material silk is cut to band by cutting equipment, then make magnesium base composite material folder by profile mould;
3) above-mentioned magnesium base composite material folder is carried out to annealing in process, annealing temperature is 350 DEG C, and annealing time is 30 minutes, is cooled to room temperature after taking-up;
4) magnesium base composite material after annealing in process is folded up in dehydrated alcohol and clean until taking-up oven dry after its any surface finish can make and can absorb magnesium base composite material hemostatic clamp.
In this embodiment, magnesium base composite material matrix is that Mg-Zn is associated gold, and Zn, as important alloying element, has the dual function of solution strengthening and ageing strengthening, can also improve the corrosion resistance of alloy simultaneously; Zr has very strong Grain Refinement Effect, improves the mechanical property of magnesium alloy; Mn can put forward heavy alloyed yield strength, simultaneously can crystal grain thinning; β-TCP granule can play grain refinement and strengthen toughness reinforcing effect.
Claims (2)
1. one kind can absorb the preparation method of magnesium base composite material hemostatic clamp, described hemostatic clamp clamp is shaped as V-type, the top angle of V-type folder and the adjacent edge angle of two flangings are all the obtuse angle that is less than 180 degree, the cross sectional shape of hemostatic clamp is rectangle, length and width is of a size of 0.9-1.1 mm, 0.65-0.75mm, it is the band that 0.2mm, spacing are 1.7mm that hemostatic clamp inner side is provided with width, it is characterized in that: employing can absorb the preparation of magnesium base composite material rod, comprise the wire drawing of magnesium base composite material rod, cutting band molding, annealing in process, cleaning, step is as follows:
1) be the magnesium base composite material silk that cross section length and width is of a size of 1.0mm, 0.7mm by Φ 8 mm magnesium base composite material rods by wire-drawing die wire drawing;
2) above-mentioned magnesium base composite material silk is cut to band by cutting equipment, then make magnesium base composite material folder by profile mould;
3) above-mentioned magnesium base composite material folder is carried out to annealing in process, annealing temperature is 350 DEG C, and annealing time is 30 minutes, is cooled to room temperature after taking-up;
4) magnesium base composite material after annealing in process is folded up in dehydrated alcohol and clean until taking-up oven dry after its any surface finish can make and can absorb magnesium base composite material hemostatic clamp.
2. can absorb according to claim 1 the preparation method of magnesium base composite material hemostatic clamp, it is characterized in that: described magnesium base composite material rod is by being prepared by the composite that adds HA or β-TCP nano-particle in alloy substrate to Mg-Zn, wherein the content of Mg is 93.5-96wt%, the content of HA or β-TCP is 1wt%, the content of Zn is 2-3.5 wt%, and other alloying element comprises the alloying element of one or more arbitrary proportions in Zr, Ca, Mn and Ag; The preparation method of this magnesium base composite material rod is: the magnesium ingot, the zinc granule that are greater than 99.95% with purity, HA prepared by Mg-Zr alloys, magnesium calcium alloy, magnesium-manganese alloy, magnesium silver alloy and chemical precipitation method or β-TCP nano-particle are raw material, melting in the vacuum drying oven that is connected with argon shield atmosphere, adopt the machinery mode of stirring to stir, be then cast into the magnesium base composite material rod of Φ 60 mm; Magnesium base composite material rod is carried out to homogenizing annealing processing, and annealing temperature is 400-420 DEG C, and then annealing time 12-24 hour takes out composite stick and be cooled to room temperature; This magnesium base composite material rod is squeezed into the magnesium base composite material wire rod of Φ 8 mm by extruder; Finally this magnesium base composite material rod is carried out to artificial aging processing, treatment temperature is 150 DEG C, and the processing time is 24 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310354547.7A CN103480035B (en) | 2013-08-15 | 2013-08-15 | Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310354547.7A CN103480035B (en) | 2013-08-15 | 2013-08-15 | Hemostatic clip made from absorbable magnesium-based composite material and preparation method of hemostatic clip |
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| Publication Number | Publication Date |
|---|---|
| CN103480035A CN103480035A (en) | 2014-01-01 |
| CN103480035B true CN103480035B (en) | 2014-11-05 |
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| CN105455869A (en) * | 2015-11-20 | 2016-04-06 | 天津理工大学 | Absorbable magnesium alloy laparoscope hemostatic clip and preparation method thereof |
| CN113262324B (en) * | 2021-05-19 | 2022-01-18 | 辽宁工业大学 | Multi-phase gradient-distributed porous Zn-Ag-TCP composite material and preparation method thereof |
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| CN101468363B (en) * | 2007-12-30 | 2011-01-26 | 哈尔滨工业大学 | Multi-pass drawing technological process for manufacturing magnesium and magnesium alloy filament |
| CN101411891B (en) * | 2008-12-01 | 2012-11-21 | 天津理工大学 | Degradable nano calcium phosphorous compound reinforced magnesium-zinc alloy bone fracture internal fixation material |
| CN202288387U (en) * | 2011-10-26 | 2012-07-04 | 杭州桐庐尖端内窥镜有限公司 | Tissue closing clip capable of absorbing magnesium alloy |
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