CN103479632B - The application of Lycojaponicumin B in preparation treatment cervical cancer medicine - Google Patents
The application of Lycojaponicumin B in preparation treatment cervical cancer medicine Download PDFInfo
- Publication number
- CN103479632B CN103479632B CN201310442509.7A CN201310442509A CN103479632B CN 103479632 B CN103479632 B CN 103479632B CN 201310442509 A CN201310442509 A CN 201310442509A CN 103479632 B CN103479632 B CN 103479632B
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- CN
- China
- Prior art keywords
- lycojaponicumin
- cervical cancer
- cervical carcinoma
- application
- human cervical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 title claims abstract description 17
- 206010008342 Cervix carcinoma Diseases 0.000 title claims abstract description 15
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 title claims abstract description 15
- 201000010881 cervical cancer Diseases 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 229930185194 lycojaponicumin Natural products 0.000 title abstract description 6
- 150000001875 compounds Chemical class 0.000 claims description 16
- 208000019065 cervical carcinoma Diseases 0.000 abstract description 10
- 230000012010 growth Effects 0.000 abstract description 7
- 101000963221 Homo sapiens mRNA guanylyltransferase Proteins 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 102100039604 mRNA guanylyltransferase Human genes 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 230000000118 anti-neoplastic effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (1)
- The application of 1.LycojaponicuminB in preparation treatment cervical cancer medicine, described compound L ycojaponicuminB structure as formula Ishown in:formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310442509.7A CN103479632B (en) | 2013-09-23 | 2013-09-23 | The application of Lycojaponicumin B in preparation treatment cervical cancer medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310442509.7A CN103479632B (en) | 2013-09-23 | 2013-09-23 | The application of Lycojaponicumin B in preparation treatment cervical cancer medicine |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103479632A CN103479632A (en) | 2014-01-01 |
CN103479632B true CN103479632B (en) | 2015-12-23 |
Family
ID=49820455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310442509.7A Active CN103479632B (en) | 2013-09-23 | 2013-09-23 | The application of Lycojaponicumin B in preparation treatment cervical cancer medicine |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103479632B (en) |
-
2013
- 2013-09-23 CN CN201310442509.7A patent/CN103479632B/en active Active
Non-Patent Citations (1)
Title |
---|
"Lycojaponicumin A-C,Three Alkaloids with an Unprecedented Skeleton from Lycopodium japonicum";Xiao-Jing Wang,et al.;《Organic Letters》;20120508;第14卷(第10期);第2614-2617页 * |
Also Published As
Publication number | Publication date |
---|---|
CN103479632A (en) | 2014-01-01 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Hongli Inventor before: Jiang Chunping Inventor before: Zhang Guang |
|
COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20151104 Address after: 325011, building 1112, building A, 209 Wenchang Road, hi tech Zone, Longwan District, Zhejiang, Wenzhou Applicant after: Wenzhou Chengqiao Technology Co.,Ltd. Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180928 Address after: 529339 4-1, table Hai Industrial Zone, Sha Tang Town, Kaiping, Guangdong Patentee after: Huang Xuemei Address before: 325011 room 1112, building A, 209 Wenchang Road, hi tech Zone, Longwan District, Wenzhou, Zhejiang. Patentee before: Wenzhou Chengqiao Technology Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20181107 Address after: 529300 Industrial Development Zone, Sha Tang Town, Kaiping, Guangdong Patentee after: Guangdong Bio Pharmaceutical Co., Ltd. Address before: 529339 4-1, table Hai Industrial Zone, Sha Tang Town, Kaiping, Guangdong Patentee before: Huang Xuemei |
|
TR01 | Transfer of patent right | ||
CP02 | Change in the address of a patent holder |
Address after: 529300 No. 4-1, Shatang Town, Kaiping, Jiangmen City, Guangdong Province Patentee after: Guangdong Bio Pharmaceutical Co., Ltd. Address before: 529300 Industrial Development Zone, Sha Tang Town, Kaiping, Guangdong Patentee before: Guangdong Bio Pharmaceutical Co., Ltd. |
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CP02 | Change in the address of a patent holder |