CN103463085B - Rapidly released fexofenadine pills and preparation method thereof - Google Patents
Rapidly released fexofenadine pills and preparation method thereof Download PDFInfo
- Publication number
- CN103463085B CN103463085B CN201310432636.9A CN201310432636A CN103463085B CN 103463085 B CN103463085 B CN 103463085B CN 201310432636 A CN201310432636 A CN 201310432636A CN 103463085 B CN103463085 B CN 103463085B
- Authority
- CN
- China
- Prior art keywords
- fexofenadine
- suspension
- parts
- piller
- pills
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses rapidly released fexofenadine pills and a preparation method thereof. The rapidly released fexofenadine pills take water as a solvent, are high in concentration of effective drugs, are simple in process, have an environment-friendly effect, are suitable for industrial production, can be applied fast, stably and efficiently and allow fexofenadine to be rapidly released in a human body. According to the technical essentials disclosed by the invention, the pills are prepared by covering a fexofenadine mixed suspension solution on the surfaces of pseudo ephedrine sustained-release pellets, wherein each 100ml of fexofenadine mixed suspension solution contains 5.0g-35.0g of fexofenadine; the preparation process comprises the following steps: adding a disintegrating agent and a bonding agent into purified water; then adding the fexofenadine; when the mixed suspension solution starts to become sticky, stopping adding the fexofenadine, and adding an anti-sticking agent; repeating the operations until the fexofenadine and the anti-sticking agent of the prescribed doses are added; then treating the mixed suspension solution by a colloid mill; placing the pseudo ephedrine sustained-release pellets into a multifunctional coating machine and spraying the fexofenadine mixed suspension solution; and drying and sieving to obtain the rapidly released fexofenadine pills. The rapidly-released fexofenadine pills and the preparation method thereof belong to the technical field of medicines.
Description
Technical field
The invention discloses a kind of fexofenadine piller and preparation method thereof, specifically, be fexofenadine piller of a kind of quick release and preparation method thereof, belong to medical art.
Background technology
Fexofenadine is the active metabolite of antihistamine drug terfenadine in human body, and selectively acting, in periphery H1-receptor, uses its hydrochlorate usually.There is good effect, onset rapidly, unify outside cardiovascular response, safety height without central nervous system, the illness such as seasonal allergic rhinitis, skin allergy, urticaria and allergic asthma can be treated, and above-mentioned patient accounts for 10 ~ 25% of whole world total population, fexofenadine becomes the medicine in the situation of selling well world.
The administering mode normally oral administration of fexofenadine, have and absorb rapidly, about 1 ~ 3 hour blood drug level peaking after single oral dose, after oral 60mg, 120mg and 180mg, drug serum peak concentration Cmax is respectively 142mg/ml, 427mg/ml, 494mg/ml.Fexofenadine protein binding rate is about 60 ~ 70%, and the elimination half-life is about 14.4 hours.Therefore, current fexofenadine makes quick releasing formulation usually.In preparation process, generally adopt and add raw material in two ways: one be raw material as addition, outer addition or inside and outside addition in solid, another kind is wiring solution-forming, to add medicine to method with solution.But fexofenadine hydrochloride is white crystalline powder, be soluble in methanol (1g ︰ 0.95 ~ 0.96ml), be dissolved in ethanol (1g ︰ 13 ~ 15ml), be dissolved in acetone (1g more than ︰ 10000ml) hardly, soluble,very slightly is in water (1g ︰ 600 ~ 700ml).If make solvent with water, suspension can only be made into.
Chinese patent CN101316580A discloses a kind of preparation method of fexofenadine suspension, this patent adopts buffer system to regulate the aqueous suspension of pH4.25 ~ 9.4, calculate with weight/volume (g/100mL), it comprises the fexofenadine amphoteric ion type dihydrate form of about 0.03% to about 4.80%.
Chinese patent CN101822646A discloses a kind of fexofenadine hydrochloride orally disintegrating tablet and preparation method thereof, and its principal agent fexofenadine dissolves completely with ethanol, finally makes tablet; Chinese patent CN101500542A discloses the controlled release preparation showing basic zero-order release kinetics, and its principal agent fexofenadine carries out spray coating with isopropyl alcohol as after solvent preparation.Above-mentioned two patents all employ organic solvent preparation fexofenadine, and its manufacture process not only not environmentally but also there is certain danger.And organic solvent preparation fexofenadine solution, easily cause the abnormal increase of the relative substance of fexofenadine, add the side effect of medicine, reduce the safety of medication.
Chinese patent CN102512389A discloses a kind of fexofenadine hydrochloride Orally disintegrating pharmaceutical composition, and its principal agent fexofenadine polyvidone, purified water are prepared; Chinese patent CN101919853A discloses pharmaceutical composition, Its Preparation Method And Use, and its principal agent fexofenadine hypromellose, purified water are prepared; The fexofenadine of above-mentioned two patents all only employs conventional binding agent, and do not have disintegrating agent in prescription, its principal agent Fexofenadine is difficult to quick release.Further, these two patents all do not disclose the preparation method of fexofenadine suspension.In fact, the phenomenon that the preparation process of fexofenadine suspension has one " to solidify instantaneously ": slowly add fexofenadine in the purified water under stirring, when the concentration adding fexofenadine to about 5% time, suspension can solidify instantaneously, remaining operation can not be carried out again, bring very large puzzlement to subsequent production.
The effective dose of the routine of fexofenadine is: 60mg, 120mg, 180mg.Piller generally adopts solution or suspension to add medicine to.If the concentration of fexofenadine suspension is too low, the amount (weight) of fexofenadine suspension will very large, and the operating process of the piller medicine-feeding of whole fexofenadine just becomes very very long, unfavorable suitability for industrialized production.Therefore, concentration being significant in suitability for industrialized production of fexofenadine suspension is improved.
Summary of the invention
For the problems referred to above, the object of the present invention is to provide fexofenadine piller of a kind of quick release and preparation method thereof, the method uses water as solvent, and active drug concentration is high, and technique is simple, and environmental protection, is suitable for suitability for industrialized production; And the piller of fexofenadine can be made to add medicine to fast, stable, medicine-feeding rate is high, Fexofenadine fixes in human body and can discharge fast.
For solving the problems of the technologies described above, last technical scheme provided by the invention is such: this fexofenadine piller discharged fast is that pseudoephedrine slow-release micro-pill surface parcel fexofenadine suspension is made, and the described every 100ml of fexofenadine suspension is containing fexofenadine 5.0 ~ 35.0g.
The fexofenadine piller of above-mentioned quick release, in described fexofenadine piller, the mass ratio of pseudoephedrine slow-release micro-pill and fexofenadine suspension is 1 ︰ 0.6 ~ 4.2.
The fexofenadine piller of above-mentioned quick release, described fexofenadine suspension is made up of the raw material of following weight parts: fexofenadine 26 ~ 182 parts, binding agent 1 ~ 10 part, disintegrating agent 4 ~ 30 parts, antiplastering aid 2 ~ 20 parts, 300 ~ 960 parts, water.
Further, the fexofenadine piller of above-mentioned quick release, described fexofenadine suspension is made up of the raw material of following weight parts: fexofenadine 100 parts, hypromellose 8 parts, pregelatinized Starch 20 parts, Pulvis Talci 10 parts, 500 parts, water.
Present invention also offers the preparation method of the fexofenadine piller that this discharges fast, the method comprises the steps: successively
1) suspension is prepared
Take the purified water of 300 ~ 960 weight portions, the disintegrating agent of 4 ~ 30 weight portions is added under stirring, 1 ~ 10 parts by weight of binder, part fexofenadine is slowly added after stirring, when suspension starts retrogradation time, stop adding fexofenadine, add antiplastering aid, continue stirring until suspension thinning, slowly add fexofenadine again, when suspension starts retrogradation time, stop adding fexofenadine, again add antiplastering aid, continue stirring until suspension thinning, repeat aforesaid operations until add to fexofenadine total amount 26 ~ 182 parts, antiplastering aid total amount 2 ~ 20 parts, again with milling treatment of colloid uniformly suspension,
2) fexofenadine release pills is prepared:
Type B error ephedrine slow-release micro-pill 100 weight portion is put in Multifunctional coating machine, regulate suitable parameter, blower fan frequency is 22.00 ~ 45.00Hz, and inlet temperature is 40.0 ~ 60.0 DEG C, and temperature of charge is 35.0 ~ 58.0 DEG C, spouting velocity 80 ~ 150rpm, atomizing pressure 2.00 ~ 3.20bar, sprays into 60 ~ 420 weight portion fexofenadine suspensions, dry, sieve, to obtain final product.
1) preparation method of the fexofenadine piller of above-mentioned quick release, described suspension mixing speed of preparing is 300 ~ 3000rpm.
Further, the preparation method of the fexofenadine piller of above-mentioned quick release, described binding agent is one of them or combination in any of hyprolose, hypromellose, copolyvidone, starch, dextrin; Described antiplastering aid is magnesium stearate, calcium stearate, talcous one of them or combination in any; Described disintegrating agent is one of them or combination in any of carboxymethyl starch sodium, pregelatinized Starch, polyvinylpolypyrrolidone, crosslinked carboxymethyl fecula sodium, cross-linked carboxymethyl fiber sodium, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose.
Compared with prior art, technical scheme tool provided by the invention has the following advantages:
1) this method uses water as solvent, safety, environmental protection;
2) this method uses water as solvent, can not cause the abnormal increase of the relative substance of fexofenadine, decrease the side effect of medicine, improve the safety of medication;
3) the suspension concentration 5.0% ~ 35.0% of this method, suspension concentration about 0.03% ~ about 4.80% in prior art, makes the piller time of adding medicine to obviously shorten, improves production efficiency; Technique is simple, is suitable for industrialized great production;
4) this method can make the piller medicine-feeding of fexofenadine quick, stable, can discharge fast in human body.
Accompanying drawing explanation
The stripping curve of Fig. 1: 6.8pH medium fexofenadine;
Fig. 2: the stripping curve of aqueous medium fexofenadine;
Fig. 3; The stripping curve of 3.0pH medium fexofenadine.
Detailed description of the invention
Below in conjunction with detailed description of the invention; claim of the present invention is described in further detail; but do not form any limitation of the invention, the amendment of any limited number of time made within the scope of the claims in the present invention, still within claims of the present invention.
Embodiment 1
The fexofenadine piller of a kind of quick release provided by the invention, pseudoephedrine slow-release micro-pill surface parcel fexofenadine suspension is made, and its fexofenadine suspension prescription is: fexofenadine 100g, hypromellose 8g, pregelatinized Starch 20g, Pulvis Talci 10g, water 500g.
Its preparation method comprises the steps: successively
1) fexofenadine suspension is prepared
Take 500g purified water, 8g hypromellose is added under stirring, 20g pregelatinized Starch, slowly fexofenadine is added after stirring (800rpm) evenly, when suspension starts retrogradation, stop adding fexofenadine, add appropriate Pulvis Talci, Keep agitation (800rpm) is thinning to suspension, slowly add fexofenadine again, when suspension starts retrogradation, stop fexofenadine, the Pulvis Talci of addition, Keep agitation (800rpm) is thinning to suspension, repeat aforesaid operations, until add the fexofenadine (100g) of recipe quantity, Pulvis Talci (10g), again with milling treatment of colloid uniformly suspension, obtain, measure suspension granularity as follows:
| Particle size distribution | Granularity (μm) |
| D10(lower limit particle size) | 4.73 |
| D50(mean diameter) | 13.97 |
| D97(upper limit particle size) | 35.03 |
2) fexofenadine release pills is prepared:
Type B error ephedrine slow-release micro-pill 255g puts in Multifunctional coating machine, regulate suitable parameter, blower fan frequency is 22.00 ~ 45.00Hz, and inlet temperature is 40.0 ~ 60.0 DEG C, and temperature of charge is 35.0 ~ 58.0 DEG C, spouting velocity 80 ~ 150rpm, atomizing pressure 2.00 ~ 3.20bar, sprays into above-mentioned fexofenadine suspension, dry, cross 16 mesh sieves, to obtain final product.
Embodiment 2
The fexofenadine piller of a kind of quick release provided by the invention, pseudoephedrine slow-release micro-pill surface parcel fexofenadine suspension is formed, and its fexofenadine suspension prescription is: fexofenadine 60g, hyprolose 3g, carboxymethyl starch sodium 6g, magnesium stearate 2g, water 409g.
Preparation method comprises the steps: successively
1) fexofenadine suspension is prepared
Take 409g purified water, 3g hyprolose is added under stirring, 6g carboxymethyl starch sodium, slowly fexofenadine is added after stirring (1200rpm) evenly, when suspension starts retrogradation, stop adding fexofenadine, add appropriate magnesium stearate, Keep agitation (1200rpm) is thinning to suspension, slowly add fexofenadine again, when suspension starts retrogradation, stop fexofenadine, add appropriate magnesium stearate, Keep agitation (1200rpm) is thinning to suspension, repeat aforesaid operations, until add the fexofenadine (60g) of recipe quantity, magnesium stearate (2g), again with milling treatment of colloid uniformly suspension, obtain, measure suspension granularity as follows:
| Particle size distribution | Granularity (μm) |
| D10(lower limit particle size) | 4.92 |
| D50(mean diameter) | 14.07 |
| D97(upper limit particle size) | 36.13 |
2) fexofenadine release pills is prepared:
Type B error ephedrine slow-release micro-pill 240g puts in Multifunctional coating machine, regulate suitable parameter, blower fan frequency is 22.00 ~ 45.00Hz, and inlet temperature is 40.0 ~ 60.0 DEG C, and temperature of charge is 35.0 ~ 58.0 DEG C, spouting velocity 80 ~ 150rpm, atomizing pressure 2.00 ~ 3.20bar, sprays into above-mentioned fexofenadine suspension, dry, cross 18 mesh sieves, to obtain final product.
Embodiment 3
The fexofenadine piller that another kind provided by the invention discharges fast, pseudoephedrine slow-release micro-pill surface parcel fexofenadine suspension is formed, and its fexofenadine suspension prescription is: fexofenadine 120g, copolyvidone 6g, microcrystalline Cellulose 10g, calcium stearate 4g, water 360g.
Preparation method comprises the steps: successively
1) fexofenadine suspension is prepared
Take 360g purified water, 6g copolyvidone is added under stirring, 10g microcrystalline Cellulose, slowly fexofenadine is added after stirring (1500rpm) evenly, when suspension starts retrogradation, stop adding fexofenadine, add appropriate calcium stearate, Keep agitation (1500rpm) is thinning to suspension, slowly add fexofenadine again, when suspension starts retrogradation, stop fexofenadine, add appropriate calcium stearate, Keep agitation (1500rpm) is thinning to suspension, repeat aforesaid operations, until add the fexofenadine (120g) of recipe quantity, calcium stearate (4g), again with milling treatment of colloid uniformly suspension, obtain, measure suspension granularity as follows:
| Particle size distribution | Granularity (μm) |
| D10(lower limit particle size) | 4.73 |
| D50(mean diameter) | 13.97 |
| D97(upper limit particle size) | 35.03 |
2) fexofenadine release pills is prepared:
Type B error ephedrine slow-release micro-pill 333g puts in Multifunctional coating machine, regulate suitable parameter, blower fan frequency is 22.00 ~ 45.00Hz, and inlet temperature is 40.0 ~ 60.0 DEG C, and temperature of charge is 35.0 ~ 58.0 DEG C, spouting velocity 80 ~ 150rpm, atomizing pressure 2.00 ~ 3.20bar, sprays into above-mentioned fexofenadine suspension, dry, cross 14 mesh sieves, to obtain final product.
Embodiment 4
The fexofenadine piller that another kind provided by the invention discharges fast, pseudoephedrine slow-release micro-pill surface parcel fexofenadine suspension is formed, and its fexofenadine suspension prescription is: fexofenadine 180g, dextrin 12g, pregelatinized Starch 18g, Pulvis Talci 9g, water 295g.
Preparation method comprises the steps: successively
1) fexofenadine suspension is prepared
Take 295g purified water, 12g dextrin is added under stirring, 18g pregelatinized Starch, slowly fexofenadine is added after stirring (2000rpm) evenly, when suspension starts retrogradation, stop adding fexofenadine, add appropriate Pulvis Talci, Keep agitation (2000rpm) is thinning to suspension, slowly add fexofenadine again, when suspension starts retrogradation, stop fexofenadine, add appropriate Pulvis Talci, Keep agitation (2000rpm) is thinning to suspension, repeat aforesaid operations, until add the fexofenadine (180g) of recipe quantity, Pulvis Talci (9g), again with milling treatment of colloid uniformly suspension, obtain, measure suspension granularity as follows:
| Particle size distribution | Granularity (μm) |
| D10(lower limit particle size) | 4.73 |
| D50(mean diameter) | 13.97 |
| D97(upper limit particle size) | 35.03 |
2) fexofenadine release pills is prepared:
Type B error ephedrine slow-release micro-pill 563g puts in Multifunctional coating machine, regulate suitable parameter, blower fan frequency is 22.00 ~ 45.00Hz, and inlet temperature is 40.0 ~ 60.0 DEG C, and temperature of charge is 35.0 ~ 58.0 DEG C, spouting velocity 80 ~ 150rpm, atomizing pressure 2.00 ~ 3.20bar, sprays into above-mentioned fexofenadine suspension, dry, cross 16 mesh sieves, to obtain final product.
In order to effect of the present invention is better described, provide fexofenadine medicine-feeding rate situation testing result in the various embodiments described above below, in table 1; Fexofenadine release pills stripping situation, the accompanying drawings (stripping curve of Fig. 1, pH6.8 medium fexofenadine; Fig. 2, the stripping curve of aqueous medium fexofenadine; The stripping curve of Fig. 3, pH3.0 medium fexofenadine); Acceleration for stabilization implementations (placing condition: temperature 40 DEG C, humidity 75% ± 10%), consults table 2; Use the change of the relative substance of different solvent fexofenadine suspensions, consult table 3.
Table 1 fexofenadine medicine-feeding yield
| Embodiment | Medicine-feeding yield (%) |
| Embodiment 1 | 96.6 |
| Embodiment 2 | 97.8 |
| Embodiment 3 | 96.0 |
| Embodiment 4 | 97.2 |
Table 2 fexofenadine release pills accelerated test result
Table 3 fexofenadine release pills influence factor result of the test
Claims (6)
1. the fexofenadine piller discharged fast, it is characterized in that, this fexofenadine piller is that pseudoephedrine slow-release micro-pill surface parcel fexofenadine suspension is made, in described fexofenadine piller, the mass ratio of pseudoephedrine slow-release micro-pill and fexofenadine suspension is 1 ︰ 0.6 ~ 4.2, and the described every 100ml of fexofenadine suspension is containing fexofenadine 5.0 ~ 35.0g; Described fexofenadine suspension is made up of the raw material of following weight parts: fexofenadine 26 ~ 182 parts, binding agent 1 ~ 10 part, disintegrating agent 4 ~ 30 parts, antiplastering aid 2 ~ 20 parts, 300 ~ 960 parts, water; The preparation method of described fexofenadine piller comprises:
1) suspension is prepared
Take the purified water of 300 ~ 960 weight portions, the disintegrating agent of 4 ~ 30 weight portions is added under stirring, 1 ~ 10 parts by weight of binder, part fexofenadine is slowly added after stirring, when suspension starts retrogradation time, stop adding fexofenadine, add antiplastering aid, continue stirring until suspension thinning, slowly add fexofenadine again, when suspension starts retrogradation time, stop adding fexofenadine, again add antiplastering aid, continue stirring until suspension thinning, repeat aforesaid operations until add to fexofenadine total amount 26 ~ 182 parts, antiplastering aid total amount 2 ~ 20 parts, again with milling treatment of colloid uniformly suspension,
2) fexofenadine release pills is prepared:
Type B error ephedrine slow-release micro-pill 100 weight portion is put in multi-functional granulating coated machine, regulating parameter, blower fan frequency is 22.00 ~ 45.00Hz, and inlet temperature is 40.0 ~ 60.0 DEG C, temperature of charge 35.0 ~ 58.0 DEG C, spouting velocity 80 ~ 150rpm, atomizing pressure 2.00 ~ 3.20bar, sprays into 60 ~ 420 weight portion fexofenadine suspensions, dry, sieve, to obtain final product.
2. the fexofenadine piller of quick release according to claim 1, is characterized in that, described fexofenadine suspension is made up of the raw material of following weight parts: fexofenadine 100 parts, hypromellose 8 parts, pregelatinized Starch 20 parts, Pulvis Talci 10 parts, 500 parts, water.
3. the fexofenadine piller of quick release according to claim 1, is characterized in that, the described mixing speed preparing suspension is 300 ~ 3000rpm.
4. the fexofenadine piller of quick release according to claim 1, is characterized in that, described binding agent is one of them or combination in any of hyprolose, hypromellose, copolyvidone, starch, dextrin.
5. the fexofenadine piller of quick release according to claim 1, is characterized in that, described antiplastering aid is magnesium stearate, calcium stearate, talcous one of them or combination in any.
6. the fexofenadine piller of quick release according to claim 1, it is characterized in that, described disintegrating agent is one of them or combination in any of carboxymethyl starch sodium, pregelatinized Starch, polyvinylpolypyrrolidone, crosslinked carboxymethyl fecula sodium, cross-linked carboxymethyl fiber sodium, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310432636.9A CN103463085B (en) | 2013-09-22 | 2013-09-22 | Rapidly released fexofenadine pills and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310432636.9A CN103463085B (en) | 2013-09-22 | 2013-09-22 | Rapidly released fexofenadine pills and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103463085A CN103463085A (en) | 2013-12-25 |
| CN103463085B true CN103463085B (en) | 2015-04-15 |
Family
ID=49788281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310432636.9A Active CN103463085B (en) | 2013-09-22 | 2013-09-22 | Rapidly released fexofenadine pills and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103463085B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6286096B1 (en) * | 2017-08-01 | 2018-02-28 | ロート製薬株式会社 | Pharmaceutical tablets |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813730A (en) * | 2005-11-22 | 2006-08-09 | 陈茜 | Fexofenadine hydrochloride dropping pill and its preparing method |
| CN101500542A (en) * | 2006-07-11 | 2009-08-05 | 共有药物有限公司 | Controlled-release formulations |
| CN101919853A (en) * | 2009-06-12 | 2010-12-22 | 广东环球制药有限公司 | Pharmaceutical composition, preparation method and application thereof |
| CN102512389A (en) * | 2011-12-27 | 2012-06-27 | 天津市嵩锐医药科技有限公司 | Fexofenadine hydrochloride oral disintegrating drug composition |
-
2013
- 2013-09-22 CN CN201310432636.9A patent/CN103463085B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813730A (en) * | 2005-11-22 | 2006-08-09 | 陈茜 | Fexofenadine hydrochloride dropping pill and its preparing method |
| CN101500542A (en) * | 2006-07-11 | 2009-08-05 | 共有药物有限公司 | Controlled-release formulations |
| CN101919853A (en) * | 2009-06-12 | 2010-12-22 | 广东环球制药有限公司 | Pharmaceutical composition, preparation method and application thereof |
| CN102512389A (en) * | 2011-12-27 | 2012-06-27 | 天津市嵩锐医药科技有限公司 | Fexofenadine hydrochloride oral disintegrating drug composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103463085A (en) | 2013-12-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6558704B1 (en) | Process for preparing pellets containing up to 90 wt.% of a pharmaceutical active ingredient | |
| CN107595795A (en) | A kind of Metoprolol succinate sustained-release tablets and preparation method thereof | |
| JP2008007458A (en) | Core particle for layering and method for producing the same | |
| CN103083319B (en) | Preparation process of compound valsartan amlodipine solid preparation | |
| CN111150714A (en) | Dabigatran etexilate mesylate solid pharmaceutical preparation and preparation method thereof | |
| CN103610650A (en) | Isosorbide mononitrate sustained-release pallets, preparation prepared from same and preparation method for isosorbide mononitrate sustained-release pallets | |
| CN104473905A (en) | Trimetazidine hydrochloride sustained-release capsule and preparation method thereof | |
| CN106890161A (en) | A kind of levetiracetam slow release capsule and preparation method thereof | |
| CN103463085B (en) | Rapidly released fexofenadine pills and preparation method thereof | |
| KR20140121478A (en) | Hydrocortisone controlled release formulation | |
| CN107412198A (en) | Duloxetine hydrochloride enteric slow release granule and preparation method thereof | |
| CN109925296B (en) | Coating method of traditional Chinese medicine pellets | |
| CN107412199B (en) | Memantine hydrochloride sustained-release capsule composition | |
| CN106265548A (en) | A kind of preparation method of carbamazepine dispersible tablet | |
| CN106806353B (en) | Iguratimod sustained-release capsule and preparation method thereof | |
| CN109481468A (en) | A kind of preparation method of paracetamol caffein atificial cow-bezoar pellet | |
| CN109200032A (en) | High drug load venlafaxine hydrochloride sustained-release pellet composition and spansule and preparation method | |
| CN101099762A (en) | Blood pressue lowering sustained-release preparation with chrysanthemum flower and pearl | |
| CN113262206A (en) | Preparation process of nifedipine preparation | |
| CN104274444B (en) | Oral double pellet pharmaceutical compositions of dabigatran etcxilate or its salt | |
| CN106983752B (en) | Preparation method of valsartan and hydrochlorothiazide capsules | |
| US20110280939A1 (en) | Oral particle including pseudoephedrine hydrochloride and cetirizine dihydrochloride | |
| CN111374953A (en) | Paracetamol tablet and preparation process thereof | |
| CN103893151A (en) | Venlafaxine hydrochloride sustained release capsule and preparation method thereof | |
| CN107260708A (en) | A kind of dual-release preparation of Betahistine or its salt and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: Three road 528300 Guangdong city of Foshan province Shunde Ronggui high tech Park Keyuan cross No. 2 Patentee after: SINOPHARM GUANGDONG GLOBAL PHARMACEUTICAL CO., LTD. Address before: Three road 528300 in Guangdong province Foshan city Shunde District of Ronggui high tech Park Keyuan cross No. 2 Patentee before: Huanqiu Pharmaceutical Co., Ltd., Guangdong |