CN103463077A - Application of Lycojaponicumin C in medicine for promoting insulin secretion - Google Patents
Application of Lycojaponicumin C in medicine for promoting insulin secretion Download PDFInfo
- Publication number
- CN103463077A CN103463077A CN2013104372210A CN201310437221A CN103463077A CN 103463077 A CN103463077 A CN 103463077A CN 2013104372210 A CN2013104372210 A CN 2013104372210A CN 201310437221 A CN201310437221 A CN 201310437221A CN 103463077 A CN103463077 A CN 103463077A
- Authority
- CN
- China
- Prior art keywords
- lycojaponicumin
- insulin secretion
- application
- medicine
- promoting insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UULHZQYEEKIMDO-CLROSIBMSA-N lycojaponicumin C Natural products CN1CCC[C@@]23[C@@H]1CC[C@]24[C@@H](CC3=O)C(=CCC4=O)C UULHZQYEEKIMDO-CLROSIBMSA-N 0.000 title abstract description 31
- 230000003914 insulin secretion Effects 0.000 title abstract description 9
- 239000003814 drug Substances 0.000 title abstract description 4
- 230000001737 promoting effect Effects 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 17
- 102000004877 Insulin Human genes 0.000 claims description 8
- 108090001061 Insulin Proteins 0.000 claims description 8
- 229940125396 insulin Drugs 0.000 claims description 8
- 230000003248 secreting effect Effects 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 229930185194 lycojaponicumin Natural products 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract description 4
- 230000002265 prevention Effects 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 description 5
- 210000004153 islets of langerhan Anatomy 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 230000003833 cell viability Effects 0.000 description 3
- 241000927897 Lycopodium japonicum Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000012528 insulin ELISA Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310437221.0A CN103463077B (en) | 2013-09-23 | 2013-09-23 | The application of Lycojaponicumin C in preparation insulinotropic hormone excretion |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310437221.0A CN103463077B (en) | 2013-09-23 | 2013-09-23 | The application of Lycojaponicumin C in preparation insulinotropic hormone excretion |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103463077A true CN103463077A (en) | 2013-12-25 |
CN103463077B CN103463077B (en) | 2015-11-25 |
Family
ID=49788275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310437221.0A Active CN103463077B (en) | 2013-09-23 | 2013-09-23 | The application of Lycojaponicumin C in preparation insulinotropic hormone excretion |
Country Status (1)
Country | Link |
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CN (1) | CN103463077B (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (en) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | Clavatine A-C and preparation method as well as pharmaceutical composition and application thereof |
-
2013
- 2013-09-23 CN CN201310437221.0A patent/CN103463077B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (en) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | Clavatine A-C and preparation method as well as pharmaceutical composition and application thereof |
Non-Patent Citations (1)
Title |
---|
WANG XIAOJING ETC: ""Nine new lycopodine-type alkaloids from Lycopodium japonicum"", 《TETRAHEDRON》, vol. 69, 13 May 2013 (2013-05-13) * |
Also Published As
Publication number | Publication date |
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CN103463077B (en) | 2015-11-25 |
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TA01 | Transfer of patent application right |
Effective date of registration: 20151029 Address after: 266000 Licang, Qingdao, No. nine East water road, No. 320, No. Applicant after: Gu Xiangmao Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing guangkangxie Biomedical Technology Co.,Ltd. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Yang Xingli Inventor after: Chen Shumei Inventor after: Xing Jinshuai Inventor before: Wu Junhua Inventor before: Wang Hui |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170322 Address after: 071000 Baoding City, north of Hebei city military science Hutong No. 1, building 1, unit 503, No. 59 Patentee after: Yang Xingli Patentee after: Chen Shumei Patentee after: Xing Jinshuai Address before: 266000 Licang, Qingdao, No. nine East water road, No. 320, No. Patentee before: Gu Xiangmao |
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Effective date of registration: 20180301 Address after: Haimen City Jiangsu city of Nantong province is more than 226153 Zhenan Bridge Village nine Group No. 101 Patentee after: Haimen Chuanghao Industrial Design Co.,Ltd. Address before: 071000 Baoding City, north of Hebei city military science Hutong No. 1, building 1, unit 503, No. 59 Co-patentee before: Chen Shumei Patentee before: Yang Xingli Co-patentee before: Xing Jinshuai |
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Effective date of registration: 20230915 Address after: 550300 Hongjun Road, Neighborhood Committee, Longgang Town, Kaiyang County, Guiyang City, Guizhou Province Patentee after: Yang Yingxi Patentee after: Wan Yun Patentee after: Wang Mei Address before: No. 101, group 9, anqiao village, Zhengyu Town, Haimen City, Nantong City, Jiangsu Province, 226153 Patentee before: Haimen Chuanghao Industrial Design Co.,Ltd. |