CN103463053A - Lycojaponicumin A在治疗肝癌药物中的应用 - Google Patents
Lycojaponicumin A在治疗肝癌药物中的应用 Download PDFInfo
- Publication number
- CN103463053A CN103463053A CN2013104368145A CN201310436814A CN103463053A CN 103463053 A CN103463053 A CN 103463053A CN 2013104368145 A CN2013104368145 A CN 2013104368145A CN 201310436814 A CN201310436814 A CN 201310436814A CN 103463053 A CN103463053 A CN 103463053A
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- CN
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- Prior art keywords
- lycojaponicumin
- drugs
- application
- liver cancer
- treating liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 title claims abstract description 17
- WGVQKABRYXBLGW-WUZBVLBZSA-N (1R,2S,5S,7S,10S,13S)-7-hydroxy-7-methyl-17-oxa-14-azapentacyclo[12.2.1.02,10.02,13.05,10]heptadecane-3,9-dione Chemical compound O=C([C@@]12CC3)C[C@@](C)(O)C[C@H]1CC(=O)[C@@]12[C@H]3N2CC[C@H]1O2 WGVQKABRYXBLGW-WUZBVLBZSA-N 0.000 title abstract description 19
- 229940079593 drug Drugs 0.000 title abstract description 13
- 201000007270 liver cancer Diseases 0.000 title abstract description 8
- 208000014018 liver neoplasm Diseases 0.000 title abstract description 8
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims description 16
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- 229930185194 lycojaponicumin Natural products 0.000 claims description 3
- 230000012010 growth Effects 0.000 abstract description 7
- 238000002360 preparation method Methods 0.000 abstract description 7
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 201000009030 Carcinoma Diseases 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000002841 anti-cancer assay Methods 0.000 abstract 1
- 230000001644 anti-hepatocarcinoma Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 241000927897 Lycopodium japonicum Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310436814.5A CN103463053B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗肝癌药物中的应用 |
Applications Claiming Priority (1)
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CN201310436814.5A CN103463053B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗肝癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103463053A true CN103463053A (zh) | 2013-12-25 |
CN103463053B CN103463053B (zh) | 2015-12-02 |
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CN201310436814.5A Active CN103463053B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗肝癌药物中的应用 |
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CN (1) | CN103463053B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
-
2013
- 2013-09-23 CN CN201310436814.5A patent/CN103463053B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
Non-Patent Citations (1)
Title |
---|
XIAO-JING WANG,ETC: "Lycojaponicumins A C, Three Alkaloids", 《ORGANIC LETTERS》, vol. 14, no. 10, 31 December 2012 (2012-12-31), pages 2614 - 2617, XP055066237, DOI: 10.1021/ol3009478 * |
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Publication number | Publication date |
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CN103463053B (zh) | 2015-12-02 |
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C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Hongli Inventor before: Jiang Chunping Inventor before: Wang Zezheng |
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Effective date of registration: 20151103 Address after: 325011, building 1112, building A, 209 Wenchang Road, hi tech Zone, Longwan District, Zhejiang, Wenzhou Applicant after: Wenzhou Chengqiao Technology Co.,Ltd. Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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Effective date of registration: 20190329 Address after: 233090 Zhongchuang Space A-43, 1st Floor, Chuangchuang Space, No. 8 Roadway 2595, Donghai Avenue, Bengbu City, Anhui Province Patentee after: Bengbu Yongyuan Electronic Technology Co., Ltd. Address before: 325011 room 1112, building A, 209 Wenchang Road, hi tech Zone, Longwan District, Wenzhou, Zhejiang. Patentee before: Wenzhou Chengqiao Technology Co.,Ltd. |
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Effective date of registration: 20191211 Address after: 233200 Jinshan Road Electronic Commerce Industrial Park, Jingkai District, Dingyuan County, Chuzhou City, Anhui Province Patentee after: Anhui Creative Technology Transfer Service Co.,Ltd. Address before: 233090 Zhongchuang Space A-43, 1st Floor, Chuangchuang Space, No. 8 Roadway 2595, Donghai Avenue, Bengbu City, Anhui Province Patentee before: Bengbu Yongyuan Electronic Technology Co., Ltd. |