CN103461362B - Sterilizing active ingredient composition - Google Patents
Sterilizing active ingredient composition Download PDFInfo
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- CN103461362B CN103461362B CN201310399722.4A CN201310399722A CN103461362B CN 103461362 B CN103461362 B CN 103461362B CN 201310399722 A CN201310399722 A CN 201310399722A CN 103461362 B CN103461362 B CN 103461362B
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Abstract
The invention relates to a sterilizing active ingredient composition, and particularly relates to the sterilizing active ingredient composition comprising prothioconazole and captan. The sterilizing active ingredient composition is characterized by comprising compounds prothioconazole and captan, and the weight ratio of the active compounds prothioconazole to captan is1:100-100:1. Due to binary compounding of the prothioconazole and captan, the prevention and therapy effects of the sterilizing active ingredient composition are improved, the bacteriocidal spectrum is enlarged, and the sterilizing active ingredient composition can be used for preventing and curing fungus and germ on frumentum, fruits, vegetables, and industrial crops.
Description
Technical field
What the present invention relates to is a kind of Bactericidal active ingredient composition, particularly relates to a kind of Bactericidal active ingredient composition containing prothioconazoles and captan.
Background technology
Fungicide be natural or synthesis source compound, its for the protection of plant not by the infringement that fungi causes.Current agricultural methods depend critically upon use fungicide.In fact, some crops can not grow effectively when not using fungicide.Use fungicide to allow the quality of grower's increase yield and crop, and increase the value of crop thus.In most cases, the value added that crop is worth is at least three times of the cost using fungicide.
But, do not have a kind of fungicide to be all useful in all cases, and reuse single fungicide and usually cause producing drug resistance to this kind or relevant fungicide.Therefore, researching and producing more safely, having the composition of the lower fungicide of better performance, the dosage that needs are lower, easy use and expense and fungicide.
Prothioconazoles (prothioconazole), its chemical name is: 2-[2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl]-2,4-dihydros-[1,2,4]-triazole-3-thioketones, its structural formula is:
Prothioconazoles is the triazole thioketone wide-spectrum bactericide that Beyer Co., Ltd develops.Its mechanism of action is the demethylation effect of precursor one by one on lanosterol or the liquor-saturated l4 position of 24-methylene dihydro Mi hair of sterol in Antifungi, i.e. demethylation inhibitors (DMIs).Not only there is good systemic activity, excellent protection, treat and root out activity, and the lasting period is long.By a large amount of field control effectiveness tests, result shows that prothioconazoles not only has good safety to crop, and preventing disease theraping effect is good, and volume increase obviously, and compare with triazole bactericidal agent, prothioconazoles has the bactericidal activity of more wide spectrum.
Prothioconazoles is mainly used in control cereal crop as numerous diseases such as wheat, barley, rape, peanut, paddy rice and legume crops.Almost there is good control efficiency, as the powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc. of Wheat and barley to all wheat class diseases.The soil-borne disease of rape and peanut can also be prevented and treated, as stalk break, and main foliage disease, as gray mold, black spot, brown spot, balck shank, stalk break and rust etc.Using dosage is generally 200g(a.i.)/hm
2, under this dosage, activity is better than or equals conventional sterilization agent as epoxiconazole, Tebuconazole, cyprodinil etc.
Prothioconazoles, and 2-[2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl]-2,4-dihydros-[1,2,4]-triazole-3-thioketones is known by WO96-16048.This compound can following formula " thioketones " form exist:
Or exist with the tautomerism of following formula " mercaptan " form:
For the sake of simplicity, " thioketones " form is only provided in each case.
Captan (captan), Chinese another name is called Gai Pudan, and its chemical name is: N-(trichloro-methylthio)-hexamethylene-4-alkene-1,2-dicarboximide; 1,2,3,6-tetrahydrochysene-N-(trichloro-methylthio) phthalimide, its structural formula is:
Captan is a kind of organic sulfur class broad spectrum activity low toxicity bactericide; based on protective effect, have certain therapeutic action concurrently, use safer; to many kinds of fungal diseases in various crop, all there is good preventive effect, be specially adapted to the crop to copper agent agricultural chemicals sensitivity.This medicine is permeable to the cell membrane of germ, and not only can disturb the respiratory of germ, but also can disturb its cell division, have multiple bactericidal action site, continuous several times uses extremely difficult induction germ to develop immunity to drugs, and sprays protection effect continuously more obvious.It mainly makes spray application, also can make seed treatment, dip product after results, and sowing is front or carry out soil treatment before planting.General use about 0.1% concentration liquid spraying, the downy mildew, powdery mildew, anthracnose, gray mold, early blight, late blight etc. of control fruit tree, vegetables, flowers and other economic crops etc.By the 0.3-0.5% process seed of seed weight, Cereal smut can be prevented and treated, disease in cotton seedling stage etc.
Because the present environmental requirement to bactericide and economic requirement continue to improve, such as to the requirement of activity profile, toxicity, selectivity, rate of application, residue composition and favourable preparation feasibility, in addition the problem of such as resistance aspect is also had, therefore, exploitation is better than the new bactericide of existing bactericide is in some aspects lasting task.
Summary of the invention
The object of the invention is to provide a kind of Bactericidal active ingredient composition for above-mentioned weak point, be to provide and there is improvement activity and the mixture of total amount of application reduction of reactive compound to harmful fungoid, that one has Synergistic mixture, to reduce rate of application and to improve the activity profile of known compound.
We find to use simultaneously, namely use together or use prothioconazoles and captan respectively, or it is better than the effect of using separately each compound to use the harmful fungoid preventive and therapeutic effect that prothioconazoles and captan provide successively.In other words, there is synergistic effect that is unpredictable, necessary being, and be not only active supplement.
When reactive compound is present in active compound combinations of the present invention with specific weight ratio, synergistic effect is obvious especially.But the weight ratio of the reactive compound in active compound combinations can change within the specific limits.
A kind of Bactericidal active ingredient composition of the present invention takes following technical scheme to realize:
A kind of Bactericidal active ingredient composition of the present invention, is characterized in that: comprise prothioconazoles and captan, wherein the weight proportion 1:100-100:1 of prothioconazoles and captan, preferred 1:50-50:1, more preferably 1:25-25:1, more preferably 1:10-10:1.
A kind of microbicide compositions, comprises the Bactericidal active ingredient composition of prothioconazoles and captan, filler and/or surfactant.
Described microbicide compositions formulation is suspending agent, seed coat agent, wetting powder, water dispersible granules, microcapsule suspending agent, coated granule, extrude granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet.
Described microbicide compositions, the content wherein containing the active ingredient compositions of prothioconazoles and captan accounts for the 5-90% of microbicide compositions.
Described microbicide compositions, the content wherein containing the active ingredient compositions of prothioconazoles and captan accounts for the 20-80% of microbicide compositions.
Prevent and treat a method for plant pathogen, Bactericidal active ingredient composition or microbicide compositions are acted on pathogenic bacteria and/or its environment, or in plant, plant parts, seed, soil, region, material or space.
Prevent and treat a method for plant pathogen, prothioconazoles and captan are used simultaneously or used respectively or sequential application.
Described Bactericidal active ingredient composition or microbicide compositions are for preventing and treating the purposes of fungus and bacterium.
Described Bactericidal active ingredient composition or microbicide compositions are for preventing and treating the purposes of fungus and bacterium on cereal, fruit, vegetables, economic crops.
Active compound combinations of the present invention has effective microbiocidal activity, and can for preventing and treating undesired microorganism in crop protection or material protection, as fungus and bacterium.
Active compound combinations of the present invention has extraordinary fungicide performance, and can be used to prevent and treat phytopathogenic fungi, described fungi is especially selected from Ascomycetes (Ascomycetes), Basidiomycetes (Basidiomycetes), Phycomycetes (Phycomycetes) and deuteromycetes (Deuteromycetes) fungi.
Active compound combinations of the present invention has and extraordinaryly kills bacterium performance, and can be used to prevent and treat phytopathogenic bacteria.As pseudomonad (Psedomonadaceae), rhizobium (Rhizobiaceae), enterobacteria (Enterbacteriaceae), bar bacterium (Cornebacteriaceae) and streptomycete (Streptomycetaceae).
The pathogene that some being included into above-mentioned generic name following cause fungal disease and bacteriosis can be proposed as an example in a non-limiting manner:
Flavobacterium bacterial classification, such as paddy rice bacterial leaf spot yellow single (Xanthomonascampestrispv.oryzae);
Pseudomonas bacterial classification, such as Bacterial leaf spot cucumber pvs oryzae and oryzicola (Pseudomonas syringaepv.Lachrymans);
Erwinia bacterial classification, such as pears water epidemic disease Irving (family name) bacterium (Erwiniaamylovora);
Rotten mould (Pythium) bacterial classification, such as Pythium ultimum (Pythium ultimum);
Epidemic disease mould (Phytophthora) bacterial classification, such as phytophthora infestans (Phytophthorainfestans);
False downy mildew (Pseudoperonospora) bacterial classification, such as careless false downy mildew (Pseudoperonospora humuli) or Pseudoperonospora cubensis (Pseudoperonosporacubensis);
Axle downy mildew (Plasmopara) bacterial classification, raw axle downy mildew (Plasmoparaviticola) of such as grape;
Dish downy mildew (Bremia) bacterial classification, such as lettuce dish downy mildew (Bremia lactucae);
Downy mildew (Peronospora) bacterial classification, such as pea downy mildew (Peronospora pisi) or Cruciferae downy mildew (P.brassicae);
Powdery mildew (Erysiphe) bacterial classification, such as Erysiphe graminis (Erysiphe graminis);
Sphaerotheca (Sphaerotheca) bacterial classification, such as garden balsam list softgel shell (Sphaerothecafuliginea);
Podosphaera (Podosphaera) bacterial classification, such as white cross hair list softgel shell (Podosphaeraleucotricha);
Venturia (Venturia) bacterial classification, such as apple black star bacteria (Venturiainaequalis);
Nuclear cavity Pseudomonas (Pyrenophora) bacterial classification, such as round nuclear cavity bacteria (Pyrenophorateres) or wheat class nuclear cavity bacteria (P.graminea) (conidial form: Drechslera, Syn: Helminthosporium);
Cochliobolus belongs to (Cochliobolus) bacterial classification, such as standing grain cochliobolus (Cochliobolussativus) (conidial form: Drechslera, Syn: Helminthosporium);
Uromyces (Uromyces) bacterial classification, such as wart top uromyce (Uromycesappendiculatus);
Handle rest fungus (Puccinia) bacterial classification, such as Puccinia recondita (Puccinia recondita);
Sclerotinia (Sclerotinia) bacterial classification, such as Sclerotinia sclerotiorum (Sclerotiniasclerotiorum);
Tilletia (Tilletia) bacterial classification, such as Tilletia caries (Tilletiacaries);
Smut (Ustilago) bacterial classification, such as naked smut (Ustilago nuda) or oat smut (Ustilago avenae);
Film lead fungi belongs to (Pellicularia) bacterial classification, such as the wooden film lead fungi (Pelliculariasasakii) of assistant assistant; Pears spore (Pyricularia) bacterial classification, such as Magnaporthe grisea (Pyricularia oryzae);
Fusarium (Fusarium) bacterial classification, such as yellow sickle spore (Fusarium culmorum);
Botrytis (Botrytis) bacterial classification, such as Botrytis cinerea (Botrytis cinerea);
Septoria (Septoria) bacterial classification, such as clever withered septoria musiva (Septoria nodorum);
Leptosphaeria (Leptosphaeria) bacterial classification, such as Leptosphaeria nodorum;
Cercospora (Cercospora) bacterial classification, such as, turn grey tail spore (Cercosporacanescens);
Alternaria (Alternaria) bacterial classification, such as rape rod method (Alternariabrassicae);
False Cercosporalla (Pseudocercosporella) bacterial classification, such as wheat Phyllostachys pubescens (Pseudocercosporella herpotrichoides);
Phakopsora (Phakopsora) bacterial classification, such as Phakopsora pachyrhizi (Phakopsorapachyrhizi) and mountain horseleech layer rest fungus (Phakopsora meibomiae); And
Rhizoctonia (Rhizoctonia) bacterial classification, such as Rhizoctonia solani Kuhn (Rhizoctoniasolani).
Bactericidal active ingredient composition of the present invention also has fabulous excitation in plant corpus.Therefore, they are also applicable to adjust system of defense in vegeto-animal body to resist the invasion and attack of undesired microorganism.
In the present invention, plant excites (resistance is brought out), and compound should be understood to such material, and they can excite the system of defense of plant, thus, time after treated plant by undesired microbial inoculant, described plant performance goes out the significant resistance of mentioned microorganism.
In the present invention, undesired microorganism should be understood to phytopathogenic fungi and bacterium.Therefore, compound of the present invention can be used for after treatment certain period in protective plant resist the invasion and attack of described pathogene.Time of the protective effect obtained to be generally from plant is activated compound process continuity 1 to 10 day, preferably 1 to 7 day.
Bactericidal active ingredient composition of the present invention is even more important to preventing and treating a large amount of fungi in various crop is as cotton, vegetable variety (such as cucumber, beans, tomato, potato and cucurbitaceous plant), barley, dogstail, oat, banana, coffee, corn, fruit variety, rice, rye, soybean, grape vine, wheat, ornamental plants, sugarcane and various seed.
Bactericidal active ingredient composition of the present invention is particularly suitable for preventing and treating following plants pathogenic epiphyte: the standing grain powdery mildew (Blumeria graminis) (powdery mildew) in Cereal, two spore powdery mildews (Erysiphe cichoracearum) in cucurbitaceous plant and monofilament shell (Sphaerotheca fuliginea), apple mildew bacterium (Podosphaera leucotricha) in apple, grape snag shell (Uncinula necator) in grape vine, handle rest fungus (Puccinia) in Cereal belongs to, cotton, rhizoctonia (Rhizoctonia) in rice and lawn belongs to, smut (Ustilago) in Cereal and sugarcane belongs to, venturia inaequalis (Venturia inaequalis) (scab) in apple, the compacted spore of length in Cereal (Helminthosporium) belongs to, wheat glume blotch bacterium (Septoria nodorum) in wheat, strawberry, vegetables, Botrytis cinerea (Botrytis cinerea) (gray mold) in ornamental plants and grape vine, peanut tail spore (Cercospora arachidicola) in peanut, eye spot bacterium (Pseudocercosporella in Wheat and barley
Herpotrichoides), Pyricularia oryzae (Pyricularia oryzae) in rice, phytophthora infestans (Phytophthora infestans) in potato and tomato, grape single shaft in grape vine mould (Plasmopara viticola), false downy mildew (Pseudoperonospora) in lupulus and cucumber belongs to, and the rod method (Alternaria) in vegetables and fruit belongs to, ball chamber bacterium (Mycosphaerella) in banana belongs to and Neurospora
(Fusarium) and wheel branch spore (Verticillium) belong to.
Bactericidal active ingredient composition of the present invention has good plant tolerance under controlling plant diseases desired concn, and this just makes to process the acrial part of plant, in-vitro propagate strain (propagationstock), seed and soil.Bactericidal active ingredient composition of the present invention also can foliage applying or for seed dressing.
Therefore, the present invention also provides the seed with active ingredient compositions dressing of the present invention.
Described Bactericidal active ingredient composition shows the toxicity of reduction and excellent plant tolerance.
All plants and plant parts all can process according to the present invention.In the present invention, the implication of plant should be understood to all plants and plant population, that such as need and unwanted wild plant or crop plants (comprising the crop plants that nature exists).Crop plants can be by conventional plant breeding and optimum seeking method or by biotechnology and genetic engineering method or the plant that obtained by the combination of described method; comprise genetically modified plants, also comprise by the protection of plant seedling power or not by the plant variety of its protection.The implication of plant parts should be understood to the ground that plant is all and position, underground and plant organ, such as bud, leaf, Hua Hegen, and specifiable example has leaf, needle, stem, dry, flower, fruit body, fruit, seed, root, stem tuber and rhizome.Plant parts also comprises harvested material, and asexual such as, with sexual propagation thing, rice shoot, stem tuber, rhizome, cutting and seed.
According to plant variety or plant cultivars, its plantation place and growth conditions (soil, weather, vegetation period, nutrition), process of the present invention also can produce superadditivity (collaborative) effect.The effect exceeding actual desired as follows can be obtained thus, such as can reduce material that the present invention uses and composition amount of application and/or widen its action spectrum and/or improve that it is active, improve vegetation growth state, improve high temperature or cold tolerance, raising to arid or to the tolerance of salt content in water or in soil, improve Flowering quality, make to gather simpler and easy, hasting of maturity, raising output, improve harvested products quality and/or improve its nutritive value, improve the Storage property of harvested products and/or its processing characteristics.
According to the present invention, reactive compound is used directly to carry out according to conventional treatment method the process that plant and plant parts carry out, or by processing environment residing for it, habitat or storage area to realize, the such as immersion liquid of described conventional treatment method, spraying, evaporation, atomizing, broadcast sowing, smear, for propagating materials, especially seed, also can carry out one or more layers dressing.Type of service depends on the object be intended to; Under any circumstance all should guarantee that inventive mixture is meticulous as far as possible and distribute equably.
When using Bactericidal active ingredient composition of the present invention, rate of application can change in relative broad range according to the kind used.
During process plant parts, the rate of application of activate component composition is generally 0.1 to 10 000g/ha, is preferably 10 to 1000g/ha.
During process seed, the rate of application of active ingredient compositions is generally 0.001 to 50g/kg seed, is preferably 0.01 to 10g/kg seed.
During process soil, the rate of application of active ingredient compositions is generally 0.1 to 10 000g/ha, is preferably 1 to 5000g/ha.
Above-mentioned dosage is only general exemplary dose, and actual those skilled in the art can according to actual conditions and needs when using, especially according to pending plant or the character of crop and the seriousness adjustment rate of application of germ.
Active ingredient compositions of the present invention can be converted into conventional formulation, such as wetting powder, missible oil, suspending agent, microcapsule suspending agent, seed coat agent, microemulsion, aqueous emulsion, water dispersible granules, foaming agent, paste, aerosol, ultra low volume liquids.
These preparations are produced by known method, such as, when selectively using surfactant, preparation is prepared by being mixed with filler by reactive compound, said filler is the diluent or carrier of liquid or liquid gas or solid, said surfactant is emulsifier, dispersant, and/or foam agent.When using water as filler, also with an organic solvent, such as, organic solvent can be used as cosolvent.
Described liquid diluent or carrier are generally: aromatic compound is dimethylbenzene, toluene or Fluhyzon such as, chlorinated aromatic compounds of group or chlorinated aliphatic be chlorobenzene, vinyl chloride or carrene such as, aliphatic hydrocarbons is as cyclohexane or paraffin such as petroleum distillate, mineral and vegetable oil, alcohol such as butanols or ethylene glycol and ether thereof and ester, ketone is acetone, MEK, methyl iso-butyl ketone (MIBK) or cyclohexanone such as, intensive polar solvent such as dimethyl formamide and dimethyl sulfoxide (DMSO), or water.
As for pulvis and water dispersible granules, the solid carrier be applicable to is: the natural minerals of such as ammonium salt and pulverizing, such as kaolin, clay, talcum powder, chalk, quartz, attapulgite, montmorillonite or silicate, and synthetic mineral such as high dispersive silica, aluminium oxide and the silicate pulverized.
Spendable solid carrier is the particle of natural minerals, as kaolin, and clay, talcum, chalk, quartz, Attagel, imvite or diatomite, and synthetic mineral particle, as the silicic acid of high dispersive, aluminium oxide and silicate.
The solid carrier that can be used for granule pulverizes and natural rock such as calcite, marble, float stone, sepiolite and the dolomite of classification, and the particle of Inorganic synthese and organic dust, with the particle of organic product, such as sawmilling, coconut husk, corncob and tobacco stem.
For making the emulsification of active ingredient compound, dispersion, solubilized, and/or wetting surfactant can be used such as can to enumerate fatty alcohol-polyoxyethylene ether, polyoxyethylene alkylaryl ether, polyoxyethylene higher fatty acid esters, the phosphate of polyoxyethylene alcohol or phenol, the fatty acid ester of polyalcohol, alkane aromatic sulfonic acid, naphthalene sulfonic acid polymer, lignosulfonates, a shape copolymer of macromolecule comb shape, butyl naphthalene sulfonate, alkylaryl sulfonates, sodium alkylsulfosuccinates, grease, fatty alcohol and ethylene oxide condensate, the polyacrylates such as alkyltaurate, protein hydrolysate.Suitable oligosaccharide thing or polymer, such as, based on the combination of independent vinyl monomer, acrylic acid, EO and/or PO or itself and such as (polynary) alcohol or (polynary) amine.
Tackifier such as carboxymethyl cellulose can be used in preparation, and the natural and synthetic polymer of powder, particle or latex form, such as gum Arabic, polyvinyl alcohol and polyvinyl acetate or natural phospholipid, such as cephalin and lecithin, and synthetic phospholipid.Other additive is mineral oil and vegetable oil.
The colouring agent that may use as inorganic pigment, such as, iron oxide, titanium oxide and Prussian blue, and organic dyestuff, as alizarin dyes, azo dyes or metal phthalein mountain valley with clumps of trees and bamboo dyestuff, and trace nutrient, as iron, manganese, boron, ketone, cobalt, molybdenum and zinc salt.
Optionally, also can comprise other annexing ingredient, such as protecting colloid, adhesive, thickener, thixotropic agent, bleeding agent, stabilizing agent, screening agent.
Described reactive compound mixes with conventional additives by known way and prepares by described preparation of the present invention.Described conventional additives is as conventional extender and solvent or thinner, emulsifier, dispersant and/or adhesive or fixative, wetting agent, waterproofing agent, if needed, drier and colouring agent, stabilizing agent, pigment, defoamer, preservative, thickener, water and other processing aid can also be comprised.
These compositions not only comprise can by suitable equipment as spraying or dusting equipment be applicable to pending object immediately, but also be included in be applied to object before need the concentrated commercial composition that carries out diluting.
Active ingredient compositions of the present invention can also be used with other active ingredient combination, such as, for expanding activity profile or preventing from forming resistance.Other active component described such as fungicide, bactericide, attractant, insecticide, miticide, nematocide, growth regulator, weed killer herbicide, safener, fertilizer or semiochemical etc.
In addition, they can also for the protection of material (such as protecting timber) such as to make it not blue or green by intending
The infringement of mould (Paecilomyces variotii).
A kind of Bactericidal active ingredient composition of the present invention a kind ofly harmful fungoid is had to the mixture improving active and total amount of application of reactive compound and reduce, and is that one has Synergistic mixture, to reduce rate of application and to improve the activity profile of known compound.
We find to use simultaneously, namely use together or use prothioconazoles and captan respectively, or it is better than the effect of using separately each compound to use the harmful fungoid preventive and therapeutic effect that prothioconazoles and captan provide successively.In other words, there is synergistic effect that is unpredictable, necessary being, and be not only active supplement.When reactive compound is present in active compound combinations of the present invention with specific weight ratio, synergistic effect is obvious especially.
Embodiment
Embodiment 1 2% prothioconazoles+10% captan wetting powder
Prothioconazoles 2%
Captan 10%
Lauryl sodium sulfate 10%
Sodium lignin sulfonate 5%
White carbon 10%
Kaolin complements to 100%
By the proportional components mixing by formula such as active component, various auxiliary agent and filler, after ultra-fine pulverizer disintegrating, namely obtain 2% prothioconazoles+10% captan wetting powder.
Embodiment 2 1% prothioconazoles+50% captan wetting powder
Prothioconazoles 1%
Captan 50%
Calcium dodecyl benzene sulfonate 1%
Sodium lignin sulfonate 2%
Sucrose complements to 100%
By the proportional components mixing by formula such as active component, various auxiliary agent and filler, after ultra-fine pulverizer disintegrating, namely obtain 1% prothioconazoles+50% captan wetting powder.
Embodiment 3 1% prothioconazoles+4% captan missible oil
Prothioconazoles 1%
Captan 4%
Ethoxylated castor oil 5%
Calcium dodecyl benzene sulfonate 3%
Dimethyl sulfoxide (DMSO) complements to 100%
Mentioned component is proportionally prepared, stirs and obtain homogeneous phase.
Embodiment 4 5% prothioconazoles+50% captan wetting powder
Prothioconazoles 5%
Captan 50%
Lauryl sodium sulfate 10%
Sodium lignin sulfonate 5%
White carbon 10%
Kaolin complements to 100%
Said components is mixed in proportion, and grinds, pulverize, be prepared into wetting powder.
Embodiment 5 2% prothioconazoles+50% captan water dispersible granule
Prothioconazoles 2%
Captan 50%
MODIFIED LIGNOSULPHONATE 5%
Lauryl sodium sulfate 5%
Urea 5%
Kaolin complements to 100%
Prothioconazoles active component, dispersant, wetting agent, disintegrant and the filler ratio in formula is mixed, becomes wetting powder through air-flow crushing; Add captan again to mix; Add a certain amount of water mixing extruding again and make material.2% prothioconazoles+50% captan water dispersible granule is obtained after drying screening.
Embodiment 6 0.5% prothioconazoles+50% captan suspension emulsion
Oil phase:
Prothioconazoles 0.5%
Methyl oleate 10%
Ethoxylated castor oil 5%
Aqueous phase:
Captan 50%
The sodium salt 1% of the naphthalene sulfonic acids-formaldehyde condensation products of sulfonation
Water complements to 100%
Prothioconazoles is dissolved in methyl oleate, adds ethoxylated castor oil and obtain oil phase; According to formula, the sodium salt of the naphthalene sulfonic acids-formaldehyde condensation products of captan, sulfonation, water are obtained after grinding and/or high speed shear the aqueous suspension agent of captan; Under agitation oil phase is added aqueous phase and obtain suspension emulsion.
Embodiment 7 10% prothioconazoles+10% captan wetting powder
Prothioconazoles 10%
Captan 10%
Sodium lignin sulfonate 1%
NaLS 2%
The silicic acid 1% of high degree of dispersion
Kaolin complements to 100%
Said components is mixed in proportion, and grinds, pulverize, be prepared into wetting powder.
Embodiment 8 40% prothioconazoles+50% captan coated granule
Prothioconazoles 40%
Captan 50%
Polyethylene glycol 3%
The silicic acid 1% of high degree of dispersion
Calcium carbonate complements to 100%
In a mixer, by levigate active component even spread on the carrier soaked by polyethylene glycol.Dust-free coated granules agent can be obtained in this way.
Embodiment 9 50% prothioconazoles+10% captan wetting powder
Prothioconazoles 50%
Captan 10%
Lauryl sodium sulfate 1%
Sodium lignin sulfonate 1%
Kaolin complements to 100%
Said components is mixed in proportion, and grinds, pulverize, be prepared into wetting powder.
Embodiment 10 20% prothioconazoles+60% captan extrudes granule
Prothioconazoles 20%
Captan 60%
Sodium lignin sulfonate 4%
Carboxymethyl cellulose 2%
Kaolin complements to 100%
Active component is mixed with auxiliary agent and grinds, mixture water-wet.This mixture is extruded, then dry in the air stream.
Embodiment 11 50% prothioconazoles++ 2% captan seed coat agent
Prothioconazoles 50%
Captan 2%
Fatty alcohol-polyoxyethylene ether sulfosuccinic acid monoesters disodium 10%
MODIFIED LIGNOSULPHONATE 5%
Xanthans 1%
Bentonite 1%
Glycerine 5%
PVP-K30 1%
Water complements to 100%
Above-mentioned each component is mixed in proportion after grinding and/or high speed shear, obtains seed coat agent.
Embodiment 12 50% prothioconazoles+5% captan microcapsule suspending agent
Atlox 4913 4%
Citric acid 0.05%
Catalyzer 0.1%
Water 13%
Captan 5%
PAPI 1.35%
Solvesso 200 10%
Atlox4913 16%
Dispersant LFH 0.3%
Defoamer 0.16%
Urea 8.4%
Prothioconazoles 50%
Water complements to 100%
The oil phase that PAPI, prothioconazoles, Solvesso 100 are formed is added in the aqueous solution containing Atlox4913, forms emulsion.Then heat and be incubated and add catalyst reaction 2 hours at 50 DEG C.The microcapsules of prothioconazoles is obtained after cooling.
Atlox 4913, dispersant LFH, defoamer, urea, captan and water mix in proportion, obtain evenly, obtaining suspending agent after grinding and/or high speed shear.
The prothioconazoles microcapsules obtained is added in the suspending agent of captan, stirs and obtain 50% prothioconazoles+5% captan ZC.
Embodiment 13 50% prothioconazoles+1% captan suspension emulsion
Prothioconazoles 50%
Captan 1%
Solvesso 200 10%
Ethoxylated castor oil 4%
Fatty alcohol-polyoxyethylene ether sulfosuccinic acid monoesters disodium 5%
MODIFIED LIGNOSULPHONATE 5%
Xanthans 1%
Bentonite 1%
Glycerine 5%
Water complements to 100%
Prothioconazoles is dissolved in Solvesso 200, adds ethoxylated castor oil, obtain the oil phase of prothioconazoles;
Fatty alcohol-polyoxyethylene ether sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, captan and water are mixed in proportion, obtains evenly, obtaining the suspending agent of captan after grinding and/or high speed shear.
By to join the aqueous suspension agent containing captan containing the oil phase of prothioconazoles, obtain suspension emulsion.
Embodiment 14 50% prothioconazoles+0.5% captan missible oil
Prothioconazoles 50%
Captan 0.5%
Ethoxylated castor oil 5%
Calcium dodecyl benzene sulfonate 3%
Solvesso100 complements to 100%
By above-mentioned each component mixing, be stirred to and obtain transparent homogeneous phase.
Embodiment 15 20% prothioconazoles+30% captan water dispersible granule
Prothioconazoles 20%
Captan 30%
MODIFIED LIGNOSULPHONATE 5%
Lauryl sodium sulfate 5%
Urea 5%
Kaolin complements to 100%
Prothioconazoles, captan active component, dispersant, wetting agent, disintegrant and the filler ratio in formula is mixed, becomes wetting powder through air-flow crushing; Add a certain amount of water mixing extruding again and make material.20% prothioconazoles+30% captan water dispersible granule is obtained after drying screening.
Embodiment 16 5% prothioconazoles+30% captan wetting powder
Prothioconazoles 5%
Captan 30%
Lauryl sodium sulfate 1%
Sodium lignin sulfonate 1%
Kaolin complements to 100%
Said components is mixed in proportion, and grinds, pulverize, be prepared into wetting powder.
Embodiment 17 10% prothioconazoles+90% captan
Prothioconazoles 10%
Captan 90%
Prothioconazoles, captan are proportionally mixed.
Embodiment 18 20% prothioconazoles+80% captan
Prothioconazoles 20%
Captan 80%
Proportioning in above embodiment is weight per distribution ratio.
Biological test example
When the effect of active compound combinations exceedes the summation of the effect when each reactive compound is used separately, there is synergistic function.The predictive role of the particular combination of two kinds of reactive compounds can use so-called " Colby formula " (see S.R. Colby, " Calculating Synergistic and Antagonistic Responses of Herbicide Combinations ", Weeds 1967,15,20-22) calculate as follows: if
X is the activity when using the reactive compound A that consumption is mppm for mg/ha or concentration;
Y is the activity when using the reactive compound B that consumption is nppm for ng/ha or concentration, is expressed as the percentage accounting for untreated control;
E is when using consumption for activity during m and n g/ha or the concentration reactive compound A and B that is m and n ppm,
So
If the activity of actual observation (O) is greater than expection active (E), so said composition super add and, namely there is synergistic effect.
Following biological test example is in order to illustrate the present invention.But the present invention is not limited to these embodiments.
Test 1 powdery mildew test (wheat)/prolection
Solvent: the N-methyl-pyrrolidon of 10 parts of weight
Emulsifier: the alkylaryl polyglycol ether of 0.6 part of weight
In order to obtained suitable reactive compound, portion reactive compound by weight or the combination of reactive compound are mixed with the solvent of above-mentioned amount and emulsifier, and is diluted with water to desired concn.
In order to measure prolection, the active agent preparations of seedling with described using dosage is sprayed.The spore of seedling wheat powdery mildew dusts after becoming dry by liquid layer to be painted.Then test plant is placed in temperature about 20
oto promote the growth of white powder scab in the greenhouse of C, air humidity about 80%.Inoculate and carry out effect assessment after 7 days, 0% refer to effect with contrast suitable, 100% refers to not observe and infects.Reactive compound, using dosage and result of the test are listed in the following table:
Test 2 powdery mildew test (wheat)/therapeutic activities
Solvent: the N-methyl-pyrrolidon of 10 parts of weight
Emulsifier: the alkylaryl polyglycol ether of 0.6 part of weight
In order to obtained suitable reactive compound, portion reactive compound by weight or the combination of reactive compound are mixed with the solvent of above-mentioned amount and emulsifier, and is diluted with water to desired concn.
In order to test therapeutical active, seedling wheat powdery mildew spore is dusted.Inoculate after 48 hours, the active agent preparations of seedling with described using dosage is sprayed.Then test plant be placed in temperature about 20 DEG C, air humidity about 80% greenhouse to promote the growth of white powder scab.Inoculate and carry out effect assessment after 7 days, 0% refer to effect with contrast suitable, 100% refers to not observe and infects.Reactive compound, using dosage and result of the test are listed in the following table:
Test 3 stalk break test (rape)/seed treatment
Reactive compound is used with dry seeds seed dressing.Said preparation is prepared by being mixed with levigate mineral matter by the reactive compound of independent reactive compound or combination, and obtaining can at the equally distributed finely powdered mixt of the surface of the seed.
During seed seed dressing, the shake 3 minutes in the glass flask closed of seed and seed seed dressing will be infected.Rape seed is seeded in 1 centimetre of dark standard soil, temperature about 18 DEG C, cultivates in the greenhouse of air humidity about 95%, every 15 h light day by day of seeds cultivation case.
After sowing 3 weeks, evaluate the illness of Brassica campestris L seedling, 0% refer to effect with contrast suitable, 100% refers to not observe and infects.Reactive compound, using dosage and result of the test are listed in the following table:
Test 4 base rot disease in seedling stage (corn)/seed treatment
Reactive compound is used with dry seeds seed dressing.Said preparation is prepared by being mixed with levigate mineral matter by the reactive compound of independent reactive compound or combination, and obtaining can at the equally distributed finely powdered mixt of the surface of the seed.
During seed seed dressing, the shake 3 minutes in the glass flask closed of seed and seed seed dressing will be infected.Corn seed is seeded in 1 centimetre of dark standard soil, temperature about 18 DEG C, cultivates in the greenhouse of air humidity about 95%, every 15 h light day by day of seeds cultivation case.
After sowing 3 weeks, evaluate the illness of corn, 0% refer to effect with contrast suitable, 100% refers to not observe and infects.Reactive compound, using dosage and result of the test are listed in the following table:
| Reactive compound | Using dosage g A.I/100kg seed | The active % observed | According to the activity (%) that Colby calculates | Synergistic |
| Prothioconazoles | 0.1 | 9 | - | |
| Captan | 5 | 0 | - | |
| Prothioconazoles+captan | 0.1+5 | 43 | 9 | Be |
Test 5 ash arrhizus bacteria test (strawberry)/therapeutic activities
Solvent: the N-methyl-pyrrolidon of 10 parts of weight
Emulsifier: the alkylaryl polyglycol ether of 0.6 part of weight
In order to obtained suitable reactive compound, portion reactive compound by weight or the combination of reactive compound are mixed with the solvent of above-mentioned amount and emulsifier, and is diluted with water to desired concn.
In order to test therapeutical active, seedling Botrytis cinerea bacterium spore is dusted.Inoculate after 48 hours, the active agent preparations of Strawberry seedlings with described using dosage is sprayed.Then test plant be placed in temperature about 20 DEG C, air humidity about 80% greenhouse to promote the growth of grey mold scab.Inoculate and carry out effect assessment after 7 days, 0% refer to effect with contrast suitable, 100% refers to not observe and infects.Reactive compound, using dosage and result of the test are listed in the following table:
Test 6 anthracnose test (capsicum)/therapeutic activities
Solvent: the N-methyl-pyrrolidon of 10 parts of weight
Emulsifier: the alkylaryl polyglycol ether of 0.6 part of weight
In order to obtained suitable reactive compound, portion reactive compound by weight or the combination of reactive compound are mixed with the solvent of above-mentioned amount and emulsifier, and is diluted with water to desired concn.
In order to test therapeutical active, seedling pepper anthracnose spore is dusted.Inoculate after 48 hours, the active agent preparations of pepper seedling with described using dosage is sprayed.Then test plant be placed in temperature about 20 DEG C, air humidity about 80% greenhouse to promote the growth of anthracnose.Inoculate and carry out effect assessment after 7 days, 0% refer to effect with contrast suitable, 100% refers to not observe and infects.Reactive compound, using dosage and result of the test are listed in the following table:
Test 7 rhizoctonia test/soil treatment
Mix the medicament by rhizoctonia contaminated soil and ormal weight in plastic basin after, the seed of sowing 7 cucumber.Sowing beginning, after 66 days, carries out effect assessment.0% refer to effect with contrast suitable, 100% refers to not observe and infects.Reactive compound, using dosage and result of the test are listed in the following table:
Test 8 leaf blight test (wheat)/prolections
Solvent: the N-methyl-pyrrolidon of 10 parts of weight
Emulsifier: the alkylaryl polyglycol ether of 0.6 part of weight
In order to obtained suitable reactive compound, portion reactive compound by weight or the combination of reactive compound are mixed with the solvent of above-mentioned amount and emulsifier, and is diluted with water to desired concn.
In order to measure prolection, the active agent preparations of seedling with described using dosage is sprayed.Seedling wheat leaf blight bacterium spore dusts after becoming dry by liquid layer to be painted.Then test plant be placed in temperature about 20 DEG C, air humidity about 80% greenhouse to promote the growth of leaf spoting bacteria.Inoculate and carry out effect assessment after 7 days, 0% refer to effect with contrast suitable, 100% refers to not observe and infects.Reactive compound, using dosage and result of the test are listed in the following table:
Test 9 Magnaporthe grisea test (paddy rice)/prolections
In order to obtained suitable reactive compound, portion reactive compound by weight or the combination of reactive compound are mixed with the solvent of above-mentioned amount and emulsifier, and is diluted with water to desired concn.
In order to measure prolection, the active agent preparations of rice seedling with described using dosage is sprayed.The spore of seedling Magnaporthe grisea dusts after becoming dry by liquid layer to be painted.Then test plant be placed in temperature about 20 DEG C, air humidity about 80% greenhouse to promote the growth of Magnaporthe grisea.Inoculate and carry out effect assessment after 5 days, 0% refer to effect with contrast suitable, 100% refers to not observe and infects.
Reactive compound, using dosage and result of the test are listed in the following table:
A kind of Bactericidal active ingredient composition result of the test of the present invention has Synergistic.
Claims (14)
1. a Bactericidal active ingredient composition, is characterized in that: comprise prothioconazoles and captan compound; The weight proportion of described prothioconazoles and captan reactive compound is 1:100-100:1.
2. Bactericidal active ingredient composition according to claim 1, is characterized in that: in active ingredient compositions, and the weight ratio of prothioconazoles and captan is 1:50-50:1.
3. Bactericidal active ingredient composition according to claim 1, is characterized in that: in active ingredient compositions, and the weight ratio of prothioconazoles and captan is 1:25-25:1.
4. a microbicide compositions, is characterized in that: comprise fungicide active ingredient compositions according to claim 1.
5. microbicide compositions according to claim 4, is characterized in that comprising the active ingredient compositions described in claim 1, filler and/or surfactant.
6. microbicide compositions according to claim 4, it is characterized in that, the formulation of described microbicide compositions is suspending agent, seed coat agent, wetting powder, water dispersible granules, microcapsule suspending agent, coated granule, extrude granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet.
7. microbicide compositions according to claim 4, is characterized in that: the content of the active ingredient compositions of prothioconazoles and captan accounts for the 5-90% of microbicide compositions.
8. microbicide compositions according to claim 4, is characterized in that: the content of the active ingredient compositions of prothioconazoles and captan accounts for the 20-80% of microbicide compositions.
9. according to the Bactericidal active ingredient composition of claim 1 for preventing and treating the purposes of plant epiphyte and bacterium.
10. microbicide compositions according to claim 4 is for preventing and treating the purposes of plant epiphyte and bacterium.
11. Bactericidal active ingredient composition according to claim 1 are for preventing and treating the purposes of fungus and bacterium on cereal, fruit, vegetables, economic crops.
12. microbicide compositions according to claim 4 are for preventing and treating the purposes of fungus and bacterium on cereal, fruit, vegetables, economic crops.
13. 1 kinds of methods of preventing and treating plant pathogen, it is characterized in that: the microbicide compositions of the Bactericidal active ingredient composition in claim 1 or claim 4 is acted on pathogenic bacteria and/or its environment, or in plant, plant parts, seed, soil, region, material or space.
14. methods according to claim 13, is characterized in that: the prothioconazoles of claim 1 or 4 and captan compound are used simultaneously or used respectively or sequential application.
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| CN107935670A (en) * | 2017-10-20 | 2018-04-20 | 成都盛世光华生物科技有限公司 | A kind of masson pine nutrient solution for preventing pest and disease damage and its application |
| FR3096872A1 (en) * | 2019-06-05 | 2020-12-11 | UPL Corporation Limited | fungicidal composition for controlling zymoseptoria infection in plants |
| CN112679925B (en) * | 2020-12-22 | 2021-11-23 | 中国农业科学院植物保护研究所 | Composite antibacterial film and preparation method and application thereof |
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| CN1252690A (en) * | 1997-04-18 | 2000-05-10 | 拜尔公司 | Fungicide active substance combinations |
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| CN1833500A (en) * | 2002-03-08 | 2006-09-20 | 巴斯福股份公司 | Fungicidal mixtures based on Prothioconazole and containing an insecticide |
| CN100438761C (en) * | 2002-03-21 | 2008-12-03 | 巴斯福股份公司 | Fungicidal mixtures |
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| CN1174193A (en) * | 1994-11-21 | 1998-02-25 | 拜尔公司 | Microbicidal triazolyl derivative |
| CN1252690A (en) * | 1997-04-18 | 2000-05-10 | 拜尔公司 | Fungicide active substance combinations |
| CN1638634A (en) * | 2002-03-01 | 2005-07-13 | 巴斯福股份公司 | Fungicidal mixtures based on prothioconazole |
| CN1833500A (en) * | 2002-03-08 | 2006-09-20 | 巴斯福股份公司 | Fungicidal mixtures based on Prothioconazole and containing an insecticide |
| CN100438761C (en) * | 2002-03-21 | 2008-12-03 | 巴斯福股份公司 | Fungicidal mixtures |
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