CN103446672A - Self-rewarding stimulating system - Google Patents

Self-rewarding stimulating system Download PDF

Info

Publication number
CN103446672A
CN103446672A CN2013104096668A CN201310409666A CN103446672A CN 103446672 A CN103446672 A CN 103446672A CN 2013104096668 A CN2013104096668 A CN 2013104096668A CN 201310409666 A CN201310409666 A CN 201310409666A CN 103446672 A CN103446672 A CN 103446672A
Authority
CN
China
Prior art keywords
module
central nervous
patient
nervous system
processing module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2013104096668A
Other languages
Chinese (zh)
Other versions
CN103446672B (en
Inventor
王立平
鲁艺
钟成
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Institute of Advanced Technology of CAS
Original Assignee
Shenzhen Institute of Advanced Technology of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Institute of Advanced Technology of CAS filed Critical Shenzhen Institute of Advanced Technology of CAS
Priority to CN201310409666.8A priority Critical patent/CN103446672B/en
Publication of CN103446672A publication Critical patent/CN103446672A/en
Application granted granted Critical
Publication of CN103446672B publication Critical patent/CN103446672B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Landscapes

  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

A self-rewarding stimulating system comprises a dopamine detecting module, a processing module and a stimulating module. The dopamine detecting module is used for measuring a dopamine level parameter of the central nervous system of a patient in real time, the processing module is connected with the dopamine detecting module in a communication mode and used for receiving, analyzing and processing the dopamine level parameter in real time, the stimulating module is connected with the processing module in a communication mode, and when the dopamine level parameter reaches a preset threshold value, the processing module determines that depression or drug addiction of the patient episodes and controls the stimulating module to exert stimulating signals on the central nervous system of the patient to carry out a stimulation therapy. Aiming at the abnormal dopamine level of the central nervous system of the patient with the depression or the drug addiction, the self-rewarding stimulating system effectively relieves symptoms of the depression or the drug addiction through the stimulation therapy carried out on the central nervous system of the patient, and in comparison with the prior art, the therapy by the adoption of the self-rewarding stimulating system is little in side effect.

Description

Oneself's reward stimulation system
Technical field
The present invention relates to medical Instrument field, particularly relate to a kind of self-reward stimulation system.
Background technology
At present the whole world approximately has 600,000,000 people being included epilepsy, Parkinson's disease, schizophrenia, depression, senile dementia, apoplexy, drug dependence etc. to perplex at interior numerous central nervous systems mental sickness of unifying.And along with the multifactorial impact such as economic, social, the quantity of these diseases, especially patients with depression has the trend increased year by year, and society and expanding economy have been caused to huge obstacle.Patients with depression often has suicidal tendency, and drug dependence not only has influence on patient's healthy and family stable, and in addition, drug dependence not only has influence on patient's the stabilizing of healthy and family, and also can cause many social problems.
For depression, traditional Therapeutic Method is Drug therapy and psychotherapy.Yet traditional Therapeutic Method all has some limitations.Drug therapy may cause the cognitive impairment of patients with depression, has larger side effect.And traditional drug dependence Therapeutic Method is mainly taked the method for enforceable withdrawal.Drug dependence patient, because pleasant sensation can't be obtained, therefore is easy to cause the addiction outbreak, has equally larger side effect.
Summary of the invention
Based on this, for the defect on traditional depression and drug dependence Therapeutic Method, be necessary to provide a kind of less self-reward stimulation system of side effect for the treatment of.
A kind of self-reward stimulation system comprises:
The dopamine detection module, for measuring in real time patient central nervous system's dopamine level parameter;
Processing module, with described dopamine detection module communication connection, for receiving in real time and the described dopamine level parameter of analyzing and processing; And
Stimulating module, with described processing module communication connection, when described dopamine level parameter reaches default threshold value, described processing module is judged depression in patients disease or drug dependence outbreak, and controls described stimulating module and apply stimulus signal the patient central nervous system is carried out to stimulation therapy.
Therein in embodiment, also comprise the control alarm module, described control alarm module and the communication connection of described processing module, when described dopamine level parameter during lower than default threshold value, described processing module is judged depression in patients disease or drug dependence outbreak, and controls described control alarm module and give the alarm.
Therein in embodiment, described control alarm module comprises wireless transmit/receive units and wireless terminal unit, described wireless transmit/receive units and the communication connection of described wireless terminal unit, when described dopamine level parameter during lower than default threshold value, described processing module is judged depression in patients disease or drug dependence outbreak, and control described wireless transmit/receive units and send control signal, described wireless terminal unit receives described control signal and sends a warning.
In embodiment, described wireless terminal unit is also for by described wireless transmit/receive units, to described processing module, sending instruction therein, and described processing module receives described instruction and controls described stimulating module and applies stimulus signal.
Therein in embodiment, dopamine level parameter and geographical position coordinates that described warning information is the patient central nervous system.
In embodiment, described dopamine detection module is specifically for measuring in real time the dopamine level parameter of the ventral tegmental area in the patient central nervous system, the ventral tegmental area of described stimulating module for stimulating the patient central nervous system therein.
Therein in embodiment, described stimulating module comprises the optical fiber that is implanted in the ventral tegmental area in the patient central nervous system and is implanted in the microlaser of patient's head, described processing module is controlled described microlaser utilizing emitted light signal, described optical signal to the ventral tegmental area in the patient central nervous system, carries out functional photostimulation with the ventral tegmental area in the patient central nervous system by described fiber optic conduction.
Therein in embodiment, described stimulating module comprises the electrode that is implanted in the ventral tegmental area in the patient central nervous system, described processing module is controlled the described electrode emission signal of telecommunication, with the ventral tegmental area in the patient central nervous system, carries out functional electric stimulation.
In embodiment, also comprise power module therein, described power module is for being powered to described dopamine detection module, described processing module and described stimulating module.
In embodiment, also comprise memory module therein, described memory module and the communication connection of described processing module, for real-time storage patient central nervous system's dopamine level parameter.
Above-mentioned self-reward stimulation system, central nervous system for patients with depression and drug dependence patient, especially the dopamine level of ventral tegmental area is abnormal, by stimulating module, the patient central nervous system is carried out to the zest treatment, make its dopamine level recover normal, effective alleviate depression disease and drug dependence symptom, and compare with traditional Therapeutic Method, adopt the side effect of above-mentioned self-reward stimulation systematic treating less.
In addition, above-mentioned self-reward stimulation system has the dopamine detection module of the dopamine level parameter for measuring in real time the patient central nervous system and the processing module of controlling for automatization, when patient central nervous system's dopamine level abnormal parameters, processing module can directly be carried out stimulation therapy timely and effectively by stimulating module to the patient.
The accompanying drawing explanation
The module map that Fig. 1 is the self-reward stimulation system in preferred embodiment of the present invention.
The specific embodiment
For the ease of understanding the present invention, below with reference to relevant drawings, the present invention is described more fully.Provided better embodiment of the present invention in accompanying drawing.But the present invention can realize in many different forms, is not limited to embodiment described herein.On the contrary, providing the purpose of these embodiments is make disclosure of the present invention is understood more comprehensively thorough.
It should be noted that, when element is called as " being fixed in " another element, can directly can there be element placed in the middle in it on another element or also.When an element is considered to " connection " another element, it can be directly connected to another element or may have centering elements simultaneously.Term as used herein " vertical ", " level ", " left side ", " right side " and similar statement just for illustrative purposes, do not mean it is unique embodiment.
Unless otherwise defined, all technology that this paper is used are identical with the implication that belongs to the common understanding of those skilled in the art of the present invention with scientific terminology.The term used in description of the present invention herein, just in order to describe the purpose of concrete embodiment, is not intended to be restriction the present invention.Term as used herein " and/or " comprise one or more relevant Listed Items arbitrarily with all combinations.
Refer to Fig. 1, the self-reward stimulation system 100 in preferred embodiment of the present invention, comprise dopamine detection module 110, processing module 120, stimulating module 130, control alarm module 140, memory module 150 and power module 160.
Dopamine detection module 110 is for measuring in real time patient central nervous system's dopamine level parameter.For patients with depression, its marked feature is that central nervous system's dopamine level is lower.And for the drug dependence patient due to when using dependence producing drug, the dopamine level of its central nervous system's ventral tegmental area significantly raises and obtains pleasant sensation and excitement, and when not using dependence producing drug, because the disappearance of pleasant sensation produces the addiction symptom.Therefore, patients with depression and drug dependence patient's common feature is the central nervous system, and especially the dopamine level of ventral tegmental area is abnormal.Measure in real time patient central nervous system's dopamine level parameter by dopamine detection module 110, can analyze exactly patient's current state.
In the present embodiment, dopamine detection module 110 is specifically for measuring in real time the dopamine level parameter of the ventral tegmental area in the patient central nervous system.
Processing module 120 specifically can be central processing unit.Processing module 120 and 110 communication connections of dopamine detection module, for receiving in real time and analyzing and processing dopamine level parameter.Processing module 120 is carried out analyzing and processing by the dopamine level parameter that dopamine detection module 110 is measured to gained, judges that whether the patient is in abnormality.Concrete, can preset a threshold value, when the dopamine level parameter, during lower than default threshold value, processing module 120 is judged depression in patients diseases or drug dependence outbreak.
The weight parameter of patient when depression or drug dependence outbreak that people can measure certain sample size in advance changes, and sets thus a threshold value comparatively accurately.
Stimulating module 130 and processing module 120 communication connections, when the dopamine level parameter, during lower than default threshold value, processing module 120 is judged depression in patients diseases or drug dependence outbreak, and controls stimulating module 130 and apply stimulus signal the patient is carried out to stimulation therapy.
In the present embodiment, stimulating module 130 is specifically for stimulating the ventral tegmental area in the patient central nervous system.130 pairs of ventral tegmental areas of stimulating module carry out the stimulation therapy treatment, with the symptom of alleviate depression disease or drug dependence outbreak.
Concrete, stimulating module 130 can carry out stimulation therapy to the patient by functional photostimulation and functional electric stimulation.Stimulating module 130 comprises optical fiber (not shown) and microlaser (not shown), the ventral tegmental area of embedded fibers in the patient central nervous system, and microlaser is implanted in patient's head, and optical fiber is connected with microlaser.
During work, processing module 120 is controlled microlaser utilizing emitted light signals, and optical signal to the ventral tegmental area in the patient central nervous system, carries out functional photostimulation with the ventral tegmental area in the patient central nervous system by fiber optic conduction.
In the present embodiment, before adopting functional photostimulation, need to adopt gene technology that excitatoty light sensation albumen is transferred in nervous system and is expressed in dopaminergic neuron, make it form special ion channel on cell membrane.These ion channels can be respectively under the light stimulation of different wave length to cation or anion pass through produce selectivity, thereby cause the transmembrane potential on cell membrane both sides to change, reach the purpose to the excitement of cell selective ground or inhibition.Wherein, the excited type channel protein gene is Channelrhodopsin-2(ChR2), inhibition type channel protein gene is Helorhodopsin(NpHR).Specifically in the present embodiment, the function of photosensitive protein is excited type.
The optical signal with specific wavelength and frequency of microlaser emission, and be directed into the dopaminergic neuron with photaesthesia gene by optical fiber.The laser of specific wavelength and frequency can activate the ion channel on dopaminergic neuron, and the variation of the transmembrane potential by the cell membrane both sides reaches the purpose excited to cell selective ground.
It is pointed out that stimulating module 130 also can comprise the electrode (not shown).Electrode is implanted in the ventral tegmental area in the patient central nervous system.
During work, the processing module 120 control electrode emission signals of telecommunication, carry out functional electric stimulation with the ventral tegmental area in the patient central nervous system, significantly to strengthen the activity of dopaminergic neuron, promote dopamine concentration to raise, thus the symptom of alleviate depression disease and drug dependence outbreak.
Control alarm module 140 and processing module 120 communication connections, when the dopamine level parameter, during lower than default threshold value, processing module 120 is judged depression in patients diseases or drug dependence outbreak, and controls alarm module 140 and give the alarm.Concrete, dopamine level parameter and geographical position coordinates that warning information is the patient central nervous system, control alarm module 140 and above-mentioned warning information can be sent to patient monitoring people and doctor place, in time the patient is treated to facilitate patient monitoring people and doctor.
Control alarm module 140 and can comprise wireless transmit/receive units (not shown) and wireless terminal unit (not shown).Wireless transmit/receive units and wireless terminal unit communication connection.When the dopamine level parameter, during lower than default threshold value, processing module 120 is judged depression in patients diseases or drug dependence outbreak, and controls wireless transmit/receive units and send control signal, and the wireless terminal unit reception control signal also sends a warning.
Wireless terminal unit can be the devices such as notebook computer, mobile phone or PDA, and patient monitoring people and doctor can be carried it, with the state of monitored patient at any time.And wireless terminal unit is also for by wireless transmit/receive units, to processing module 120, sending instruction, processing module 120 receives instruction and controls stimulating module 130 and applies stimulus signal.Patient monitoring people or doctor carry out long-range active treatment by wireless terminal unit to the patient, have further improved the promptness for the treatment of.
Power module 160 is for being powered to dopamine detection module 110, processing module 120, stimulating module 130, control alarm module 140 etc.
Specifically in the present embodiment, power module 160 adopts the mode of radio frequency powered to be powered to above-mentioned module.Be appreciated that in other embodiments, power module 160 also can be battery, together with other module integration and install in patient body or by the patient and carry.
Memory module 150 and described processing module 120 communication connections, for real-time storage patient central nervous system's dopamine level parameter.150 couples of central nervous system's of memory module dopamine level parameter is carried out real-time storage, with the genesis mechanism to diseases such as depressions and the machine-processed research for the treatment of, provides in real time data accurately.
Specifically in the present embodiment, memory module 150 can be storage chip, and, together with other module integration, installs in patient body or by the patient and carry.Be appreciated that memory module 150 also can be remote computer, processing module 120 is connected with the remote computer wireless telecommunications, with in real time to the remote computer transmitting data.
Above-mentioned self-reward stimulation system 100, central nervous system for patients with depression and drug dependence patient, especially the dopamine level of ventral tegmental area is abnormal, by stimulating module, 130 couples of patient central nervous system carry out the zest treatment, make its dopamine level recover normal, effective alleviate depression disease and drug dependence symptom, and compare with traditional Therapeutic Method, adopt the side effect of above-mentioned self-reward stimulation system 100 treatments less.
In addition, above-mentioned self-reward stimulation system 100 has the dopamine detection module 110 of the dopamine level parameter for measuring in real time the patient central nervous system and the processing module 120 of controlling for automatization, when patient central nervous system's dopamine level abnormal parameters, processing module 120 can directly be carried out stimulation therapy timely and effectively by 130 couples of patients of stimulating module.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.

Claims (10)

1. a self-reward stimulation system, is characterized in that, comprising:
The dopamine detection module, for measuring in real time patient central nervous system's dopamine level parameter;
Processing module, with described dopamine detection module communication connection, for receiving in real time and the described dopamine level parameter of analyzing and processing; And
Stimulating module, with described processing module communication connection, when described dopamine level parameter reaches default threshold value, described processing module is judged depression in patients disease or drug dependence outbreak, and controls described stimulating module and apply stimulus signal the patient central nervous system is carried out to stimulation therapy.
2. self-reward stimulation system according to claim 1, it is characterized in that, also comprise the control alarm module, described control alarm module and the communication connection of described processing module, when described dopamine level parameter during lower than default threshold value, described processing module is judged depression in patients disease or drug dependence outbreak, and controls described control alarm module and give the alarm.
3. self-reward stimulation system according to claim 2, it is characterized in that, described control alarm module comprises wireless transmit/receive units and wireless terminal unit, described wireless transmit/receive units and the communication connection of described wireless terminal unit, when described dopamine level parameter during lower than default threshold value, described processing module is judged depression in patients disease or drug dependence outbreak, and control described wireless transmit/receive units and send control signal, described wireless terminal unit receives described control signal and sends a warning.
4. self-reward stimulation system according to claim 3, it is characterized in that, described wireless terminal unit is also for by described wireless transmit/receive units, to described processing module, sending instruction, and described processing module receives described instruction and controls described stimulating module and applies stimulus signal.
5. self-reward stimulation system according to claim 2, is characterized in that, dopamine level parameter and geographical position coordinates that described warning information is the patient central nervous system.
6. self-reward stimulation system according to claim 1, it is characterized in that, described dopamine detection module is specifically for measuring in real time the dopamine level parameter of the ventral tegmental area in the patient central nervous system, the ventral tegmental area of described stimulating module for stimulating the patient central nervous system.
7. self-reward stimulation system according to claim 6, it is characterized in that, described stimulating module comprises the optical fiber that is implanted in the ventral tegmental area in the patient central nervous system and is implanted in the microlaser of patient's head, described processing module is controlled described microlaser utilizing emitted light signal, described optical signal to the ventral tegmental area in the patient central nervous system, carries out functional photostimulation with the ventral tegmental area in the patient central nervous system by described fiber optic conduction.
8. self-reward stimulation system according to claim 6, it is characterized in that, described stimulating module comprises the electrode that is implanted in the ventral tegmental area in the patient central nervous system, described processing module is controlled the described electrode emission signal of telecommunication, with the ventral tegmental area in the patient central nervous system, carries out functional electric stimulation.
9. self-reward stimulation system according to claim 1, is characterized in that, also comprises power module, and described power module is for being powered to described dopamine detection module, described processing module and described stimulating module.
10. self-reward stimulation system according to claim 1, is characterized in that, also comprises memory module, and described memory module and the communication connection of described processing module, for real-time storage patient central nervous system's dopamine level parameter.
CN201310409666.8A 2013-09-09 2013-09-09 Oneself's reward stimulation system Active CN103446672B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310409666.8A CN103446672B (en) 2013-09-09 2013-09-09 Oneself's reward stimulation system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310409666.8A CN103446672B (en) 2013-09-09 2013-09-09 Oneself's reward stimulation system

Publications (2)

Publication Number Publication Date
CN103446672A true CN103446672A (en) 2013-12-18
CN103446672B CN103446672B (en) 2016-08-10

Family

ID=49729774

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310409666.8A Active CN103446672B (en) 2013-09-09 2013-09-09 Oneself's reward stimulation system

Country Status (1)

Country Link
CN (1) CN103446672B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109965872A (en) * 2019-04-01 2019-07-05 安徽效隆科技有限公司 The electro photoluminescence for craving for state based on smoker triggers platform

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101537228A (en) * 2009-04-23 2009-09-23 哈尔滨奥博医疗器械有限公司 Transcranial magnetic therapeutic instrument for computer diseases
US20100312305A1 (en) * 2004-10-05 2010-12-09 The Trustees Of Dartmouth College Apparatus And Method For Modulating Neurochemical Levels In the Brain
US20130144358A1 (en) * 2011-12-02 2013-06-06 Stephen Daroe Dopamine Stimulation Device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100312305A1 (en) * 2004-10-05 2010-12-09 The Trustees Of Dartmouth College Apparatus And Method For Modulating Neurochemical Levels In the Brain
CN101537228A (en) * 2009-04-23 2009-09-23 哈尔滨奥博医疗器械有限公司 Transcranial magnetic therapeutic instrument for computer diseases
US20130144358A1 (en) * 2011-12-02 2013-06-06 Stephen Daroe Dopamine Stimulation Device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109965872A (en) * 2019-04-01 2019-07-05 安徽效隆科技有限公司 The electro photoluminescence for craving for state based on smoker triggers platform
CN109965872B (en) * 2019-04-01 2021-09-21 安徽效隆科技有限公司 Electrical stimulation trigger platform based on smoker craving state

Also Published As

Publication number Publication date
CN103446672B (en) 2016-08-10

Similar Documents

Publication Publication Date Title
CN102613971B (en) Electroencephalograph (EEG)-based epilepsy detection and intervention device
CN102283137B (en) Animal behaviour testing platform for optogenetics regulation and control
US8554324B2 (en) Mobile device for transcranial auto-stimulation and method for controlling and regulating the device
CN103721343B (en) Biological feedback headache treating instrument and headache medical system based on Internet of things technology
CN105311750B (en) A kind of sacral nerve stimulation system
ES2643045T3 (en) Apparatus for calibrating an invasive, electrical and desynchronizing neurostimulation
US11771918B2 (en) Optical stimulation system with on-demand monitoring and methods of making and using
ES2532140T3 (en) Device for the prescription and controlled administration of transcranial stimulation treatments with direct current in humans
CN106669030B (en) Optimization of current application
CN101557855A (en) Method and apparatus for promoting restorative sleep
ATE536911T1 (en) METHOD AND DEVICE FOR SAFE LONG-RANGE TELEMETRY WITH IMPLANTABLE MEDICAL DEVICES
US20180008145A1 (en) Dual eeg non-contact monitor with personal eeg monitor for concurrent brain monitoring and communication
CN104623808A (en) Deep brain stimulation system
CN104622468B (en) Deep brain stimulation system with external prediction function
CN103816614B (en) Biological feedback type headache therapeutic instrument and headache medical system based on internet of things technology
CN101485920B (en) Laser therapy device
US10420939B2 (en) Nerve stimulation to promote neuroregeneration
KR101541358B1 (en) Tissue treatment energy controlling device using tissue impedance and method thereof
CN103446672A (en) Self-rewarding stimulating system
WO2024083193A1 (en) Pulse generator, stimulator, medical system and computer-readable storage medium
CN109875553A (en) A kind of extensive epilepsy automatic detection early warning based on EEG equipment and treatment intelligence system
CN103446673A (en) Epilepsy treatment system
CN109069832A (en) Cerebral tissue stimulating method, equipment and computer program
CN102397623A (en) Implanted electrical nerve stimulation system with automatic alarm function and method
CN103445789A (en) Epilepsy monitoring system for test

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant