CN103446253A - Miao medicine composition for treating urinary calculus and preparation method thereof - Google Patents
Miao medicine composition for treating urinary calculus and preparation method thereof Download PDFInfo
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- CN103446253A CN103446253A CN2013104237026A CN201310423702A CN103446253A CN 103446253 A CN103446253 A CN 103446253A CN 2013104237026 A CN2013104237026 A CN 2013104237026A CN 201310423702 A CN201310423702 A CN 201310423702A CN 103446253 A CN103446253 A CN 103446253A
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Abstract
The invention discloses a Miao medicine composition for treating urinary calculus and a preparation method thereof. The Miao medicine composition is prepared from the following raw materials in certain proportions: plantain, talc, lygodium japonicum, radix achyranthis bidentatae, desmodium, licorice, cluster mallow fruit, endothelium corneum gigeriae galli, eucommia ulmoides and mirabilite. The raw materials can be made into various agents by using Chinese patent medicine conventional preparation methods. The Miao medicine composition has the effects of promoting diuresis for stranguria, relieving sclerosis and removing urinary calculus and is suitable for young patients with calculus and aged patients. The Miao medicine composition has the characteristics of treating both symptoms and root causes, being convenient to take, having no drug dependence and the like, the total effective rate of the Miao medicine composition reaches 96% in clinic, and therefore, the Miao medicine composition is worthy of popularization and application.
Description
Technical field
The present invention relates to a kind of Miao Ethnomedicine compositions for the treatment of urinary system calculus, particularly Miao Ethnomedicine is medicament prepared by raw material, belongs to the Chinese medicine category.
Background technology
The place that Miao in Guizhou is lived has advantageous natural environment.Here the peaks rises one above the other in the distance, have a moderate climate, rainfall is abundant, and natural vegetation is in great numbers, plants, moves, the mineral drug resource is very abundant, Miao people and other brother nationality multiply and live in Guizhou mountainous area for thousands of years, in the very long years that combat the disease, utilize local medical material treatment disease, summed up many effectively experience secret recipes, formed the national medicine of characteristic, be referred to as-Miao Ethnomedicine of medical circle.Because medical material great majority used are Chinese medicine, Miao Ethnomedicine returns root still to belong to the Chinese medicine category.Past, Miao ethnic group did not have word, and many secret recipes only depend on and pass from mouth to mouth, and was that the father passes son mostly.Obtained calculus the many people in mountain area of Zun Yi Miao ethnic group and can look for local pharmacist to treat with Miao Ethnomedicine, the effect that usually can obtain being satisfied with very much.Yet, due to the form of succession of passing from mouth to mouth, seriously restricted the development of Seedling medicine.Many people are flaunting the banner of Miao Ethnomedicine and are practising medicine in all parts of the country flowing, and make the people hard to tell whether it is true or false, also to Miao Ethnomedicine, bring many negative effects.Therefore the necessary medical heritage to this preciousness arranges exploitation, eliminates the false and retains the true, and allows outstanding Miao Ethnomedicine benefit more people, and regrettably, Miao Ethnomedicine treatment calculus also rests on traditional mode so far.
Summary of the invention
Order of the present invention is to provide a kind of having heavily fortified point, lithodialysis, calculus, treats the urinary system calculus effect significantly and the Miao Ethnomedicine compositions of taking convenience.
Solution of the present invention is to take into full account the internal and external factor that causes urinary system calculus, in view of urinary system calculus has the symptom of waist distending pain mostly, so the present invention treats calculus, at first from the strong waist of the kidney invigorating, sets about, and utilizes Radix Achyranthis Bidentatae, Cortex Eucommiae Bu Shen Zhuang waist function; Utilize sub-relieving stranguria by diuresis function of Herba Plantaginis, Talcum, Spora Lygodii, Herba Lysimachiae, the last of the ten Heavenly stems in winter; Utilize Endothelium Corneum Gigeriae Galli, the hard Sal Nitri function of Natrii Sulfasization; Utilize Radix Glycyrrhizae harmonizing drug sexual function, all medicines share, and have treating both the principal and secondary aspects of a disease, cure rate high and cure after be difficult for the characteristics of recurrence.
The present invention is achieved through the following technical solutions: (consumption is weight portion) Herba Plantaginis 10-20, Talcum 10-20, Spora Lygodii 25-35, Radix Achyranthis Bidentatae 8-18, Herba Lysimachiae 25-35, Radix Glycyrrhizae 2-8, Semen Abutili 10-20, Endothelium Corneum Gigeriae Galli 10-20, the Cortex Eucommiae 8-18, Natrii Sulfas 15-25.
Preferred feedstock weight (part) ratio range of making pharmaceutical composition of the present invention is to be Herba Plantaginis 13-18, Talcum 13-18, Spora Lygodii 28-33, Radix Achyranthis Bidentatae 10-15, Herba Lysimachiae 28-33, Radix Glycyrrhizae 3-6, Semen Abutili 13-18, Endothelium Corneum Gigeriae Galli 13-18, the Cortex Eucommiae 10-15, Natrii Sulfas 18-23.
The optimum weight of pharmaceutical composition of the present invention (part) proportioning is: Herba Plantaginis 15, Talcum 15, Spora Lygodii 30, Radix Achyranthis Bidentatae 12, Herba Lysimachiae 30, Radix Glycyrrhizae 5, Semen Abutili 15, Endothelium Corneum Gigeriae Galli 15, the Cortex Eucommiae 12, Natrii Sulfas 20.
The pharmacological action of its each raw material is:
1. Herba Plantaginis: cold in nature, sweet in the mouth.Return kidney, liver, lung meridian.Effect: relieving stranguria by diuresis;
2. Talcum: cold in nature, sweet in the mouth is light.Return stomach, urinary bladder channel.Effect: relieving stranguria by diuresis;
3. Spora Lygodii: cold in nature, sweet in the mouth, salty.Return small intestinal, urinary bladder channel.Effect: relieving stranguria by diuresis;
4. Radix Achyranthis Bidentatae: property is flat, bitter in the mouth, acid, return liver, kidney channel.Effect: blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome;
5. Herba Lysimachiae: property is flat, sweet in the mouth, light.Return liver, gallbladder, kidney, urinary bladder channel.Effect: relieving stranguria by diuresis, removing toxic substances and promoting subsidence of swelling;
6. Radix Glycyrrhizae: property is flat, sweet in the mouth.GUIXIN, lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, the property of medicine that is in harmonious proportion, cushion is strong;
7. Semen Abutili: cold in nature, sweet in the mouth.Return large intestine, small intestinal, urinary bladder channel.Effect: relieving stranguria by diuresis;
8. Endothelium Corneum Gigeriae Galli: property is flat, sweet in the mouth.Return spleen, stomach, small intestinal, urinary bladder channel.Effect: change hard Sal Nitri;
9. the Cortex Eucommiae: sweet in the mouth warm in nature, micro-suffering.Return kidney, Liver Channel.Effect: invigorating the liver and kidney, bone and muscle strengthening;
10. Natrii Sulfas: cold in nature, salty in the mouth, hardship.Return stomach, large intestine channel.Effect: under rushing down, softening the hard mass, heat clearing away.
Pharmaceutical composition of the present invention can adopt the conventional preparation method of Chinese patent medicine to prepare, and preparation method of the present invention realizes by the following method: first Herba Plantaginis, Radix Achyranthis Bidentatae, Herba Lysimachiae, Radix Glycyrrhizae, Semen Abutili, Endothelium Corneum Gigeriae Galli, the Cortex Eucommiae are cleaned respectively to hot-air seasoning, be ground into 120 order fine powders, then mix to mix all with Natrii Sulfas, Talcum, the Spora Lygodii of powdery and process by ultraviolet disinfection afterwards, finally incapsulate (every 1 gram).
Present composition result in clinical application shows to have following advantage:
1: the present invention's medicine used and consumption all meet pharmaceutical control law and state-promulgated pharmacopoeia regulation, the avirulence side effect;
2: the present invention is without decoction, the sterilization standard, and taking convenience, meet the state food health law;
3: compatibility is reasonable, and therapeutic effect is obvious, and the cycle that takes effect is shorter, can not produce drug dependence.Not only person between twenty and fifty can use, and the old people also can use.
For showing the therapeutic effect of the present invention to urinary system calculus, holder Zunyi sunlight hospital of special commission uses the present invention through 100 routine clinical observations, and select symptom, medical history, age, the roughly the same identical number patient's matched group of sex, Details as Follows: the diagnostic criteria of urinary system calculus in diagnostic criteria reference " new Chinese medicine guideline of clinical investigations " [1]: 1. there is typical renal colic, stomachache and hematuria history (comprising routine urinalysis or microscopic hematuria or gross hematuria), and can be with symptom and percussion tenderness over kidney region such as frequent micturition, urgent micturition and dysureas.2. ultrasound diagnosis prompting each position calculus of urinary system or with hydronephrosis.3. the abdominal X-ray plain inspection shows the calculus shade.Possess have 1. Xiang Bingyou any one is diagnosable 2. or 3..All without obvious renal function injury and other acute abdomen, calculus diameter<1.0 cm, and eliminating ureteral obstruction, obstructive nephropathy, kidney and ureter are in congenital malformation, renal tuberculosis, or severe cardiovascular disease, hepatic renal dysfunction get rid of anemia of pregnant woman, psychotic, other all can include this group therapeutic domain in.
Observe case and all derive from Zunyi sunlight hospital outpatient and inpatient totally 200 examples, the symptoms such as waist abdomen pain in various degree and paruria are arranged mostly, waist stomachache shows as the paroxysmal aggravation and to lower abdomen and perineal position radiating pain, or with feeling sick, vomit, be in a cold sweat etc.; 33 routine symptoms are not obvious, find lithangiuria in health check-up.All cases is all taken the photograph sheet or intravenous urography or CT scan through B ultrasonic or abdominal X-ray and is diagnosed as urinary system calculus.Stone location: renal calculus 82 examples, ureteral calculus 76 examples, vesical calculus 9 examples, calculus of urethra 5 examples, renal calculus ureteral calculus 28 examples; Merge 66 examples of hydronephrosis in various degree, gross hematuria 31 examples, urinary system infection 59 examples.The calculus transverse diameter is greater than 0.5 cm and is less than 0.8 cm, and vertical footpath is greater than 0.6 cm and is less than 1.0 cm.200 routine patients are roughly the same by calculus size, medical history, age, sex, are divided into treatment group and matched group.Treatment group 100 examples, male 63 examples, female's 37 examples; 18~64 years old age, average 37.2 years old; The course of disease average (1.15 ± 0.49) year.Matched group 100 examples, male 60 examples, female's 40 examples; 20~65 years old age, average 37.4 years old; The course of disease average (1.20 ± 0.46) year.Relatively, difference there are no significant meaning (P > 0.05), have comparability for 2 groups of sexes, age, the course of disease etc.
Treatment group is used the Chinese medicine of embodiment 2.The Chinese medicine of embodiment 2 is ground into respectively to 120 order fine powders, mixes to mix all and after sterilization treatment incapsulating (every 1 gram).Every day three times, each 6, bfore meals, old weak person reduces by half.Instruct the patient suitably to strengthen amount of drinking water every day, and coordinate suitable jumping exercise, in order to promote calculus to discharge.
Matched group is taken uralyt (German Warsaw pharmaceutical factory produces, and China imports and exports No. X960447, medicine registration certificate, No. 1014886th, China trademark registration certificate), each 2, every day 2 times.Within 15 days, be 1 course for the treatment of, according to the state of an illness, can treat continuously 1~3 course for the treatment of.If occur in therapeutic process, the violent person of renal colic can coordinate the Western medicine relieving spasm to stop pain, and the concurrent infection person can select suitable antibiotic infection control, after transference cure or pain relief, stops using.
The curative effect judging standard of the middle urinary system calculus of criterion of therapeutical effect reference " new Chinese medicine guideline of clinical investigations " [1] is also drafted in conjunction with clinical symptoms.Cure: clinical symptoms and sign disappear, and hematuria is turned out cloudy, and calculus is discharged, and check B ultrasonic or abdominal X-ray are taken the photograph sheet and shown that calculus shade and hydronephrosis disappear.Effectively: clinical symptoms and sign disappear or obviously alleviate, and hematuria is turned out cloudy or reduced, and B ultrasonic or abdominal X-ray are taken the photograph sheet check calculus and before dwindled more than 1/3, or, more than moving down 3 cm, hydronephrosis obviously reduces or disappears.Invalid: clinical symptoms is without significant change or slightly alleviate, and it is unchanged without mobile that B ultrasonic or abdominal X-ray are taken the photograph sheet check calculus, and hydronephrosis is without improvement.
Therapeutic outcome shows: 3 the course for the treatment of internal therapy group cure 62 examples, effective 34 examples, invalid 4 examples, total effective rate 96%; Cure 45 examples, effective 36 examples, invalid 19 examples, total effective rate 81% in the matched group same time.And in the healing case 1 the course for the treatment of internal therapy group 27 examples, matched group 15 examples, 2~3 the course for the treatment of internal therapy group 35 examples, matched group 30 examples.Relatively, difference has significant (P<0.01) to 2 groups of curative effects, and prompting treatment group curative effect obviously is better than matched group.
The treatment group calculus is cured 62 examples (cure rate 62%), and discharge or extinction time are (7.35 ± 3.05) d.The matched group calculus is cured 45 examples (cure rate 45%), and discharge or extinction time are (13.28 ± 3.52) d.Relatively, difference all has significant (P<0.05) for two groups of calculus discharge rates and efflux time.Untoward reaction is observed: all do not find obvious untoward reaction during 2 groups of case treatments, severe complication appears in none example.
the specific embodiment
Embodiment takes raw material (kilogram) by following proportioning:
1. Herba Plantaginis 13, Talcum 18, Spora Lygodii 33, Radix Achyranthis Bidentatae 10, Herba Lysimachiae 33, Radix Glycyrrhizae 3, Semen Abutili 18, Endothelium Corneum Gigeriae Galli 13, the Cortex Eucommiae 15, Natrii Sulfas 18;
?2. Herba Plantaginis 15, Talcum 15, Spora Lygodii 30, Radix Achyranthis Bidentatae 12, Herba Lysimachiae 30, Radix Glycyrrhizae 5, Semen Abutili 15, Endothelium Corneum Gigeriae Galli 15, the Cortex Eucommiae 12, Natrii Sulfas 20;
3. Herba Plantaginis 18, Talcum 13, Spora Lygodii 28, Radix Achyranthis Bidentatae 15, Herba Lysimachiae 28, Radix Glycyrrhizae 6, Semen Abutili 13, Endothelium Corneum Gigeriae Galli 18, the Cortex Eucommiae 10, Natrii Sulfas 23.
Production method is first Herba Plantaginis, Radix Achyranthis Bidentatae, Herba Lysimachiae, Radix Glycyrrhizae, Semen Abutili, Endothelium Corneum Gigeriae Galli, the Cortex Eucommiae to be cleaned respectively to hot-air seasoning, be ground into 120 order fine powders, then mix to mix all with Natrii Sulfas, Talcum, the Spora Lygodii of powdery and process by ultraviolet disinfection afterwards, finally incapsulate (every 1 gram).Also can be produced into other medicament by the conventional production method of Chinese patent medicine.
[list of references][1] of State Food and Drug Administration new Chinese medicine guideline of clinical investigations [S] 1993:175-178.
Claims (5)
1. Miao Ethnomedicine compositions and a preparation method for the treatment of urinary system calculus is characterized in that what it was comprised of the medicine material of following weight proportion:
Herba Plantaginis 10-20, Talcum 10-20, Spora Lygodii 25-35, Radix Achyranthis Bidentatae 8-18, Herba Lysimachiae 25-35, Radix Glycyrrhizae 2-8, Semen Abutili 10-20, Endothelium Corneum Gigeriae Galli 10-20, the Cortex Eucommiae 8-18, Natrii Sulfas 15-25.
2. the Miao Ethnomedicine compositions for the treatment of urinary calculi according to claim 1, wherein the weight proportion of each raw material is:
Herba Plantaginis 13-18, Talcum 13-18, Spora Lygodii 28-33, Radix Achyranthis Bidentatae 10-15, Herba Lysimachiae 28-33, Radix Glycyrrhizae 3-6, Semen Abutili 13-18, Endothelium Corneum Gigeriae Galli 13-18, the Cortex Eucommiae 10-15, Natrii Sulfas 18-23.
3. the Miao Ethnomedicine compositions for the treatment of urinary calculi according to claim 1, wherein the weight proportion of each raw material is:
Herba Plantaginis 15, Talcum 15, Spora Lygodii 30, Radix Achyranthis Bidentatae 12, Herba Lysimachiae 30, Radix Glycyrrhizae 5, Semen Abutili 15, Endothelium Corneum Gigeriae Galli 15, the Cortex Eucommiae 12, Natrii Sulfas 20.
4. according to the Miao Ethnomedicine compositions of claim 1,2 or 3 described treatment urinary systems, it is characterized in that said medicament is capsule.
5. the preparation method of the Miao Ethnomedicine compositions of the described treatment urinary system of claim 4, it is characterized in that first cleaning by Herba Plantaginis, Radix Achyranthis Bidentatae, Herba Lysimachiae, Radix Glycyrrhizae, Semen Abutili, Endothelium Corneum Gigeriae Galli, the Cortex Eucommiae, respectively hot-air seasoning, be ground into 120 order fine powders, then mix to mix all with Talcum, Spora Lygodii, the Natrii Sulfas of powdery and process by ultraviolet disinfection afterwards, finally incapsulate.
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Cited By (3)
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CN105079333A (en) * | 2014-05-14 | 2015-11-25 | 黄思齐 | Medicine for treating urinary calculi |
CN106943559A (en) * | 2017-05-05 | 2017-07-14 | 青岛市黄岛区中医医院 | It is a kind of to treat Chinese medicine composition of stone in urinary system and preparation method thereof |
CN108339033A (en) * | 2018-05-02 | 2018-07-31 | 湖南众医药咨询有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating calculus |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105079333A (en) * | 2014-05-14 | 2015-11-25 | 黄思齐 | Medicine for treating urinary calculi |
CN106943559A (en) * | 2017-05-05 | 2017-07-14 | 青岛市黄岛区中医医院 | It is a kind of to treat Chinese medicine composition of stone in urinary system and preparation method thereof |
CN108339033A (en) * | 2018-05-02 | 2018-07-31 | 湖南众医药咨询有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating calculus |
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